First and foremost i'm not looking for a definite answer more of a general idea or even just some guesses because I know there's no way to truly know without sending to a lab and testing. This is specifically for the sulfate form. I take this stuff medicinally and I've had sulfate that looks like a fluffy but fine white powder. But the stuff I've gotten recently has felt heavier and it's more of a sparkly crystalline powder substance. This sparkly powder has been causing me a lot of GI issues and causes a ton of vasoconstriction and more heart palpitations. I know it's most definitely what they're cutting it with but I can't even think of something that would cause cause such side effects. I've looked everywhere for something or someone else with a similar experience and can't find anything at all. I'm using really low doses of it too.

Edit: it also has a very grainy texture as well

That's pretty much it. Just wondering if there's any risks I should be worried about if I start taking probiotics along with tianeptine.

Hello I am taking Tianeptine- sodium since 3 1/2 months now (therapeutic dose : 3* 12,5mg).

The thing is I don’t feel any of it anymore or did I just get so used to it ? The first weeks I did feel it slightly, now nothing. Is it so subtle that you literally can’t feel any of it ?

Good thing is that it’s the first antidepressants that doesn’t give me unbearable side effects.

I actually have no side effects at all .. which is a big surprise cuz all other antidepressants made everything way worse for me for example paradox reactions, aggressions , brain fog etc ..

Hi, I've been dealing with gastritis for 1.5 years following my gallbladder surgery. My doctor recently prescribed sodium tianeptine (Coaxil) for my GAD, but since starting it, my stomach pain has intensified significantly. I'm now wondering if this could be a side effect of the tianeptine, especially since I'm taking it on an empty stomach.

Hi, does anyone have experience taking tianeptine 12.5 mg 4 times a day (tianeurax) witch is what I get as prescribed? Been on 3 times a day now for 3 months with some benefits, doctors wants to up too 4 times a day. Since it lasts 4 hours max. Between 25-50 mg a day is max dose for theraputical. Thanks in advance!

Basically I’m fed up of nothing working for my major depression and social anxiety. Benzo’s, 16+ antidepressants, TMS, ketamine, nothing has worked. I got my order of 25mg tianeptine sodium and sulfate yesterday. Sodium, woah, what a relief it gives me. I am an ex opioid addict so I’m well aware of the dangers with addiction and tolerance.

Sulfate I took 25mg today, and it made me feel possibly MORE social anxiety than baseline, the sodium at 25mg (I think that is possibly a high dosage isn’t it in sodium form? These are capsules..) obliterated my anxiety, and my mood became elevated because of the anxiety reduction; without the sedative effects as well. I felt completely normal.

I really want the sulfate to work, I really don’t feel like dosing sodium multiple times a day, hitting my opioid receptors everytime. Sulfate also made me extremely brain fogged and fatigued, it felt horrible. What could I try to make it work?

Any way to turn Free-Acid, Sodium, Sulphate etc. into Free-base at home easily

If your reward system is pretty much dysfunctional and you can't feel pleasure from daily activities, is tianeptine (12,5mg) good for that? Serotonergic meds seem to make it even worse.

I’m getting back on Subs to curb my Kratom habit for a few months. I’ve been taking Tia off and on for a few weeks, 2 days on 4 days off. Question is do I need to wait for Tia to be out of my system before I take a Suboxone? Will it cause precip or nah. Thanks everyone.

I recently got a 10g portion of tianeptine sodium powder that came with a measuring spoon. It is white, one scoop on one end, about 3¼" long. I can't find an exactly similar dosing scoop & have not received a return email from the supplier of how much this scoop holds. It is most similar to yellow shops you can buy on Amazon or wherever else I've found pictures of scoops.

It's important to me that I know how much I'm taking & can't afford a mg scale right this moment. Anyone, help?!

Never taken this kind before and wondering what your opinion and experiences are with it? Do you know if its it the sodium or the sulfate type? I can't find this info at all anywhere and the label don't say one way or the other, only that it contains 73 mg tianeptine and turmeric (whatever the purpose of that is idk)

Interestingly enough, tianeptine binds to the mu opioid receptor with affinity very close to dihydrocodeine while having 99% oral bioavailability. Of course, this doesn't mean they're the same potency as there are many other variables. But it does explain some of the abuse potential associated with tianeptine. Neither compound fully relies on a prodrug to exert its effects although both tianeptine and DHC have active metabolites. This is also in line with tianeptine being described  as a "moderately potent but highly efficacious and selective MOR agonist".

