Probably will stick to only one of top 3 stims as my heart might explode

Ephedrine

Modafinil

Armodafinil

L-Tyrosine

L-Theanine

Theacrine

Lion Mane

Rhodiola

Caffeine Pills

Magnesium

Zinc

Vitamin D3

Vitamin C

Already taking Ashwagandha, Creatine, Nicotine

Let me know if theres something to improve

Stacking for a wicked dopamine deficiency.
Starting out with the usual suspects: L tyrosine -500mg L theanine -200mg Yohimbine -5mg B Complex

A soon as I wake up:

• Transfer factor (colostrum) 125mg [source naturals wellness]
• Spermidine 10mg [neurogan]
• Pregnenolone 100mg [nutricost]
• Iodine 1 drop (survival shield x2)

Breakfast:

• Multivitamin Alive! Max3 x2 [nature's way]
• Potassium gluconate 90mg [nature made]
• 1 softgel of garlic + parsley
• Ginger root 1.1g [nature's way]
• Black seed oil 1g [healths harmony]
• Clorophyll 60mg [horbaach]
• Glucosamine + Chondritin [kirkland]
• Horsetail 760mg
• Collagen (big scoop)

Around 3 hours later:

• Curcumin + coconut
• Arginine + cirtulline [nutricost]

Lunch:

• Ginger root 1.1g [nature's way]
• Glutathione + Vitamin C
• MSM + Hyaluronic Acid [horbaach]
• 1 softgel of garlic + parsley

Around 3 hours later:

• GNC AMP Gold Protein - 1 serving

Dinner:

• Omega Norwegian Cod Liver Oil 1250 Mg
• Multivitamin Alive! Max3 x1 [nature's way]
• Beetroot 750mg [purebulk]
• Black seed oil 1g [healths harmony]
• Liposomal Nicotinamide Riboside (NR), Resveratrol, Quercetin [Reus Research]
• Magnesium

Right before bed:

• Taurine [nutricost]
• L-Lysine [NOW]
• Pterosilbene [nutricost]
• Reishi + Cordyceps + Lion's Mane
• Spermidine 10mg [neurogan]

Besides all of this, I make sure not to eat fried food or sodas. I used to take cinnamon bark and NAC too, but I stopped after experiencing hypotension, I plan on re-adding one of these when I run out of beetroot and see how I feel.

I'm interested in hearing other's opinions on this list.

I am new to Nootropics and created this stack after a few months of research to enhance cognitive function, long-term and short-term memory, cognitive processing, etc. I intend to take this stack over the course of five years as I have several things I need to study, learn, and memorize—hundreds of books, courses, skills, fields of study, etc. I researched and specifically selected each compound to achieve my cognitive goals. I don't have depression, anxiety, ADHD or any other mental disorders/conditions minus a fcked sleep schedule. I have perfectly healthy brain function. I seek to raise base cognitive levels higher. Here is my stack:

Choline-Based Compounds:

Alpha GPC: Enhances cognitive function by increasing choline for acetylcholine synthesis.

Uridine Monophosphate: Supports brain health, improves synaptic connections, and enhances choline synthesis.

Huperzine A: Prevents breakdown of acetylcholine, enhancing memory. Cycling once every other day due to 14h half-life

Phosphatidylcholine: Contributes to choline levels supports cell membrane structure.

Non-Choline Based Compounds:

Coenzyme Q10 (CoQ10): Supports energy production at a cellular level, antioxidant.

Omega 3 fish oil - DHA (Docosahexaenoic Acid): Essential for brain health, supports cognitive function.

DMAE (Dimethylaminoethanol): Mood enhancer, indirectly supports acetylcholine production.

Phosphatidylserine (PS): Vital for cognitive function, stabilizes cell membranes.

Vinpocetine: Enhances cerebral blood flow, supports cognitive functions.

Bacopa Synapsa (Bacopa monnieri): Enhances memory, supports cognitive function.

7,8-Dihydroxyflavone (7,8-DHF): Mimics BDNF, supports brain health and memory.

Lion's Mane (Hericium erinaceus): Stimulates nerve growth factor, supports brain health.

Theacrine (TeaCrine®): Provides energy, enhances mental clarity without tolerance build-up.

Adaptogens for Physical Performance:

RedBeet (Nitric Oxide Activator): Enhances blood flow, improves endurance.

Tongkat Ali Complex: Supports hormonal balance, enhances muscle strength.

Rhodiola Rosea Extract: Enhances physical and mental endurance, reduces fatigue.

Siberian Eleuthero Root: Increases energy, stamina, and reduces stress.

