Hi everyone! After quitting alcohol a few months ago, I’ve been on a journey to find natural ways to recreate that after-work boost I used to get from a drink—something to help me unwind, feel uplifted, and stay energized. I recently felt a similar “party vibe” while listening to music on a walk, and it got me thinking: there must be ways to achieve this feeling naturally, especially with adaptogens and nootropics.

I’ve done some research and put together a list of ingredients that seem like a good fit, but I’d love input from others who’ve tried similar stacks. Here’s what I’m thinking of using:

Rhodiola Rosea (100-200 mg): For an energy and mood lift.

Lion’s Mane Mushroom (500 mg to 1 g): For focus and mental clarity.

Ashwagandha (300-500 mg): To reduce stress and create a relaxed, balanced energy.

Cordyceps Mushroom (500 mg): For physical energy and stamina.

L-Theanine (100 mg) + Caffeine (50-100 mg): To create a calm yet focused state.

Holy Basil (Tulsi) Tea: As an added relaxing ritual.

I’m hoping this combination can give me a fun, upbeat, and focused vibe without overstimulation or crashing. Has anyone here tried a similar stack or have advice on dosage/timing? Also open to any alternative suggestions or experiences with specific brands and forms (powders, capsules, etc.).

Thanks in advance for any insight! Looking forward to chatting with others who are on the same journey toward natural mood-boosting alternatives.

Is it safe or are there any dangerous interactions?

I am taking bupropion for inattentive adhd, while the medicine seems to work i am having severe itching and hives as a side effect. I dont want to take antihistamines everyday nor do i want to drop the meds as it seems to be the only thing that is helping my condition.

[Morning supplements]

Rhodiola Rosea (weekends only).

Caffeine.

Mucuna pruriens extract, Green tea extract, Saint johns wort, black seed oil and ginseng.

Agmatine Sulfate, Taurine, NAC, ALCAR, high dose niacin. Activated b complex

[Evening supplements]

Bacopa Moneiri, Taurine, Multivitamin, Fish oil, 5htp (sleep).

Anyone tried this stack, if so what dosages of each? I plan on taking 30mg 9mebc with 30-40mg nsi189 for 20-30 days

What can I take with my Bupropion (Wellbutrin) & Pregabalin (Lyrica) without any dangerous interactions or issues:

• Bacopa
• Rhodiola Rosea
• Gingko
• Ginseng
• L-Tyrosine

I want to try one of these to help me study and focus but I‘m afraid and cautious because I already take the meds Bupropion & Pregabalin.

I've had Rhodiola Rosea for about a month, but only used it a handful of times, I'm a little afraid of it, reading some people became kind of addicted or dependent on it (maybe quite rare).

I wonder what is a good daily dose amount, and if breaks should be taken from it (like taking a month or two off every once in a while)? Would you just dose once per day in the morning/early afternoon?

Have you found there to be any downsides/side effects for yourself?

I would be taking it to (hopefully) help a bit with depression and anxiety/stress.

I have it in a tincture form, which always confuses me a bit for dosing. It's 1ml per dropper, so half would be 500mg then? I have been taking 250mg when I take it. I tend to be pretty sensitive to things. I'm also taking it alongside Saffron supplements, so do I need to be careful about serotonin levels or anything? I'm sensitive to anything that affects serotonin as well.

Thanks for clearing anything up! It's probably not something that requires a lot of caution, I just want to make sure I'm using it correctly and safely as possible.

I’m currently taking ginger and peppermint teas is there any other stuff I can add to reduce inflammation, specifically for the brain. I believe my mental fog comes from that.

I am new to taking creatine, today will be the first day. But, I take amino acids (supplement form) as well. When should I take the Creatine? And when should I take the amino acids? Pre-workout vs Post-Workout? The amino acids are Glutathione, Branch Chain Amino Acids (BCAA), Taurine and Lysine. I only pour 1/4 of a capsule of each into water and take it on empty stomach post-workout. How & when can I add the creatine into this routine? 42 years old. 5'6". 145lbs.

Hey! I’m currently using 100-200mg of modafinil to treat my narcolepsy symptoms but needed something with an extra kick. I did a little research and ran across Paraxanthine or “enfinity”. Saw my local supplement store carried it and decided to take it on top of my modafinil.

