Is it even possible that additional pro-dopaminergic actions result from the combination of norepinephrine reuptake blockade in prefrontal cortex due to SNRI actions with 5HT2C actions of a alpha 2 antagonist (like mirtazapine), disinhibiting dopamine release?

Source: https:/nei.global/rocketfuel

https://preview.redd.it/670g88jwfnk81.png?width=5000&format=png&auto=webp&s=42ad2ec78c5e9aeae278204fe63717dc49eadb8e

In this age you have to be VERY cautious about your dopamine intake.

How much, where it comes from and why you are looking to get your fix.

Not to get any kind of addiction or live life on "zombie" mode (not getting enjoyment in the little things like just having a normal conversation etc)

Am i right with the fact, that if you know how this hormone affects you, things in life will probably become "easier" (more painful, but real) for you to go through?

I am beginning to really understand this:

• Why everyone around me is doing what they do.
• How i was looking for dopamine rushes (addictions and escaping pain) throughout my whole life
• When i need to slow down on my use of "technology" not to be overstimulated

Just i general it has do with my whole behavior.

Can you relate?

As discussed in this Podcast - by Dr. Andrew Huberman - https://podcasts.apple.com/us/podcast/huberman-lab/id1545953110?i=1000536717492

Hello, I am suffering from depression for 8 years. Tried almost every ssri and welbutrin..almost nothing helped and just feel more lost and lifeless...i think my brain needs more dopamine than serotonine due to depression. Is there any medicine there for depressìon that boost dopamine so i can talk to my doctor? Thank you

So well hello people....

I'm suffering anhedonia for about 2 years , caused by lifely stress and pain.

finally i found medication which is really helping me and it's name Selegiline... So visited many various docs in my country , they give me a bunch of SSRIs , SNRIs , Atypicals and Antipsychosis , so this medications do nothing for me , so after many tries i decided to support dopamine by me , not by doctors , because they don't prescribe here Maoi and dopamine medications and they also aren't available in my country (I'm ordered Selegiline from online).

Taking Selegiline For 2+ weeks and it's really working for my case , taking 2.5mg sublingually doses and thinking about to increase and also inhibit Mao-A if this dose doesn't work for me , but Mao-A inhibation needs dietary restrictions and i don't want to protect diet on this time , so i've got hope this dose be enought for me if i can also boost my dopamine levels in natural ways , also interested if i will do anything with my dopamine receptors ? Yes i know by getting selegiline i'm inhibiting Mao-B which gets more dopamine in brain but maybe i will do anything with receptors also? So suggest if anyone know this case also...

So now i want suggestions from people who really knows this case... Except Selegiline , how i can support my dopamine in natural ways ?what would be better to eat , do and etc... I think it will be better to spend more time outside , no fap only sex , get a healthy diet (maybe u can suggest diet for dopamine boosting specially) , no alcohol no drugs , exercise , good sleep...

I'll try everything to be cured from this hell finally , please give me suggestions for my case , thanks...

• ( I want to add Lion's mane and B6/B3 vitamin in my stack for more energy and mood , B6 because maoi can decrease level of it and B3 because it's antinflamatorry and it would be good for brain)

9/17/21 update: Just thought I'd pop in and thank everyone for helping me out and letting me know that my symptoms sounded like classic bipolar. I've gotten a lot of armchair diagnoses over the years, but this was the first time I'd been recommended to look into it and see a psych rather than continue self-medicating with increasingly strong and strange combinations of sleep aids. I spoke with a psych, and about a month ago started treatment for cyclothymia. I feel so much better, and now sleep like a normal person. No more racing thoughts, no more heart palpitations, no more cold, clammy hands and shakes. Thank you so much /r/AboutDopamine. Wouldn't be here without you.

tw: suicide

I've been trying to figure out what "this" is for most of my adult life, and my latest research has me looking into dopamine. I tried asking about it on r/ADHD but the mods deleted the post and told me to see a doctor. (I lol'd, because I would have years ago if I thought they'd do anything.)

Basically, I get these endogenous chemical "swings" that make me feel like I'm on drugs, though I don't actually do any drugs and never have. It ticks all the boxes for a "too much dopamine" episode, and for all intents and purposes ticks most of the "high on meth" boxes too. Libido goes through the roof, I can't sleep, I'm bombarded with intrusive thoughts like snippets of movies or images or songs that won't stop playing, I lose interest in food, and my ADHD gets astronomically worse and I do a lot of mindless scrolling. But on the upside, it feels really good. I feel competent, attractive, energetic, and fully in my body. So if I'm not careful, the feel-good chemicals can lull me into some complacency and I'll wind up feeding "this" headspace for days on end. Sometimes some of the effects, like the insomnia, can last for weeks and won't respond to sleeping pills or massive doses of melatonin (30mg). It also didn't often feel like I'd reach REM most nights.

The most recent episode was the first time that it got scary, though. It's also the first time that I decided to try nipping it in the bud by "detoxing". I stopped using social media, cancelled most of my social life, went nofap, practiced some really intense sleep hygiene (in bed an hour before I needed to fall asleep), picked up meditation again, started taking a slew of supplements in addition to my usual Adrenal/HPA Axis herbal formula and St. John's Wort: creatine, B-complex, melatonin/magnesium for bedtime.

The comedown was brutal. In the first 24 hours, I experienced body aches, muscle weakness, an IBS flare-up, and intense brain fog that made me want to call in sick for work. (I didn't, and that was a mistake.) At some point 48-72 hours after starting the "detox", I felt a noticeable change in my thought patterns and soon after that was plunged into anhedonia that culminated in very strong and very persistent suicidal ideations; I couldn't stop thinking about wanting to die of COVID or that black fungus spreading in India, or killing myself if I "had to". Smoking some weed just made me derealize and depersonalize even more, so at that point I knew I just had to go to sleep and see how I felt in the morning; if it continued I would have to get a Dr involved because it was bordering on psychosis. Thankfully, when I woke up, I was mostly back to normal. Mostly, as in, over a week later I'm still repaying my sleep debt.