Creatine (not a adaptogen)

General Health:

Men's Multivitamins: Provides essential vitamins and minerals for overall health maintenance.

I have been taking this stack for about 2 days, and I feel pretty good; I have improved motivation, energy levels, and short-term memory, and my thinking feels smooth and clear. No negative side effects yet except for difficulty falling asleep; using Melatonin, Chamomile, valerian, B6, L-theanine, 5-htp, and GABA concoction to help with falling asleep.

Now comes the questions: I am 20M new to nootropics and

1. Will taking this for the next 5 years fck me up badly? (Obviously, there is risk involved, but how much?)
2. I take all of this stack all at once in the mornings. Is this bad and will this decrease the effectiveness of the stack.
3. None of these upsets my stomach. Sometimes, I take the stack with food, and sometimes, I don't. Is this a problem?
4. Is there any compound worth removing to save money?
5. Open to advice and further suggestions.

https://preview.redd.it/f08ke95d5bxc1.jpg?width=4030&format=pjpg&auto=webp&s=cc25fd164abcb1f60f4788459eb3cef73ac5404f

Hi r/StackAdvice,

If you all would be willing to look at my stack and point out anything that is redundant, useless, or negative interactions between supps I would greatly appreciate it! I want to try to save money by cutting out supps that are unnecessary.

Also, I'm interested in supplementing niacin. If anyone thinks it would be a great addition to my stack lmk.

Important background info - I count my macros consistently and I make sure to get RDA of calcium and vitamin C (usually more than RDA - 200mg+) from foods (pineapple and strawberries) instead of supps. I train in the gym 6 days a week. I do cardio 6-7 days per week for a total of 180-210 minutes of weekly low to moderate intensity cardio (about 60-90 min of total weekly cardio is moderate). Sleep 7-8 hours every night (on weekend by I fall asleep an hour later than usual but I also sleep closer to 8 hours on the weekends). I drink about 3/4-1 gallon of water per day. Diet consists mainly of meat, eggs, potatoes, white rice, and fruit (barely any veggies).

Stimulants

• Adderall IR 10mg 4x/day: I do this M-F and then 30mg typically on Saturdays followed by a break on Sunday.
• Caffeine 150mg: I use this on Sunday via Yerba Mate

Water Soluble Supps

• Magnesium Glycinate - 200-300mg/day. I have an electrolyte solution I use to make my own sports drink at home which has magnesium. On days I don't use it I will usually get a total of 400mg/day. 200mg in the afternoon and 100-200mg at night.
• Trace Minerals from Pure Encapsulations - 1x/day
• Zinc Picolinate - 30mg/day (Total of 45mg/day when accounting for Trace Mineral Supp)
• Kre-Alkalyn Creatine - 4g/day (Monohydrate causes unwanted stomach sides)
• L-Citrulline Malate - 8g/day (Helps out with vasoconstriction brought on by adderall)
• Hydroxy B12 - 2000 mcg/day (Based on a genetic test I did, this is the most absorbable version. COMT mutation)
• Methyl-Folate - 1mg/day (MTHFR mutation)
• L-Glutamine - 10g/day
• Betaine Anhydrous (TMG) - 1.5g/day (3g total on training days)
• Taurine - 1g/day (starting this week)
• R5P - 50mg/day
• Tyrosine - 500mg on the days I take Adderall (taken with first addy on an empty stomach, starting this week)
• Boron - 5mg/day (starting this week)

Fat Soluble Supps

• Vitamin D -5000 IU
• Krill Oil - 1-2g/day
• Astaxanthin -10mg/day
• Vitamin A (Retinyl Palmate from Cod Liver Oil) - 9,000 IU/day (I have keratosis pilaris and I'm gonna see if this helps)
• Benfotiamine - 300mg/day
• Phosphatidylserine - 100mg/day (Hyper-responder. I will up this dose on Thursday and Friday due to my stress load increasing).
• Garlic Oil (Sports Research Brand) 2 softgels/day (1000mg of extract 100:1)

Sleep Stack Supps

• Glycine 3g
• L-Theanine (suntheanine)-200mg
• NAC w/cofactors (Doctor's Best - 600mg NAC 1 capsule
• Mag Glycinate - 100mg (This is accounted for in the total I stated above)

Workout Supps

• My Company's Pre-Workout 6 days/week - 3g Citrulline-Malate, 2g L-Carnitine Tartrate, 1.5g Nitrosigine, 1.5g Betain Anhydrous, 50mg Astragin, 50mg Senactiv, 10mg Black Pepper Extract.

Protein Supps

• Santa Cruz Paleo CBD Beef Isolate Protein - 50mg CBD per serving. I use this daily.
• Collagen Peptides - 18g protein/day.
• Gelatin - 12g protein/day. I make protein gummies out of this and stevia.

