So I make homemade cough Syrup with tia & when I make it like that it’s great don’t add anything else sometimes hydroxyzine but what I’m saying is when I dose it regularly without making it into a syrup, it either barely works, or it makes me sweat n feel sick. So it makes no sense to me what is making such a difference when I just take a dose vs making the syrup and pouring it up into soda and sipping it??

Doest it work fine? Issues with addiction /withdrawal? Europeans/Germans who use it a a prescribed antidepressant? I read it 'right be good antidepressant with tja Main issue that it could lead to misuse because of opioid effects.

I was presribed Coaxil (tianeptine) in addition to Valdoxan (agomelatine). I read that tianeptine is serotonine reuptake enhancer and I'm interested could it, therefore, mess up Valdoxan effects on serotonin receptors?

I can't take SSRIs and SNRIs because of emotional blunting so I am destined to these "atypicals".

I’m new to this and trying to figure out what I’m dealing with ..

I've been trying to find this info without success so I hope someone here will be able to help. I've struggled with addiction for 35+ years now. My use of opiates is directly tied to my anxiety/depression/anhedonia. I'm on methadone for life and I'm ok with that but I've yet to find any meds that treat my symptoms except tia. I'm not trying to get high off of it, I can find dope for that if I want. I just want to be able to feel pleasure again and nothing else has worked but tia. It's been so long now I don't know what came first the use or the depression but now, even on methadone, I'm incapable of enjoying anything. Tia helps with that better than anything else I've tried and believe me I've tried a shit ton of meds and supplements. I'm just worried that the tia and methadone will be fighting for affinity to my mu receptor causing pwd's. Does anyone know if this will happen? Has anyone else used tia and methadone together? Thanks

I am going to have to use 60mg codeine for a few days after a procedure and I am wondering if I need to come off tianeptine for codeine to work. I have been on 12.5mg daily for a couple of years. I have heard that tianeptine blocks other opioid painkillers even at low doses.

Has someone experience with Tia and Tilidin ?

I just started on tianeptine sodium about 3 months ago. What are its side effects? How does it feel if you've overdone it? This past weekend, I think I took too much. I had what I would call dull chest pain & (I knew this one- difficulty breathing) harder to get air in my lungs. I've read tia is supportive of cardiac strength, but, uh... strength was NOT what I was feelin'! Has anyone here OD'd?

I dose when I feel pain. In general, I'm taking 25mg (50mg if I'm having an especially bad time with pain all over) every 2-3 hours. No more than 8 doses a day. Usually just 7.

I ran out of tianeptine yesterday (Monday), around noon. I have some coming today. I've been dealing with the pain with Kratom. It's not super effective for my pain, so I'm looking forward to my package today. I am able to fill my oxy script on Friday. When I have that, I only take that. Last month, it only lasted 2 weeks-i need to buckle down & at least TRY 40mg/ day. (I don't wanna! It's not fair!)

Some back story: My pain clinic has had many changes & after 6 months of screwing around with her, my pain Dr went back to private practice. I was on 60mg oxycodone a day & they've reduced me to 40mg/ day. My primary care Dr won't dose any more than 40. So I had a heads up that everything was about to blow apart. The closest clinic taking new patients is over an hour away & of course, it's taking forever for medical records to arrive at the new clinic, so I'm waiting on making my first appointment.

Hi everyone, I started taking tianeptine sodium 3 days ago, to start with, I started with 25mg, 1 time a day. But I'm not getting any benefit. I wanted to ask those who have been using it for a long time, how long it takes for the drug to produce the therapeutic effect, 1 months like usual antidepressants? . Furthermore, if I don't feel any effectiveness, how far can I go with the dosage, preventing the drug from acting like an opiate? some say 50mg but I have not read any scientific studies to support this thesis. In addition to suffering from treatment-resistant depression, I also suffer from chronic fatigue syndrome, due to mitochondrial disease. Tianeptine attracted my attention due to its action on BDNF (increased neurogenesis), increased IGF-1 (with increased production of collagen, cartilage, bone and muscle development, etc.), its influence on dopamine and its ability to increase brain mitochondrial activity. at least that's what we can read in numerous studies, but I don't know if this is true. I wanted to know if any of you have had any beneficial effects in terms of physical and mental energy, cognitive functions, reduction of bone, joint and muscle pain, etc. lastly, can you confirm that the drug acts on dopamine and not on serotonin? I ask because SSRIs cause an exacerbation of all my symptoms for me, as my problem is a dopamine deficiency. thank you all

As a warning, there are fake TD Red’s on the market. I don’t know what’s in these, but definitely not tianeptine. The bottle was taller than the usual - referenced tianeptine in ingredients, but this stuff has given me major anxiety. Stay away, who knows what the hell is in this. Anyone have similar (recent) experience?

