/r/StackAdvice
Purpose:
Due to an overwhelming number of posts in /r/nootropics where people post their stacks and ask for advice on dosages, feedback, recommendations, etc, we have created a supplementary subreddit for requesting and giving personalised advice.
Consider this a friendly environment for stack advice, Nootropics recommendation, supplement information, and any question concerning Nootropics.
Please include medications/supplements you use, any health conditions, your sleep, diet and exercise habits.
Posts need to be either asking for stack advice, offering stack advice, requesting someone to rate a stack, or other Q&A type posts.
Advertisers should not advertise your products here and product advertisements will be removed.
Links to resources and references are fine.
Other subreddits:
/r/StackAdvice
I have a few questions regarding acetylcholinesterase inhibitors and other nootropics that modulate choline in the brain. My goal is to enhance choline levels so that racetams will be more effective and choline levels in the brain will not be depleted as quickly. For reference, I take vyvanse 20mg 5 days a week, am prescribed pregabalin (200mg/day), and sometimes if I need to study I will add oxiracetam, pramiracetam, and/or noopept, sometimes adding a bit of matcha or Kratom as well. I take CDP choline with these to avoid excitotoxicity as much as possible.
I was looking for a list of acetylcholinesterase inhibitors and I couldn’t find it. I remember someone posted a list of herbal maois at some point, I’m basically looking for that for AChEIs. I’m looking for supplements/nootropics I can take, not medications. I’m wanting these to enhance racetams/vyvanse, which I take often. I’m also not really sure if I entirely understand the difference between acetylcholinesterase inhibitors and nootropics that modulate the acetylcholine system. I sort of understand how they work in the brain based on my biology courses, but I don’t entirely understand how they affect nootropics.
I already have huperzine-a, which I know works for what I’m asking here, but I’m just looking for other alternatives. I know noopept and emoxypine modulate choline in some way but I don’t entirely understand how, and iirc quercetin and memantine has some effect on choline, but again I don’t fully understand how that works.
My current (not complete) stack in addition to nootropics/vyvanse is: pycnogenol, co q-10, magnesium, vitamin d, b complex, cdp choline, and psilocybin mushroom microdose .1G 4-5x a week with lions mane as well.
I know this is a lot of questions but I would really appreciate any response 🙏
I recently started on 30 mg of Vyvanse, and while I know that taking supplements isn’t absolutely necessary with this medication, I’d like to optimize my routine to maximize its effects and support my overall health and ADHD symptoms.
Based on my research so far, here are the supplements I’m considering:
• L-Tyrosine
• ALCAR (Acetyl-L-Carnitine)
• DLPA (D,L-Phenylalanine)
• Choline
• Omega-3s
• Vitamin D + K
• Multivitamin
• Magnesium Glycinate
I exercise daily and follow a whole-food diet with an emphasis on protein. I also drink electrolytes mixed in with plenty of water throughout the day.
Any suggestions on other supplements to add, or adjustments to make? Thanks in advance!
Estrogen levels came in high after bloodwork so began taking 300mg DIM. For the past few days, I’ve thrown up in the morning after my post workout meal and have been experiencing nausea early in the day. 300mg DIM 4200mg Omega-3 fish oil Multivitamin 5000ui D3+K2 50mg zinc 5 billion CFU probiotic Any suggestions?
I suffer from decreased attention span after a head injury, chronic fatigue, brain fog, and ADHD, but when I take medication to increase noradrenaline, everything improves at once.
However, when I take serotonin, I feel like noradrenaline is suppressed. (For example, taking Cymbalta, an SNRI, is effective for the first month, but gradually becomes counterproductive, and when I switch to a medication that increases noradrenaline alone, I feel better.)
On the other hand, there is something that bothers me, and that is that increasing noradrenaline puts a lot of strain on my heart. My blood pressure exceeds 160 and my QT is greatly extended.
What I am wondering here is:
①Is there a way to increase noradrenaline only in the brain (prefrontal cortex?)? (Also, is there a way to reduce the side effects on the body?)
