/r/PharmacoGenomics

Photograph via snooOG

A community for discussion and news surrounding genetic medicine and pharmacogenetics in specific. We are interested in the field of BioInformatics and gene sequencing.

R/PharmacoGenomics is intended to be a resource for those interested in the field of genetic medicine, pharmacogenomics, pharmacogenetics, and gene sequencing. We intend to foster discussion surrounding this sphere of Bio Informatics and think the growth this industry presents is exciting. Dive right in and get involved.

Related Subreddits

R/epigenetics

List of PharmacoGenomic Resources PharmaCoGenomic Company News Site

Wiki Entry

Millenium Health

FDA Guidelines

/r/PharmacoGenomics

1,167 Subscribers

7

23AndMe or Ancestry kit -> drug response

I'm a geneticist who put some quarantine time into making this consumer kit adaption of existing PGX chip tests. The PharmHand project

I realize this is a bit of an advertisement, but I'm not really sure how else to put word out for such a specific interest other than communities like this. As compensation, I'd be more than happy to answer any drug-gene questions (10 years building clinical and ancestry tests).

8 Comments
2020/05/07
17:18 UTC

2

Cure for Coronavirus

• Ampk inhibitor:

Compound C

Metformin

actiponin (damulin A and B)

Aicar

• MTOR Inhibitor:

Rapamycin

• Sirt1 inhibitor:

EX-527

Suramin

NAM

• Parp1 inhibitor sirt1:

olaparib

mefuparib hydrochloride

BMN 673 (talazoparib)

• CD38 inhibitor

CAS 1700637-55-3 (78C)

Daratumumab

Isatuximab

Apigenin

• Glycation:

Pyridoxal 5 Phosphate (P5P)

Metformin

• Mapk/p38:

SB239063

Skepinone-L

LY2228820 dimesylate

FGA-19

Puerarin?

Baicalein?

• Sirt3/sod2:

Honokiol inhibition of ptp1B protects against atherosclerotic plaque formation 

Honokiol inhibit PTP1B and sirt3

LC- 0296

NAM

• STAT3 INHIBITOR:

FLLL32

Erasin

piperlongumine 

Mm-206

S3I-201 

Cryptotanshinone

LY5

HJC0152

Pectolinarigenin

Atovaquone?

Niclosamide?

• IL-6/STAT3 inhibitor:

Andrographolide

• REST/NRSF (Master regulator neurogenesis)

• HDAC inhibit REST protein (RE1-silencing transcription factor)

• HDAC inhibitor:

LBH589

Panobinostat

AR-42

MPT0E028

trapoxin

Trichostatin A

Santacruzamate A

Thailandepsin B

Pyroxamide

Sulforaphane?

Tributyrin?

(3 main pathways in neurogensis)

REST, TLX, FOXO3 

REST INHIBITS MIR9

MIR9 INHIBITS TLX

MIR 9 INHIBITS NOTCH PATHWAY

• Notch inhibitor:

RO4929097

bms-906024

LY3039478

• Wnt/β-catenin inhibitor:

Sulforaphane

DK419

prodigiosin

WIKI4

ETC-159

CWP232291

IWP-4

KYA1797K

Niclosiamide

pyrvinium

‐---------------------‐----‐----

Dont yall agree one of these compounds can be modified and made for a cure for covid-9 Example: sulforaphane, Andrographolide

Atovaquone is another example...

Only a Pharmacologist would know....

0 Comments
2020/03/30
20:47 UTC

4

Does testing cancer tissues for mutations count as pharmacogenomic testing

Just curious because I had a polite disagree with one of my co workers who felt like it counted. I thought cancer mutations weren’t part of a persons genome.

1 Comment
2019/10/08
17:43 UTC

0

Brave New Love paper

During recent years, a paper has been written about theoretical pharmacogenetic intervention that will enable an individual to choose whatever orientation they wanted. Methods suggested include neuropharmacology, brain surgery, deep brain stimulation and genetic alteration. What do people think about the ethics and possibilities?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932804/

0 Comments
2019/09/04
12:30 UTC

2

Dr. Leroy Hood, Co-founder, Chief Strategy Officer, and Professor, Institute for Systems Biology talking about the future of systems (P4) medicine in health, wellness, and aging

0 Comments
2019/07/01
14:21 UTC

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