Tianeptine Ki value for the MOR: 383–768 nM

Dihydrocodeine Ki value for the MOR: 325 nM

Lower Ki value - higher binding affinity for the receptor

So I make homemade cough Syrup with tia & when I make it like that it’s great don’t add anything else sometimes hydroxyzine but what I’m saying is when I dose it regularly without making it into a syrup, it either barely works, or it makes me sweat n feel sick. So it makes no sense to me what is making such a difference when I just take a dose vs making the syrup and pouring it up into soda and sipping it??

Doest it work fine? Issues with addiction /withdrawal? Europeans/Germans who use it a a prescribed antidepressant? I read it 'right be good antidepressant with tja Main issue that it could lead to misuse because of opioid effects.

I was presribed Coaxil (tianeptine) in addition to Valdoxan (agomelatine). I read that tianeptine is serotonine reuptake enhancer and I'm interested could it, therefore, mess up Valdoxan effects on serotonin receptors?

I can't take SSRIs and SNRIs because of emotional blunting so I am destined to these "atypicals".

I’m new to this and trying to figure out what I’m dealing with ..

I've been trying to find this info without success so I hope someone here will be able to help. I've struggled with addiction for 35+ years now. My use of opiates is directly tied to my anxiety/depression/anhedonia. I'm on methadone for life and I'm ok with that but I've yet to find any meds that treat my symptoms except tia. I'm not trying to get high off of it, I can find dope for that if I want. I just want to be able to feel pleasure again and nothing else has worked but tia. It's been so long now I don't know what came first the use or the depression but now, even on methadone, I'm incapable of enjoying anything. Tia helps with that better than anything else I've tried and believe me I've tried a shit ton of meds and supplements. I'm just worried that the tia and methadone will be fighting for affinity to my mu receptor causing pwd's. Does anyone know if this will happen? Has anyone else used tia and methadone together? Thanks

Has someone experience with Tia and Tilidin ?

I just started on tianeptine sodium about 3 months ago. What are its side effects? How does it feel if you've overdone it? This past weekend, I think I took too much. I had what I would call dull chest pain & (I knew this one- difficulty breathing) harder to get air in my lungs. I've read tia is supportive of cardiac strength, but, uh... strength was NOT what I was feelin'! Has anyone here OD'd?

I dose when I feel pain. In general, I'm taking 25mg (50mg if I'm having an especially bad time with pain all over) every 2-3 hours. No more than 8 doses a day. Usually just 7.

I ran out of tianeptine yesterday (Monday), around noon. I have some coming today. I've been dealing with the pain with Kratom. It's not super effective for my pain, so I'm looking forward to my package today. I am able to fill my oxy script on Friday. When I have that, I only take that. Last month, it only lasted 2 weeks-i need to buckle down & at least TRY 40mg/ day. (I don't wanna! It's not fair!)

Some back story: My pain clinic has had many changes & after 6 months of screwing around with her, my pain Dr went back to private practice. I was on 60mg oxycodone a day & they've reduced me to 40mg/ day. My primary care Dr won't dose any more than 40. So I had a heads up that everything was about to blow apart. The closest clinic taking new patients is over an hour away & of course, it's taking forever for medical records to arrive at the new clinic, so I'm waiting on making my first appointment.

Hi everyone, I started taking tianeptine sodium 3 days ago, to start with, I started with 25mg, 1 time a day. But I'm not getting any benefit. I wanted to ask those who have been using it for a long time, how long it takes for the drug to produce the therapeutic effect, 1 months like usual antidepressants? . Furthermore, if I don't feel any effectiveness, how far can I go with the dosage, preventing the drug from acting like an opiate? some say 50mg but I have not read any scientific studies to support this thesis. In addition to suffering from treatment-resistant depression, I also suffer from chronic fatigue syndrome, due to mitochondrial disease. Tianeptine attracted my attention due to its action on BDNF (increased neurogenesis), increased IGF-1 (with increased production of collagen, cartilage, bone and muscle development, etc.), its influence on dopamine and its ability to increase brain mitochondrial activity. at least that's what we can read in numerous studies, but I don't know if this is true. I wanted to know if any of you have had any beneficial effects in terms of physical and mental energy, cognitive functions, reduction of bone, joint and muscle pain, etc. lastly, can you confirm that the drug acts on dopamine and not on serotonin? I ask because SSRIs cause an exacerbation of all my symptoms for me, as my problem is a dopamine deficiency. thank you all

As a warning, there are fake TD Red’s on the market. I don’t know what’s in these, but definitely not tianeptine. The bottle was taller than the usual - referenced tianeptine in ingredients, but this stuff has given me major anxiety. Stay away, who knows what the hell is in this. Anyone have similar (recent) experience?

