I’ve had 23 and Me done, originally out of sheer curiosity to see if I have any surprise siblings - my dad has slept around a lot (so far, no siblings).

Anyway, I uploaded the raw data to promethase as 23 and Me seemed boring, and of course it came with a lot of notes risks. I am not the type to doomsday over this, which is why I was good with running it. I’d love to know some risk factors so I could potentially make some informed healthier life choices.

Anyway. Theoretically, let’s say I have 5 different genes which each individually increase my risk of a specific condition by 2.0x, in which the typical population risk is 2% (numbers selected for simplicity). Is the overall risk of being affected cumulative, or does it sit at 2x risk? Or, is it somewhere in between?

Thanks for any insight - I think I broke my brain. I did some undergrad work years ago in genetics, but it’s been quite awhile. I know enough to just confuse myself.

Superarchaic introgression is introgression from earlier diverged hominids. Hominids such as Homonerectus and floresiensis or luzonensis are more distanced from Homo sapiens than Neanderthals and Denisovans are.

What are all the people around the world with significant superarchaic introgression ?

Need help, please.

Long term outcomes are influenced by three factors: genetics, shared family environment, nonshared environment. Twin studies show us how heritable a trait is. Adoption studies show us how important shared family environment is. And whatever's left over is chalked up to the nonshared environment. Great! At a high level, this makes sense.

But I'm a bit confused how shared family environment is being defined here. For example, I see adoption studies regress child IQs and financial outcomes against their adoptive parents' IQs and financial outcomes. But what is that really measuring? Whether smart parent give their children their brains via osmosis? It's not all that surprising that these studies find that: no, this doesn't seem to be happening.

The more interesting question is: to what extent do different parenting techniques affect a child's longterm outcomes. And since it is not obvious to me that higher-IQ parents practice e. g. authoritative parenting more than lower-IQ parents, it's also not obvious to me that any of the variance explained by these parenting techniques would be captured by adoption studies.

What am I missing?

[Edit]

Changed "genetic" to "heritable."

So I’m pregnant and the baby had quite a few anomalies found. Today we were told I’m a carrier for ga-type 1, however my husband is not a carrier. The doctor tried explaining how baby could still get it but I just can’t understand. Is there a way baby could just have a gene mutation that caused it because of me? Is there a chance my husband wasn’t tested well enough? We don’t have our full amnio results still, but one of baby’s gene did show the ga-1, but not on both sides? The doctor said he assumes he will see more dna with the condition when we get the results back, does that sound normal? Everything I look up says it’s not possible, but I don’t know.

Hello y'all! I've been thinking about going to college to pursue a career in genetics, but I wanted to know more about the field and the best route to take.

The school I plan on attending (for distance and cost reasons) doesn't currently offer a genetics program, but I compared their classes to another school that did have a genetics track, and they offered most if not all of the same classes within their biology/microbiology department, would one of those work for my bachelor's?

I'm specifically interested in the research and development of In vitro gametogenesis technology, and would absolutely love to do something in the area of assisting people to have kids. However, I do have a job history in the Cannabis industry and think it would be cool to work towards creating strains to target different conditions/disorders. I'm sure that job market is heavily oversaturated right now, though.

Any advice or tips are greatly appreciated! Feel free to ask questions too :)

I understand that the prices differ quite a lot in the states due to college tuition but how about Europe? How different are the salaries of these two careers? Thanks

Is a man with mosaic trisomy 21 less fertile than a normal male?

Are their offspring more likely to have mosaic trisomy 21?

*** I’m not asking for specific advice or an explanation on my specific child. Just using him as an example of a genetic condition.

My 2 year old son has a partial missing 5th chromosome (Cri du chat syndrome) and has a partial duplication in his 16th (yaaaaay unbalanced translocation), because of this he will be disabled in various ways for life. We have sunk a lot of effort into helping him have a great start in life with therapies and specialists and my daughters both know about and celebrate his differences. They know he processes info differently and will need help to achieve many milestones. Up until now that has sufficed. The other day my 6 year old asked me “but WHY do his genes make his brain different?!” and, guys, I swear to you I have been so preoccupied with everything else that not once did I stop to wonder what makes him have all these delays. I did quickly google it but I feel like I wasn’t getting the “explain it like I’m 6” response.

So why do people with genetic conditions have delays? Would a brain from a kid with a genetic condition look different than one from a typical kid? Obviously he doesn’t have Down Syndrome but he’ll have many of the same concerns like low muscle tone, delayed speech, poor fine motor skills, etc. Why do they have so many overlapping concerns? I really need to take a dang genetics class sometime.

Hi everyone 19m just found out my mother was just diagnosed with lynch syndrome she has beat endometrial cancer once already and is now going through breast cancer treatment, she has been incredibly strong and resilient, she let us know that she was diagnosed for lynch syndtome and that it can affect us 50% chance we have it as well(me and siblings) what can we do now/ what is the process of detecting lynch syndrome for me and my younger siblings? Where can I get testing for this?

