What is the safest dose of both Norco and Pregabalin combined together, before I risk serious CNS depression. I have 75 mg capsules prescribed (I take one cap three times a day) as well as only 5mg tablets of Norco scripted for a severe foot injury that I have surgery for in two days (one every 6 hours, so essentially what comes out to a 3 day supply) which of course do nothing). In a lot of pain and I cannot fall asleep on top of suffering from severe insomnia that has had me up for 3 nights. Will start with the safest dose of both combined people suggest, remember I am trying to sleep through my pain not fucking die. And hopefully my insomnia won’t keep me awake after using the safest dose of both people suggest, because along with both drugs I also have an HHC pen that tests at 91% if that also occurs.

Edit: Four broken bones and a dislocated bone in my foot. It’s swollen to hell and fucking throbs. Medium pain tolerance, pain is at a 6. Thought y’all should know.

I am seeking someone to talk to.

Tripping off 1.5 gs of golden teachers n feeling great watching David Attenborough. How are y'all today?

I was in my room smoking weed (I know you don’t normally trip off weed but this trip was so insane I don’t know what happened) I literally woke up in a dream on my knees begging to a unknown figure and I felt true fear and I was telling him all of my darkest secrets and the truth about the way I live and it all sounded so evil while I was begging and I don’t even know why I was begging in the first place then after I was done he said I have never knew you begone from me and I was sent to what felt like hell I was falling into a pit and then out of no where I was sent to a white room with this person inside telling me all of that was fake and that he was the true way and told me to put something on my head and body and told me it would protect me and would help me worship the right god I tired asking him who he was but he said to trust my gut and trust in him I’m not skitzo but I feel like I’m going insane I had a panic attack shortly after that happened and ever since then nothing has felt real and I feel like I’m running out of time even though I can’t change the loop I keep living In

I am tripping on 700ug lsd and I am getting tired. It's overwheling and exausting. Can you guys help me get though this, please? I am not sure whether 'I am overthinking or -underthinking or 'tired of all thinking' ...but i am physically exausted. How can I make this better?

Edit: its been 7 hours. I am just lyin in my bed. I watched some psychedelic trans music on youtube.

Thank you everyone for helping me through this. It really helped me! Peace.

Wanted to get properly holed for the weekend and I got just what I asked for. This stuff is magic but damn it lasts so long

Methods:Smoking through a cigarette Amount:1 Gram of tobacco = 1 MG Nicotine Time:04:11

It doesnt feels good on throat and lungs. But it feel nice, kind of a unique pleasure. I want to smoke more afterwards but that doesnt feel good. So I dont know why I want it.

Experience over...

Gonna light up one more, my tooth hurts.

I made it as a joke, wasnt serious. But thanks for the help, i really smoke. I know that it is horrible for me, but when you compare the situation i am living in right now, it kind of helps me. I know there are other ways but i am mentally so tired that i dont have any will to make a change about it, i have more serious problems. So i am spending my will on more important things. Thank yall again, felt more worthy hehe.

So yeah this is a post ill keep updating if i can about my imminent trip gonna be up all night long for it.

I found an old synthesis on hyperlab where a man methylated tryptamine hcl with betaine while I was looking for the simplest way to make dmt. He used three times as much betaine he did tryptamine hcl for 3 hours at 250 C

https://hyperlab.info/inv/index.php?s=8460759e1130a3feff2b182904ed9bf8&act=ST&f=17&t=29119&hl=tryptophan?s=8460759e1130a3feff2b182904ed9bf8&act=ST&f=17&t=29119&hl=tryptophan

It might be nmt, maybe some dmt. If you guys think there's only some dmt in it like I do, how would the procedure be tweaked to produce more dmt instead? Could a solvent be used to help or maybe freebase tryptamine instead of it as an hcl salt?

I planned to do a Jedi mind flip, but things went south. Shortly after boofing my mdma dose I started to feel confused, agitated and anxious. I had to drink a lot of water and threw up a lot. I think I may have developed mild serotonin syndrome because I also took Kratom today which can increase serotonin levels, and I did not think about that (this will sure as fuck never happen again lol). When it was at its worst I felt like I was on the verge of having a seizure or something, it was pretty scary. I also put my head in the cold shower earlier which was super uncomfortable but I think it helped. My last dose was 2 hours ago, and I have been drinking a lot of water and trying to relax. I just took 1mg Ativan and it’s helping a lot. Is there anything else I can do to make this more manageable? I would appreciate any info. 🙏

To be clear, I am feeling mostly better and it’s wearing off. It does not feel bad enough to go to the emergency room or anything, although earlier it did. I’m sorry I know I messed up, just looking for any info on if there’s anything I can do. I’m also wondering if pregabalin would make this better or worse? I have pregabalin and more Ativan on hand but I don’t want to take anything else before consulting here.

