I avoid alcohol for moral reasons as well keeping my short-term/long term health optimal.

But as someone who is very introverted by preference and keenly sociable when I have to, (and frankly witty and quirky when in a fully relaxed state:) alcohol can turn me into a controlled social machine with extremely impressive verbal fluency, verbal ideas, as well as more risk apt. I’m usually very calculated in my response and approach to all social interactions regardless of familiarity. Alcohol makes those interactions super automatic while defaulting to positivity, wit, curiosity, charisma and creative ideas

Im not claiming alcohol makes me a better person but there is a clear neruochemical change that brings about different and valuable thoughts which leads to social behaviors that gives me greater access to social dexterity and emotional freedom.

This is important because responding well to independent social environments allows me to invoke positive and creative energy from other I interact with, making for more meaningful interactions, and quite frankly a system for strong attraction towards me with minimal attraction.

I put about 30mL of a MB solution into about 30mL of water with about a TSP of ascorbic acid powder purchased on Amazon, then stir.

The mixture never turns clear. It still stains my mouth, but I have noticed that the stains aren’t as deeply blue, and wash away more easily with followup sips of water.

Just wondering why I can’t get the clear mixture that people talk about. Is it because it needs to be shaken, not stirred?

Thanks

I read that higher Salidroside than Rosavin causes too much stimulation. I’m wondering if I get a supplement that had a higher Rosavin ration if I won’t have this issue? Anyone with experience know?

I got St. John's Wort capsules last year because I wanted to get off antidepressants, and was fearing I would not get through. Surprisingly, I got off them and I seemed to function decently (I am talking about suicidal thoughts/ideations and severe depression at some point in my life).

I know that to treat depressive feelings, your daily life and mindset plays a big role, and I know I am pretty far from an ideal point, although much better than last year.

The problem, though, I am always sleepy and tired (I checked thyroid, blood work, vitamins, everything is alright), and I feel like I use sleep as a coping mechanism, because managing work and study (plus all family and relationships problems) is overwhelming enough for me at the moment, but I know that I should cultivate some healthy habits to make myself more mindful and serene.

So I thought that St. John's Wort could help somehow to aid these mild symptoms, but I've noticed that the one I bought is a standardized to 0,003% in hypericin, so really low. Should I maybe start with this dosage (the box recommends taking 3-4 pills a day) and see how it goes?

27M. I have been using it for for epilepsy (JME), but i have always been socially anxious, emotionally numb and mildly depressed and low energy, even some problems to focus. i take it since i was 13 years old

currently i am trying this plus 3x week lifting weights. any idea of something tochange or add? i'm in Brazil.

1. omega 3 (1500mg DHA 600mg EPA)
2. Ashwaghanda 500mg at night
3. D3 10000UI K2 mk7
4. B6 50mg
5. B12 3mg
6. Co Q10 100mg
7. magnesium threonate 600mg
8. paroxetine 10mg
9. creatine 6mg

Any of the big supplement brands don’t have it, there are a lot of brands on Amazon but I’m not sure about the quality. Is there a brand in particular that is actually high quality? Also is the tea better than the supplement? Would appreciate any help

I question if anyone can relate to my experience but whenever i use anxiolytics like ashwagandha and bacopa i feel like my blood sugar gets lower than healthy. When i drink any caffeine while on those i feel my blood levels drops even more and i get pretty tired, relaxed, hungry and especially zoned out. This caught me really off guard the first time, xd

But whenever i consume caffeine when there are anxiolytics in my system i get blurry vision and don’t notice much from my surroundings. Whenever i feel like this my college’s tell me that my right eye is also drooping and ask if i’m ok… Me don’t like it but still do it for the relaxed focus.

Are there people who react the same like me!? Do i might have some weird chemistry? Or disease? Or what are your guys speculations??