I'm also in college don't currently have a job altho I will soon, so I don't have health insurance at the moment altho if this testing is obtainable I can pay for it

Please any advice or help is greatly appreciated

So I got my ancestryDNA test and I only share 25% (should be 50%) of DNA with my mother, 14% (should be 25%) with my aunt, 7% (should be 14%) with my cousin, and 14% (should be 25%) with my grandparents. How did I only get half of the DNA I was supposed to get from my mom? If I was someone else’s child, the rest of the line (aunt, cousin, grandparents) wouldn’t be half the amount as well. My mom had me at 23, so there’s no way she’s my actual grandmother. Are there any scientific explanations for this? Also, my mom has already offered to re-test. My dad is dead (and cremated) so there’s no comparing the DNA there. My only sibling is in the wind and I don’t know how to find her, let alone try to get her to take a test.

What are the transcription, protein and metabolic consequences resulting from Heterozygosity for a non-functional HADHA gene?

Does the body modulate, up-regulate HADHA transcription?

Is there a specific chromosome, example: Chromosome 22, that contains the YDNA? Or, does it differ with each individual man?

Both parents were tested for weak D antigen as well. Both came out negative. Thanks everyone!

Researchers have given mice "supercharged" hearing by altering a single gene, improving their auditory capabilities beyond normal levels. This breakthrough could lead to advanced treatments for human hearing loss in the future.
https://www.sciencealert.com/changing-a-single-gene-gave-mice-supercharged-hearing?utm_source=tldrnewsletter

CRISPR gives the potential to edit genes, and perhaps fix part of our damaged DNA.

What does this mean, if at all, for people who live with chronic or atopic health problems? Is there potential in future to fix these?

For instance, it has been widely discussed whether something like Dermatitis is caused by genetics.

I’m a total lay person but I saw a video earlier and it got me excited at the possibilities of what CRISPR could accomplish.

Husband swabbed daughter (buccal swab), he has the gene mutation/disorder being tested for. She pops up positive despite not showing any of the physical signs. I am grasping at straws here but is there a chance his DNA got on the swab somehow, and would the test be able to differentiate if so?

For instance, variant of the SHANK2 gene is associated with ADHD, but there's no information like "A,T" or "C,G" or anything like that. " A comparison between the two aggregated samples identified significant evidence of disease association for three SHANK2 SNPs with both ADHD and ASD, even after multiple testing correction: rs11236616 (OR = 0.762, permuted p = 0.0376), rs7106631 (OR = 0.720, permuted p = 0.0034), and rs9888288 (OR = 0.770, permuted p = 0.0407)."
Everything I look at is basically like this. I thought every SNP would have A,C,G,T. For instance, "rs4141463 (T;T)", not associated with ADHD necessarily, just an example. Do I have it wrong?

I saw a video on YouTube about blood types and genes and I realized I found something strange about blood types in my family. So my mother is AB+ my father is o+ my older brother is o+ one of my sisters is A the other B and I am AB+. Is there any recourses that anyone has referring to a ABo type blood genes? I don't know how to exactly find a coinciding article about it. I know my mother was 100% faithful we all resemble my father and tested through ancestry and matched each other dad and mother included.

Hi everyone, I have a question: if I need to perform a Whole Exome Sequencing analysis on a gene that has 97% homology with a pseudogene, could I increase the sequencing coverage from 100X to 400X for that sample to avoid false positive variants? Or, since the gene and pseudogene are homologous, would I still be unable to discriminate between them?

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I've heard about people having a certain gene about making cilantro taste like soap to them, is it possible to have that kind of gene on taro as well? at least the vegetable taste like soap cause taro milk tea tastes fine to me. I've also never eaten cilantro before so idk if its the same "gene"

Is definitely true the Andamanese and Onge not only have Neanderthal and some slight Denisova introgression, but also a 2%-3% from another unknown source ? What other species could this be if it is so ?

I may have misunderstood them to be TF binding sites that don't get transcribed into RNA, now I'm hearing that they need to be transcribed to function. What is true here? Please explain like I'm 5

Hi! Thought you guys could know, what are the easiest flowers to breed for colors? I'm very interested in breeding some inexpensive small flowers that could give me some new colors and variations. I've always been intrigued by genetics that make animals or flowers have certain colors. How does breeding flowers work? I'd love some articles if you guys had any. (Sorry for any mistakes, English isn't my native language)

If my husbands cousins come from his mothers sister and his fathers brother, what would that make his cousins in relation to him?

Basically, his aunt and uncle are siblings of his mom and dad respectively.

Are him and his cousins genetically more similar than cousins who don’t share parents/aunts/uncles this way? I can’t wrap my brain around this lol. TIA!

Honestly ngl everything good for genetics wise I've only seen in the US, I don't see many jobs for genetics in the EU at all. I'm thinking of pursuing a PhD in something genetics related, and then going into industry, ideally in UK or Ireland but I'm kind of getting scared out of it because there just doesn't seem to be any industry careers in genetics in the UK, and the ones I see in the EU are pretty basic too. Nothing that seems to pay as well and honestly very little r&d wise. Am I looking for things wrong? My alternative is to go into medical genetics, but I can only really choose one of those two options, as medical genetics takes 4 years to get qualified for here, and the statements are not great at all ("it's enormous pressure and we're not treated great...but it's worth it" which just sounds like "it sucks but I have to say good things" haha)

For reference I'm about to graduate next year with a bsc degree in genetics with what I guess is a 3.9?4.0? GPA equivalent (for americans), it's a first class honours degree for here. I also have both research experience in wet labs and dry labs as well as some experience in a medical genetic oriented lab (doing genomics). Now I'm immensely stuck in between these two options because neither career seems to have good prospects where I am. Am I fucked if I dont consider moving?