I am AB+. Is that a good blood type to have?

Does anyone know of specific researchers or journals that deal with historical disease mysteries in genetics? I'm a nerd for medical science, history, and genealogy. And genetic genealogy, etc.

Going through reams of lists and old documents and family tree data, I sometimes come across interesting examples of probable genetic diseases. (Like an x-linked brittle bone disease.)

Is there anyone who'd be interested in this stuff? Academically, or just here on reddit? Would this sub be appropriate, or is there somewhere else it might fit?

I did at home test bought at Walmart test goes through ddc a few months ago the results came within a week results were 99.9% now I feel a bit unsure due to the fact that I think what if there was an error at the lab or anything wrong could have happened I did follow exactly how the instructions said. Anyone has done ddc test kit after birth ?

Hi all! This is a question for genetics professionals, and particularly if there are any MDs in the crowd.

I am M3 at a US MD program. It's about time for me to apply for away rotations... My problem is that I'm pretty poor, and I'm not sure if it's worth it to take out more student loans to do an away in genetics.

Pros:

• An away rotation gives me an opportunity to experience clinical genetics before I apply for residency.
• There's a specific place I've been before, and I'd love to go back
• Thinking about doing a rotation at what might be my #1 for residency
• Getting to travel!
• I've been hyperfixated on doing away rotations for 3 years so I've been looking forward to it!!

Cons:

• Broke, and an away will cost probably $3k
• I feel like genetics programs will be understanding if I can't get much experience before applying, given that it's so niche, so I don't know if the $3k investment would be worth it
• I am a decently competitive applicant (lots of research, good academics, lots of extracurriculars) so I've heard that doing an away might only hurt me if I make a mistake or otherwise don't make a very good impression
• Thinking about doing an away where federally-funded research is prioritized, so with all the stuff going on with Trump admin, it's like an unnecessary layer of added stress

Please let me know if you have any advice for me! thank you.

If a deceased person has n children, is there a general formula that can predict how much of their genome can be reconstructed if the genomes of their children and the other parent's/s' are all known? For one child, I know that 50% should be reconstructable and two children should average about 75%, but I'm not sure how the math should shake out for higher numbers

Some people congenitally lack this sodium channel and feel no pain

Hello! To make a long story short my grandmas dad came to iceland in world war 2, got her mom pregnant with her, went to germany and my grandma and her mom never heard from him again. We know his name and that hes from kentucky. Ive gone deep diving trying to find him and my grandma has one photo of him. Thats it. I really want my grandma to know more about her family since shes sick and will probably go soon. I want to buy her one of those kits to find some info but im struggling deciding which one is best.

As titles implies, just an extremely stupid hypothetical on our current genetic modification. Specifically, could we get it to not just be the horns like normal Zebrak, but also the black with Red, orange, or yellow markings? Quick answers are appreciated

Can someone dumb down the difference between all the various tests? My son has had a chromosomal microarray that came back with a variant of unknown significance. My husband and I both had no abnormalities on ours. He’s also had a whole exome sequence with no abnormalities & now they’re encouraging a whole genome sequence. We’re prepared to do it, of course, but I don’t feel like I get the difference well enough to make that decision?

For context, he has low tone and has had a developmental regression. He has sleep apnea & a whole host of other concerns.

Thanks!

Hi all,

I really want to pursue grad school for bioinformatics, as I love the fusion of data science and biology. I specifically wanted to work in genomics, but also being qualified for machine learning jobs was a plus. However, I've stumbled across this program that has bioinformatics in the title, but is almost entirely genetics/biology based, with very little bioinformatics/data science/biostatistics electives offered (mostly looks like the courses I've already taken as an undergrad). I love biology and actually started college with it as my major. I'm not opposed to this transition, as I still believe it would lead to careers in bioinformatics, but am wondering what else it would qualify me for.

Hi, I have a question. I'm a biology student, and I'm currently taking a course called Genetic Engineering. I'm having a hard time understanding the concepts in this class.

I tried using the recommended books from the course syllabus, but the main suggestion is a general genetics textbook. While it’s obviously related, I feel like the topics we're covering aren’t explained in enough detail, or sometimes I can’t find them at all.

