Hello, I got some hello mood gummies and was cutting them up for a little while. I've heard that method is kinda iffy, there may not be even amounts distributed in a gummy.

Can anyone recommend a capsule or individual mints? Would prefer to buy online

Thank you! <3

Hi everyone, I am 23 F and bordering on BMI 29 for the last year. I have been trying to get a prescription for Wegovy but the doctors say I am just not quite overweight enough (bullshit). I was wondering if anyone would be able to order Wegovy for me from their account or create an account if you are eligible overweight. Of course, I would pay you for your kindness and the medicine of course. I will give anything to lose weight and get my self esteem back. By the way, I am located in Denmark but will go anywhere in the EU/UK to pick it up if necessary.

If you're a Further Education student in NW England, please follow the link to find out more and take part

https://forms.office.com/e/Jd3ApRbsiq

It's becoming unmanageable, but between the cost, insurance hassle, and my abusive parents, I can't get properly assessed, let alone get prescribed anything to help.

I hope this isn't too on the nose, but is it possible to.. acquire adhd meds on your own(Europe), like sort of DIY treatment?

If not, any "natural" stuff, like, how I usually use melatonin or valerian to pathetically attempt self-medicating. Literally just anything to take the edge off, because it's impossible to study or attempt school properly, and it's getting harder and harder to take care of myself all because of adhd and it's symptoms, which also accelerates my depression.

Thanks for any help, I'm desperate.

I’m pretty sure I’ve got ADHD, currently undiagnosed and probably won’t be for a while. Everything is so unbelievably difficult. My grades are slipping, I can’t focus on anything, and I feel like I’m losing control of my life. I can’t keep living like this anymore

I wanted to ask if anyone has any recommendations for things that could help. I’ve tried caffeine, exercise and iron supplements, none of which have helped. Vitamin B has helped somewhat, but not nearly enough.

I’m in the UK if that affects access to certain things, but may be moving to the Netherlands sometime in the near future.

I‘ve been diagnosed depression and social anxiety since I was a young teen. I‘ve tried over 15 different meds of different classes and 3 therapies (2 analytical depth psychological & 1 cognitive-behavioral). Nothing worked out.

Even my doc says at this point my issues are very probably biological/biochemical/neurological.

Only thing that worked was my last prescription: Pregabalin. But it‘s something I don‘t want to take daily because of the horror stories about dependance and withdrawal. Also tolerance is decreasing my effects already after 3 days of daily intake anyways - so that‘s like a safety sytem keeping me from taking it daily.

I also like Kava and Kratom. They don‘t make me very functional like Pregabalin that enables me going out, socializing, working on my personality and future and such but they definitely reduce my pain of depression. Kava relaxes me a lot and Kratom even enables me to be active like work on university stuff, clean my apartment, finish some organizational things of my to do list and so on. They both make me not suffer for as long as I use them.

So I thought about cycling them and maybe other things with some off-days of course to keep awareness of the „sober feeling“ and reflect on these days.

An example would be like:

Mon: Kava Tue: Pregabalin Wed: Kratom Thu: Off Fri: Kava Sat: Pregabalin Sun: Off

I would also want to try out and add to the cycle following substances (if I find them to be effective): Mulungu, Passion flower, Skullcap, Wild Lettuce (what I already tried and is quite effective: stack of Bacopa, Gotu Kola and ALCAR or high dose Inositol).

Now I‘m wondering if anyone of you follows a cycle like this to reduce the risks of taking one single substance daily. What does your cycle look like?

Just today my new doctor told me I will get diffrent pills because fevarin was already old when she started working, its ment for kids and also they sperently stoped making it. But I still have a half full box at home so i was wondering if anyone has somekind of experience with it?

It's been a few years since I used to trip, back when I didn't smoke or even eat my weed. Since then I've had some major life experiences including living on my own, being homeless, working, and two relationships, which I had never really dabbled in before seriously. Last fall I got put on an SSRI for the first time... then another one on top of it, then mood stabilizers, then sleep aids, then stimulants, then antipsychotics for anxiety, then more SSRIs... I was in the hospital twice through this and tried residential treatment once (of which I only lasted 6 days, its crazy the mistreatment those companies can get away with) and since then I've stopped everything. The SSRI withdrawal is by far the worst. To be fair, its the drug I was on the longest and a handful of the different medications I tried only for a few weeks. It's been about four weeks since I started tapering it and about 3 since I've been off it completely. It's been hell, but it's finally starting to come down. I only take nausea meds (sedatives) and some of my leftover antipsychotics (atypical, also sedative, prescribed off label for nausea and advised by the prescriber of the other sedative) in half doses for the nausea as well, although less often than the nausea meds. When this is over all I want to do is start tripping again. I was happy back then. I've been depressed all my life and struggle with PTSD which is why that joy was so prominent to me. It's an insane difference between the me who trips every other weekend (or maybe like once a month at this age lol) and the me off OR on meds, of which I've tried a vast variety. I've been prescribed a lot of stuff off label because of my condition being treatment resistant and have ruled out any possibility of psychotic disorders, schizophrenia, and personality disorders, so all I'm dealing with is depression, anxiety, and PTSD. ADHD with OCD traits is something I'm closely monitoring and something that although affected by recommended medications, not quite "fixed" thanks to the former 3. Psychotherapy is helpful but not healing. Any other treatment has fallen through the cracks. Any legal psychedelics aren't covered by insurance. I'm just tryna find myself again and that's the last time I remember seeing him, when I was tripping. Hopefully I can get back there soon.

