I've been prescribed Tianeptine for depression and i have been taking the recommended dose of 12,5mg 3 times a day. I have never abused it. Recently my joint and muscle pain has been crazy, especially in my knees and elbows. I've not experienced something like this before. Can it be related to this medicine? Or is the dosage i'm taking too low to cause effects like this and my pain is just unrelated?

I take tianeptine for ADHD moreso than depression. This is why I regularly take breaks.

I took a break for multiple days and afterwards could note mild depressive symptoms. After multiple days of using again things improved. Then I only took a one-day break and I could again note mild depressive symptoms.

Am I the only one? Is this to be expected?

if taken in small doses, such as 12.5mg of tianeptine and 50mg of tramadol for depression(especially treatment resistant depression), which medication do you think would be more effective for depression, based on your experience and knowledge?

I also take Pregabalin 225 mg and I am very depressed and find everything difficult. Does anyone have experience with this and could it be due to the Tianeptine?

I can‘t Even stand Up and take a shower, everything is very difficult for me

Does anyone know if tianeptine goes bad i found some from about a year and a half ago while cleaning out a room in my house they were just sitting in the capsules out in the open but it was a dry place and they werent in sunlight would it be safe to take one or should i just throw them out

Just trying to find out if there are any interactions.

Ive got an old jar of 5ish grams of tianeptine but the labeling was scuffed so I have no idea what salt-form it is. Does anyone know how I'd go about finding out if it's sulphate, sodium, or any of the other forms it was being sold in almost a decade ago?

All the best

Of course, I mean medical dosages like 12.5mg three times a day. I started taking it about a month ago, and it's been working fine for my depression, but will it eventually lose its effectiveness if I continue taking it at the same dosage?

This sub won’t allow us to post pics. But there is a scene in Detroit Become Human, where the robot is cleaning up her owner’s room. She grabs a pill bottle with the generic name of ambien on it. Maybe there was one more bottle. When you see the bottle from her robot vision, it’s says on it ANTIDEPRESSANT. Contains Tianeptine. May cause behavior disorders. I think that was the devs making a shout out to Tianeptine. It should be noted though that the person whom that bottle belongs to is not a good person and has serious addiction issues. I just found it all interesting. I know this is not a video game sub. But it’s an interesting video game, the inclusion of Tianeptine in it I think is setting up the story that this man has some serious issues. I’ve been clean from Tia for several years. Got off of it by using kratom. I’m 100 percent dependent on kratom since then, but that compared to my experience with Tia does not even compare when it comes to it being a problem. I was not myself then and was a complete slave to the drug. Be careful out there guys. You’re better off without it.

There was literally no information on dosing for this type of tianeptine, so I’m starting a thread to discuss it. I am not a recreational user of tianeptine, I use it in therapeutic doses (in the past just used 25mg of the sulfate once a day) and have found it to be really helpful for depression in ways that nothing else has.

I was curious about the ethyl ester sulfate because it supposedly lasts longer than sulfate and potentially is more potent, but I’m not sure.

It does NOT dissolve in water.

So far I’m trying 20mg to see how it goes and will compare it to 25mg sulfate.

Update: 20-30mg seems like an appropriate dose once a day. No euphoria, just mood lift and cognitive enhancement.

People who choose to contribute to this thread: please do not weigh in if you’re using this to get high. There are plenty of other threads discussing getting high on tianeptine. This thread is specifically talking about therapeutic doses of tianeptine ester ethyl sulfate.

Let’s get some good, clear information out there so people can use this safely.

I take vortioxetine (20mg/day) and recently started tianeptine (12.5mg x 2 /day). This dosage was suggested by my doctor and I'm quite happy with the results. Even tho I feel like I could benefit more if I increase my dosage, but not sure if higher dosage is good idea when combining 2 meds.

So if you take it with other antidepressants, what is your dosage?

Been taking tianeptine sulfate just 25mg for a few days now and have noticed a very obvious but mild pain in my left chest, almost like a pinprick sensation, that crops up around 3 hours after dosing. Also gave me horrible runs, I mean the faucet was just on. I’m not sure if this would be in line with opioid w/drawal or excess? Either way it’s annoying at the very least and I probably won’t be continuing my trial of tianeptine at this point. Just wanted to add to other anecdotes that report the same thing.

I've been taking tianeptine off and on for the last two years. Lately whenever I dose I get this strange sense of panic and racing heart. The longer I go without dosing the better I feel. It's just weird I was able to take it fine up until recently. Just curious if anyone else has experienced anything similar. Thanks in advance

Theres a lot of propaganda posts on sites about bans nationwide. It’s only in select states. They’re banning it everywhere. It’s dangerous that people think a ban is the solution. Plenty of other drugs are illegal and they still use them everyday. A ban just stops people who have no self control from purchasing it in stores that sell it. Stay safe out there and don’t believe everything you read on the internet. Do your own research. Bills and floor meetings are public information when it comes to our nation’s health.

Hello everyone, I'm curious about some of the ways that you like to prepare tianeptine to take throughout your day? I just started using it and I need to find ways to use it cheaper so I ordered bulk. The gas stations are ripping people off like no other.

