I damaged my brain with alcohol abuse, drug abuse and not sleeping. Also have some nerve damage. Does anyone has experience with treating these things with stemcells? Or know a location that can help with these things thats trustworthy?

My son is 3y3m diagnosed with autism. We thinking to get him stem cell therapy. We’re located in US. Any leads regarding hospitals? Also, I read a lot of positive and negative reviews regarding stem cell therapy. I want to really know if this helps my son in anyway. Thanks in advance!

Has anyone here being treated by Dr. Kong? I have listen to her interviews and I like what she says, but this is all I know.

Hello all, I got an estimate a few days ago for 50mil stem cells from Immunotherapymx in Puerto Vallarta for a knee issue. I tried to do my research on them and see some positives, some negatives. The thing that makes me question them is that they are like $1500usd less than most other places posted prices. Has anyone had the same experience? or Thoughts?

Hello,

Has anyone have good experience with R3 stem cells in Tijuana? They quoted me $4700 for 50 million cells. I’m going for foot pain due to scar tissue after several foot injuries. My doctors in California told me stem cells might help as they did not have any other surgical recommendations for me. I thought $4700 was pricey, but other clinics in TJ charge even more. Any good experiences at R3?

I'm looking for stem cell treatment for Osteoarthritis of both of my knees. Hoping someone that had the treatment can provide some guidance from someone that's done it before. I found these two places just on the internet.

Panama: https://www.cellmedicine.com/ 26,900USD

Costa Rica: https://stemcellstransplantinstitute.com/ $8,500USD

How come prices vary so much? Does any have recommendations, and is it worth doing?

I have been looking into stem cells for a while now in regards to auto immune diseases and from what I gather mexico or Panama are the places to go. In particular I have been considering stem cell Institute in Panama or Dream body clinic in Mexico. Im just confused as to why Stem cell institute is so much more expensive is it really better quality or are you mainly paying for the name and reputation? Also not sure how legit dream body clinic is, I have read some odd reviews on reddit but it’s so difficult to get any information without bots shilling for other clinics or bad mouthing other clinics. If anybody with experience has any insights or recommendations I would be extremely grateful for any kind of help!

Hello, I have bulging disc in my l5 s1 joint, and another less severe in the next joint up I believe. I am trying to find all information I can on stem cell treatment for this issue, and what the outcomes have been. I am talking to ways 2 well in Texas, and daisy stem cell therapy center in south Carolina. Does anybody know anything about either of these places? what their success rate is like? Or anywhere else I should look into? Of course I have to pay for this out of pocket, and the recovery time is estimated to be 8 weeks. It's going to be a big financial hit so I want to make the best choice I can. Thank you

Hi! I'm looking for places people like for stem cell treatment in Washington state. Specifically to treat osteoarthritis of the knee. Thanks!

I've done 2 of his PICL (BMAC for cervical spine) treatments, and he's currently answering questions on my sub r/cervical_instability. If you miss it, he also does a live Q&A on Sundays on his youtube.

AMA link - https://www.reddit.com/r/cervical_instability/comments/1gy6nox/dr_centeno_here_answering_questions/

His Youtube link (usually does 11 or 12pm EST live on Sundays and fields questions) -

https://www.youtube.com/@centenohome/streams

Anyone heard of, or used, this company? It’s run by Dr Sandra Kaufman - who is an author and on a lot of YouTube videos.

They do quarterly “events” that seem to be well priced. Exosomes only.

https://clubexosome.com/

Longevity Biohacker Dave Pascoe has used them and talks about it on his site.

Hello everyone,

I’m part of a startup based in Canada, and we’re planning a project that involves generating iPSC lines with specific gene knockouts (KOs). We’re exploring the costs involved in subcontracting this work and would appreciate any insights from those experienced with iPSC line generation.

Project Overview:

We will work with two iPSC line backgrounds:

1. A standard, widely used line that can be provided by the subcontractor.

2. An iPSC line we already have and will supply.

For each line, we aim to create knockouts for 20 different genes (one KO per gene).

For each knockout, we require:

A pool of nucleofected cells.

Two heterozygous clones.

Two homozygous clones.

This adds up to 200 lines total:

5 samples per KO (1 pool + 2 heterozygous + 2 homozygous).

100 lines per iPSC line background (20 genes x 5 samples).

2 backgrounds (our line + their line).

Question:

What is the approximate cost of such a project (I don't need an exact number, a range would be good enought as starters)? Would it likely fall into one of these ranges (in CAD)?

$125,000–$250,000? Or more $250,000–$400,000 Even $400,000–$600,000? 600K+?

If you’ve had experience with iPSC generation, particularly in a high-throughput setup or with academic/commercial providers, I’d love to hear your insights or recommendations!

How many times can cells be expanded before they become useless in therapy?

