Source : Nature review drug Discovery

https://deserthopetreatment.com/addiction-guide/drug-industry-trends/

Outwardly they are effective in the reduction of psychotic symptoms initially, but their mechanism remains unusual, and in many cases may cause the symptoms for which they are marketed to treat.

The dopaminergic system underlies reward. By capping this system, pleasure can no longer be experienced, and in many cases, such as those of OCD, Depression, and Substance Abuse Disorder, prognosis is worsened. Antipsychotics should be a last resort treatment when all other differential diagnosises are entertained.

These words are my opinion and my conclusion can be drawn through first hand experience. I tried to illustrate my points as clearly as possible. I cannot convince the majority of psychiatrists that their current treatment is logically flawed and ethically questionable. But, hopefully, I can inspire healthy skepticism into a trillion dollar industry.

"What is right is not always popular and what is popular is not always right.” Albert Einstein

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-Risperidone may induce psychiatric symptoms and psychosis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231559/

-Risperidone irreversibly binds to and inactivates the h5-HT7 serotonin receptor

https://pubmed.ncbi.nlm.nih.gov/16870886/

-Drug-induced supersensitivity psychosis revisited: characteristics of relapse in treatment-compliant patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736929/#bibr10-2045125311431105

-Risperidone-induced psychosis and depression in a child with a mitochondrial disorder

https://pubmed.ncbi.nlm.nih.gov/16092915/

-Risperidone-induced mania: An emergent complication of treatment

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231559/

-Improper Use of Antipsychotic Medication

https://www.americanbar.org/groups/law_aging/publications/bifocal/vol44/bifocal-vol-44-issue3/improper-use-of-antipsychotic-medication/#:~:text=According%20to%20Human%20Rights%20Watch,are%20meant%20to%20help%20patients.

-"It is not easy to differentiate ASD from psychosis among some adult patients, even for expert psychiatrists. Cognitive rigidity in ASD may be similar to delusions in psychosis. Unusual behaviors in ASD can be confused with disorganized behaviors in psychosis."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943599/#:~:text=It%20is%20not%20easy%20to,with%20disorganized%20behaviors%20in%20psychosis.

-Dissociation and misdiagnosis of schizophrenia in populations experiencing chronic discrimination and social defeat

https://pubmed.ncbi.nlm.nih.gov/36065490/

-Consequences of Antipsychotic Medications on Mental Health

"Importantly, these drugs do not cure the disease, but only treat the symptoms of the disease"

https://pubmed.ncbi.nlm.nih.gov/35170421/#:~:text=Antipsychotics%20may%20lead%20to%20increased,%2C%20renal%2C%20or%20respiratory%20disorders.

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Its ridiculous to me that people still don't understand the horrors these companies put people through and the dogmatism everyone adopts surrounding a Doctor's opinion.

https://www.census.gov/history/pdf/api-082021.pdf

https://fiscaldata.treasury.gov/americas-finance-guide/federal-spending/

https://www.scmp.com/news/china/science/article/3243209/cocaine-price-hike-chinas-new-cancer-drug-approved-us-will-cost-30-times-more?campaign=3243209&module=perpetual_scroll_0&pgtype=article

A cancer drug created by chinese researchers has been approved by the FDA. In China 1 vial costs 280 $ USD. Once in America, the same vial goes for 8900$. There is no way any person in the industry can justify the massive price hike. This is an insult to people who just want to live, get their lives back and move on. You thought the Shkreli thing with the insulin was funny? Wait until more chinese backed medicines enter the U.S. Our FDA is also clearly bought and sold.

I just saw one of those ridiculous medication commercials, and the medication is supposed to help women with hot flashes during menopause. When they go on the speel on the end about the possible side effects, one of the damn side effects is hot flashes.

So I think the medication doesn't work for most, and they just have to legally cover their asses. What do you all think? Why does this medication exist if the side effects are the symptoms?

I am currently reading the book "Overdosed America" by John Abramson, M.D.

In the book he discusses how pharmaceutical companies only care about profit and making their shareholders happy. Not actually making lives better or improving old medications.

The ways that these drug companies are distorting their data is actually sickening. It's crazy to think that they OWN THEIR OWN DATA, it's not public. They can hide whatever they want. Sometimes, they will drop participants, leave out 6 months of data, certain types of study design that hide adverse effects, give only relative risk reduction and not absolute risk reduction, just to name a few. It's all advertising and there is no regulation to prevent them from straight up committing fraud. The FDA does what it can, but sometimes things fall through the cracks with clever study design and advertising/data manipulation. He also shows that even prestigious journals like JAMA and NEJM cannot be trusted as accurate since the pharmaceutical companies are involved in the publishing. Sometimes peer-reviewers are have commercial interests with these Pharma companies.

So, how as physicians, can we trust that the sources that we are taught? We are all taught "evidence-based medicine", but how can we see through the B.S. and really find studies/data that hasn't been manipulated? I have heard the "5 year rule" from many physicians. They tell drug reps to not talk to them about a new drug until 5 years as passed. This is probably a solid way to go about it.

If there is 50-100 studies about a certain drug being effective (p=0.01), then we can assume it's not false data, right? Believing so would be downright conspiratorial.

tl;dr - How do we practice evidence based medicine in the face of commercially-spun data?

P.S. - If you haven't read the book, I highly recommend. He also went on Rogan.