No idea what to attribute this to. But I vaped like 5 pretty big hits of a dmt pen and nothing happened. I was wondering if tianeptine would be the reason why since it is a tca tho idk if that effects dmt. I don’t take any antidepressants or antipsychotics so I’m not sure what else could be causing this. I made sure what I have is real dmt I’ve tripped on it multiple times in the passed and on smaller doses but I took zazas like a couple hours before

Is it more/less potent, is it dangerous? I have a prescribed pack of “Coaxil”, it has been expired for 2 years. Never tried it beacuse I had another medication to treat my depression. And it worked wonders for me. But now after a year of solid mental health I can feel the depression crawling back again. And I am thinking of taking Tianeptine.

Sorry I don't have a link right now, I will add one later

The Link

I’m talking about 25mg Tia Sulfate a day. I take opioids daily, but am interested in Tia as an antidepressant.

Would taking 25mg Tia Sulfate every morning either:

A) Not work since I have an opioid tolerance?

B) Block my opioid dose?

C) increase my opioid tolerance?

Thank you.

recently acquired 2gs of tianeptine free acid, but overall wasn’t 100% satisfied with it so i decided to convert some of the sodium to see if i got better results. i used a 5:1 ratio of FA to baking soda. here is the recipe :

1.measure out 100ml of water then pour nto ceramic cup

2.microwave water for a minute

3.measure out 200mg of baking soda

4.pour into hot water gradually stirring as you do it until its dissolved

5.measure out 1g of FA

6.pour into hot water gradually stirring as well , stir for a good minute.

7. put back in microwave in one minute increments, taking it out to stir well every time

8.keep microwaving it in one minute increments and stirring until water is clear.

9.should have a 10mg/100ml solution!

I've been on tia sulfate for about 6 years, 80mg a day.
I'm wondering if people think this is a reasonable plan: travelling to New York, ordering 100g to a hotel beforehand. Seeing the sites, and then travelling back to Europe with 100g.

I figure 100g would last me several years and let me come off in my own time.

I just don't know if this would be dodgy, or if ordering to hotels is a no no. Or flying with 100g say in a creatine bottle would look very suspicious. From what I can see, it is legal in New York. It is banned in these states: florida, Alabama, Georgia, Indiana, Kentucky, Michigan, Mississippi, Ohio and Tennessee.

Hi guys!! Help me out here pls: I have histamine intolerance and I‘ve read that opioids like tia stimulate histamine release. I‘m starting tianeurax and am already noticing the symptoms that I normally get from food rich in histamine.. which mostly are rashes and breakouts. Are histamine intolerant folk just better off not taking opioid agonists??

Hi there. Just starting tianeptin sodium for the first time. I popped the first pill (12.5mg) yesterday. Felt nothing out of ordinary. How should i get adjusted to it? How many pills for starters? The maximum is 3 pill a day i know that. How fast should i up my dose to that number? Im also taking bupropion 150mg for 6months. Any interferenc i should know about? Im asking strictly about therapeutic doses bc Im from eastern europe. Its legally prescribed here and no sulfate or other form available and i do not care about them. I tend to get addicted to things. I smoke weed daily and some alcohol on the weekends. I got tianeptine prescribed by my doctor. No desire to abuse. Advices suggestions? What i suppose to feel after taking it? Im depressed and having some hard time with anxiety like psychosomatic. Sorry for bad english and thanks for any input guys :]

The Johns Hopkins University School of Medicine is seeking volunteers to complete an online survey study about substance use. In particular, we are hoping to learn more about experiences with novel or less commonly used substances, including tianeptine.

If you have used tianeptine, you may be eligible to complete the survey.

The survey is anonymous and does not collect personal health information about you. Completion times will vary based on substance use experiences, but we estimate the survey to take approximately 30-35 minutes to complete.

There is no treatment as part of this study and survey completion is not compensated.

If you are interested in volunteering to complete this online survey, please see the link below which will provide you with additional information and access to the survey.

https://jhmi.co1.qualtrics.com/jfe/form/SV\_0B1Ggc39JnRFj0i

Thank you!

The Principal Investigator for this study is Kirsten E. Smith, Ph.D.

Study Protocol: IRB00417685

There is a thread on here heralding this as good news, but I don't think so. If it gets FDA approved, then tianeptine will be federally scheduled as a controlled substance.

And do you really think medical professionals would be avid to prescribe an opioid-based medication? While it's known that the endogenous opioid system is at the center of depression, it would still require a LOT of marketing and convincing to make prescriptions commonplace.

tional use.

Hey all, I wonder if anybody can answer this question, perhaps from personal experience. When I look it up online there is essentially no precedent from which to draw. I'm currently on Parnate which is an irreversible maoi. The main reason I am asking is that I have noticed the order in which I take my medicines makes a big difference. For example, if I take my MAOI first, the Tia does not seem to work. Whereas, if I take Tia first and then Wait to take the Parnate it just seems to work out more smoothly that way. Anybody?

Hey folks

I was prescribed Stablon last week - 12.5x2 a day for the first week and then 12.5x3 per day after that.

I have had generalised anxiety disorder since 2014 following a bad LSD trip. Not even sure if it was LSD or NBOME. I’ve never taken any medications for it earlier but I decided to turn my life around and seek help now.

So far I haven’t felt any benefits or side effects from taking tianpetine and it’s my 6th day today.

Any idea if it’ll work if I keep Stablon as prescribed. Or is that since it hasn’t shown any benefit yet, it may not work at all?

Thank you!