Long term or short term users Kindly share your experiences regarding bacopa how did it affect your memory aspect weather it helped you with study and exams or everyday normal activities kindly share it all thank you ))

I have a bottle of ND Rhodiola Crenulata 500mg 3% salidroside. I’ve been taking 1000mg and only notice a very mild effect if anything (I know it’s not supposed to be a major stimulant). Is there any information on dosing i.e. does it have the same not too low/ not too high ideal range as Rhodiola Rosea or is that a result of the rosavins? Has anyone had more success from a higher dose of Rhodiola Crenulata?

I recall several years ago back on ND they used to sell all sorts of Racetams. Hoping back on the stuff I noticed they now have none. What are the trusted alternatives we have these days? I browsed the vendor alerts on the sub and they basically blacklisted most of the top results.

Looking for good supplement recommendations while in India to pick up.

Thinking shilajit, ashwaganda, bacopa moneri but what else is good and what brand?

Sometime ago I made this post: https://www.reddit.com/r/Nootropics/s/wC1EhgBk3n

Some people in the comments said that I haven't been taking it for long and that this experience is a typical placebo post.

Nah.

I've since experienced animal-like aggression on doses around 4.800 mg and found out 400 mg helps my memory the same without any anger side effects.

It helped me stay on Lamotrigine, which is the only med that works for my depression.

My stack this year's been Latuda 80 mg, Lamotrigine 2x200 mg and Pira 400 mg.

I feel awesome. These meds I asked my psychiatrist to put me on are the best combination I've ever been on. I can finally live life like a normal person, instead of a psychotic paranoid tweaker with dementia.

Has anyone done this? I would assume the stimulation would wear off after just a few days but the memory benefits should stay right? Also given the short half life even if it was taken at the common dose (10mg) it would wear off within 3-4 hours and redosing increases risks considerably as theoretically it could be an HDAC inhibitor. I'm aware we don't know for sure with this chemical what it does, technically we don't know anything about it, but if theorycrafting can get us closer to some brief understanding or some scope of what it is, I'll take that.

Now I have done PRL before but never frequently and I have a series of tasks coming up that I could achieve better if I were to take PRL for this 1-2 month period I'll be doing them. I've read a report of a guy taking it for 28 days and I spoke to him, fortunately he didn't kick the bucket so atleast there's some assurance it wouldn't immediately k** you.

Obviously I'll quit (possibly taper off instead of cold turkey) if I start to notice side effects but I do intend on starting PRL daily at 10mg, if anyone can provide any info on this I would greatly appreciate it, might help me build a better understanding of what I'm about to do.

For my next order I m considering the sunifiram as well as the isrib trans , the first is an ampa agonist , the second is an Integrated stress response inhibitor, both are related to be memory enhancer. what do you think of this combination and if there are those who have already tried?

Each capsule contains: Arginine 20 mg. Boron 130 mcg. Biotin 60 mcg. Pollen 25 mg. Chromium 50 mcg. Copper 2 mg. Calcium 55 mg. Folic Acid 400 mcg. Ginseng 40 mg. Iron 9 mg. Iodine 150 mcg. Lysine 20 mg. Magnesium 35 mg. Manganese 5 mg. Molybdenum 30 mcg. Nickel 4 mcg. Niacinamide 20 mg. Potassium 10 mg. Pantothenic Acid 10 mg. Riboflavin 5.1 mg. Royal Jelly 3.33 mg. Safflower Oil 30 mg. Selenium 50 mcg. Soybean Phosphatides 90 mg. Vitamin B1 4.5 mg. Vitamin A 5000 IU. Vitamin E 180 IU. Vitamin C 150 mg. Vitamin B6 4 mg. Vitamin B12 12 mcg. Vitamin D3 400 IU. Vanadium 15 mcg. Wheat Germ Oil 50 mg. Zinc 15 mg. Phosphorus 25 mg

as you have seen contains many nutrients but in very low doses my brother and mom told me that this supplement helped them with fatigue.

https://preview.redd.it/uvxp24rrse4e1.jpg?width=1014&format=pjpg&auto=webp&s=a9deb64961e6bd9fb217f74a035c7e4e9ce22ada

Looking for a legit website that I can buy Selank and Semax from that’ll deliver to Australia?