Hello i am thinking of taking a regular dose of alpha gpc for study purpose since my exams are approaching in a month. any suggestion pr incite would be helpfull

Is it ok to stack modafinil and emoxypine and take it daily ?

I was prescribed Concerta for ADHD, but it hasn't been available since and won't be available anytime soon.

At some point I was prescribed Piracetam 1.2g in the morning, but I stopped it after a couple of months. Now I'm planning on trying out Armodafinil, and was thinking to get back on Piracetam to help with other cognitive functions alongside.

Do both interact or can have amiplified effects or are they safe togethee? Also is it even worth getting back on Piracetam? I couldn't feel much difference for the short time I've used it.

Worth mentioning, I'm on 30mg Mirtazapine and 25mg Amitriptyline at night.

TIA

Hi all!

I (22M) started taking L-theanine (2x/200MG), Ashwaganda (2x/500MG) and Rhodiola (1x/200MG) 3 weeks ago to treat my moderate anxiety and depression. For the first ten days I felt confident, happy and present— just like my old self. However, while I do feel much less anxiety, the depression returned a few days ago. My aim is to live a life of emotional stability free from the chains of anxiety and depression, and I am doing the work outside of supplements to get there (CBT, meditation, exercise, etc.). I was thinking of adding 5HTP to my stack but the lack of research deters me, and I have had bad reactions to SSRIs. I would appreciate any advice or suggestions ❤️

Hey, everybody. Can you please recommend something like (ar)modafinil? If it works like it does, that's great. Only in Germany and without prescription. Or maybe there are some good nootropics without a prescription? Need boost) I'm studying, working. And I have an exam coming up. Thank you.)

I’m planning on taking it 3-4x this week at around 1.3 grams and pretty much stopping afterwards for a long while,I’ve used phenibut already in the past and I’ve quit pretty easily so I know pretty well what I’m getting into I’ve taken larger doses by a good amount, would it be unwise if I took it 4x or 3x this week for a vacation and then pretty much drop it (i know ill drop it) I’m certain i wont use again for a long while I’m just not very certain how dosing like this would work or react if its only for this one week my tolerance is 0 it’s been months since I’ve had any as well

Hello guys I had a quick question on Zynamite. I saw one post saying that zynamite causes dopaminergic cell damage. I was wondering if anybody knows if this is actually true, I bought it in hopes of helping my ADHD.

Good evening

I suffer from severe insomnia (I can only sleep 2-3 hours a day even with BZD and trazodon) and ADHD, but I'm extremely sensitive to medication, which is a problem.

I'm wondering if I have a cyp2d6 deficiency.

Also, my theory is that there are two types of ADHD: dopamine-deficient and noradrenaline-deficient, and in the latter case, dopamine vaccination may actually make the symptoms worse.

My medication results are

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Atomoxetine 15mg→ My short-term memory has improved tremendously, but I feel some discomfort in my brain, and my insomnia has worsened to the point where I can only sleep for an hour.

Methylphenidate 18mg → Becomes manic and becomes absorbed in pleasurable activities. There was a time when I went into a crazy state where I would masturbate for 18 hours straight.

Nortriptyline　10mg → Short-term memory improved tremendously and insomnia worsened, but I felt it was more effective than atomoxetine. However, after using it for 10 consecutive days, his heart palpitations increased and he panicked, resulting in him being rushed to the emergency room. After that, I stopped taking this medication, but even now, three months after stopping, my ADHD symptoms continue to improve. (This is a big mystery to me. The fatigue, procrastination, and clumsiness of the past five years have disappeared all at once.)

Zinc　25㎎→Become manic, like when you take concerta

tak653 1~2mg → I didn't feel any particular effect, or I only felt a slight improvement in intelligence (however, I don't know for sure because I haven't done an accurate examination. At the time I took it, I felt like my intelligence had improved). (Motoshita)

Sodium Valproate　200㎎　→　It feels calming. There are no side effects at all.

other symptoms

・I also have ASD and had OCD when I was in elementary school.

-Throat is always dry（hoarse）

·Dry eye

・ED

・If you don't take zinc or Methylphenidate, your sex drive will be very low.

・You won't gain weight even if you eat it

・It was not Graves' disease.

・I'm in my 20s, but my fecal occult blood test is positive, and Helicobacter pylori is probably present in my stomach.

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What I'm having trouble with right now is severe insomnia and low norepinephrine.

Atomoxetine works wonders, but the trade-off is that it worsens the insomnia at night.

Is it a little too much of a wish to improve both?