I’m suffering depression and especially social anxiety. For more than 5 years now and I‘ve tried almost everything out there regarding therapy (3 times without success), prescribed medication, antidepressants, valium, lyrica, kratom. Life is still a total mess, painful and unbearable. Nothing helped.

I just found that I have Bacopa, SAM-e and Mulungu at home. Anyone experiences with one of these regarding mood, relaxation, mental changes or especially improved sociability and reduced social anxiety?

Any other OTC, supplement, or whatever, that you want to recommend because you think, read or experienced it‘s very helpful for social anxiety (and depression) issues?

I‘m very grateful for any help. For real!

I suffer from depression and social anxiety since I was 15 years old (symptoms occured even before but with 15 I started noticing it very clearly, with 17 I first started going to a psychiatrist and therapist). Now I'm 23 and tried 3 different forms of therapies as well as over 14 different types of meds. Nothing helped so far, nothing reduced my symptoms. It's now called treatment resistant depression and even my doc says normal therapy is not effective for my type of depression, it definitely is caused biochemically/neurologically/biologically.

Except for my very last one: Lyrica. Lyrica helps at least a bit and makes my anxiety and depression a bit better. But I know Lyrica can cause dependance and horrible withdrawal as well as tolerance, so best would be to not use it daily but only as rarely as possible. I don't want to use any substance daily at all anyways, cause I've been through many horrible withdrawals. Hence my plan of cycling substances, meds, supplements, whatver to finally have a painless life.

My doc wanted to try every possible med left with me, so she's very open for new meds, which I'm too. She mentioned Tianeptine to try on me soon as - as said - Im trying my 15th med now without success or symptom reduction, for years, 2 depth psychological (analytical) and 1 cognitive behavioral therapy failed to help. I also do sports weekly (tennis and/or gym, skiing sometimes).

I might just take it if needed then, even if she prescribes it for daily. I mean, if it‘s an opioid and one says even harder to get off than oxy… Maybe if needed same as my Lyrica so one can switch them to reduce risk of tolerance/dependance/withdrawal of each. A 3rd med of different class would still be better to have a good cycle and get maybe at least 3, maybe even 5, worthful to live days and free of suffering days a week. 2 days completely off then.

Any idea? Lyrica is gabapentinoid = calcium channels, a teeny bit of GABA receptors itself too. Tianeptine is opioid = opioid receptors. What else could be added but not using the same receptor or system? What about Buspirone, Hydroxyzine, Clonazepam? So far I only have found Lyrica & Kratom to be helpful (even if it's not "curing" me, just making my day and symptoms by maybe 20-50% better, but only if not taken daily - hence the need for a cycle and not taking any similar chemical daily)

As I don't want to use any similar chemical daily or many days in a row or a week at all and in the best case only one neurotransmitter/CNS system once a week max, I thought about cycling following, each one only once a week to reduce any risk of possible dependance, withdrawal or tolerance:

Voltage gated calcium channels (Gabapentionoid):

• Lyrica (Pregabalin) => said to don't have much GABAergic affinity on its own, rather acts indirectly and weakly on GABA, hence hess less risk of cross tolerance with GABAergics (if I should add any GABAergic as a benzo to my cycle, too)

Opioidergic:

• Tianeptine (opiodergic antidepressant)
• Kratom (legal opioidergic plant) => question is, how strong would the cross-tolerance with Tianeptine be if used with a break of many days in between as both are opiodergic afaik?

GABA:

• Benzodiazepine => Valium/Diazepam didn't work so I told my doc to quit my script for it as I don't find any use for it => a friend of mine with very similar symptoms had great experience with Clonazepam instead

Dopamine and/or Norepinephrine:

• Ritalin
• Adderall
• Modafinil
• or similar AD(H)D stimulant medication
• => big issue: I guess I only have a 10% chance of getting any of these stimulant AD(H)D meds cause even if I strongly suffer from symptoms very similar to ADD (without the H for hyperactivity) no doc ever wanted to test me for ADD as long as my depression and anxiety weren't cured, that's why I never got a diagnosis until now and now docs tell me, you can mainly only get a diagnosis for ADD if it has been diagnosed in the childhood or when one has been very young, also one had to have very bad grades in school for one of the diagnosis checks => so my school grades have only been medium bad, not very bad + I'm now 23 and maybe a bit too late for school medicine to hop on the ADD train even if I always had the thought of suffering from ADD cause of my very bad cognitive symptoms (focus, memory etc.) + ADD goes hand in hand with depression and anxiety and might be a cause of these symptoms afaik (so why the hell no doc ever tested me for it before trying to always continue treating me with typical depression therapy and meds instead of giving the ADD train a go???)