Woah. It’s almost like I am just wide awake and aware emotionally and physically. No jitters or anxiety. It’s like I have enough brain power to think and talk big time. I took 100mg of Paraxanthine and 200mg of Modafinil.

Has anyone tried this? And is it safe? What are some side affects do you know of using enfinity? I am really liking the out of this world mental boost, but at the same time I’d like to be safe as well.

From what I know, Paraxanthine is a metabolite of caffeine so it shouldn’t cause anything bad right?

This is my idea of the best injury healing stack for my bicep tendonitis and damaged rotator cuff… I already run test e, primo and HGH…

ED: 500mg BPC-157 10-20mg anavar 3iu HGH 6000mg omega 3

EW: 5000mg TB-500 250mg test E 100mg primo

Considering: Epithalon IR-sauna several times a week

Any other ideas?

I suffer from chronic fatigue, brain fog, and ADHD, and since general stimulants do not work, I have been using antidepressants.

Specifically, when I take 10mg to 20mg of Cymbalta, almost all of my symptoms disappear, and I am able to live a stable life (my chronic fatigue, brain fog, and ADHD symptoms disappeared).

However, Cymbalta became almost ineffective within the first 1-2 months, and Trintellix and other SSRIs that had worked until then also stopped working.

Currently, I always have severe brain fog, and even going outside for a short time makes me very tired.

Also, tricyclic antidepressants are also effective for my symptoms, so I would like to use Nortriptyline, but I once developed atrial fibrillation with just 10mg of Nortriptyline, and I am hypersensitive to it, so I cannot use it.

So, what I am wondering is,

① Why does an antidepressant (in this case, Cymbalta) that was so effective at first obviously stop working?

②My hypothesis is that I have a lack of electrolytes or nutrients, or that receptors have been downregulated. What is your guess?

③What should I do in this situation to get the antidepressants to work again?

As an experiment, I tried taking Cymbalta at 40mg today, but I got symptoms similar to serotonin syndrome and couldn't use it. I can't feel anything anymore when I take 20mg.

Oh, brain fog and chronic fatigue are messing up my life. When Cymbalta was working, not only were my brain fog and chronic fatigue significantly reduced, but my ADHD was also greatly reduced. Are these due to the same mechanism in my case? I have a head injury, allergies, and a herniated disc, so I think my brain and body itself are vulnerable. Should I give up on treating it with psychiatric drugs and suspect other diseases and self-medicate? ? (However, I have tried many supplements and nutritional therapies other than psychiatric drugs, but they were of no use. Psychiatric drugs were the most effective for my brain fog.)

Does noopept need to be taken for awhile to work or does it work after the first use? I’m confused and am seeing mixed opinions.

Hey guys, I am currently prescribed 30mg adderall XR and 10mg IR for adhd pi. I am a very busy guy, usually jumping from college to the gym to work. My body seems to process the medication extremely fast for some reason. However, I started taking tumeric/curcumin as well as being more cognizant about dosing with a meal and eating enough throughout the day. I saw a reddit post somewhere that said curcumin may make adderall more effective/stronger. I decided to give it a shot. This stuff is great. I feel as though the meds aren't cleared out of my body in a few hours. Not only this, but the comedown is so much smoother. I usually get irritable and on edge, even with some fidgeting/restlessness. In fact, it seems to take the edge/discomfort off in general. I feel as though it is working much better now. I wouldn't say it made it stronger, rather a clearer experience. It also made both XR and IR seem to last an extra hour or two, or it could just be that I am actually able to still function when the med is wearing off. I know the curcumin played a huge role, because the comedown came back after I ran out. Took me about 3-4 days to notice, but I finally pieced together why I was uncomfortable towards the end of the day again. Def will be taking this stuff as long as I am on adderall. It is not like NAC where the anti-oxidative properties seem to dull the medication. I believe it is not placebo because I didn't even realize it could be the curcumin making the comedown smoother, or the fact that it came back when i ran out until a bit after for a good bit, was more hoping for potentiation/extending the duration, but I am very pleased with the results.