I've looked into ADHD hyperfocus states as a possibility (but I can experience those without the other negative side effects), I've looked into PMDD because the swings follow something of a monthly/every-other-monthly cycle (but research is pathetically sparse), and I've looked into mania but I'm not sure if hypomanic states follow with a predictable and debilitating crash/comedown.

Complicating things a little bit, I'm transgender FtM, and ever since I started experiencing these swings, feeling doped up coincided with feeling very masculine and "euphoric" (the opposite of dysphoric), which was another reason I would historically try to prolong these states even at the expense of my health. I am now on testosterone therapy, but I have to be careful as the increased libido and euphoria makes it much easier for me to wind up getting lost in the high. I've even decreased my dose in response to this.

What's the current understanding of dopamine dysregulation in people without Parkinsons? Is something like this a potential predictor for Parkinsons, or is it just an addiction-prone brain addicted to itself? I would... like to not feel like this anymore lol.

Please excuse my ignorance if this is a common question or if this is obvious (I'm not a smart man...). I have ADHD and thus have been studying dopamine since it seems to be at the core of my issues. Treatments for ADHD all seem to revolve around helping the body to make more dopamine, but I also know that throttling the system with too much from things like porn, excessive youtube, or the like. My question is this: How do you manage your dopamine correctly so that you get enough to be motived and engaged in life, but not so much that you get caught up in addictions?

My mileage has been the exact opposite.

I nearly completely have given up added sugars and have completely given up caffeine. As I noticed both of these increased my irritability and risk of anxiety attack or psychosis...

My wife surprised me with bringing me home some flower (whole cannabis) recently after the shut-down hit here in America...

Since then, I’ve experimented with dry-herb vaping with it using a convection-style vaporizer as well as infusing with coconut oil. The last batch of it I made had at least 30 to 40% hemp flower as I’ve found that smoothes the high out for me likely due to evening out the ratio between THC to CBD... I even got it dialed in so much as I could take an eight teaspoon for a micro-dose that basically erased my anxiety including social and relaxed my muscles a bit without feeling high whatsoever.

A few times I ran out of cannabis and exclusively vaped hemp flower during the week to two week hiatus and every time my old psychotic tendencies would start to creep back into my mind while showering, commuting, etc... and eventually I’d land onto a small freak-out — psychosis leading into it and lingering after...

To be clear my experience / definition of psychosis is that of having maddening thoughts, slowly gaining traction and speed, heading into mania. Feeling split between attachment to my life working out well and feeling as though everything’s fake (depersonalization)... to the point that I’m nearly laughing (maddeningly, and I used to actually do so when it came on more severe) at my life as though I were the butt of a great satire... and what’s the point in anything... existential crisis much?

This has been rearing its gorgeous-ass, ugly head here and there for probably the last 10 years... maybe even a little more... of my life. I’m now 30.

Anyway, only vaping cannabis / cannabis -hemp flower mixes... only over the weekend and the occasional middle of the work week has been completely keeping the psychosis at bay...

I don’t feel addicted to marijuana whatsoever and am a week-in-a-half into a break now... this time all I’ve been experiencing is seemingly low-dopamine, overwhelm, and depression.

The things I do get addicted to are:

Porn: I’ve been fully of it since December

Reddit: Reading posts and occasional scrolling

Video Games: only one game on my phone and it’s a turn-based strategy game

Researching maladies, diets, or things I want to buy... and the effects feel worse if I make it an urgent thing and am skim-reading...

Honestly I can tell when I’m due for a dopamine fast... and boy am I a few days pushing it into the red-zone lol...

For example:

I’ve experienced the benefits of brief dopamine fasting sometimes but not opening my phone while donating plasma (takes about an hour). Feeling so refreshed when I’ve done this.

While other times when I’m getting into the red-zone of internet addiction... I put my phone down and find myself in a fog, readjusting to the world present around me... and feel this tension (not a headache) but in my head that’s like a dull, slow throb.

Another time I drive two hours to a job-site in silence, and then did the same on the way home because I knew I needed it. This was honestly due to Reddit Porn Scrolling... but sometimes a crazy mind like mine just needs the quiet to slow down...

I really need to get back to meditating. I used to do it regularly enough that I was starting to get in touch with the momentum of my mind... sometimes when I would sit, it would be a wild whirlwind in there... and sit still long enough, the storm will break just by not being fueled and given space to run its full course.

The total diagnosed prevalence of Parkinson’s Disease is rising exponentially; and the total diagnosed prevalent population of Parkinson’s disease in the 7MM (the US, EU5 (the UK, Germany, France, Italy, and Spain) and Japan) is expected to reach 3,284,084 in 2030.

However, to tackle the situation some of the key pharmaceutical and biotech companies like Prevail Therapeutics, Axovant Gene Therapies, Neurocrine Biosciences/Voyager Therapeutics, Denali Therapeutics, International Stem Cell Corporation, Living Cell Technologies, and others have come up with their candidates that might prove to be a turning point in the Parkinson’s disease therapy market in the coming years.

Similarly, stem cell therapies, gene therapies, growth factors, and various other options are also in the clinical trials underway for the treatment of Parkinson’s disease.

Source: Parkinson’s Disease Pipeline Therapies

What's the difference between dopamine and serotonin? And are there natural ways I can increase both in my life?

Thanks for your help.