In a world where drug use had become both rampant and increasingly hard to control, governments and powerful cartels devised a chilling solution: nanobots hidden in vape juices. The concoction hit the market under the guise of new, exotic flavors, promising everything from enhanced relaxation to lucid dreams. However, within each drop lurked an army of microscopic, clawed machines programmed with a sinister purpose.

Once inhaled, the nanobots activated, flowing seamlessly through the bloodstream and binding to the drug user’s nerve terminals with their metallic claws. Their mission: harvest dopamine directly from the nerve cells, depriving the brain of its natural “feel-good” molecule. They mined dopamine like gold, meticulously draining reserves, altering moods, and leaving users in an unpredictable haze. Each time a person took any other drug, the nanobots would detect the substance, releasing mirror molecules to mimic the effects but twisting them slightly, turning every experience into a game of roulette. No user could tell what their next hit would feel like, as their high was at the mercy of the nanobots.

But the true horror lay in the long-term effects. Over weeks and months, the nanobots’ relentless harvesting of dopamine left nerve terminals damaged, crushed under the pressure of the nanobots’ claws. Users began feeling more and more hollow, their ability to feel joy slipping away, until they reached a state of complete desensitization. Slowly, but surely, the nanobots drained them dry, waiting for the inevitable.

Once a user’s body was depleted and they reached their tragic end, the nanobots disengaged. With microscopic wings unfurling from their metallic shells, they journeyed to the body’s exit, stealthily navigating through organs and tissues until they reached the intestinal tract. From there, they emerged, ascending into the night air, untraceable and invisible, flying back to their mothership, massive, covert facility hidden in plain sight, where the nanobots returned with their precious dopamine haul.

The mothership itself, a fortress managed by the highest powers of the cartel and the government, collected the stolen neurotransmitters for experimental research. Rumors spread among underground circles that this dopamine was harvested to synthesize the ultimate substance, a controlled euphoria that governments would one day use to control the masses, ensuring that only those deemed "deserving" would ever feel happiness again.

Today morning I took my first dose of lsd. My dealer sold it to me dissolved in sugar. I took 1/3 of it today morning listening to music and it was an amazing time but I didn't notice any visuals during the trip. It's been around 7 hours since I took it and I think I'm almost sober now. Can I take more after a few hours or should I give it some time?

Thank you in advance.

Triggers: suicidality

Hi everyone,

I’m planning to do my first psilocybin (mushrooms) trip soon. Over the past couple of months, I’ve been struggling with depression and feelings of suicidality, but recently I’ve been feeling better thanks to microdosing psilocybin. Since I feel better I am arranging for a (paid) trip sitter in London who I found through networking. Since I’m not based in the UK, I’ll be traveling there and staying with a friend who kindly agreed to host me.

Now that the trip experience is getting real (I have been thinking of it for the last 3-4 years but never got this close) I’m feeling both excited and scared. The trip sitter should be experienced and will guide me through it, but I’d love to hear any positive experiences you’ve had. I know that reading about it is very different from actually experiencing it, and I’m aware that my emotional state has been quite unstable lately. For context, I have a history of chronic major depression, fibromyalgia and suicidal feelings and thoughts (though please don’t worry—I have no plans to act on them and just want relief from these feelings), and I may have some traits of borderline personality disorder. I’ve also been off medication for about a year.

It’s been hard to find trustworthy people in my home country, but I feel confident in the support I’ve set up in the UK. Still, if you have any personal insights or positive stories to share, I’d really appreciate it. I trust the trip sitter to help keep me grounded if things get difficult, but hearing your experiences might help me feel a bit more prepared.

Also, if there are any important precautions or warnings I should keep in mind, please share those too.

Thank you so much for your support!

howdy everyone. I have these microdose acid mints and have been doing these 1 day on, 2 days off for almost 3 weeks now. This is the first time I've taken microdose anything in about 6 years. Off the 2ish weeks I've been doing this, I've noticed that I respond to "threats" or stress in a less violent way. Am I supposed to be feeling anything else? the mints are 0.1ug per piece.