For context: Im talking about Coaxil (Tianeptine Sodium). Im stating this again just in case someone misses the title. :)

So Im planning to try 2 doses of 12.5mg per day instead of the recommended 3 times per day because i want to take as little as possible while keeping some effectivity and if that won't feel like enough then i would add the third dose.

But, im wondering, is it like other anti-depressants where you slowly increase the dosage over time or can i take another one 4 hours later after my first ever dose, which i already took?

Thanks for any input. :)

Does it expire sooner than sodium?

What kind of tia is in the stuff we all buy from the head shops?

Is it dangerous to use these two together? What is the effect

I sometimes take tianeptine with an energy drink but I don't have one today so I'm going to have to settle with coffee but I drink it with quite a bit of creamer and sugar and I know tia doesn't work like at all on anything other than an empty stomach so I'm wondering will it still work the same if I drink coffee with it? Would using less cream and sugar help? Thanks

Maybe this will help as there are little testimonials for long-term use.

October 2022

Got prescribed Coaxil (europe brand) on twice a day x 12.5mg for bad long covid symptoms and for depression. I had neurovegetative symptoms which included:

*bad cold intolerance that led to fatigue (which were related to a bad thyroiditis spell for which I had to take half the starting dose of synthetic hormone but just for a winter; even though the thyroid started functioning again, I still remained with senzitivities to cold)- which Tia cured instantly

*fatigue and malayse that was related to long covid- which Tia cured over time

*anxiety- which Tia cured over time at 12.5mg x2 per day for 6 months until hay fever made it worse. n.b. never had mental health symptoms for hay fever allergy season before I got Covid

*depression- which Tia kept under control, with 2x 12.5mg per day, for about 6 months until hay fever made it worse. n.b. never had mental health symptoms for hay fever allergy season before I got Covid

Also helped with:

*inhibition- made me more open in social situations and enhancing sexual performance, both phyisical(nitric oxid releaser) and mental. I was never a dancer but my body adapted very easily to the rhythm and melody and you feel "locked and loaded" in every activity that requires physical effort i.e. sport, sex, dancing; even while communicating you use your mannierism more and in a controlled way

*you feel centered and more in control

*better long term memory but worse short term memory; better communication skills

*confidence

*priorities and organizational skills greatly enhanced

*cured/maintained under control my chronic gastritis and IBS(the only med that worked)

*breath easily

*recent dissapointments or stressful situations are much easier forgotten

*helps ADHD in unique ways due to its jack-of-all trades farmacology

*way less hay fever symptoms. I dont even need antihistamines, can control the allergy season with just a nasal allergy spray

*helps a lot with cardio and aerob endurance exercises

Downsides: fatigue, if not spacing between pills at least 6 hours. 8 is perfect; some degree of anhedonia, changes in personality the first 1-2 months after starting; greater fatigue after crash (around 4-5 hours mark) which lasts for several hours.

On the other hand after 1 year - 1 year and a half i started to experience some bad mental symptoms: brain blancness "blocked brains" - which greatly impacted communication skills; mental fatigue after redosing; problems with finding the right word sometimes, problems with small talk, greater anhedonia, feeling disconnected and uninterested about everything that happens around or everyone around, small libido problems, compulsive negative thoughts more present and towards obsession, weak hearted feelings(low moral) even though the anxiolitic effects are still strong, and though the confidence and the lack of inhibition are still enhanced.

Started taking 3/4 x 12.mg 3 weeks ago but I am going to stop it after 2 years in total, as the fatigue is too hard for me to increase the dosage above 50mg, and my brain feels tired from it, feels 'mooshed' and slowed down. Tia is one of the best mental and physical maintainers in a single pill and i would advice ANYONE with or without obvious reasons to start taking it, to give it a try.

What do you think about using Tia in therapeutic doses in the long term to treat depression and deal with stress Do you have experience with that ?

Ive obtained a prescription from my psychiatrist for the therapeutic dose of TIANEPTINE. Im hoping that it will help with my mood and neuropathic pain, what should I expect? Thank you.