Edit/Update: Since r/supplements was giving me some backlash for not providing any evidence despite making it clear my experience was purely anecdotal: heres a thread to back it, which cites some research articles https://www.reddit.com/r/StackAdvice/s/kvitZZ4UyG Discusses how inhibition of an enzyme that metabolizes adderall could lead to it lasting longer

I just started taking supplements that contain Gotu Kola,Skullcap,Ginko Leaf, Sage, and rosemary. Does any one know if it could have negative reactions with L Theanine

hey guys, bodybuilder here coming off my first cycle of test. ran 500mg test e for 20 weeks. planning on using enclomiphene for pct. was just wondering if anyone had recommendations for supplements to aid in the process. i am aware there isn't really supplements that will help raise testosterone directly. i was more wondering about things i could take to improve quality of life while dealing with suppression symptoms. was looking for anything to assist with libido, confidence, mitigating lethargy, and boost mood. very active (always on my feet), lift 4-6 days a week, sleep 7-9 hours a night. my main concern is energy levels, as i'm a busy person. not too worried about libido, i can live without women for a bit. confidence boost would be nice tho. basically i just want to be functional and not incredibly miserable. if there are any supplements that may directly aid the pct process, that would be nice too. confidence is a bit of a concern, as i would rather not get bad social anxiety when existing around women.

currently taking: zinc, magnesium glycinate, multivitamin, vitamin b complex, 4-dma 7'8dhf, polygala tenuifolia (towards the evening as it makes me tired sometimes), maca, and panax ginseng, omega fish oil

ideas for other supplements, but some I am unsure if they may hinder the PCT process rather than help in combination with enclomiphene: tongkat ali, fadogia agrestis, melanotan 2 (nothing boosts my libido more than this stuff), p5p for prolactin, cistanche

side note: ashwaganda makes me very lethargic and gives me some anhedonia, so i won't be touching that one.

any help would be appreciated, thanks guys. well aware that i'm bound to experience low testosterone symptoms regardless, consequences of my actions i know. just looking for things that may help make it a little more tolerable.

I've had negative reactions. I tried each separately on different evenings a few hours before bed without food. Always small doses 50-100mg max. All seem to drop my blood pressure. All of them ultimately made me feel slower in every way, including slow in the head, I felt dumber, moving slower. They all made me sleep, but I wake up with a slight hangover, again in super slow motion until it wears off. 5-htp was better as it had a nice serotonin kind of happy feeling but only as it was peaking, the downside afterwards made it not worth it. What have been your experiences?

Hoping someone has some insight on this….I’ve been taking Vyvanse at varying doses for years and I’m trying to reduce my dose , yet make it as effective as possible. Currently taking 70 mg total ( 40 mg around 6 am and then 30 mg at 12:00 pm). I take the vyvanse with a high-protein food and water. I should mention that I’m also taking Prozac 20 mg.

I’ve been taking Vitamin B-50 once a day and L-tyrosine (750 mg per capsule) 2x-3x day on an empty stomach. I think it’s helping but I’m not sure, do you think I’m taking the right amount? I was thinking of adding DLPA, but I’m not sure if DLPA should be taken instead of tyrosine , or with tyrosine? In the past, I tried 5-HTP but it made me violently ill, which was weird.

Thanks for any advice that you have, appreciate it!

I see a fair amount of information online suggesting that they shouldn't be taken together, but can I just not take Lion's mane on days I want to take Adderall, or does there need to be multiple days of separation? I also take saffron, but only a few days a week.

I have a few questions regarding acetylcholinesterase inhibitors and other nootropics that modulate choline in the brain. My goal is to enhance choline levels so that racetams will be more effective and choline levels in the brain will not be depleted as quickly. For reference, I take vyvanse 20mg 5 days a week, am prescribed pregabalin (200mg/day), and sometimes if I need to study I will add oxiracetam, pramiracetam, and/or noopept, sometimes adding a bit of matcha or Kratom as well. I take CDP choline with these to avoid excitotoxicity as much as possible.

I was looking for a list of acetylcholinesterase inhibitors and I couldn’t find it. I remember someone posted a list of herbal maois at some point, I’m basically looking for that for AChEIs. I’m looking for supplements/nootropics I can take, not medications. I’m wanting these to enhance racetams/vyvanse, which I take often. I’m also not really sure if I entirely understand the difference between acetylcholinesterase inhibitors and nootropics that modulate the acetylcholine system. I sort of understand how they work in the brain based on my biology courses, but I don’t entirely understand how they affect nootropics.