For context: Im talking about Coaxil (Tianeptine Sodium). Im stating this again just in case someone misses the title. :)

So Im planning to try 2 doses of 12.5mg per day instead of the recommended 3 times per day because i want to take as little as possible while keeping some effectivity and if that won't feel like enough then i would add the third dose.

But, im wondering, is it like other anti-depressants where you slowly increase the dosage over time or can i take another one 4 hours later after my first ever dose, which i already took?

Thanks for any input. :)

Does it expire sooner than sodium?

Is it dangerous to use these two together? What is the effect

I sometimes take tianeptine with an energy drink but I don't have one today so I'm going to have to settle with coffee but I drink it with quite a bit of creamer and sugar and I know tia doesn't work like at all on anything other than an empty stomach so I'm wondering will it still work the same if I drink coffee with it? Would using less cream and sugar help? Thanks

Maybe this will help as there are little testimonials for long-term use.

October 2022

Got prescribed Coaxil (europe brand) on twice a day x 12.5mg for bad long covid symptoms and for depression. I had neurovegetative symptoms which included:

*bad cold intolerance that led to fatigue (which were related to a bad thyroiditis spell for which I had to take half the starting dose of synthetic hormone but just for a winter; even though the thyroid started functioning again, I still remained with senzitivities to cold)- which Tia cured instantly

*fatigue and malayse that was related to long covid- which Tia cured over time

*anxiety- which Tia cured over time at 12.5mg x2 per day for 6 months until hay fever made it worse. n.b. never had mental health symptoms for hay fever allergy season before I got Covid

*depression- which Tia kept under control, with 2x 12.5mg per day, for about 6 months until hay fever made it worse. n.b. never had mental health symptoms for hay fever allergy season before I got Covid

Also helped with:

*inhibition- made me more open in social situations and enhancing sexual performance, both phyisical(nitric oxid releaser) and mental. I was never a dancer but my body adapted very easily to the rhythm and melody and you feel "locked and loaded" in every activity that requires physical effort i.e. sport, sex, dancing; even while communicating you use your mannierism more and in a controlled way

*you feel centered and more in control

*better long term memory but worse short term memory; better communication skills

*confidence

*priorities and organizational skills greatly enhanced

*cured/maintained under control my chronic gastritis and IBS(the only med that worked)

*breath easily

*recent dissapointments or stressful situations are much easier forgotten

*helps ADHD in unique ways due to its jack-of-all trades farmacology

*way less hay fever symptoms. I dont even need antihistamines, can control the allergy season with just a nasal allergy spray

*helps a lot with cardio and aerob endurance exercises

Downsides: fatigue, if not spacing between pills at least 6 hours. 8 is perfect; some degree of anhedonia, changes in personality the first 1-2 months after starting; greater fatigue after crash (around 4-5 hours mark) which lasts for several hours.

On the other hand after 1 year - 1 year and a half i started to experience some bad mental symptoms: brain blancness "blocked brains" - which greatly impacted communication skills; mental fatigue after redosing; problems with finding the right word sometimes, problems with small talk, greater anhedonia, feeling disconnected and uninterested about everything that happens around or everyone around, small libido problems, compulsive negative thoughts more present and towards obsession, weak hearted feelings(low moral) even though the anxiolitic effects are still strong, and though the confidence and the lack of inhibition are still enhanced.

Started taking 3/4 x 12.mg 3 weeks ago but I am going to stop it after 2 years in total, as the fatigue is too hard for me to increase the dosage above 50mg, and my brain feels tired from it, feels 'mooshed' and slowed down. Tia is one of the best mental and physical maintainers in a single pill and i would advice ANYONE with or without obvious reasons to start taking it, to give it a try.

What do you think about using Tia in therapeutic doses in the long term to treat depression and deal with stress Do you have experience with that ?

Ive obtained a prescription from my psychiatrist for the therapeutic dose of TIANEPTINE. Im hoping that it will help with my mood and neuropathic pain, what should I expect? Thank you.

Here is the article thanks to which I met her:

https://neurosciencenews.com/neuropathic-pain-antidepressant-23679/

So far Ive noticed a slight improvement in my mood, in my dopamine.

I will be traveling to Brazil with my wife next week to visit her family and I'm having a lot of anxiety over it. I have not been outside the country since I was 12 years old which is over 23 years ago. I suffer from social anxiety and the thought of being in a foreign country where no one speaks my language is I don't drink alcohol so that's not an option and my Doctor won't give me any anxiety meds.

Do you think tianeptine would be a good short term solution for my 10 day trip?