②I am looking for the root cause of chronic fatigue, and what are the possible causes involving noradrenaline? (Even though I have been diagnosed with ADHD, when I take medications that increase dopamine, they all have the opposite effect. It seems that the mechanism by which noradrenaline is produced from dopamine is not working well for me.)
I am very interested in "safely" increasing noradrenaline, and I am worried that there is no other way to save myself (but increasing noradrenaline has very large physical side effects, which is troubling me. Also, for some reason, Atomoxetine is the only thing that is supposed to increase noradrenaline but does not work at all. I get side effects, but my executive function does not improve with Atomoxetine)
Background:
Hi so I'm very new to all of this so I apologize if my knowledge isn't completely accurate. I'm currently suffering with pretty severe social anxiety and lack of sharpness and focus due to my ADHD. I've been trying to talk to more people in hopes of improving my social skills and lowering my anxiety but lately it's just been making me lose faith in myself and getting me more anxious. I remember hearing about Bromantane a while back and reading about on the various subs seems like it could work in terms of helping me calm down due to being Anxiolytic with some long term's effects. The only other drugs I've tried was Fluoxetine and Nicotine. Fluoxetine worked kind of for a bit it gave me a lot of fatigue and later actually made me more anxious. Nicotine actually did help however I only took it once in a form of Zyn a friend gave me. I might be overexaggerating the effects but for the first time in really long time I felt normal and calm. I was able to communicate without having to overanalyze every little thing. I of course didn't take it again because it's nicotine I don't want to develop an addiction.
Current Plans:
I'm currently taking 10mg of Ritalin and 2000mg Magnesium L Threonate. I've tried looking if there were any effects if you take Bromantane with Ritalin however I couldn't find any information. My Bromantane is coming next week it's in Solution form. (Bromantane – Solution, 1500mg). After a separate a reddit post I've decided to go with the Intranasal route with 25mg each day for 30 days. If I can't handle intranasal, I'll go with 50mg orally each day. I have been suggested make a Nasal Spray or Sublingally(The thing where you put it under your tongue awhile don't remember the spelling) by mixing it with a fat such as olive oil or MCT oil. But I'm not sure if I trust myself to be able to do it properly so I'm just going with either intranasal or orally for now.
Questions:
I need to know if I can take this medication while on Ritalin.
I also need to know if I should be taking any other Nootropics to see an actual effect. Of course, I'm not looking to rely on this soley but I really need these feeling of anxiety and stress to be dumbed down a bit if I can make any process in my social skills so if you have any suggestions on what I should get for a better effect please let me know.
Edit: I don't know if this matters but I also suffer from sentence formation and word retrieval and verbal fluency a lot. If there is something that can help with that please let me know.
Hey everyone, I wanted to share some recent observations and see if anyone here has had similar experiences with combining Agmatine and DHEA.
Background: Quick story on my context – a few years ago, I went through a pretty rough burnout that hit my adrenals hard. Since then, I've been on a recovery path, trying to balance things out, physically and mentally. Part of that journey included supplementing with 100 mg of DHEA daily, but my levels have barely moved over the years. Even on 100 mg, my DHEA-S level was hovering around 280, not really responding. But then... I decided to give Agmatine a go.
My Agmatine Experience (so far): I started with 200 mg of Agmatine and noticed something strange – it felt like the effects took a full 24 to 48 hours to kick in. It’s been one of the strongest supplements I’ve tried: big boosts in energy, motivation, emotional stability, and drive. I actually feel way more balanced with it and can even sense Agmatine’s known tolerance-resetting effects, like on caffeine or THC (which I use occasionally). Right now, I’ve scaled it down to 30 mg a day to manage the overstimulation, but the positive effects are still there.
The DHEA Change (and Side Effects): Since starting Agmatine, for the first time in 2 years, my DHEA-S has actually moved up, now sitting around 380. I can really feel the difference – deep voice, strong libido, vivid dreams, high energy, and more… plus some side effects. I’m dealing with extra oily skin and more breakouts, which I didn’t have on 100 mg of DHEA alone. I also get occasional diarrhea and am definitely feeling a bit overstimulated from time to time.