I'm looking into doing ketamine for therapeutic purposes. I'm not sure if my provider will go for it though. I was thinking about doing low dose treatment. If they say my meds won't interact I may try it without telling my psych doctor. I'm desperate for relief. I just really don't want to lose my psych doctor or PCP. Is there a way that they could see that I'm doing in home treatment? Could the records show up somewhere? Does it show up in a drug test? I take 2 controlled substances and get generic drug tests with no cut off levels.

Is there some sort of search engine, app, or tool where you can enter prescription drugs with specific dosages and see if there are any interactions? The level of risk? It would help if you could see interactions with illicit drugs too. Lol. This is pushing it, but taking sex and weight into account would be mind blowing 🤯 lol

Hey guys,

So I've recently been diagnosed with stage 3 renal failure at 29, I dont during alchol that much but when I do I go all out now I can't have any and my 30th birthday is approaching does anyone have any knowledge on what drugs I could take that won't do as much damage if any to my kidneys I've taken mushrooms before and would take them again I just don't know where to look there isn't exactly a lot of research on the subject.

Thanks

I was perfectly fine up to abt 1-2 weeks ago my head started feeling weird. I felt like nothing that i was looking at was real and i couldn’t be alone. it was almost like i was going crazy. i smoked weed with my friends after quitting for abt 3 days after this and as soon as i was like 4 puffs in out of no where i felt like i was in 3rd person and nothing felt real we went back to my house after and all i wanted to do was go to sleep but i couldn’t and im usually active and up when my friends are over but all i did was lay in my bed and put my blanket over me like sum weird shit and then i stopped for the next day and then smoked again bc i didn’t think anything of it i just thought it was my anxiety but then when i was smoking again i felt like i was in 3rd person and went to mcdonlads wit my mans to grab a drink and i felt so fucking weird almost like my brain wasn’t working normally. i’m now 2 days clean and i still am feeling this way i also took shrooms abt 3-5 times (bars and normal) mad long ago but i feel like im just now getting the flashbacks and im stuck in it for like 5-10 times each time and i seriously feel like im losing my mind and there’s something wrong. Please tell me what i should do and how i should go about this situation that keeps repeating (sorry for the long ahh question)😭😭

I’ve been an unofficial trip-sitter for quite some time, but I’ve seen jobs online where you can get paid to do it. They ask for a certification that proves you know what you’re doing, but I haven’t been able to find one for less than $2000.

Does anyone know of any trainings or certificates that are more affordable?

I've been having such a hard time finding how my prescription interacts with anything at all, or even what type of drug it is to search more broadly. I take it for anxiety, but I know that it's also used as an antidepressant, and that it isn't an SSRI, and.. idk, it's just confusing. This is my only prescription and I'm just wondering what's off the table for me between acid, mushrooms, and party drugs. I did have a small dose of mushrooms the other week and didn't feel much, but neither did my partner so she thinks they were just old and ineffective

DMT vs Psilocybin: A Comparison of Experiences and Science

Hey everyone,

I wanted to open a discussion about the differences between DMT (N,N-Dimethyltryptamine) and psilocybin (found in “magic” mushrooms). Having experienced both in controlled, mindful settings, and having researched the science behind them, I thought I’d share some insights into how these two substances compare, both in terms of subjective experience and biological effects.

Subjective Experience

DMT (N,N-Dimethyltryptamine)

•	Duration: The most striking difference is the duration. DMT is often called “the businessman’s trip” because it lasts 10-15 minutes (with smoked/ vaporized DMT), but feels like it could be hours or even timeless. The intensity hits you almost immediately.
•	Intensity: DMT is often described as a rocket launch. Users commonly report instantaneous entry into vivid, otherworldly realms filled with complex geometric patterns, entities, and sometimes even beings. It’s an overwhelming flood of visuals, thoughts, and emotions, which makes it hard to control or steer the experience.
•	Ego Dissolution: Ego death can happen almost instantly, and there’s no gradual build-up. You’re just thrown into a space where your sense of self completely dissolves. This can be incredibly profound, but also terrifying if unprepared.
•	The Afterglow: Surprisingly, the aftereffects are often peaceful and grounded, despite the intensity of the experience. People come out of it with a sense of calm, wonder, or understanding that lasts for hours or days.