Other psychiatric medication (with need of a prescription by my doc) I thought of to add to cycle for the other left days in my week full of suffering that may be helpful for finally making my life painless and livable:

• Hydroxyzine
• Buspirone
• Lamictal
• Abilify
• Amisulpride
• Selegiline
• any other ideas? as said my doc is really open to try new meds with me cause she knows how desperate and treatment-resistant I am and have been for years now

OTC meds/supplements/herbs I thought of to add to cycle for the other left days in my week full of suffering that may be helpful for finally making my life painless and livable:

• Kava: legal anxiolytic plant, had some good experiences with it reducing my symptoms strenghts, being anxiolytic and antidepressant BUT it's a big hit and miss, causing skin issues for me (when taken some days daily in a row) and very expensive, hence surely also nothing to take daily => ALSO: there's not much science about rather it's GABAergic or also rather a voltage gated calcium channel blocker (VGCC blocker) as Lyrica, or how it really works, but it's said to not have any physical dependance or withdrawal issues or risk => question again, is there any cross tolerance with Lyrica or Benzodiazepines?
• DXM (Dextromethorphane): dissociative antitussive => originally a cough medicine, now officially used for depression and I already read years ago many times about people using it to self medicate their depression and anxiety in non-trip-doses (cause some people abuse it in mega-doses to get a psychedelic trip from it, which I never planned or wanted to)
• Kanna (Sceletium tortuosum): natural SSRI => sadly never noticed any effects from it when I tried the plain herb as well as extract orally or sublingually in low to medium dosage (some swear on having to take it intranasally to get antidepressant/anxiolytic effects but I already hate the thought of having to take something through my nose)
• Gotu Kola => seems to help a bit, might be good for my "off-days" off "real stronger medication"
• Lemon Balm => seems to help a bit, might be good for my "off-days" off "real stronger medication"
• Beta Alanine => some studies promise anxiolytic effects because of it's GABAergic properties

Some probably very weak herbs having no sense to try for my severe treatment-resistant depression and social anxiety:

• Tongkat Ali => testosterone increasing, read some reviews about people having success with it for depression and/or (social) anxiety
• SAM-e => read some reviews about people having success with it for depression and/or (social) anxiety
• Bacopa => read some reviews about people having success with it for depression and/or (social) anxiety
• Lions Mane Mushroom => read some reviews about people having success with it for depression and/or (social) anxiety
• KSM-66 (Ashwagandha) => read some reviews about people having success with it for depression and/or (social) anxiety BUT tried one KSM-66 product from Amazon for more than 2 weeks daily and never had success with it or any symptom reduction sadly...
• Taurine => read some reviews about people having success with it for depression and/or (social) anxiety BUT never worked for me, maybe I have to increase dosage to a mega dose?
• L-Theanine => read some reviews about people having success with it for depression and/or (social) anxiety BUT never worked for me, maybe I have to increase dosage to a mega dose?
• Silexan/Lasea (Lavender extract) => read some reviews about people having success with it for depression and/or (social) anxiety BUT never worked for me even after trying it for more than 2 weeks daily
• Rhodiola Rosea extract => read some reviews about people having success with it for depression and/or (social) anxiety BUT never worked for me even after trying it for more than 2 weeks daily as well as only as needed
• Akuamma
• Wild Lettuce
• Skullcap
• Mulungu
• Passion flower
• GABA (plain powder supplement of GABA, infamous for not crossing the BBB so not being able to have any psychoactive effects)

Sure, last resort for me is also still:

• stronger MAOIs as Nardil or Parnate (I already tried the weaker MAOI "Moclobemide"/"Aurorix")
• Ketamine therapy
• rTMS
• ECT

This is no recommendation. Daily use of any substance especially psychoactive is connected to big health risks and dangerous withdrawal. This is just a thread to summarize your experiences and opinions on using DXM for depression, social anxiety and other mental health issues.

I don‘t want to use it daily, max. 1x a week to introduce it into my cycling plan so I don‘t have to use lyrica or kratom daily anymore and can switch them. Rn I‘m only using Lyrica as prescribed for 2 weeks doing some days off here and there, but I don‘t want to prolong this use due to tolerance & withdrawal risks of regular lyrica use - even if prescribed like this. I‘d love to be able to use Lyrica 1x a week, Kratom 1x a week, DXM 1x a week and that‘s the cycle. Day off between everytime. Just some insights into why I‘m creating this post + the fact to have a reddit post to collect all the information, science, experience stories and opinions regarding DXM for mental health issues.

DXM works similar to Ketamine and is now even used in a new 2023 antidepressant medication (called „Auvelity“ containing 45mg DXM + 100mg bupropion/wellbutrin compound). This new antidepressant, which should act rapidly in comparison to other ADs, is meant to use daily for weeks to months (as most antidepressants) so it seems that science sees the danger of daily DXM lower than usually thought.