I’m wondering if Agmatine somehow amplifies DHEA’s effects or helps with its absorption. It’s known for resetting tolerances to things like caffeine and THC, so could it be “resetting” my DHEA tolerance too? It’s making me curious if there’s some biochemical interaction here that’s finally getting DHEA to work more effectively in my body.
Questions: Has anyone here experimented with Agmatine and DHEA together? Have you noticed similar effects or have any insights on why Agmatine might make DHEA so much more noticeable? I’d love to hear any theories, personal experiences, or science-y explanations. I’m kind of just baffled (but excited) about what’s happening here and would really appreciate any advice or stories from anyone who’s had something similar happen.
Thanks a ton for reading, and looking forward to any insights you can share!
Hi guys, my daily stack:
Morning:
30mg bromantane
30mg noopept
300mg alpha GPC
300mg NMN
300mg ecdysterone
1g Milk thistle extract
400mg Ashwaganda 5%
1g Lionsmane extract
5gs 5:1 maca extract
500mg liposomal vitamin C
50mg synephrine
1g magnesium bisglicinate
5gs Tribulus
500mg ginseng
50mg 10:1 bacopa monnieri extract
2000 IU liposomal vitamin D
15ml of C8 MCT oil
Afternoon:
300mg alpha GPC
300mg NMN
1g magnesium bisglicinate
50mg synephrine
3gs Tribulus
15ml of C8 MCT oil
2hours before sleep:
2gs GABA
500mg L-tryptophan
1000mg magnesium threonate
Any advice on what to add to or remove from my stack, or to use at a different time? My goal is to improve cognitive abilities and burn excess fat.
Has anybody tried this stack? Most of it seems focused on 9-me-bc and semax or noopept or NSI-189. Nobody seems to have tried it with 7'8DHF or 4'DMA-7'8DHF, which are potent TrkB agonists. If I wanted to create a super nuerogenesis stack, wouldn't is make sense to add these together?
I've been taking Glycinate, but would like to try Threonate. Which brand do you recommend? I am on Amazon Canada looking at the following three brands: NOW, Naka and New Roots. For all three, each capsule contains about 50mg of elemental calcium.
https://www.amazon.ca/gp/product/B07JKC649X/ref=ox_sc_act_title_3?smid=AA6HZOD7L3BGH&psc=1
https://www.amazon.ca/gp/product/B08HGGRZCB/ref=ox_sc_act_title_2?smid=A2PX70099UMSEH&psc=1
https://www.amazon.ca/gp/product/B079V4YLYB/ref=ox_sc_act_title_1?smid=A36YIB64I4BZLU&psc=1
A second question is what happens if I am also taking GABA supplements?
I’ve struggled with CFS/ME (and probably undiagnosed ADD) for over a decade. At the point where I cannot get through the day without stimulants. (Yes, I am well-versed in pacing and PEM and all the potential problems with stimulant crash, but until a better treatment is found I need these medications to function and care for my family even though a “good day” for me is probably 25% of a normal day for most other people.)
So my question is about stacking. I was doing reasonably well on Vyvanse, but it stops working as well and I did not want to increase my dose past 40 mg. Also, I was noticing that it was giving me waves of - not sure how else to describe but , dysphoria? Does that make sense?
In any case, I wanted to try some thing else and my doctor recommended modafinil. I’ve been on a low dose (50mg) and am supposed to increase to 100. The problem is the modafinil is giving me nothing as far as energy. I am wondering if it would be more beneficial to stack it with either Adderall or Vyvanse?
Please share any stacking, supplement and or cycling (alternating meds on different days) that has worked for you. Thank you.
Rhodiola ashwagandha lions mane maca root St. John’s wort and gaba
Working heavy construction from 7am- 3pm than again from 12am-10am. Hopefully I get a snooze in between but was looking for a food stack to get me thru the night. My go to is usually ECA stack or just caffeine/theanine but wondering if anyone had other suggestions. Thanks
Can i stack these? Have some leftover bromantane and i’m starting 9-me-bc. I also have a new pack of methylene blue. I suppose that’s fine to add? Using L-tyrosine and ALCAR as support for bromantane/9-me-bc. Anything to add/remove or other tips? I have alot of stuff at my disposal, and can get basically everything home.