I'm a 26-year-old woman who's always had some social anxiety, but I used to be able to manage it and communicate without issues. However, after facing significant trauma last year and losing close friends, my ability to socialize has drastically decreased. Now, I mainly go to work and then straight home, with little social interaction outside of that.

Lately, speaking has become physically difficult for me. It feels like I've lost the natural ability to move my mouth and lips when I talk. It just feels so difficult to be able to physically make those oral motor movements. It’s like I’ve completely forgotten how to use my lips or what tongue movements I have to make to produce words. I'm constantly aware of how my mouth looks when I speak, and talking feels awkward and forced. This issue seems to be worsening with people I'm not comfortable around, though it varies even with those I am comfortable with.

On top of this, I've been diagnosed with being on the autism spectrum, OCD (with disturbing intrusive thoughts that aren’t that bad in my life currently, learned to accept it but could be better), ADHD, and PTSD within the past year. I was already diagnosed with BPD 2 years ago but I have been in therapy every single week since then and as of right now my triggers and symptoms are manageable. I believe the lack of social interaction, compounded by my recent trauma and diagnoses, has caused a regression in my speech abilities. It's surprising and challenging, especially since I've been relatively high-functioning and was only diagnosed with autism later in life.

I just started taking vyvanse for ADHD 2 weeks ago and it’s been life changing and I’m able to be more functional and get things done. I’ll likely continue taking them

I tried phenibut and it’s nice for anxiety but I’m still struggling with my speech. I may take it once a week or biweekly

I take magnesium glycinate for sleep

L theanine hasn’t been much help

Out of everything I’m struggling with, my speech issues are definitely what’s causing me the most distress. Please help

TL;DR: I aim to reset caffeine tolerance every 10 days with a 2-day non caffeine period. What could I take those days to replace caffeine with?

CONTEXT: After 10ish days, caffeine tolerance builds up heavily where I notice a significant reduction in productivity, motivation and focus. I want to do a 2-day reset every 10 days. But those days are very slow. Brainfog, lethargic and all of that. It takes a LOT of effort to get anything done on those days.

What supplements or nootropics should I consider looking at to take on those days as adirect replacement for caffeine? I'm asking about things that give a good boost (increase in focus, or cognition, or energy, or all of that), not something you need to take for 2 weeks before you notice any effects.

(Example of what I am NOT looking for: rhodiola is great for anti stress and some energy, but I don't think you can consider it as a replacement for caffeine.)

There are many factors that I have caused this, I need a plan to slowly recover. I basically don't play video games, even though I sometimes want to. Yes, the situation is so dire that I feel like it would be an improvement and sign of commitment if I could take 90 minutes to dedicate to playing a game.

NOrmally if I launch the game (or work program) I'd immediately feel pressure to be doing some relief activity (stretching, eating something healthy, clean my glasses, take nap, listening to asmr to relieve hearing condition and/or hearing hypervigilance).

​

It's not the point of "I have to have everything perfect " it's more like hyper awareness of signals the moment i have to do anything even bordering on medium-hard.

Essentially I can't do consistent effort at anything. This is due to 3 things:

- physical and mental issues become more obvious when I try to concentrate, focus my eyes/read and sit still

- learned habits of consuming youtube when symptoms of resentment towards work/concentration come up (takes about 30 seconds into a task).

As a result my brain is so used to "finding shortcuts" that I can't even do something that requires the least bit of cognition or multi-step thing, like playing a video game.

​

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Anyway, this is clearly a complex multi factor problem that has been building for years, that many people also experience (to a lesser degree).

There will be therapy needed, gradual exposure to practicing focusing, as well as biohacking "exploration" (ie TENS, light).

CLearly there is no way 1 thing will be the complete solution to this problem. It won't be just "meditate and practice" or "chew nicotine gum", it's going be a discovery process, trial and error, an commitment

​

there's so many factors at play, I also wake up exhausted at all the time and coffee / amphetamines, if attempted ( it tend not to use these), just usually make me feel worse.

most of the time what "works" to help me have energy and do shit is overly lengthy self care, such as foam rolling while listening to asmr videos, sleep induction mats used in the middle of the day (acupuncture) various pain relief things, and sometimes things like prednisone or licorice root in the morning have been known to help.

low dose benzos can help, sometimes. Like combining a benzo with caffeine has a chance of making the caffeine actually work and not making me feel worse. Obviously this strategy has to be used sparingly.