There are a bunch of people having success with DXM treating their depression & social anxiety with it. Only a few examples:

https://www.reddit.com/r/Drugs/comments/3jx7h7/anything_like_dxm_for_social_anxiety/

https://www.reddit.com/r/Nootropics/comments/izrxma/low_dose_dxm_eliminates_depression_and_anxiety_is/

https://www.reddit.com/r/dxm/comments/s0a2g5/treated_my_social_anxiety/?utm_source=share&utm_medium=ios_app&utm_name=iossmf

https://www.reddit.com/r/dxm/comments/a6emu1/has_dxm_the_potential_to_cure_depression_and/?utm_source=share&utm_medium=ios_app&utm_name=iossmf

https://www.reddit.com/r/dxm/comments/88lows/safe_to_take_45mg_daily_for_anxiety/?utm_source=share&utm_medium=ios_app&utm_name=iossmf

https://www.reddit.com/r/dxm/comments/5m8ppb/people_whose_depressionanxiety_are_relieved_from/?utm_source=share&utm_medium=ios_app&utm_name=iossmf

https://www.vice.com/amp/en/article/9kzkje/dxm-cough-syrup-antidepressant-ketamine

Or comments like:

„Dex also helped me with my social awkwardness and helped my confidence a lot.“

„This is analogous to a dxm trip i took yesterday. I took a much smaller dose, but noticed a huge relief in social anxiety. I much better at just thinking of what to say in any particular situation i imagined. This is probably related to why ketamine and ibogaine are so effective for depression and anxiety, both if them being huge dissociatives“

„It [DXM] works great for me at low levels. I usually take 60-120mg a few days a week and it yas been incredibly helpful for my depression and anxiety. It seems to be helping my ADHD, as well. At that low of a dose I don't really feel "fucked up" and I find that I actually function even better.

I've been on a variety of different meds / treatment combinations for debilitating anxiety and depression, OCD, and bipolar II since I was a teenager (with a couple stints of being off them completely). Many of them helped to an extent; they allowed me to function and reduce the frequency of severe depressive episodes. But they also came with a lot of negative side effects and more so numbed my emotions, so the depression felt more mild, but so did my joy.

I did ketamine infusions last summer, followed by at home nasal spray for maintenance. After my 3rd infusion it was like the cloud that has hung over me my entire life was completely lifted. It didn't just blunt the pain. It actually healed it and allowed me to face my pain and try to work through it. Unfortunately.....

(Official/medical) Ketamine is very expensive and not covered by insurance. I was doing a ton of in depth research about the science / mechanisms behind it and that's when I discovered that DXM works in an extremely similar way as ketamine and there is actually an antidepressant that's close to FDA approval that combines DXM and Wellbutrin.

The cost is way more affordable on a long term basis. It all comes down to knowing the window of effectiveness and taking the correct dose.

TL:DR: smaller doses of dxm, taken a few days a week can help depression/anxiety tremendously (seems to also help ADHD). Its underlying mechanisms of action are very similar to ketamine, but DXM is way more affordable.“

A bit about the Psychopharmacology via Wikipedia:

It is in the morphinan class of medications with sedative, dissociative, and stimulant properties (at lower doses). Dextromethorphan does not have a significant affinity for the mu-opioid receptor activity typical of morphinan compounds and exerts its therapeutic effects through several other receptors.[6] In its pure form, dextromethorphan occurs as a white powder.[7] Dextromethorphan is also used recreationally. When exceeding approved dosages, dextromethorphan acts as a dissociative hallucinogen. It has multiple mechanisms of action, including actions as a nonselective serotonin reuptake inhibitor[8] and a sigma-1 receptor agonist.[9][10] Dextromethorphan and its major metabolite, dextrorphan, also block the NMDA receptor at high doses, which produces effects similar to other dissociative anesthetics such as ketamine, nitrous oxide, and phencyclidine.

Dextromethorphan has been found to possess the following actions (<1 μM) using rat tissues:[14][30]

• Uncompetitive antagonist of the NMDA receptor via the MK-801/PCP site[30]
• SERT and NET blocker (cf. serotonin–norepinephrine reuptake inhibitor)
• Sigma σ1 receptor agonist
• Negative allosteric modulator of nicotinic acetylcholine receptors
• Ligand of the serotonin 5-HT1B/1D, histamine H1, α2-adrenergic, and muscarinic acetylcholine receptors

Dextromethorphan is a prodrug of dextrorphan, which is the actual mediator of most of its dissociative effects through acting as a more potent NMDA receptor antagonist than dextromethorphan itself.[31] What role, if any, (+)-3-methoxymorphinan, dextromethorphan's other major metabolite, plays in its effects is not entirely clear.[32]

Anyone here experiences with it? What dose? How long has it been taking until significant effects showed up?

Re effects I especially mean depression/mood, anxiety, social anxiety/sociability, better outlook, positive thoughts, motivation and drive instead of lack of drive, energy, joy to do things go out and live life. Also cognitive plus points?

Very thankful for hearing your experiences!