I started taking magnesium and vitamin d at night before bed. Usually, I only take it in the morning, but I read these two can be taken together at night for improved sleep. I found the opposite to be true. Does anyone know why? I take half the magnesium capsule in the morning, and half at night. So that's 100mg in the morning, and 100mg at night. It doesn't seem that much. Why does it have this insomnia effect. I spend time rolling around in bed instead of falling asleep. I always take it with fat, like cheese or flaxseed oil. Is it the Vitamin D or Magnesium that's keeping me up? What if I keep the Vitamin D for mornings only and take Magnesium at night? Or should I not take any vitamins or minerals at night at all?
I've been reading conflicting things about Magnesium Glycinate, some say you should take 600mg/day, others say max daily dose for men is 420mg/day so I started taking Magic Magnesium because the front made it look like 600mg of Magnesium Glycinate but now reading the back there's only 240mg of Magnesium Glycinate per 2 tablets which is how much it tells you to take so I was looking to change brands but I'm struggling to understand what a good brand and dose is because I'm looking on Amazon and there's products like these that claim to have 1000mg of Magnesium Glycinate in them which jusr doesn't make sense with the doses I'm reading and makes me not trust the products. Can anyone help me with understanding what dose I should be taking and what brands to look out for cause I'm just lost with it all. My goal for taking Magnesium Glycinate is mainly to help with nerve damage and a slipped disc. These are the other products I'm taking as well so if anyone has any other comments or suggestions on any of them or other supplements that would help I'd be happy to hear them, really just want this pain to go away ASAP
B Vitamin Complex 2 tablets split AM/Afternoon
Vitamin C 1 tablet broke in half split twice a day, 500mg morning 500mg at night
Vitamin K2 1 capsule taken in morning
Type 2 Collagen 1 capsule every morning
Tumeric 1 capsule 3xday
Magnesium Glycinate 1 tablet 2xday on empty stomach
Cod Liver Oils 2 capsules 3xday
Glucosamine Sulphate & Chondroitin 1 tablet 3xday
Niacin 1 tablet in the morning
Lions Mane Mushroom extract 1 capsule 2xday split AM/PM
Can’t find the strain anywhere.
I’m interested in what pairs well with methylphenidate. Not looking to reduce anxiety or jitters, as that’s not an issue—just curious about anything that complements it for motivation, mood, or cognitive benefits. Thanks!
I’m a 30yo F, dx include adhd, major depression, experiencing serious burnout from being a single mom. i usually lose a lot of energy midafternoon and my motivation and concentration levels are so low that i am just able to do the bare minimum in keeping my household run smoothly. because of my impulsivity, i tend to jump on supplements thinking if drugs.com doesn’t explicitly mention any adverse reactions, then they’re safe.
first thing in am: 120mg duloxetine 60mg lisdexamphetamine 5000 iu vitamin D women’s probiotic 2500 mg collagen peptides
after eating (usually 3-4 hours later): 1200 NAC
3-4 hours after that: women’s multivitamin (to replete any minerals from the NAC)
before bed: 50mg trazodone
~1mg phenibut 3-4x a week when i have a busier day.
i’m considering adding NMN to the stack but i’d like some advice about what i’ve got going on now.
TIA.
I'm reading information about taking 5-htp and egcg. What dosage and when to take? Looking to decrease depression, anxiety and increase seratonin. I workout - I meditate and I'm still struggling! Thank you so much for your help!! ☮️ ❤️
Daily: Vit C - 80 mg
Niacin - 10 mg
Vit E - 6 mg
Bit B5 - 1.8 mg
Riboflavin - 1.4 mg
Vit B6 - 1.2 mg
Thiamine - 1.1 mg
Vit A - 800 ug
Vit B9 - 200 ug
Vit D - 5 ug
Vit B12 - 2.5 ug
Magnesium - 92.25 mg
Iron - 6.15 mg
Zinc - 3 mg
Manganese - 0.6 mg
Fluoride - 0.525 mg
Copper - 0.33 mg
Iodine - 50 ug
Molybdenum - 15 ug
Rutin - 15 mg
Potassium - 150 mg
L-aspartic acid - 36 mg
Creatine - 8g
AAKG - 5g
Mirtazapine - 15 mg
Noopept - 6mg nasal
NAC - 800 mg
Daily running/calisthenics
I'll also add CDP choline soon.
