I'm going to get my full genome sequenced soon, for medical purposes. I've seen people talking about getting hold of their full bam file, at around 100gb, or you could also get a vcf file at 5gb or something. I understand the bam file contains more information because it has the value of each read at each locus, and the vcf condenses this into maybe a float for probability of each snp or similar.

So, why would I bother keeping the raw data? The vcf file seems to be pretty extensive already anyway for my purpose, and the bam is huge. If I wanted to do some kind of re-analysis of my genome in 10 years time, what would be the benefit of reanalysing my bam file instead of getting it sequenced again? It's reasonably affordable at this point and presumably it's only going to get cheaper and the methods should improve with time

https://www.prnewswire.com/news-releases/label-free-detection-market-worth-747-million-by-2029-driven-by-technological-advancements--marketsandmarkets-302217729.html

I'm in the U.S. looking to get myself tested so I can design my own supplement regimen, etc. I don't have much money, have no insurance, and won't be able to do multiple tests, so I want one that is as complete as possible, maps everything, and gives me all the information upfront without a subscription.

All the sales jargon is quite confusing, and it's not at all clear if some that claim they sequence 100% actually provide the patient with all that data.

I'm looking for recommendations of a reasonably priced test that gives me everything all at once so I can sift through it over time as I learn more. I don't care about ancestry, etc. Just health. If not a specific company / test recommendation, then what are some particular things I should be looking for or red flags to stay away from?

Hi! Is there any course anyone could take online that is on Microbial Genetics/Genomics? I'm looking to take a course that offers something like that offered online through a university.

Nobody replied at all... Please anyone? https://www.reddit.com/r/genomics/comments/oqod55/learning_resources_genomics/

Hello world! I think I could fall in love with this from just reading a few articles. How could I break into this skilled job market. Job titles, company names, anything at all greatly appreciated

TL;DR: I want to get my PhD from the UK because it's faster. But after that, I want to work in the industry in the US. Would my PhD be considered less valuable/competitive against graduates from US universities?

Hi everyone!

I hope you are doing great and thanks for reading this long post.

I am currently a Master's student entering my second (and final) year at NYU. I am in the US on a Fulbright scholarship which has a drawback: going back to my home country for 2 years after completing my Master's before I am eligible to apply for permanent residence visas (like the H1B) again. This means that I cannot work in the industry after my Master's and, unfortunately, my home country (Pakistan) doesn't have much in the way of biotech R&D. Some big Pharma have their operations in Pakistan, but they mostly have manufacturing, quality control roles, or administrative roles - nothing like Scientist I, or Research Associate.

Therefore, I can:

1. Either wait for two years and start my 5-7 year long PhD in Fall 2027 in the US - which means I will complete it by 2032-2034.
2. Or I can start my PhD in the UK in Fall 2025 (haven't applied yet) and finish it by 2028-2029. I would still need to complete my home country requirement of 2 years before I can start working in the US. That means The earliest I can get a job in the US is probably going to be 2030 or 2031, if things go according to plan.

After my PhD, I hope to enter the longevity biotech industry on a Scientist I position where my role is around 70-80% computational and around 20-30% wet lab. For context, I am NOT a computational biologist or a CS major. I am a traditional molecular biology student, but I am learning some bioinformatics in my Master's. I know a fair bit of genomics now, and I am delving into ML. I don't intend to become an ML researcher - I want to stick to molecular biology research, but I want to heavily design and power my experiments with genomics and ML. Therefore, I know I need to learn a lot more bioinformatics, statistics, and ML before I can compete for positions like Scientist I or Bioinformatician, but here's my question: would it make a difference that my PhD is from the UK and not from the US when I am applying for a job in the US?

I understand that doing my PhD in the US will help me build more connections here, but I am also thinking about the cost here. If I do my PhD in the UK, I could, potentially start working 2 years earlier than I would if I had to wait for my PhD from the US. And since I already would have a Master's degree, I think a PhD from the US would become a bit too long. Not that time matters that much to me, but money does. I have realized (from being a research trainee and a Master's student on a stipend), that money in academia isn't something that can keep me going. I love research. I am super passionate about helping people with breakthroughs. But I can't do it while living in a shoebox apartment and trying to budget my iced lattes. I can do it for a while, but not when I am well into my 30s. So, I want to start making money fast.

I would appreciate any helps or thoughts. I am very clueless about the industry in the US except that it's insanely competitive. So I don't know whether a PhD from the UK would put me at a disadvantage. My long-term plans (for now), include getting a PhD (UK or the US) and then working and living in the US (preferably in New York City).

Thanks so much for reading! Here's a cookie: *insert cookie emoji* Sorry I am typing this from a laptop.

Just got suspended from r/genetics for writing a factually correct comment about polygenic scores. Erroneously viewed as "pseudoscience". I've been a member of the American Society for Human Genetics for 40 years. Fuck off reddit, your model is fundamentally flawed.

Hello all, I am looking for a bioinformatics course for conservation science. Does anybody have any leads? I work on mammals, and I am basically a total nincompoop at bioinformatics. I need a course which will help with the following topics, in descending order of importance:

1. Whole genome assembly

2. From fecal/degraded DNA

3. lcWGS datasets

4. Functional genomics would be a bonus

I already have an idea that I will most likely be using tools like ANGSD. Something adjacent to paleogenomics would probably work.

Free or cheap stuff would be great! I already know about Physalia.

Thanks in advance!