I tried over 13 meds and 3 therapies of different classes. None of them helped, fighting this war for 7 years now. Now there are not many other meds left that I could try. So looking for unusual supplements that might help.

Any other herbs or supplements that helped you? Also OTC meds like DXM if they can even help.

I know there is no magic pill but maybe some supportive one.

I have tried every possible antidepressant, ssris, snris, atypicals, tetracyclics etc. as well as antipsychotics, benzodiazepines, z-benzos and gabapentionoids (gabapentin & lyrica) + 3 talk therapies going to the root of my issues and 3rd one treating cognitive-behaviorally.

Well it did a shit, for real, nothing. Im a wrack, still suffering big mental pain, daily.

Sure, I also tried many supplements already but still I'd be happy about any experience reports of these substances I listed down on my "still to try list" or any others you tried that helped your mood/depression and/or anxiety (esp. social anxiety/sociability/social fluidity/talkativeness/extroversion).

Especially imporant to name, please:

• the brand of the product
• the dosage, how long it took until effects occured
• what did the effects feel like (regarding mood/depression, anxiety/social anxiety/sociability/talkativeness, drive/energy/motivation, anhedonia/feelings of joy,passion,interest, cognition and so on)

I'd also be happy about anyone here open to share his background story, maybe similar to mine, tying everything of traditional medicine and even trying self medication to treat mental disorder (which Ive been having since my childhood).

Before one recommends THC/CBD, Kratom or Phenibut I already tried thouse without longterm success:

• Kratom (very strange, for years 99% ineffective for me, suddenly like a year ago after years of experimenting with it, still hoping for that effect everyone writes about, it started working, but if used daily, always only one week, then second week declining, third week being in sudden withdrawals even if still dosing same amount, no effects, only dosing to feel a bit less horrible, got addicted)
• Phenibut (best ever, gave me 2 years full of loving my life, got addicted, hell on earth withdrawing but survived and not touched it again, but by giving me years of a good life at least, i dont regret)
• THC/CBD/HHC etc.: All make me more anxious and depressed, sadly.
• also: Agmatine (1-3g for a time period over a month, no effects)
• and all the typical vitamins (D, K, C, B, Methylfolate 1mcg never the 15mcg as used in studies), Inositol (had slight good effects but not really steady or clearly profound), most other typical first hand for depression supplements

The list of supplements I still want to try giving me a bit of hope (some of these I can just give a go to try as soon as I'm clean off my antidepressants, because of potential interaction risks like serotonin syndrome):

• Kanna (Sceletium tortiosum)
• SAM-e
• 5-HTP + L-Tyrsoine
• DXM (so many report about big improvements in their depression and anxiety after self medicating with these OTC cough meds)
• Lions Mane Mushrooms
• GABAergics I already have at home: Skullcap (no extract, plain herb), Lemon Balm (no extract, plain herb), Magnolia Bark (Swanson extract), Gotu Kola (Extract), Passion flower (extract), L-Theanine, Taurine, Beta-Alanine
• Rhodiola Rosea (have this in pharmaceutical grade prescribed by a doc once)
• Lavender extract (have this in pharmaceutical grade prescribed by a doc once)
• Nutmeg (i know very dangerous as tiny doses can be deathly, many kids abused this)
• Bacopa monnieri
• Saffran + Piperine
• Shilajit
• Horny Goat Weed
• Polygala
• Mulungu
• Curcumin/Turmeric + Piperine
• High Dose EPA (compound of fish oil)
• DHEA
• NALT + ALCAR
• NADH by NOW
• Allithiamine (sadly Sulbutiamine is illegal where I live)
• Blue Lotus
• Paracetamol / Ibuprofen (some report antidepressant/anxiolytic effects)
• Eugenol
• "Intoxicating mint"
• Albizia Calm
• Cordyceps
• L-Carnosine
• Citrulline + L-Arginine
• Phosphatidylserine
• Resveratrol
• Semax
• Racetams but all illegal in my country too (Phenylpiracetam, Piracetam, Aniracetam, Oxiracetam, Fasoracetam)

Hey dear community,

I already wrote single posts to these but didn‘t really got answers on my question. I‘m really looking out for herbs to help me with my diagnosed treatment resistant depression & social anxiety (and undiagnosed ADHD, so let‘s say big cognitive issues, memory, focus, learning).

Has anyone here experiences with any of the in the titled listed herbs/supplements and wants to share his experience with it/them regarding possibly psychotropic effects? I read about following substances to be helpful for social anxiety and depression: Tongkat Ali, Gotu Kola, Lemon Balm, Magnolia Bark, Mucuna Pruriens.

It‘s not that I don‘t know about others as same as with prescription meds by a psychiatric doc or neurologist as well as talk therapy and lifestyle changes I tried a lot already, so these are especially some that I didn‘t try yet and am therefore interested in, but still very open and thankful for any other herb/supplement or alternative treatment recommendations or experience stories anyways.

I‘d really love and be so thankful for any information, experience report and/or your own „mental health and search for supplements to self medicate“-story.

