Dear epigenetics enthusiasts of Reddit, 

I am a graduate student working with the Yale Journal of Biology and Medicine (YJBM). In June 2025, YJBM will be publishing an issue devoted to the topic of Epigenetics. We are currently identifying potential authors for this issue. If you or any of your colleagues in the field are interested in submitting, please see the full call for manuscripts below and visit our website (http://medicine.yale.edu/yjbm/index.aspx) to learn more about us.

Call for manuscripts - Epigenetics Issue

Submission Deadline: March 3, 2025

Publication Date: June 2025

YJBM will be publishing an issue devoted to the topic of Epigenetics, ranging from public health and medicine to basic molecular biology. We are inviting authors to submit reviews, perspectives, case reports, or original research articles within this field. We are also now accepting original research featuring negative results. The following list includes the guiding themes for the issue, but it is by no means exclusive: 

• Epigenetics and Disease
• Environmental Epigenetics 
• Developmental Epigenetics (Fetal Programming)
• Social Epigenetics
• Molecular Mechanisms Regulating Gene Expression
  • DNA methylation 
  • Chromatin Remodeling 
  • Histone Modifications 
  • Noncoding DNA/RNAs
• Epigenetic Inheritance 
• Epigenetic Therapies

YJBM is a Pubmed-indexed, open-access journal whose mission is to provide both graduate students and medical students with experience in writing, reviewing, and publishing articles. The journal has been in publication since 1928 and is supported by an editorial board of both students and faculty members. Manuscripts are peer-reviewed by faculty in the field and there is no publication fee. YJBM has a Scopus CiteScore of 5.0 for 2023 and an Impact Factor of 3.434 for 2021.

The length of the manuscript can vary roughly between 2000 (min) to 6000 (max) words depending on the article type, with no more than 6 figures and around 25-50 references. For more specific information, you can find guidelines for authors on our website (http://medicine.yale.edu/yjbm/authorguidelines/index.aspx). Once you are ready to submit, please do so through Scholastica (https://yjbm.scholasticahq.com/for-authors)

As part of YJBM’s diversity efforts, we are switching to double-blind peer review. Reviewer bias (conscious or otherwise) should not affect the science that is published. While we encourage you to submit an anonymized manuscript, we will not reject a manuscript if it is not blinded. 

So the older I get, 42 now, the more I realize the massive amount of people in the US that had a coke habit for years on end. Boomers especially.

I recently even found out my mom and dad who were always antidrug had cocaine related charges from the 70s and 80s.

Is it possible that all of these people spiking their dopamine levels for years on end made their progenies neurons more "tolerant" of dopamine and thus required more dopamine than their bodies produced to achieve the effects of feeling fulfilled, motivated, focused, etc?

I've always struggled with motivation and focus and am ADD AF as the kids say.

Or maybe I'm just looking for anyone else to blame but myself.

I am a student in the UK and I am currently studying a T Level in hopes I will be able to form a career broadly around neuroscience and epigenetics. Are there any recommended universities to visit? Any recommended research to make before I send my uni applications out?

The question I have is related to my husband.

He has hemachromatosis and has elevated iron and liver enzymes. He’s under the care of doctors and is starting phlebotomy treatments. He also has severe psoriasis that the doctors believe is related to elevated levels of iron.

I am possibly very newly pregnant. I’m wondering what the epigenetic impact could be on the (potential) baby. Does illness impact the likelihood of my new baby experiencing more negative health consequences?

When we conceived our first baby three years ago he was healthy and has no visible health problems. Now, I’m afraid that there are some epigenetic changes that could make it more like that baby #2 has issues.

Does this make sense? Am I crazy? 😂

Hey all, glad there's a subreddit here for this-I'm currently an independent scholar who does a bit of interdisciplinary work revolving around liberation psychology, trauma informed medicine, and how that ties in with epigenetics. I occasionally run into discussions with people who should know better (they have chemistry and/or biology backgrounds) but try to dismiss me outright even though I make it clear I am merely echoing not just 30 years but especially the last 10 years of evidence that many scientists have found supporting how and why epigenetic inheritance occurs.

I’m open to the fact that maybe I’m wrong, perhaps the body of work is not strong enough to posit so strongly but I’ve been learning about epigenetics since the last year of my bachelors of science in psychology and its relevance to understanding trauma in psychological science and then following it since (almost a decade). I’ve read the work of Dr. Rachel Yehuda along with the groundbreaking study in 2013 involving rats and cherry blossom scent, I’ve read so much I’m been losing track and I took medical biology courses about 4 years ago for a year focusing on microbiology and physiology to be able to keep up.

I suppose I’m looking for guidance and informed opinions on how I should be discussing this and how I can do it more confidently (or less confidently perhaps). Delete if not appropriate. Thanks y’all.

Your descendants will have darker features ?