It depends on the type of cells to be used in therapy, quantities produced and availability of source tissue. Mass produced mitotic cells such as mesenchymal stromal cells don’t need to be repeatedly expanded unless umbilical cord tissue is scarce in the region. Differentiated cells such as neural lines may be expanded repeatedly by entities not producing them originally.

Cells cannot undergo infinite division. At the end they will stop dividing, and therefore expansion reach an ultimate inhibition. The number of times cells have already divided will limit their division capacity in-vivo. This restricts therapeutic strategies involving long-term goals such as immune modulation. Short term therapeutic goals do not require cells to divide in-vivo but differentiate very quickly. Their division limiting factors won’t matter, unless their role is of greater value in the long term.

Repeated expansions may also impact cellular product viability especially where it is not being thoroughly checked before human administration. This applies to entities merely estimating their cell count instead of using cell sorting equipment to objectively measure productivity and purity.

I have Dysautonomia stemming from multiple autoimmune diseases (Sjogren’s, Lupus, Psoriasis with Psoriatic Arthritis). I have neuropathy that is worsening/spreading. The Dysautonomia was diagnosed at Stanford. It is effecting most areas of my functioning; GI issues, severe heat intolerance, I do not sweat nor have any skin (or eye gland) oils, chronic sleep problems, transitory episodes of POTS, joint pain and bad fatigue, a myriad of skin issues, adrenal failure, hair loss and other health problems.
I had a PRP/stem cell injection in my hip for degenerative hip (as I am not a safe candidate for surgery/physical therapy) last January and it has been very very helpful. That gives me some hope that I might be a good candidate for stem cell treatment for my Dysautonomia. Has anyone used stem cell therapy for Dysautonomia that is driven by autoimmune diseases?

My husband’s cousin used The Healing Revolution clinic for stem cell treatment. She has had Lupus and Fibromyalgia for over two decades. She was fairly homebound due to the extreme fatigue. She reports having very good results. Anyone else with experience there?

There are reps that market to dermatologist, plastic surgeons, estheticians, etc, about their exosome products. Since the FDA has not approved any exosome products, does this mean what these reps are doing is illegal? However, what if they only market topical treatment of exosomes (not injecting or IV systemically)? Is this still illegal and how is it illegal when you can purchase facial products all over the US with exosomes in their products and creams?

"Exosome products marketed for the treatment of human diseases and conditions are regulated as drugs under the FD&C Act and biological products under the PHS Act and are subject to premarket review and approval requirements." Is this referring to being injected or used systemically, but being used topically is okay? Does this mean even though its not FDA approved, as long as it is under the FDA GMP then its not technically illegal to distribute and can be used in the "wild west" until we get more information?

I guess since the exosomes are regulated under Good Manufacturing Practices (standards from the FDA themselves) that this makes it "okay" to distribute, not to mention that exosome therapy has shown promising results. Is it okay because it is all "still in review" to be approved by the FDA. I'm just wondering how can something be illegal, yet the FDA is okay with it being distributed and sold? It doesn't make sense to me so that is why I am asking for clarification.

I understand exosomes being injected or used systemically is more regulated by the FDA and I assume would be illegal, especially for a representative of a company to pitch to the local orthopedic surgeon for joint pain. I am talking about topical treatment of exosomes. Would this be illegal for reps to promote since its not being injected or used systemically?

Thanks, thanks, thanks for any input concerning these things and the legality for companies to promote exosomes to providers.

Is secretom good for diabetic type 2?

My functional wellness doctor is recommending an annual infusion of Vitti Lab's EV Pure exosome product and Wharton's Jelly. Does anyone have experience with this? Any guidance on pricing? They're quoting $2,650 for 4.5 cc of the EV Pure and $985 for the Wharton's Jelly.

EV-Pure™ IV Infusion and Wharton’s Jelly Pure Injection from Vitti Labs—are part of the emerging field of regenerative medicine, which aims to repair or replace damaged tissues through advanced biological treatments.

EV-Pure™ IV Infusion
This product contains exosomes derived from placental mesenchymal stem cells. Exosomes are small vesicles involved in cell communication and are being studied for their potential therapeutic benefits.

Wharton’s Jelly Pure Injection:
Derived from the gelatinous substance in the umbilical cord, Wharton’s Jelly is rich in mesenchymal stem cells and other bioactive components.