1. Which substance have you tried? For how long have you been taking it at what dose?

2. What effects from which substance(s) have you experienced and how would you describe them regarding mental health factors as especially mood/depression, stress/anxiety, social anxiety/sociability/talkativeness/openness, drive/energy/motivation, anhedonia, cognition/focus/memory and side effects? Were the effects significantly helpful for mental health/mood/depression/anxiety? Profound and Psychoactive/nootropic or just weak possibly placebo?

To note: I‘m actually on Mirtazapine (mainly antihistaminergic, little serotonergic antidepressant) and my second trial of Wellbutrin (noradrenergic/dopaminergic antidepressant). They do not help at all. They are my 12th and 13th meds now. So I can‘t (or rather don‘t want to risk it) try supplements/herbs that act on serotonin too strongly as Kanna, SAM-e, 5-HTP, Tryptophan and so on - because of possible serotonin syndrome.

Not necessary but if you want to know more about my trials to treat my mental health issues or background, here you go:

I‘ve now been trying to treat my disorder(s) since I was 17, today I’m 23. I‘ve been 15 when I first clearly noticed the symptoms, that there‘s something wrong with me, but looking back (also together with therapists) the symptoms occurred already since my childhood). So with 15 the suffering slowly started as it was only then when I started being aware of my mental health issues.

17 years and I secretly called the psychiatric hospital near by to ask for help. Started visiting a therapist and got my first antidepressant which was a SSRI of course. After months in depth-psychological therapy and months of even increased dosage of the SSRI I didn‘t get better. This was the beginning of my trial to „heal“ myself or improve until now, 6 years later. In this time I‘ve been through 13 different meds (SSRIs, SNRIs, Wellbutrin, Antipsychotics, Tricyclics, MAO-A-Inhibitor, Atypicals, Benzodiazepines & Anticonvulsants) and 3 talk therapies with therapists (2 depth-psychological/analytical, 1 cognitive-behavioral).

Until today nothing has helped, my symptoms are still present, contributing to every single part and moment of my life and making living a really painful big suffering from the moment I open my eyes in the morning to the moment I close them at night. I also made a general test for possible issues caused by abnormalities in vitamins, minerals, thyroide and all that microbiological stuff: nothing, everything came back with perfect values. I tried Keto diet as well as Carnivore diet, nothing. Going to the gym helps, but life is still just pure suffering. I know (and also as discussed with my therapists) that one of the biggest sources or my depression is definitely my social anxiety. I’ve always been shy/silent, even as a child, as my mother told me. So this shyness has already been or has became a disorder, social anxiety disorder. However, all the bad sides of social anxiety as social isolation, not being able to socialize well, canceling many appointments with friends, not leaving the house, not going to classes, sports or leaving the house at all led to cause or worsen my already present depression extremely and still does. It‘s as bad that on my worst days I don‘t really eat, drink, wash, move at all or go out.

I want to use it for depression, lack of drive and mainly social anxiety. So especially for the daytime, taking it in the morning. I already tried over 13 psychmeds and 3 therapies so you don‘t need to recommend me visiting a doc, get professional help or using strong psychopharmaceutical meds.

If you have experience with this supplement, I would love if you could share your experiences of the effects with me, I have a few questions:

1. What effects do you experience from it if you would have to describe it? Regarding mood, anxiety relief, stress, sociability, talkativeness, cognition, motivation/drive. Are they subtle or significantly helpful for depression/anxiety-disorder, profoundly noticeable, even psychoactive?

2. What dose do you use that is effective or is recommended? Please also differentiate between no extract vs extract as this is a main factor ofc. What do you use?

3. Any brand you can recommend?

I want to use it for depression, lack of drive and mainly social anxiety. So especially for the daytime, taking it in the morning. I already tried over 13 psychmeds and 3 therapies so you don‘t need to recommend me visiting a doc, get professional help or using strong psychopharmaceutical meds.

If you have experience with this supplement, I would love if you could share your experiences of the effects with me, I have a few questions:

1. What effects do you experience from it if you would have to describe it? Regarding mood, anxiety relief, stress, sociability, talkativeness, cognition, motivation/drive. Are they subtle or significantly helpful for depression/anxiety-disorder, profoundly noticeable, even psychoactive?

2. What dose do you use that is effective or is recommended? Please also differentiate between no extract vs extract as this is a main factor ofc. What do you use?

3. Any brand you can recommend?

Hi I've been diagnosed with anxiety without panic attacks and got fluoxetine prescription. Unfortunately my doctor gave up his position three days before my appointment °_°. I have to wait for appointment with new doctor for four months, but I have pills only for next 28 days and I start university in two weeks grfxghhbcxs 🤬 So I need a temporary alternative.

Telling You guys that fluoxetine is a "selective serotonin reuptake inhibitor" wouldn't make much sense so I'll describe it's effects. It's obviously an antidepressants but it is also energising and helps me focus but in much more stable wave then coffee or sugar.

Out of herbs I know that ginseng is popular for focus But Rhodiola rosea description sounds more similar. Dose anyone have experience with one of these or maybe do you have a better idea?