I know its a stupid question but im interested to know if its possible

Hi. I am a master student in medical genetics in “Tabriz university of medical sciences” in “Iran” Im looking for a research partner to communicate and even writing paperes to raise our knowledge. Here is the list of my interested topics Medical genetics Cancer genomics Reproductive genetics Infertility Gene therapy Pharmacogenetics Personalized medicine Epigenetics Neurogenetics

I’ve been digging into how psychedelics like psilocybin might help heal trauma, and it’s amazing to see how many layers are involved—from psychology to epigenetics to consciousness theories. Here’s the analogy that made it click for me: imagine the mind as a snow globe. Each life experience stirs up the “snowflakes” of memories, thoughts, and emotions, which eventually settle into patterns. But trauma creates deep, rigid grooves, locking these snowflakes into fixed paths.

At a biological level, trauma doesn’t just affect the mind; it also leaves epigenetic marks that influence gene expression without altering DNA itself. Think of these marks as grooves in the snow globe, reinforcing stress responses and keeping us in a cycle of reactivity. Psychedelics, like psilocybin, seem to give the mind a “shake,” allowing these patterns to reset and potentially reshaping these epigenetic marks.

A few theories I came across that support this:

1. Epigenetic Reset – Psychedelics might help “reset” trauma-imprinted gene expression, possibly by promoting neuroplasticity, which opens up more adaptive pathways in the brain.

2. Restoring Harmony – Trauma throws off mental “harmony.” Psychedelics seem to act like a resonant wave, helping the mind realign and connect to a state of inner balance and healing.

3. Softening Mental Grooves – Trauma creates deep grooves in the brain’s “sand garden.” Psychedelics smooth out these pathways, freeing us from repetitive trauma-based reactions.

4. Creating Stable Change – People report lasting effects from psychedelics. Some researchers think psychedelics help form stable, resilient mental patterns, “anchoring” us in healthier ways of thinking.

5. Quantum Coherence – A bit heady, but there’s a theory that psychedelics might help synchronize particles in our brains, aligning thoughts and memories in a clearer, more unified way.

All these ideas combined suggest psychedelics could heal trauma by reshaping the biological and mental patterns trauma leaves behind, breaking us out of old cycles. Would love to hear if anyone else has explored this or come across studies in this area!

Psychedelics shaking up trauma and reordering consciousness

Hey there everyone,

Does anyone have any resources for using calculus to calculate gene expression?

Full disclosure, I'm doing a project for school and I have come across some resources via Google, but wanted to check here too!

Thanks in advance ☺️

I want to discuss the intriguing role of psilocybin in healing trauma, particularly for people dealing with PTSD and seeking emotional recovery. This isn't about recreational use or regular microdosing for an altered or artificial sense of wellness; instead, I’m referring to deep, intentional journeys that confront the roots of trauma and promote genuine healing.

Psilocybin has the potential to facilitate profound experiences that allow us to explore and resolve the underlying issues contributing to trauma. This process leverages the brain's neuroplasticity, which helps to repattern thought processes and emotional responses. Imagine shaking a snow globe—during a psilocybin experience, old patterns can be disrupted, allowing for new, healthier ones to settle in.

What’s particularly fascinating is the potential epigenetic impact of these experiences. The insights gained during psilocybin journeys can influence gene expression related to stress and trauma. By addressing the psychological roots of trauma, psilocybin may help reshape not only mental patterns but also how our bodies respond to stress at a genetic level.

Exploring the therapeutic potential of psilocybin in trauma healing represents an exciting shift in our understanding of emotional wellness and its biological underpinnings. It offers a pathway not only to cope with symptoms but also to fundamentally transform our relationship with past experiences.

What are your thoughts on this intersection of psilocybin and epigenetics. Have you explored the therapeutic aspects of psilocybin? What are your insights on its potential for meaningful change in trauma healing? Let’s discuss!

#Psilocybin #Epigenetics #TraumaHealing #PTSD #Neuroplasticity

Thought this was interesting (if not also serious)

My dad had recurring glomus jugulare tumors that were removed for ten years (25+ operations in total, including feeding tube, revisions etc) until one metastasized and he passed away.

This is where it gets interesting. My sister now has tumors on both of her adrenals, and one gland will be removed next month and the tumor biopsied.

I was doing research because that feels so.... statistically improbable after being told what my dad had "wasn't genetic". Granted, he was initially diagnosed in the 90s and passed away in 2005.

It seems like both conditions might be related to the SDH gene, yet it expressed in different ways. I'm by no means a researcher but it seems the most probable gene. I'm encouraging my sister to get a good cancer genetic screening to learn about her variants, partially out of curiosity but also because it may give insight.

She's under good medical care, so I'm not attempting a diagnosis here. I might just be over rationalizing since it's a bit scary but I can't help but be intrigued. I always felt like it had to be genetic, even as a kid, because genes tell the body what to do, so something in the genes kept telling his body to do this bad thing, over and over again!