Hello, my name is Saint for short, I was recently in this episode of deep thinking and came across a rabbit hole of sorts. I was looking into HBOT (hyperbaric oxygen therapy) and came to the realization that oxygen increases cell growth/promotes cell growth even in the brain. I then thought about cells themselves, NSC can become specialized cells when renewing themselves so I thought hey if you used increased oxygen to promote cell growth in the brain (what the cells would need to differentiate into based on the need) and I started looking into further I found that neural stem cells usually differentiate on there own so my original question became what if we used increased oxygen with hNSC to try and promote brain repair I realized that similar clinical trials were ongoing a few years back but nothing that really hit my point links to the papers I'm more or less reading to ensure feasibility at some level.

https://health.ucdavis.edu/news/headlines/startup-developing-technology-to-combat-degenerative-diseases/2022/07

https://clinicaltrials.gov/study/NCT03269071?cond=Neural%20stem%20cells&rank=7

After looking to it a little better I realized the many complications of a system based on oxygen and HNSC overgrowth, cancers, etc. but if there were a way to limit the ammount of repair , use some sort of tumor supressent , find a way to make a kill switch so that the stem cells self destruct if abnormal growth is present kind of like a muti layered security system with real time imaging I think that most concerns can be mitigated by trials of animals and phasing in bigger animals then humans as a normal trial would most likely go.

I was just wondering if there was anyone else looking into things like this and could help me analyze the system a bit more with more insight.

I might sound like a stupid person asking stupid questions but I feel like this is needed for innovation.

Hi everyone,

I’m exploring BMAC stem cell therapy for a partial rotator cuff tear and was curious about how many stem cells are typically injected for this type of treatment in the UK. Any insight into the dosage, experiences, or reputable clinics would be very helpful.

Thank you!

My parents are looking into Healing-Revolution.com stem cell therapy. I’m worried they are jumping in without thinking. The stem cells they draw from umbilical cords of live babies, which has convinced them they can do it. Has anyone here had this type of stem cell therapy done? What are the benefits and drawbacks?

I was reading this article https://www.researchgate.net/publication/385426654_Systematic_Intravenous_Administration_of_Autologous_Mesenchymal_Stem_Cells_Is_Safe

but after reading it, I saw that it mentioned "Not Peer Reviewed Version" any idea what does that mean in the term of publication like this one ?

I spent years masturbating. I have pain in my testicles, back, I have trouble bending, if I ejaculate I have intense pain for days. Do you think stem cell therapy can help me heal and be virile and procreate?

I was diagnosed earlier in the year with this and the best understanding that I have of it is that my bone marrow stem cells are producing blood cells with the deleted chromosome. With the advances in stem cell research, i don’t understand why there aren’t any stem cell treatments, a way to propagate my good stem cells in a lab, or a way to modify my stem cells to attack the Myelofibrosis. Their only cure is chemo with bone marrow transplant. I’m open to trials or visiting other countries for non FDA approved therapies. Anyone in this sub have any insight into this, not ready to die just yet.

Hi all,

I am a 27 years old who suffers chronic pain on the left lower trap area most likely from a disc budge, I also came to know I have multiple disc bulges in the neck upper and mid back. As you already figured out, I have tried every possible treatment out there but no help. I tried swimming and a lot of back strengthening - no help. Surgeons told me surgery wont be a good idea since the area of the disc is not easy to operate on due to its proximity to the lungs and any mistakes could take my life out. I also have a noticeable disc degenerative disease on my full spine. I recently came to know about Stem cells therapy and from what I read it is too good to be true. Also, in my experience in seeking health care i learned that health care is mostly commercial and a business vs who are there to actually help cure you, So here in my country UAE, they offer stem cells therapy where they take it from my own body where as I heard in Mexico they take it from donors. My life has been terrible since the age of 21 and I am 27 years old now. I mean to the level I cant use the toilet or shower or wash my face without pain. I cant make me coffee without pain, My nerves symptoms are going crazy and my mental health is declining. To not have higher expectations and be disappointed, Do stem cells really work and how do i know if i am a good candidate? If any doctors here please advise. Thanks

https://pubmed.ncbi.nlm.nih.gov/37623503/

I spent the last 2 hours reading this very good and informative article.

I don't know what to think about Regenexx, but I respect Dr. Centeno a lot. He puts mfrs on blast on LinkedIn. He's ferocious.

May not always agree with what he says, and I'm not smart enough to know if what he's saying is right or wrong scientifically, but it's always a good read and I highly recommend it.

https://www.linkedin.com/in/chris-centeno-m-d-b6838024/

Here's a good one. QC Kinetix, his main competitor, named a new CEO. For some reason they tagged Dr. Centeno and thanked him for being a visionary.

He said to the CEO "Please don't tag me on anything involving QK Kinetix. IMHO, this company never demonstrated that it's anything other than it's a sales machine pushing expensive treatments onto patients who don't need them delivered by underqualified mid-levels who shouldn't be doing them. See https://regenexx.com/blog/what-is-qc-kinetix/ "

https://www.linkedin.com/posts/markmontini_qc-kinetix-appoints-new-chief-executive-officer-activity-7263172533569351680-5-1i?utm_source=share&utm_medium=member_desktop

And he goes ham on Platinum Biologics quite a lot which is always entertaining.