Just please don't even mention Lemon balm it makes me sleepy and unmotivated what in turn makes me feel worthless and even more depressed 🤢🤮

Thanks anyway

Anyone here experience with Amisulpride, Tianeptine, Pregabalin (Lyrica), Hydroxizine or Selegiline?

For depression and especially social anxiety it would be interesting for me.

Planned to use on only as needed basis (if possible and no need to be taken daily to build up as most antidepressants).

I‘m on Mirtazapine daily but it‘s doing nearly to nothing regarding social anxiety while it helps depression a tiny bit (more than any other of the 12 other antidepressants I tried so I stay with it but need sth for social days which can be used only as needed like an emergency medication).

I don‘t want to take anything daily that‘s why I ask if anyone here has experience with one of the mentioned substance AND if they or which of them can be used as needed for social anxiety and has no need to be taken daily to be effective. This and what are the effects like if you would have to describe them regarding mood, drive/energy/motovation & especially socializing (social anxiety, talkativeness, will to socialize etc.).

I already cycle Kratom, Kava, Magnolia Bark & Lemon Balm (all max. 1x a week) and need another one or two substances for other days and making breaks of these cycle substances. They shouldn‘t be too strong GABAergics as Kava, Magnolia Bark & Lemon Balm already are „weak“ but still GABAergics. I also do Sunday off everything in this cycle.

I was an ex abuser of Kratom & Phenibut so I really don‘t want to take any substance daily anymore, I‘m planning a cycle way to help me with depression & social anxiety due to that, sth like:

Mo: Instant Kava (5-20g) Tue: Lemon Balm (1500mg plain herb) Wed: Kratom (1-3x2-3g) Thu: Magnolia Bark extract (400-800mg) Fri: Diazepam for social events (as I dont drink alcohol) Sat: Gabapentin (1200mg, Idk?) Sun: Agmatine & Ashwagandha

I also take Vitamin/mineral complex, Vitamin B complex, Vitamin C, Vitamin D & K, Zinc, Selen, Calcium, NAC, Magnesium glycinate daily (except for Zinc only every 2nd day & Vitamin D & K only few times a week)

Any issues regarding withdrawal of the more profound GABAergics like Gabapentin & Diazepam by that + the fact that Magnolia Bark, Lemon Balm & Kava are gabaergics too (well Kava should rather downregulate GABA as reverse tolerance is present)?

Any ideas for other substances to add and replace? Any ideas for other order of the substances?

Please no recommendation for therapy or professional psychopharmaceutical help as I already went through 3 therapies and 13 meds without success.

Thank you for every help!

I have undiagnosed adhd and I’ve been waiting for a referral for almost a year now.

I’m in second year of university and I can feel my concentration and overall mind getting worse and worse.

I’ve done my research on self medicating and I understand all the side affects and recommend dosages. I’ve also tried Modafinil 100mg - 200mg but that keeps me up rather than focused.

I’ve tried to search for reliable sources but I would rather use a service that’s has been reviewed just incase I get scammed also I’m in the uk so I need one that ships discreetly.

Female researchers at Maastricht University would like to gain insight in the general health status, past drug use and well-being of women. If you are female and/or identify with the female gender, we would like to hear from you.

Click on the link below to read more about the study and fill in the online questionnaire. The online survey is completely anonymous and will take approximately 10 to 15 minutes to complete. There will be no reward given for participating. The study has been approved by the Ethics Review Committee Psychology and Neuroscience (ERCPN-Reference Code: 229_113_10_2020). For questions, contact fpn-pim_p129@maastrichtuniversity.nl.

Survey: Health status of women - Maastricht University

Thank you for your interest and effort.

ONLY FOR PEOPLE FROM INDIA AS THIS IS AN INDIAN POPULATION BASED STUDY.

I invite you all to participate in our study on Self-medication practices entitled "SELF MEDICATION PRACTICES – GETTING RID OF TROUBLESOME OR TAKING RISKS FOR TROUBLESOME - DURING COVID PANDEMIC: A PROSPECTIVE CROSS-SECTIONAL STUDY". This is an online survey to assess the knowledge pursued from various resources and reasons that can impact the patient to practice self-medication.

The Google form link to this survey has been disclosed here - https://forms.gle/sWjgg28BCVKUNvjd6

It would take around 5-10mins for you to complete this survey. The survey consists of 5 sections (2-5 questions in each section).

Thank you in advance for taking the time to respond.

I have some skullcap powder here but have no clue how to use it. I originally bought it for having something for my depression and social anxiety because I just came off my antidepressant (which didnt do a thing for me). I wanted to try some supplements I never tried before instead. One of it: skullcap.

To my questions:

1. Can I use it one week after quitting my antidepressant (Amitriptyline)? Or will there be possible dangerous interactions still?

2.1 What would you describe the effects of Skullcap like? Are they very subtle, near placebo or rather significant and psychoactively noticeable?

2.2 What was your experience with Skullcap? What did the effects feel like? Regarding depression, mood, anhedonia, motivation, anxiety, ESPECIALLY social anxiety, sociability, talkativeness, not worrying or thinking too much what others might think about you etc.