How was your life before and after taking it?

My dog is currently 16 and on mushrooms as one of her supplements. She’s currently using either the freshcap human ultimate complex or the Fera pets mushrooms. The most important mushroom in her case is Turkey tail (for preventing cancer) or anything that helps with cognition.

After browsing the internet and this sub everyone is recommending Oriveda, Antioxi, or Realmushrooms. I noticed none of these are Canadian and was wondering if you guys have a Canadian rec???

I’ve been eyeing the following brands: North Hound life, Purana, Stay Wyld Organics but I don’t think any of them have as much backing as the top three.

Everything seems like a gimmick and marketing these days with supplements. I wish I could just start my own mushroom company for my dog 🥲

So my testosterone is around 450ng/dL according to blood tests. I was under the impression that those are normal levels. I was also under the impression that testosterone boosters don't really give you any perceivable effects unless you're deficient. Now I'm wondering about the validity of that. Does anyone have experience with mood enhancements or increased confidence with testosterone enhancement beyond normal levels? I'm wondering if this might be an avenue to rectify my low confidence, extreme external validation seeking, and people pleasing behavior.

if you're familiar with the work of Iain McGilchrist and related on brain lateralization you know how important it is for the right hemisphere to be engaged and the two hemispheres to work in tandem with each other. That said, are there any nootropics/supplements that help with this purpose?

After finding the rather popular post on Thiamine High-Dosing on this sub, I looked into the EO Nutrition Youtube Vids on it.

What is said there seems rather intriguing and I have been wondering about what EO establishes in the priced protocols, which is not already common knowledge.

If anyone with this information cares to elaborate on this topic I'd be extremely thankful!

I have a 10mg/ml bottle of Dihexa dissolved in DMSO and wanted to know the best way to apply it. I’ve bought some sterile, non-medicated, waterproof, adhesive patches, so should I put the solution directly onto the patch then apply? Should I apply it to my skin then place the patch on top? Should I leave the patch out altogether?

Hey, everyone. I'm an 18-year-old guy with autism spectrum disorder (ASD), and I've been struggling with my long-term memory...

Is there any nootropic that can help improve the creation/preservation of long-term memories? How effective are these medications? Are they just a little 'boost,' or can they actually make a substantial difference in the way we think and reason?

I'm a beginner in this topic, so please respect my lack of expertise. Thanks!

Took some phenylpiracetam dissolved in DMSO yestersay and today. Mom and sis said she smelled something funky like sour milk around the house, eventually came to the conclusion of my sweat and breath. Yes I've showered lols. Was wondering if anyone else experienced something similar.

For the past two years after getting covid my ability to focus and collect my thoughts has been heavily kneecapped and my motivation has been down the gutter as a result of that. I basically feel like I’m not even "awake" so to speak and the gears in my head just aren’t turning. Ive already done the basic stuff like improve my diet and lifestyle but it just isn’t working to get me to feel like my old self again. I am considering medication but before that i wanna experiment with the racetams so if anyone who’s had a similar experience as I do can testify its effectiveness and can recommend me a vendor I would appreciate it greatly.

Based on some recent work by Makino et al. (2024) it seems that there is a neurological developmental issue in males (females seem protected) where by early life stress or poor maternal care can create an imbalance between D2 and D4 receptors in the Anterior Cingulate Cortex (ACC). This was resolved (in mice) by either activating D4 receptors or antagonizing D2 receptors. One popular press article states:

Intriguingly, Hensch’s team identified a brain mechanism underlying the attention deficits: a difference in the balance of dopamine receptors in the anterior cingulate cortex (ACC), which regulates emotions and control of thoughts and actions. One receptor, D2, was elevated, while another, D4, was reduced — whether the attention deficits resulted from parental neglect or directly from sleep loss in adulthood.