​

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Right now I have been taking this stack for about a week - I was on Adderall for a few months, then taking Stasis with it, and now just trying life without meds again, but + supplements

(Throughout day) Caffeine + theanine, Vitamin D3, L-tyrosine, Vitamin B complex, Cognizin citicholine, L theanine, Ashwaghanda ksm 66, Vegan multivitamin, Vegan omega 3s,

The things I noticed for sure are tyrosine and theanine doing what they are supposed to. When I was on Adderall taking tyrosine in the evening really did help with the crash. Now I assume it is helping things level out.

Anything anyone would take out or swap? I also am considering L-phenylalaline, lions mane, a specific magnesium supplement rather than relying on multivitamin, and saffron.

Looking for test boost for muscle growth and to be more relaxed in general.

I have ADHD and Methylphenidate makes it worse and

Atomoxetine works wonderfully.

However, Atomoxetine has troubling side effects such as constipation and increased blood pressure.

In addition to Atomoxetine, drugs that increase noradrenaline often work well for me, but are there any supplements, or prescription medications you would recommend?

*What I would like to ask about is not a drug that suppresses side effects, but a drug that acts as a substitute for atomoxetine.

I dont need to take every one of these but the target was to improve in anxiety, testosterone, blood flow.

Btw i workout, dont take any meds, dont have any diseases,etc...

I have been using AlphaBrain for a couple of weeks now, and I started to notice that after 5-6 hours of taking it, I get irritated easily by anything someone says (mainly when I get home from work). Is this a known side-effect? Would it be possible?

I have been doing some research, and I am planning to substitute AlphaBrain for Alpha-GPC, Huperzine A, and Bocopa since is much cheaper than taking the blend, but now I am not sure if any of these components are responsible of my mood changes recently.

Ok so i am a 31 years old sometimes socially charming, but mostly an irritated guy “who always seemed to be having a bad day”. On my best days, i was a super confident speaker, the kind that was creative with his words. Since my teenage years i have always been a very playful small talker and could walk anywhere and make a bunch of people laugh. But that part of me just died slowly between 23-27. I also suffered depression and i simply stopped trying to being that socially playful guy, just so afraid that i will rub someone the wrong way. My social confidence took a hit. It’s like I had this great superpower and i just lost the ability to turn it on though i knew it was still there.

I was also very capable of locking in my attention on an analytical task or something that required careful execution. That capability is still there but it has been so hard to invoke it when needed and I have to align so many things in my environment and routine to be productive that way. Also once i lock out again, i feel like “oh gosh i am never gonna finish this project and its a shame as I have made so much progress.”

Since i lost these “superpowers”, i fulfilled my dopamine urges with all sorts of hedonistic pleasures(no hard drugs though) like weed alcohol, clubbing and it seemed to have fried my working memory and focus so badly.

Long story short, i went from “I could do anything” attitude and vibe to “ I am a boring isolated guy who will just have to work his entire life to sustain” outlook.

My stack only had L theanine to counter balance some stress most of us guys living in big cities would feel in their 30s. BTW I am a quant working in finance in Mumbai

And then I decided to try L tyrosine, had my doubts because it acts on dopaminergic system and that neurotransmitter system has complex interactions, but Huberman’s shout out to it gave me the will to try it.

Tried 500 mg empty stomach and holy cow it was like that guy from early 20’s woke up. On my commute I am just playing and teasing every one i met on the way, banter with anyone in the office. I simply started feeling like some sub-god species. That feeling lasted a week, and now it has become more stable, still not so subtle dose of energy that lasts me 6-7 hours and I am so driven, social anxiety is zero and I have got back this feeling of “anything is possible”. And that one pill sort of still continues the next day though it’s more subtle. It’s been a month since i had that first dose, still effective.

I am cycling it already to keep it effective. 2-3 pills of 500mg a week on empty stomach and it has been that one god send of a thing that i needed.

I can still not focus on things that require lock in attention and are analytical in nature but I am doing well with creative tasks. I am doubting choline deficiency because of the horrible scores i am getting on working memory tests. Which i am sure was not the case always, because i was above average IQ since childhood with great verbal fluency. So going to try Alpha GPC next.

I just wanted to share this experience with the community here because i don’t have someone in life who understand these things.

Now i guess i would have these questions -have you had the similar experience with Tyrosine? If yes, does it’s effectiveness reduce with time? -alpha gpc, theanine and Tyrosine stack? Particularly, have you mixed alpha gpc with tyrosine

Alpha gpc have some concerning side effects related to stroke and depression once the stores are full. But is there a serious side effect of Tyrosine? Particularly, the one about melanoma? I do notice that one of my moles just look darker now, but memory has been so fried that I wonder if thats just my fear and anxiety brain kicking in.

Also, I am an ENTP mentioning fir relatability if you are familiar with MBTI

Has anyone done this or is it a big No-go? Just got a delivery 😀