I'm so curious to know what type of tumor she has. I'm near certain it's not a glomus, which would be research study worthy 😆. She also has PCOS and Hashimoto thyroiditis, so she's exhausted. She's had some bad luck.

Anyway, if anyone has insight into SDH I'd love to hear about it

Hi, I'm interested in the subject and would like to take a course to start learning. Are there any good online courses/books that would be a good place to start?

Hey everyone, advice is very much appreciated here. So for context, I have an interview/chat set up with a PI at my nearby state university to talk about his research and the potential of me working in his lab. I graduated from a small catholic university in May 2024 with a degree in data science. I have been extremely interested in epigenetics/behavioral nutrition for years, but there were very limited options for programs and/or research at my uni because it was so small (less than 2000). Hence the reason I went into data science, because I knew it would be really helpful for me to understand analysis and machine learning because it is such an important part of the research process. The most relevant research that I have is an investigating the gut microbiome brain axis as a potential treatment cite for ADHD.

Anyway, I have been following this PI's work for awhile, and he does SUPER cool shit. His lab works with investigating epigenetic mechanisms/markers that are associated with neurological conditions, as well as the environmental factors that influence them. Additionally, he also works primarily with the NHPI (native Hawaiian pacific islander) community. I have been actively self studying epigenetics for years on and off, as it is just something that I find extremely fascinating. However, I am afraid I don't know how to talk about it on a technical level enough. I'm looking for advice on how to seem knowledgable, while also being honest that I do not have a formal education in biology but can offer a valuable skill set of analysis and R coding

Thought you may find it interesting: a pod episode with PhD in molecular biology who talks about many concepts in the field of epigenetics:

https://www.youtube.com/watch?v=d9k1jGUk78o&t=2701s

Hello, first of all, I’m sorry if my English is not good, I’m from Spain and I’m going to use a translator. I have a difficult situation, I had to abort my son in week 34 because of a serious problem, his father and I are carriers of the same gene and we didn’t know. Now I have become pregnant again and in week 12 they did the CVS to rule out the carrier gene, they did the qf-pcr, array and karyotype tests. They called me at 48 that qf-pcr went well 18,13,21 and sex XX, 10 days later they called me for the array, they told me to go to consultation that they had to talk to me... the gene was not in the girl but in array result it said this (RESULT AND INTERPRETATION:

Arr [GRCh38] (X) xl[?]. The lack of a chromosome is observed

Sexual in the chorial villos sample received,

Surely in mosaic,

That clinically would correspond to a

Turner syndrome.

CONCLUSIONS:

The lack of a sex chromosome has been identified, on the other

X chromosome probably in mosaic,

Compatibie with Turner syndrome) • Because there may be mosaics confined to the placenta,

We recommend the study of the sample of

Amniotic fluid to confirm the result. The doctor

You can also evaluate the ultrasound findings

To relate them to the result of the study carried out)

The doctor told me that I needed to do an amniocentesis to determine if I was in the placenta or if I was also in a baby. The following week we went to a major ultrasound to look for some ecographic defect and everything was normal and with the surprise that the long-growing karyotype arrived and here I leave the result: (Karyotype (chorial cell): Chromosomal formula

46, XX

No chromosomal alteration has been detected. Compatible with a normal female karyotype

LONG CULTIVATION

Cytogenetic study carried out on chorial villi, with a

Resolution of 300 bands. No numerical anomalies or

Structural.

CHROMOSOMAL FORMULA: 46,XX

Prenatal cytogenetic studies in chorionic villi

Present mosaicisms confined to the placenta in a low

Proportion of analysis. If abnormalities are observed in the ultrasound

Fetal and/or the results of the cytogenetic study and the QF-PCR

And/or the array-CGH are concordants, then the probability of

Mosaicism is even more reduced. Yes, as in this case, I don’t know

Comply with the above assumptions, it would be advisable to carry out

An amniocentesis to confirm the result with karyotype,

QF-PCR and perform an ultrasound follow-up)

15 days ago I had amniocentesis and the first qf-pcr results are normal again but without array response, I have been desperate and sunk for 8 months to ask my son and now I am 18 weeks I do not want to suffer the same thing again. What opinion can you give me? Thank you

Have humans deliberately changed epigenetics?

I am currently a "pre sciences" major at my school who plans to pursue Neuroscience as a degree so I can enter this field.

The lab I'm currently doing research in isn't necessarily epigenetics centered but students do have the option to pursue their own research, which I plan to do.

I'm planning to take a class in Genomics and Proteomics as a way to build relevant knowledge. Is this a good choice in class if I'm trying to prepare for research in this field?

Thanks in advance!

(19M)Can I use epigenetics to grow taller,and if so how can i trigger the epigenetics

In east asia families that are darker are seen as lower class bc they worked fields while paler asians stayed inside. Would a family, where many generations work in sunlight for majority of the day, eventually start producing tan kids bc of epigenetics ?