I use to take my prescribed Pregabalin 100-300mg if needed and Kratom almost daily in the last 2 weeks (sadly, I definitely am reducing atm, planning to quit).
I am very interested in supplements and herbs and have many at home to try but am worried about possible risks or dangerous interactions with the Pregabalin or Kratom or both together.
Maybe someone here more knowledgeable about pharmacology or biochemistry can give some advice on what would be okay and would be rather potentially risky. It would be nice to add some stack that is possible to take with my kratom/pregabalin in the beginning (without risky interactions) so I am able to take less and less kratom/pregabalin for my depression and anxiety disorder.
Following supplements/herbs I have laying around but never got to try:
Gotu Kola
Bacopa
Lemon Balm
Melissa (extrac) - i guess Lemon Balm
Passionflower
Blue Lotus
Wild Lettuce (10:1 extract)
Magnolia Bark
Mulungu (plain herb)
Silexan (Lavender standardized extract)
Rhodiola Rosea (extract „WS“?)
Taurine (1-3g and what about higher doses like up to 6-8g?)
L-Tyrosine
Mucuna Pruriens
Muira Puama (10:1 extract)
Ashwagandha
Black Seed Oil
Hydroxyzine (antihistamine medication)
SAM-e
Gingko
Ginseng
GABA
Anything to remove fear for a 85yr old?
My friends grandma has a lot of fear that’s what they told me
‘She is extremely afraid of being alone, even in the presence of the family. She feels extremely anxious and trapped, especially in an unfamiliar environment. She feels like a prisoner. There is a strong pressure on the head and chest. Became very forgetful. Please support quickly, thank you!’
So I suggested propranolol but maybe there’s something else? Also what would be the recommended dosage?
Docs here are mostly useless and just prescribed her an anti depressant.
She also needs a mood enhancer along with something for fear but age is also a factor so I don’t want to recommend something which I might recommend to someone younger as she might not be able to tolerate it or get side effects
Let me know
Thanks
Which additional supplements with different mechanisms of action could I add to improve mood? I'm 22 yo male. I already take the following supplements, with their respective mechanism of action.
Multivitamins and minerals:
Acetylcysteine (NAC):
Bacopa monnieri:
Iron:
Zinc:
Electrolytes:
L-theanine:
Choline Bitartrate:
Vinegar:
Healthy eating (antioxidants, macronutrients):
Coffee:
Fish and fish oil:
Olive oil:
Coffee fruit extract:
Rhodiola rosea:
Phosphatidylserine:
Venlafaxine:
Mirtazapine:
Ketamine:
Hatha yoga:
Pranayama:
Meditation:
Exercise:
8h of Sleep:
Light box therapy:
I've had negative experience with creatine, ashwagandha and high dose psilocybin.
So i am in a deep dark benzo hole, dual addicted to diaz and alp
i know i have to stabilize on diaz and taper off that but would it be a bad idea to take agmatine during the process? or would it act as a potentiator and make things worse? i wasnt able to find much info online about this and apparently its banned some places, i dont know for what reasons.
anything else that could possibly be of aid? im thinking lions mane would probably help prevent BIND?
i know i should be in a hospital setting, im trying to get in asap.
Just curious, what supplements should I take to get rid of fear ultimately?
Currently taking DLPA 500mg, L-Tyrosine-500mg, ALCAR - 500mg, and B-Complex for a week.
I've found I have more energy throughout the day. Not as stimulating as coffee (which is okay) and also doesn't have the drop down I sometimes get with coffee. It's consistently throughout the day. Definitely elevated mood (probably from the DLPA?).
Today, I didn't take them in the morning to see how it feels. Definitely feel groggier but I also didn't workout this morning so that could attribute to it.
Questions I have are: