Hi, I am currently looking for an online graduate level biochemistry course that I can take without pursuing a master's degree. Does this exist? Are there schools that offer this?

Hello everyone! As someone who already has a masters in biochemistry, what's the fastest I could complete a PhD? Considering options in North America, Australia and Europe. Any insight appreciated!

Hey biochemists. So I just started my career at my lifetime company. Don’t wanna name it out of fear of like confidentiality breach or anything. But it’s one of the largest pharmaceutical companies in the world. I am on one of their largest campuses that has everything from manufacturing to RnD all housed on site. I am currently an Environmental monitoring technician. My goal is to eventually become a principal RnD scientist. But I only have my bachelors in biochemistry. Do you guys have any ideas for how I should laterally try to move up to that position? I am thinking I move from sampling to testing to get me analytical experience, and from there maybe something data related? But then I’m stuck trying to bridge the gap. I also plan to use the tuition reimbursement program at some point to try and pick up a masters. Any advice or suggestions/ criticism is welcome. Thanks everyone

I’m starting to study for an exam which requires a lot of memorisation and I’ve heard a lot about Anki and how helpful it is. However, I find it to be very time consuming. Does anyone have any tips on how to make this process super fast and efficient so I can spend more time studying than making flashcards?

I’ve been looking for a job since my grad in May nothing yet. Any leads or help???

Dont know if questions like this are allowed here and if it isn't im sorry

I didnt have much luck on google, so i came here. I saw a question asking "oxygen binding does not oxidize the iron in the heme portion of hemoglobin because..." and the answer is supposed to be that the iron is already in its oxidized form. Which would mean that after oxygen binds, the iron is in the ferric state? I thought oxidation happens after oxygen is released, so im a bit confused here (i may be wrong as well). I'd appreciate it if someone could enlighten me

Trying to decide what classes to take?

Want to know what the job outlook is with a biochemistry degree?

Trying to figure out where to go for graduate school, or where to get started?

Ask those questions here.

Hello everyone. I'm a high school student working on a proposal for a cell-culture experiment I designed. For this experiment, I'm testing the effect of a few chemicals on BBB permeability using the Millipore Sigma Vascular Permeability Assay. I'm measuring permeability by finding the FITC fluorescence using a fluorometer, which I know give units in RFU.

My teacher commented on my proposal saying that I need to clarify what the RFU units are relative too. I had no idea what she meant, and I cannot find any clarifying information. Do any of y'all know the answer?

I just finished up a biochemistry class this semester and I thought learning about the interconnections between all of the metabolic pathways was super cool. Learning about those pathways (I’ll admit in a weird way) has sorta made me interested in getting healthy because I have a deeper understanding of what’s going on in my body on the molecular level and feel like I can make a difference now that I know better. Does anyone have any book recommendations (PREFERABLY NOT TEXTBOOKS) that talk about the methods or eating healthily / how to have a healthy lifestyle and actually go into the biochemistry of it all? It doesn’t have to go down all the way to mechanisms or crazy stuff like that, but maybe just talk more about the metabolic map and how you can base a healthy lifestyle around that? Super specific request but I thought I’d ask to see if anyone has any recommendations bc I think I would really enjoy something like that!

So, I'm looking into what potential damage could be caused by regualr use of ivermectin. For as long as its been around and all the doses that have been used it seems most research is done in vitro.

Of course many were using it during the height of covid (human and animal formulations alike) and most adverse effects I can find info on were about simple acute overdoses that people usually fully recovered from quickly.

I'm looking into what potential permenant or at least long term effects could occur though.

See there's many articles about its potential immune modulating effects so I wonder if that could inflict autoimmune conditions perhaps? Or at least trigger or aggrevate existing ones. (I've seen a few people claim those with autoimmune conditions shouldn't use it but have found no sources about that in particular.) What about lasting effects to the nervous system and brain, to the lymphatic system or the various gland systems (exocrine, endocrine ecltc.) Of the body as I've seen some claim it had some bad drying effects. Also what conditions other than pregnancy are contraindications of ivermectin?

Amd lastly, what can be done to heal or potentially reverse the effects?

I am trying to align one protein with the epitope of another protein using TM-align. After alignment, I am trying to visualize that using PyMOL. However, using PyMOL inbuilt functions like "super" or "align" lead to a different alignment due to their different algorithms. I also know that US-align generates a PDB file of both regions aligned but that includes only the aligned part (very small region in my case). I wanted to show more portion of the protein along with the alignment (as shown in the attachment). What are the best ways to do it?

https://preview.redd.it/wzahe8yq6h7e1.png?width=531&format=png&auto=webp&s=8440d4103ac95b2db08776454565e1e41197fe99

It's widely known and accepted that two sulfahydryl (-SH) R-groups can covalently link together in the tertiary protein structure. With a hydroxyl (-OH) R-group, is it possible to covalently bond the central C of two amino acids together? That is, can the hydroxyl R-group undergo dehydration synthesis with the H bonded to a different central C on another amino acid?

Hey guys, i am doing an bacharelors degree in nutrition here in Brazil, and biochemistry is one of the disciplines that i loved, recently bought the biochemistry ilustrated book from Denise Ferrier, and i am trying tô study from it, the chemisty in high school wasn't very good to me, só somethings are Very new too. Do you guys recommend any study method, any yt channel that compactuates with the book or anything?(Just reading alone isn't the way i am used to study) Thanks in advance.

Let's say someone heard that substances in grapefruit inhibit CYP3A4. Let's say that, even though they understand it's not ideal, one of their coping mechanisms is xanax. Because of a limited supply, they could try to combine 0.4 dcl grapefruit juice with at most 2,0 mg alprazolam. If they made this a long-term habit, could there be any unexpected health risks?

Hi all, hoping for some clarification from the experts! Was doing some questions in prep for the mcat and came across a bond that looked like this. They labeled it as an alpha 2-3 linkage.

However I’m a bit confused on why it is not beta. I had learned that you take the C5/6 Carbon and compare it to the direction of the anomeric carbon. Both groups here appear to be in the equatorial position on C2 and C6. On these carbons, equatorial groups face downwards so I assumed it to be a Beta 2-3 linkage. However this was not correct.

Any help in understanding this would be greatly appreciated!!!!

Hi all, I am seeking a pharmaceutical scientist to help me create an innovative over-the-counter product. Where would I go about finding professionals like this? Specifically seeking those who have experience navigating the regulatory and manufacturing process for fairly common over-the-counter drugs (but this will be a new formulation and if successful, a new product category). Thanks!

I'm a lab tech student so teachers only explain how things work and that's it.

I'm willing to study biochemistry in the future but I don't think they'll explain how cell things were discovered. I really want to read a book explaining how the kreb's cycle, cori's cycle, glucolisis, hormones... were discovered. Even one that explains how new artificial molecules are done, like the new intelligent insulin.

Does anyone know if such a book exists? Or a youtube channel or podcast. I don't really mind as long as it covers (almost) everything.

I have one talking about proteins but it's not that deep...

I made a flashcard website for learning various topics, including biochem.

Putting it out there in case it can be helpful for others.

Writing a paper?

Re-running an experiment for the 18th time hoping you finally get results?

Analyzing some really cool data?

Start off your week by sharing your plans with the rest of us. å

I reckon we can safely say they'd have to go @least as far as oxygen … I'd say it's prettymuch a no-brainer that the periodic table could not be curtailed short of oxygen, & life as we know it still be possible.

But what about phosphorus (Z=15) & sulphur (Z=16) & chlorine (Z=17)? The compound adenosine triphosphate is an extremely important link in the chain whereby metabolism converts chemical energy into muscular action; & sulphur is a constituent of certain metabolically important compounds, eg methionine; & chloride ions, together with sodium ions, play an important role in electrical potential gradients across cell walls. And calcium (Z=20) (together with phosphorus, again) is essential in bone. So maybe our curtailed periodic table would have to go @least as far as 20 … or just maybe 'workarounds' could have come-about involving only elements up to oxygen? … but it seems rather unlikely, though.

And elements yet higher-up than calcium play a role: an obvious one is iron in hæmoglobin; & there's cobalt in vitamin B12 … but it's my intuition (which might be wildly awry - it's why I'm asking!) that in the absence of these elements 'workarounds' involving only lighter elements could have emerged. One major item that possibly strongly militates against this notion, though, is the iodine in the thyroid gland: I entertain somewhat stronger doubts that such a workaround could have come-about for that … but then … maybe it still could have.

And it seems to me that the higher up we go the greater the likelihood is that life could have found a way to subsist on the basis of the elements of lesser atomic № only. I've heard, here-&-there, that certain of the elements of really quite_ high atomic № are required in miniscule amounts as 'trace elements' … but it seems easier to suppose that there could be workarounds in the absence of those - other ways of accomplishing in metabolism whatever it is those trace-elements help with.

So I wonder what the cutoff actually is , & whether anyone else has any thoughts or information along those lines.

My father is an endocrinologist and has a PHD in biochemistry. He’s… always talking about lipids… due to his work.

Every year we get him a chemistry themed silly shirt. For example his current favorite is a shirt that says “I were this shirt periodically” with the table of elements on it.

Anyways, we have custom made some shirts and I am asking for help.

He’s a super smart dude and the joke could honesty be pretty deep. He can wear it when he goes to the AHA conferences or any of the other 3-4 conferences he attends yearly.

Hello! I’m currently majoring in pharmacology and minoring in biochem and was thinking of switching to a business minor (business double major not allowed).

In high school I wanted to have a career in industry and maybe go for med eventually, or at least pharmacy. But I’ve been struggling with STEM courses and I’m honestly burnt out and not sure if I even want this still. Besides, my GPA took a hit and at this rate, I’ll never be able to fully recover and graduate with 3.5+ (no sharp learning curve so far). I’m not ready to let go of my pharmacology but was thinking of minoring in business instead. Although I don’t have a business background, I once took an economics class in first year that I greatly enjoyed and if anything, at least it will boost my a GPA a bit and help lighten the STEM load.

What are my career options in pharma/biochem with a STEM bachelors and business minor? i own a family business back home so it might be somewhat useful but I want options outside of that. I understand theres only so much I can do without an MBA too. I considered pharma and other health sciences, but like I said I need backups because of my GPA (I have tons of volunteer experience though).

I know I dont know much but I’m feeling very lost, please be kind! If youve majored in biochem or similar and minored in business, hows it going for you? Advice please.

I've been thinking about acrylamide formation using amino acids other than asparogine, so naturally, I went straight to glutamine.

Basically, I wanna know if the top reaction could happen in slightly basic conditions around 7.6 pH, no lower than physiological pH, because the Maillard reaction and acrylamide formation happen at slightly basic conditions.

Even if wouldn't happen like it's drawn in the "basic conditions," would it be realistically possible for the double bond to move over?

I drew a hypothetical acidic rxn mech too just in case, although I've been under the impression that carbocations (without any resonance) are too unfavorable to happen in organisms (with some small exceptions?), but acrylamides are often made at upwards of 100°C anyway.

Hi all,

I'm currently reading through the enzymes section of a biochem textbook and was hoping someone could explain the math behind the following: "catalase reduces deltaGdouble dagger Ea from +71 kJ/mol in the uncatalyzed reaction to just +8kJ/mol and, in doing so, increases the reaction rate 10^15-fold." I thought the reaction rate would increase around 10^9 fold (71/8)..

I know this is probably a minor detail but would really appreciate some clarification. Is there some sort of equation I'm missing here? Thanks

I have a biochemistry exam tomorrow I need to lear Glycolysis PPP, Urea cycle, AA synthesis and AA catabolism as well as Fa degradation and Fa synthesis, and also lipolyses and Lipogenesis any advice