3. Also what was your dose?

4. Is it something that works right away from first dose or rather something like antidepressants or St Johns Wort that needs to be taken daily regularly for a long time until effects start kicking in noticeably?

5. Are there any other substances like supplements/nootropics that you found to be effective and more than subtle/placebo having a significant and noticeable psychoactive effect or helping immensely with depression or social anxiety?

Thank you for every info!

I‘m very sick of no medication working for me. I‘m suffering from depression and social anxiety since I was 15 (today 21). My quality and will of life and self esteem sink always more and more. I tried all the SSRIs and SNRIs available in my country as well as moclobemide (MAOI), amitriptyline (tricyclic), promethazine, quetiapine (seroquel), wellbutrin, opipramol etc in high doses for many months. I tried 2 depth psychological therapies and one behavioral therapy (I‘m still doing). None of these ever did a thing for me, not even a tiny bit, only sexual side effects.

I also tried many many supplements already but maybe there are some I could still give a try. Maybe you could mention some supplements that were most significantly effective for you regarding depression and social anxiety (the biggest source of my depression and self esteem issues).

I didn’t try Silexan, lemon balm, SAMe, Kanns for example. Kratom (tried countless strains, vendors, batches) does sadly have no effect on me. Phenibut is cool but too addicting and I abused it too often so its magic is lost already years ago...

I would be very very thankful for any advice, suggestions or assumptions!

Please share the name of the substance, your experience (regarding what were the effects like, what did they feel like, effects on depression, mood, anhedonia, motivation, anxiety, sociability, talkativeness), your dose and the time it took until the effects started kicking in.

What could I still do or try out? I know ketamine and ECT or rTMS but those are very expensive and I would rather try out some cheaper alternatives before. Anything you could think about? Psychedelics?

Much love from a young man down on the bottom...!

Agmatine is getting some more attention here on the nootropic/supplements/stack advice reddit. Also it‘s used for many substances and drugs for tolerance, withdrawal and potentiation. Many people reported great success with Agmatine and even reduction and relief of their depression or anxiety. I read many studies about Agmatine and these studies show the various great health benefits (physiologically as mentally) it offers. In theory it’s a amazing stunning substance!

I’m taking 2-3x 1000mg of Agmatine per day for maybe 4-5 months already. I have to say that I can‘t really notice any significant effects or improvement/relief of my symptoms of my diagnosed depression and social anxiety. I still plan continuing to take it daily because I read so many other benefits in studies (even if I don‘t notice much psychoactivity myself) that are positive for cognition and brain development, functionality in the central nervous system and health in general.

To my main questions:

1. Did/do you guys notice any significant psychoactive effects right away after you first dose or just some minutes after you take your dosage? Is it more than subtle/placebo? How would you describe the effects that you get from Agmatine? Is there a point when you notice „okay, now agmatine’s effects are starting.“? Maybe I have to focus a bit more on any slight/subtle signals so I can notice „okay this is the agmatine working right now“.

2. For me there never was anything noticeable that‘s worth mentioning. Even after daily use fo months... Does one have to take agmatine regularly/daily for many weeks or months in a row to finally start showing effects? I mean does agmatine have a cumulative effect similar to antidepressants which need to be taken 2-6 weeks daily to build up a certain blood level? Maybe agmatine might be similar, so that the efficiency gets greater by daily intake for some long time because it‘s level in blood gets increased in one‘s system?

3. One thought of me has also been that maybe I just have a low quality product because I never used another product/brand than the one I also use now (ops-pharma „4 your v3inz“. Is there any product/brand that you guys could recommend me?

4. Could it theoretically maybe also be that I need higher doses than 1g? Is this a possibility? How high could I go with my dosage? Anyone here used doses higher than 1g? Any difference?

I want to use a cycling method for psychosomatic pain, lack of drive and mood/social anxiety. I already did 2 depth-psychological therapies and am in a behavioral therapy right now and will also keep doing this therapy while cycling these substances. So I don‘t need any suggestions about „therapy is what you need“, I‘m already very deep into it.

I have prescribed gabapentin, my doc tells me to use it daily but I 100% won‘t do this as it causes tolerance, dependence and then withdrawal. Also daily use will vanish the effects of the gabapentin. Then I have phenibut which I will only take 2-3x max in a week. I don‘t get any strong but only subtle effects from Kratom but it helps me with motivation (studying, cleaning, to-do-list etc) and kills my negative thoughts.

1. What would be a perfect cycle for using these 3 substances in a week?
2. Is this even a possible thing to do or will this bring any negative and dangerous effects on my body, brain and mind with it?
3. Are you cycling any substance use weekly? What substances do you use, how often on which days?
4. Are there any other (preferably legally available) substances you know that I could use in my cycling method?

I thought about something like this: Mo: Phenibut, Tue: Kratom, Wed: Gabapentin, Thu: Phenibut, Fri: Kratom, Sat: Gabapentin, Sun: off

What are your thoughts? Any suggestions, tips, assumptions or valuable information?