Could anyone recommend a good book for studying genetic engineering and better understanding its concepts? I’d really appreciate any suggestions!

I've been researching hair follicle regeneration and gene editing, and I’m wondering if there have been any recent advancements in using CRISPR, stem cell therapy, or tissue engineering to change follicle shape, rather than just regrow hair.

From what I understand, follicle shape determines curl pattern, with round follicles producing straight hair, oval follicles creating wavy/curly hair, and elliptical follicles producing coily (Type 4) hair. If gene therapy can edit hair growth patterns, could it also reshape follicles over multiple growth cycles?

I came up with a list of questions:

• Are there any current studies or clinical trials exploring follicle shape modification?
• Could stem cell injections or tissue engineering create new follicles with a controlled shape?
• Is there any existing treatment that gradually alters follicle shape without surgery or damage?
• If anyone has knowledge of early-stage biohacking experiments, I’d love to hear about it.

Right now, research into 3D-bioprinted follicles, CRISPR for hair regeneration, and microenvironment reprogramming seems promising, but I’m wondering if anything is close to real-world application.

Me personally, I have 3B hair, but I always wanted type 4 hair, which is much tighter and coily. I would indefinitely be up for trials if enough research allowed for it.

Any insights or links to studies would be really appreciated

Hi - as the question goes. I’m asking if I marry/have children with someone completely unrelated to me obviously.

However I am the product of a second-cousin marriage, what are the chances of me passing on any birth defects to future children or latent genes?

I’ve pretty much been healthy all my life. Been tested for PKD as my Mum has it, but don’t have either - recessive or dominant. Been screened for thalassemia but dont have that either.

Thank you!

Help I have a paternal haplogroup of r-u152 and maternal of H1. From united states. Trying to figure out how to find a less broad haplogroup or just some advice on navigating this. Or if anyone knows this origin that would help as well.Thanks

Is it possible to change the phenotype of an adult mouse (e.g., eye/hair colour) by injecting it with genetically edited cells, or can changing the phenotype of an organism only be accomplished during early embryonic stages ?

600.00 seems a bit steep but appears to be very comprehensive. I am looking for a test to tell me about vitamin deficiencies and what to supplement.

Cheers

I don't think my mom is the type to cheat on my dad though.

Hey everyone I am going to start I'm going to start my second year of my master's program and I wish to do a thesis in the chair in the department of genetics especially focusing on plant genetics I was wondering people in this subreddit can help me find a topic or where can I start looking for one I would like to do something which is very unique I always wanted to do a thesis which is related to CRISPR Cas9 but I've heard that it is pretty saturated at this point so I want to listen to some suggestions

Like what's the biochemical mechanism of it? And how do they not get affected by mutations? Every textbook lists them as being highly conserved - what sort of conservation is being talked about here?

So I saw some video about "weird facts" and it was a story about two sets of identical twins, getting married to each other, and each couple having a baby at the same time. So, according to the video, the children, though technically cousins, were also genetically brothers. Which seems to make sense to me, since identical twins are genetically identical. Is this true, or is there some misunderstanding?

Just a thought about genetics, that formed when reading about effects of malnourishment on children, then also about premature births. Does this kind of complications, that in most trivial case cause a person to be shorter in any way affect their offspring? (given that all ancestors were otherwise [genticaly?] healthy).

Based on fact that enviroment affects expresion of genes in living creatures.

When I look up my DRD4 gene in my 23andme raw data, this is the first in the sequence.

Marker: rs587776842 Position: 637537 Genotype: CCGCCGACCTCCT / CCGCCGACCTCCT

When I click the marker, it shows it is a Indel variation type and that it is a frame shift variant.

What do you think the impact of this could be?

This is my mom’s twin sister’s result. My mom and aunt were always told they were fraternal because my mom didn’t have the same congenital defect as my aunt, though they’ve always looked very similar (to the point that people who knew one in passing would approach the other in public). Is it likely/possible that I could get this result from a fraternal aunt, or is this only possible if they’re identical?

Anybody ever done this test through Baylor? My geneticist says it's pretty uncommon, wanted to hear what people thought about it.

Hi folks, any insight on how and why the methionine, cysteine, SAM, and taurine metabolism subpathway gets thrown off? Methionine (methionine sulfone) in particular?