Psilocybin (Magic Mushrooms)

•	Duration: Psilocybin has a much longer duration, typically lasting between 4-6 hours. It’s a more gradual climb to the peak, with visuals and emotional shifts ramping up over time.
•	Intensity: While mushrooms can produce vivid visuals and altered states, they tend to be more fluid and organic. The visuals are often connected to nature—patterns in trees, the movement of clouds, and exaggerated colors. The trip is generally slower and more contemplative compared to DMT’s “flash-bang” approach.
•	Ego Dissolution: Ego dissolution can happen with psilocybin as well, but it’s often a more gradual, unfolding experience. Users report feeling at one with the universe or nature, with a sense of connectedness that builds over time.
•	Emotional Depth: Psilocybin tends to bring up deeply emotional and introspective states. Many people find themselves reflecting on relationships, past traumas, or life purpose. It’s often therapeutic in a way that feels more grounded compared to DMT.

Scientific Differences

Mechanism of Action

•	DMT and psilocybin are both tryptamines, meaning they share a similar molecular structure and both bind to the serotonin 5-HT2A receptors in the brain. This is where their psychedelic effects originate. However, the way they are metabolized and affect consciousness differs:
•	DMT: Smoked or vaporized DMT is metabolized rapidly, which is why the experience is so short but intensely concentrated. It’s also endogenously produced in small amounts by the human brain, though its precise function remains unclear.
•	Psilocybin: Once ingested, psilocybin is converted into psilocin, which then activates the 5-HT2A receptors over a longer period, leading to a more prolonged and mellower experience.

Neuroplasticity and Therapeutic Potential

•	DMT: Some studies suggest that DMT may promote neuroplasticity, which is the brain’s ability to reorganize itself by forming new neural connections. This is why people report profound realizations, creative insights, or even healing experiences. However, DMT’s therapeutic use is still in early stages of research compared to psilocybin.
•	Psilocybin: Psilocybin has seen a surge of research, especially in mental health. Studies have shown that it can be effective in treating depression, PTSD, anxiety, and addiction. One of the reasons behind its therapeutic potential is its ability to reset neural networks, particularly the Default Mode Network (DMN), which is overactive in individuals with depression and anxiety. It has been proven to promote long-lasting positive changes in mood and cognition, even after just one experience.

Cultural and Historical Context

•	DMT: Known as the active compound in ayahuasca, DMT has been used for centuries by indigenous peoples in South America in ceremonial settings. The traditional brew combines DMT-containing plants with an MAOI to prolong the experience for hours.
•	Psilocybin: Magic mushrooms have a long history of use in various cultures, particularly in Central and South America, where they were used in spiritual and healing rituals. The Mazatec people, for instance, have used psilocybin mushrooms in ceremonies for centuries.

Choosing the Right Experience

If you’re curious about the differences and considering trying either in a safe and responsible setting, here are some final thoughts:

•	For deep, fast, and intense exploration: DMT will plunge you into a powerful, otherworldly experience. It’s not for the faint of heart, and preparation is key due to its intensity. It can feel more “alien” or abstract.
•	For a slower, introspective journey: Psilocybin is more forgiving in terms of intensity and time to process the experience. It allows for gradual immersion and offers opportunities for reflection and emotional healing. It feels more “earthy” and connected to human emotions and nature.

In both cases, set and setting are paramount. These substances can lead to profound experiences, but they can also be challenging, especially without proper mental preparation or support.

Has anyone else here had experiences with both? What differences stood out to you?

Thinking of taking around 130ug acid but I'm scared to do it because of bad experiences I've had in the past. I'm alone with parents and scared I'm gonna lose control of myself if I'm having a bad trip. But I know I need the acid because I'm extremely depressed and need solutions to my problems.

Not sure if I'm gonna do it yet cos of the fear.

8 day sober from speed and its horrible I'm a bigger stim fan and for personal reasons I'm not at my usual place so no drug anymore for idk how long and I have the urge of taking speed or 3mmc I feel weird and sometimes I have a big nauseous feeling barely can stay awake for a long period

i took half and mdma pill about 30 mins ago and i cannot stop throwing up and shaking - i’ve used these pills before and had no issues , and help as im quite shaken up by it

I took 1 tab of acid at 2:40 am and went to sleep, thought i would be woken up after the come up but i cant fall asleep now instead just feel the come up and it's made me regret taking acid a bit, i need to roll with it though, any tips?