I know that epigenetics doesn’t directly alter the DNA sequence in humans. But what about indirectly altering it? Such as via certain epigenetic alterations that makes a human susceptible to get a certain disease (such as a form of cancer). Can epigenetic changes indirect genetic changes?

I'm an undergad student and I'm struggling to figure out how does gc rich regions matter. Maybe it's a stupid question but I really need help with this. I thought it was because of the three hydrogen bonds which provides stability but then found out that stability comes from base stacking. So what exactly is the role of GC rich content?

I am a PhD in pharmacology and have been reading a lot of articles on cancer genomics (specifically prostate) and find it overwhelming.

For example when I try to learn about a particular assay being used in a pub, I realize that I need much more basic knowledge to completely understand the rationale.

What would be the most effective way to learn genomics to get to the appropriate knowledge level?

When I was working (was a medical writer, now retired) I had access to many bio-scientists’ brains (worked at big pharma).

I qualify for free courses at state universities since I am senior citizen.

I have a degree in Animal Science that I acquired overseas. I focused heavily on molecular biology, genetics and genomics. Although it was an animal focused degree I am fascinated by genetics regardless of the species. Now I’m in the United States looking to further my education and I don’t know where to continue. I’ve considered going into human genomic research. Is it possible to transfer over to human genetics? What is possible considering the degree I have and my idea for a possible shift in focus?

A new book by a UNT historian argues that American medicine overlooks how the ailments of many Black Americans are influenced by the diets of their African forebears.

https://www.texasmonthly.com/news-politics/ancestral-genomics-geography-black-health-disparities/

I stumbled upon this captivating article exploring the revolutionary effects of genomics on personalised medicine. It thoroughly examines how our genetic information can be employed to customise medical therapies specifically tailored to individual genetic makeups, thus transforming healthcare. The article explores a wide range of topics, from the technological aspects of genomics to its practical implementations and potential future developments. I thought it could initiate some intriguing conversations here! You can find the full article here: Full Article

Hello everyone, I have a question: how can I distinguish or determine whether a genetic variant (f.e. WES) seen on IGV is heterozygous, mosaic, or a PCR duplicate?

Hi all, I am working on a gwas and I need some advice on early data qc and processing. I’m reading a lot but there is still some “experience gap in knowledge” - [advisors are not knowledgeable or helpful]

The data from illumina is made up of 3 batches (there are some batch control duplicates included in 2 and 3).

Each batch has multiple illumina reports GSGT files (as *.cvs.gz).

1. my plan is to convert the reports to a plink supported format, then merge them into 1 file for the batch. Is that the right approach?

2. next, I planned to do the QC on each batch, and impute each batch separately?

3)how best to approach batch control and combining the 3 batches? - truong et al, 2022 suggest comparing the avg maf and genotyping call rate across the batches . . .

4. do I need to run QC again after combined the 3 batches into 1?

Please help, any insight is greatly appreciated!

Hello! This is (hopefully) a quick question, but as a non-bioinformatics person who just received g.vcf.gz.tbi files, how do you open them? I have no idea which program to use. Thanks!

Hi! I'm a sophomore majoring in Microbiology at the moment. I'm enjoying it, but I've been thinking of a major at my school called Genomics and Molecular Genetics at my school. The reason I want to switch is because I recently picked up a minor in anthropology, which is a major interest of mine, and my dream is to work biological anthropology research, broadly. I'm going with the flow... currently I'm working in a mosquito research lab until I find a lab where I can shadow in biological anthropology.

I do not wish to work in anything medical, and it seems like thats my only option if I stay in micro. I would also prefer to focus on eukaryotic cells.

One more thing- all my current credits would transfer if I switched.

Any advice? Feel free to ask questions, I know I left a lot of information out.

I am wondering how a methyl group could be added and what it could do. I don't have background in science. Thanks

I was tryna blast TERC gene in humans and zebrafish - unable to get any results on blastn while clustal omega gives an output for the alignment. I could get results with TERT gene - did I download the wrong sequence files or what am I doing wrong?

Ensembl didn't have TERC for Zf and i downloaded from NCBI -

Danio rerio non-coding telomerase RNA gene, complete sequence

Sequence ID: EF569636.1 Length: 317 Number of Matches: 1

and

Homo sapiens telomerase RNA component (TERC), telomerase RNA

Sequence ID: NR_001566.1 Length: 451 Number of Matches: 1