I already have huperzine-a, which I know works for what I’m asking here, but I’m just looking for other alternatives. I know noopept and emoxypine modulate choline in some way but I don’t entirely understand how, and iirc quercetin and memantine has some effect on choline, but again I don’t fully understand how that works.

My current (not complete) stack in addition to nootropics/vyvanse is: pycnogenol, co q-10, magnesium, vitamin d, b complex, cdp choline, and psilocybin mushroom microdose .1G 4-5x a week with lions mane as well.

I know this is a lot of questions but I would really appreciate any response 🙏

I recently started on 30 mg of Vyvanse, and while I know that taking supplements isn’t absolutely necessary with this medication, I’d like to optimize my routine to maximize its effects and support my overall health and ADHD symptoms.

Based on my research so far, here are the supplements I’m considering:

• L-Tyrosine

• ALCAR (Acetyl-L-Carnitine)

• DLPA (D,L-Phenylalanine)

• Choline

• Omega-3s

• Vitamin D + K

• Multivitamin

• Magnesium Glycinate

I exercise daily and follow a whole-food diet with an emphasis on protein. I also drink electrolytes mixed in with plenty of water throughout the day.

Any suggestions on other supplements to add, or adjustments to make? Thanks in advance!

Estrogen levels came in high after bloodwork so began taking 300mg DIM. For the past few days, I’ve thrown up in the morning after my post workout meal and have been experiencing nausea early in the day. 300mg DIM 4200mg Omega-3 fish oil Multivitamin 5000ui D3+K2 50mg zinc 5 billion CFU probiotic Any suggestions?

I suffer from decreased attention span after a head injury, chronic fatigue, brain fog, and ADHD, but when I take medication to increase noradrenaline, everything improves at once.

However, when I take serotonin, I feel like noradrenaline is suppressed. (For example, taking Cymbalta, an SNRI, is effective for the first month, but gradually becomes counterproductive, and when I switch to a medication that increases noradrenaline alone, I feel better.)

On the other hand, there is something that bothers me, and that is that increasing noradrenaline puts a lot of strain on my heart. My blood pressure exceeds 160 and my QT is greatly extended.

What I am wondering here is:

①Is there a way to increase noradrenaline only in the brain (prefrontal cortex?)? (Also, is there a way to reduce the side effects on the body?)

②I am looking for the root cause of chronic fatigue, and what are the possible causes involving noradrenaline? (Even though I have been diagnosed with ADHD, when I take medications that increase dopamine, they all have the opposite effect. It seems that the mechanism by which noradrenaline is produced from dopamine is not working well for me.)

3. Is it possible that increasing noradrenaline is not the true solution, and that other brain substances or hormones that are linked to the increase in noradrenaline are important?

I am very interested in "safely" increasing noradrenaline, and I am worried that there is no other way to save myself (but increasing noradrenaline has very large physical side effects, which is troubling me. Also, for some reason, Atomoxetine is the only thing that is supposed to increase noradrenaline but does not work at all. I get side effects, but my executive function does not improve with Atomoxetine)

Background:

Hi so I'm very new to all of this so I apologize if my knowledge isn't completely accurate. I'm currently suffering with pretty severe social anxiety and lack of sharpness and focus due to my ADHD. I've been trying to talk to more people in hopes of improving my social skills and lowering my anxiety but lately it's just been making me lose faith in myself and getting me more anxious. I remember hearing about Bromantane a while back and reading about on the various subs seems like it could work in terms of helping me calm down due to being Anxiolytic with some long term's effects. The only other drugs I've tried was Fluoxetine and Nicotine. Fluoxetine worked kind of for a bit it gave me a lot of fatigue and later actually made me more anxious. Nicotine actually did help however I only took it once in a form of Zyn a friend gave me. I might be overexaggerating the effects but for the first time in really long time I felt normal and calm. I was able to communicate without having to overanalyze every little thing. I of course didn't take it again because it's nicotine I don't want to develop an addiction.