Even more strikingly, the imbalance was reversible with drugs that either suppressed the D2 receptor or stimulated D4. In either case, treatment improved attention well after the critical period was over.

“We think dopamine signaling in the ACC is closely related to attention,” says Hensch.

ChatGPT tells me that the types of drugs that would create this functionality are as follows:

The drugs that suppress the D2 receptor or stimulate the D4 receptor likely involve pharmacological agents targeting dopamine receptor subtypes. These drugs might include:

D2 receptor antagonists: Drugs that block D2 receptors, such as:

Haloperidol

Risperidone (used in conditions involving dopamine overactivity, such as schizophrenia or Tourette syndrome).

D4 receptor agonists: Drugs that specifically stimulate the D4 receptor, although these are less common. Examples include:

Apomorphine (a non-selective dopamine agonist that can stimulate D4).

Emerging drugs in clinical trials designed for ADHD and other attention-related disorders.

These drugs aim to balance the dopaminergic signaling in the anterior cingulate cortex (ACC), improving attention even beyond critical developmental periods. Always consult medical literature or a specialist for up-to-date and precise pharmacological options.

Anyone with intelligent thoughts on the best way to stimulate D4 and/or inhibit D2 in the ACC, as this is really out of my depth?

EDIT: Sorry for not including refs

https://www.science.org/doi/10.1126/scitranslmed.adh9763

https://neurosciencenews.com/stress-neurodevelopment-dopamine-sleep-27999/

I took creatine for approximately 1 month and i stopped it recently, since then i have been feeling really down and depressed, extremely tired and unmotivated, has anyone else experienced similar?

I started taking DLPA on Friday but reading up on some of the side effects I'm nervous.

I've been struggling with anxiety and depression from weed withdrawal and I thought maybe DLPA would help some.

I don't know if I'm just in my head or what but after seeing some people who have had anxiety spikes after taking it for a few days I'm scared to continue.

Anyone have any advice? Am I being paranoid? My symptoms have been slowly going away on their own since going sober 48 days ago. I probably don't really need anything else, and I'm very new to all of this.

I also take l-theanine, magnesium and elderberry and I'm tapering off of ashwagandha, on top of some prescription meds from my psych.

Any advice is appreciated. Thank you in advance.

Hi

Im hoping someone here might be able to shed some light on why this supplement has such a profound impact on my body. Ive been on prescribed trt for many years. Ive used anastrozole in the past as a means of regulating elevated estrogen levels but even that doesn’t impact my body with such a profound effect. Ive found taking 50/100mg of p5p dries me out so much my joints hurt. I lose loads of water weight. My libido goes through the roof and its already high normally. It happens almost overnight and the effect lasts for weeks. Bloodwork shows e2 is lowered after using it as is prolactin. T remains high. I thought id ask here what people thought of this as the steroid and trt forums arnt particularly helpful at the best of times. Many thanks in advance for any feeback

I'm a software developer with long-term memory issues, often forgetting things I learned just two weeks ago. In the mornings, I experience brain fog, making it hard to focus and complete tasks properly; I tend to do them just superficially. After work, I study for upcoming exams, learn more development skills, or work on personal projects for fun. I also research crypto and the market, and I do weight training almost daily.

I sometimes don't think about what I'm doing mid-task, like where did I put my phone while doing this thing. When praying, I forget till where did I get in prayer.

I think I need support for cognitive function, energy, motivation, and memory—both short and long-term.

My diet is generally good: I have eggs and cheese in the morning, followed by meat and carbs later. I take omega-3 occasionally, and I'm waiting for creatine and protein to start again.

Currently, I plan to take:

Bacopa Monnieri

Creatine

Omega-3 Lion's Mane

Magnesium (Glycinate and Malate)

Vitamin B12

Vitamin D3 & K2

L-Theanine and Caffeine

Also would adding small dose of modafinil/phenylpiracetam and/or noopept to that be good and is it good long term?

Can you suggest any changes or additions to this stack?