I'm a geneticist who put some quarantine time into making this consumer kit adaption of existing PGX chip tests. The PharmHand project

I realize this is a bit of an advertisement, but I'm not really sure how else to put word out for such a specific interest other than communities like this. As compensation, I'd be more than happy to answer any drug-gene questions (10 years building clinical and ancestry tests).

• Ampk inhibitor:

Compound C

Metformin

actiponin (damulin A and B)

Aicar

• MTOR Inhibitor:

Rapamycin

• Sirt1 inhibitor:

EX-527

Suramin

NAM

• Parp1 inhibitor sirt1:

olaparib

mefuparib hydrochloride

BMN 673 (talazoparib)

• CD38 inhibitor

CAS 1700637-55-3 (78C)

Daratumumab

Isatuximab

Apigenin

• Glycation:

Pyridoxal 5 Phosphate (P5P)

Metformin

• Mapk/p38:

SB239063

Skepinone-L

LY2228820 dimesylate

FGA-19

Puerarin?

Baicalein?

• Sirt3/sod2:

Honokiol inhibition of ptp1B protects against atherosclerotic plaque formation 

Honokiol inhibit PTP1B and sirt3

LC- 0296

NAM

• STAT3 INHIBITOR:

FLLL32

Erasin

piperlongumine 

Mm-206

S3I-201 

Cryptotanshinone

LY5

HJC0152

Pectolinarigenin

Atovaquone?

Niclosamide?

• IL-6/STAT3 inhibitor:

Andrographolide

• REST/NRSF (Master regulator neurogenesis)

• HDAC inhibit REST protein (RE1-silencing transcription factor)

• HDAC inhibitor:

LBH589

Panobinostat

AR-42

MPT0E028

trapoxin

Trichostatin A

Santacruzamate A

Thailandepsin B

Pyroxamide

Sulforaphane?

Tributyrin?

(3 main pathways in neurogensis)

REST, TLX, FOXO3 

REST INHIBITS MIR9

MIR9 INHIBITS TLX

MIR 9 INHIBITS NOTCH PATHWAY

• Notch inhibitor:

RO4929097

bms-906024

LY3039478

• Wnt/β-catenin inhibitor:

Sulforaphane

DK419

prodigiosin

WIKI4

ETC-159

CWP232291

IWP-4

KYA1797K

Niclosiamide

pyrvinium

‐---------------------‐----‐----

Dont yall agree one of these compounds can be modified and made for a cure for covid-9 Example: sulforaphane, Andrographolide

Atovaquone is another example...

Only a Pharmacologist would know....

Just curious because I had a polite disagree with one of my co workers who felt like it counted. I thought cancer mutations weren’t part of a persons genome.

During recent years, a paper has been written about theoretical pharmacogenetic intervention that will enable an individual to choose whatever orientation they wanted. Methods suggested include neuropharmacology, brain surgery, deep brain stimulation and genetic alteration. What do people think about the ethics and possibilities?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932804/