Current Plans:

I'm currently taking 10mg of Ritalin and 2000mg Magnesium L Threonate. I've tried looking if there were any effects if you take Bromantane with Ritalin however I couldn't find any information. My Bromantane is coming next week it's in Solution form. (Bromantane – Solution, 1500mg). After a separate a reddit post I've decided to go with the Intranasal route with 25mg each day for 30 days. If I can't handle intranasal, I'll go with 50mg orally each day. I have been suggested make a Nasal Spray or Sublingally(The thing where you put it under your tongue awhile don't remember the spelling) by mixing it with a fat such as olive oil or MCT oil. But I'm not sure if I trust myself to be able to do it properly so I'm just going with either intranasal or orally for now.

Questions:

I need to know if I can take this medication while on Ritalin.

I also need to know if I should be taking any other Nootropics to see an actual effect. Of course, I'm not looking to rely on this soley but I really need these feeling of anxiety and stress to be dumbed down a bit if I can make any process in my social skills so if you have any suggestions on what I should get for a better effect please let me know.

Edit: I don't know if this matters but I also suffer from sentence formation and word retrieval and verbal fluency a lot. If there is something that can help with that please let me know.

Hey everyone, I wanted to share some recent observations and see if anyone here has had similar experiences with combining Agmatine and DHEA.

Background: Quick story on my context – a few years ago, I went through a pretty rough burnout that hit my adrenals hard. Since then, I've been on a recovery path, trying to balance things out, physically and mentally. Part of that journey included supplementing with 100 mg of DHEA daily, but my levels have barely moved over the years. Even on 100 mg, my DHEA-S level was hovering around 280, not really responding. But then... I decided to give Agmatine a go.

My Agmatine Experience (so far): I started with 200 mg of Agmatine and noticed something strange – it felt like the effects took a full 24 to 48 hours to kick in. It’s been one of the strongest supplements I’ve tried: big boosts in energy, motivation, emotional stability, and drive. I actually feel way more balanced with it and can even sense Agmatine’s known tolerance-resetting effects, like on caffeine or THC (which I use occasionally). Right now, I’ve scaled it down to 30 mg a day to manage the overstimulation, but the positive effects are still there.

The DHEA Change (and Side Effects): Since starting Agmatine, for the first time in 2 years, my DHEA-S has actually moved up, now sitting around 380. I can really feel the difference – deep voice, strong libido, vivid dreams, high energy, and more… plus some side effects. I’m dealing with extra oily skin and more breakouts, which I didn’t have on 100 mg of DHEA alone. I also get occasional diarrhea and am definitely feeling a bit overstimulated from time to time.

I’m wondering if Agmatine somehow amplifies DHEA’s effects or helps with its absorption. It’s known for resetting tolerances to things like caffeine and THC, so could it be “resetting” my DHEA tolerance too? It’s making me curious if there’s some biochemical interaction here that’s finally getting DHEA to work more effectively in my body.

Questions: Has anyone here experimented with Agmatine and DHEA together? Have you noticed similar effects or have any insights on why Agmatine might make DHEA so much more noticeable? I’d love to hear any theories, personal experiences, or science-y explanations. I’m kind of just baffled (but excited) about what’s happening here and would really appreciate any advice or stories from anyone who’s had something similar happen.

Thanks a ton for reading, and looking forward to any insights you can share!

Hi guys, my daily stack:

Morning:

30mg bromantane

30mg noopept

300mg alpha GPC

300mg NMN

300mg ecdysterone

1g Milk thistle extract

400mg Ashwaganda 5%

1g Lionsmane extract

5gs 5:1 maca extract

500mg liposomal vitamin C

50mg synephrine

1g magnesium bisglicinate

5gs Tribulus

500mg ginseng

50mg 10:1 bacopa monnieri extract

2000 IU liposomal vitamin D

15ml of C8 MCT oil

Afternoon:

300mg alpha GPC

300mg NMN

1g magnesium bisglicinate

50mg synephrine

3gs Tribulus

15ml of C8 MCT oil

2hours before sleep:

2gs GABA

500mg L-tryptophan

1000mg magnesium threonate

Any advice on what to add to or remove from my stack, or to use at a different time? My goal is to improve cognitive abilities and burn excess fat.

Has anybody tried this stack? Most of it seems focused on 9-me-bc and semax or noopept or NSI-189. Nobody seems to have tried it with 7'8DHF or 4'DMA-7'8DHF, which are potent TrkB agonists. If I wanted to create a super nuerogenesis stack, wouldn't is make sense to add these together?