Here is the article thanks to which I met her:

https://neurosciencenews.com/neuropathic-pain-antidepressant-23679/

So far Ive noticed a slight improvement in my mood, in my dopamine.

I will be traveling to Brazil with my wife next week to visit her family and I'm having a lot of anxiety over it. I have not been outside the country since I was 12 years old which is over 23 years ago. I suffer from social anxiety and the thought of being in a foreign country where no one speaks my language is I don't drink alcohol so that's not an option and my Doctor won't give me any anxiety meds.

Do you think tianeptine would be a good short term solution for my 10 day trip?

Hi, I’ve been prescribed tianeptine at a dose of 3x12.5 mg before main meals. I’ve been taking it for 10 days and haven’t noticed any effect. I have a few questions for you: how long does it typically take for tianeptine to show its anti-anxiety/antidepressant effects at therapeutic doses as indicated in the leaflet? Is there any difference when taking tianeptine with food, before/after meals? I’ve seen studies suggesting that it doesn’t really matter, but I’m not sure if that’s true. Someone also mentioned that the sodium salt form of tianeptine is best absorbed in the presence of fat, is that true?

I’ve been apathetic and barely able to get out of bed for years now. Ive been on benzos for 8 years and currently been tapering with xanax (3.5mg to 2.5mg now). Diazepam has either no or very sudden effects (i was on diazepam for 3 years), which is why im tapering with xanax.

Ive been on Lexapro, Prozac and Mirtazapine with very unpleasant side-effects. Which is why i today got prescribed Tianenptine 3x a day 12.5mg.

Thing is, ive occasionally taken other opioids (Codeine and lately Tapentadol). It’s been a week since my last dose.

Will this opioid use negate the 12.5mg effect of Tianeptine, as it also works on opioid receptors? Ive never used heavily or been addicted to opioids and rather used it in low-doses.

Im a bit afraid to start Tianeptine and to be dissapointedonce again. I’m also not too sure if i want to take a higher dose, because i definently don’t want another addiction…

Also im curious if Tianeptine would change the effects of other opioids if i were to take both?

Not a native speaker so i hope i come across clearly.

I have a addictive personality but im very “picky” if that makes sense. Like i can be depressed and drink for months and i never get addicted but benzos got me after 5 years of effective use, even going months off it, so i was stupid and oblivious that i wouldnt get addicted. Last 4 years ive been on benzos daily tho and get quite severe side effects even while tapering slowly.

I’d appreciate all responses and personal experiences.

Thanks.

Hi all! I recently acquired some tianeptine sulfate and am really enjoying it. (Duh)

Many years ago I tried tianeptine sodium back when ceretropic sold a solution of it, and while the effects were amazing and fast acting, it was also short-lived and the addiction and withdrawal risk felt really high

Now with sulfate im trying to find a sweet spot and avoid overdoing it, considering the horror stories on it and drugs that affect opioid receptors in general.

• So id like to hear if youve gotten consistent results with a dosing regimen, and what that is?

• Other than a healthy lifestyle are there other supplements that can support tianeptine efficiency of effects in a healthy way?

I am currently experimenting with dosages and found 40mg twice per day to be great, altho from what ive read on here that might be too high to be sustainable?

Thanks for reading, let me know about your experiences :)

Is anyone on combination of Tianeptine (tianeurax) 12.5 mg 3 times a day and vortioxetine (trintellix) ? Any success stories with that combination for GAD, and panic disorder?

Will I get serotonin syndrome if I combine the two?

I haven't taken my venlafaxine yet today and dosed about 5 mg, could be more could be less, it came in powder form with a scoop.

Can I feel safe to combine them

4 years ago I purchassed 30g. of tia sodium. Never got around to trying it but over time the powder had turned into a blob of hard rock? It also turned yellow from white even though i kept it out of sunlight. I also purchassed sulfate and its still in good shape. I wonder what the potency differential is from the time it arrived in the mail?

I recently discovered this stuff. It’s really nice. Incredible for my anxiety. If I were to use it two day on 1 day off. Would I still become physically addicted?

The vape shop I used to get my TD Reds at ran out like everyone else for a long time. Today they were stocking the shelves with new. I’ve heard there is a new variety out with a taller bottle/different label. These were absolutely identical to the old. I found one of the old bottles just to make sure. The odd thing is, even the expiration date is the same. But when you open these up, it’s definitely a different substance inside. Much much finer.