/r/researchchemicals

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[STRICTLY NO SOURCING] subreddit for the discussion of synthetic psychoactive research chemicals a.k.a. Novel Psychoactive Substances (NPS)

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Any drug solicitation, sourcing, mentioning or linking to vendors for any reason in this subreddit will result in an immediate banning.

This includes links to legal drug vendors and PM requests/offers, as well as posts on shipping, vendors, costs etc.

If in doubt, then DON'T. If your post, or a reply to it would make it easier for someone to get drugs, it's not permitted

If you notice sourcing, unpleasantness or anything else out of place, please use the report button under the offending post.


About

A dedicated subreddit for the discussion of psychoactive synthetic research chemicals.

Experience reports are highly encouraged. Check out Erowid for examples. If you find a great experience report on Erowid and want to post a link, that's also welcome.

Do also check out Psychonaut Wiki and Tripsit. Both are superb resources on novel compounds.

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/r/researchchemicals

222,637 Subscribers

2

anyone tried 4-MPM?

It's a phenmetrazine analogue, not too new either. Developed around 2016-ish, but I haven't found any reports of human consumption which is really weird to me. I've found lots of Pubmed reports, but those were done on rats obviously. I'm not really jumping to be the first person to ingest this chemical, even if it'd probably be fine. Surely some of y'all have tried this one, no? Anyways yeah, experiences with 4-MPM?

2 Comments
2025/02/03
01:16 UTC

1

Flualprazolam vs alprazolam

Can someone explain to me how these feel and are different and similar?

5 Comments
2025/02/02
23:15 UTC

3

4F-MPH vs EPH. Which do you prefer?

4-Fluoromethylphenidate or Ethylphenidate.

Which of these do you prefer and why?

I've been using 4fmph for while now, but I also got myself some EPH, but haven't tried it yet. What are your experiences in researching this?

3 Comments
2025/02/02
22:41 UTC

4

Nicotine alternative

I was vaping and was thinking if out there exist a chemical compound that gives the same effects as nicotine. Is not like the one in plants and nicotine salt. Just wondering if something like this exist out there. Will this compound have the same dosing as nicotine? Or is an "heavy" chemical that mimics nicotine only in minor doses?

15 Comments
2025/02/02
22:22 UTC

7

Best Benzo that You can feel so you know not to Redose

I cant feel pyrazolam which is dangerous because then it compels you to do more, what would one be, Clonazolam? Bromazolam, etc, have a effect so I/We know to not redose as we can feel its psychoactive properties.

38 Comments
2025/02/02
21:50 UTC

1

4-MPD - is it useless?

Been testing this one out of curiosity since I searched this sub and a few users were saying it's better than NEP, which I use either for partying or in a couple small doses for small energy boosts, or for something productive that doesn't require the robotic speed/phenidate focus, or as add-on to phenidates, it's energy/mood boosting for sure and mildly ergogenic if you keep it low.

4-MPD on the other hand seems completely useless, the rush comes with the usual adrenaline physical symptoms (vasoconstriction, heart rate and blood pressure, bowel movement, decongesting nose) but very mild effects. It's just a little euphoric, but lazy unlike NEP, even with all the physical symptoms. I've never managed to do anything on it other than being very chatty and listening to music. Followed by a very mediocre tail that's like a phenidate focus but without any of the motivation to do anything. Even NEP has a slightly ok tail, you can get some things done on it, you don't feel lazy.

So what's the deal with 4-MPD? What do you see in it?

5 Comments
2025/02/02
20:45 UTC

15

O-pce: some thoughts for those looking for dissociatives with antidepressant proprieties

O-pce has its place as a functional dissociative, analgesic and stimulant at low dosages but the therapeutic dosage window is pretty slim. Its antidepressant properties allowed me to experience some of the happiest days of my life, but I needed to recognize its dark side.

Here’s the flipside of the coin: as with most dissociatives, if taken too often (not that uncommon because it feels good, kicks fast and has a pleasant rush) it can lead to disorganized thinking, biased and delusional inner narratives, as well as erratic behavior. I’ve experienced psychosis on it and saw it happening in a couple of people.

Prior experience (if relevant): 2fdck, mxpr, mxipr, ephenidine, diphenidine, dxme, memantine, dxm. If I had to rank, o-pce seems to be the most habit forming alongside with the unpopular diphenidine.

O-pce has its place, but please respect it or you will regret it.

We need to stop glamorizing dissociatives and see them objectively, with their pros and cons. They can save lives (due to their rapid antidepressive relief) but also lead one down a dangerous route if taken irresponsibly.

Happy travels and stay safe!

P.S.: which dissociative helped with the most regarding depression?

14 Comments
2025/02/02
15:32 UTC

1

Rilmazafone vs bromazolam

Can someone please tell me which one of these is better for panic attacks and general anxiety? Need to be able to function at work so can't be knocked out either. Any dosing recommendations for someone with no benzo tolerance? Thanks

4 Comments
2025/02/02
15:11 UTC

3

Nootropic stack for ASD/ADHD - Thoughts and Comments

Hello, world!

I'm new to the, "wanting to get better", world and fresh off a cocktail of amphetamines, benadryl, and street opioids. I've been off the life 7 years, off the needle 4, and haven't eaten an amphetamine tablet in months.

My current stack is inhibiting my coding skills, i'm wondering if anyone knows some tolerable RC's based on the following list:

  1. Coffee 3-6 x daily
  2. Piracetam ( 50mg oral 6x daily )
  3. Nicotine
  4. Hemp-based THC

I want to find something that helps with the anhedonia and brutal ED. Any firm ideas?

10 Comments
2025/02/02
12:44 UTC

4

Questions about IPPH

3 days ago I got my package with IPPH. Beforehand, I read the Psychonaut Wiki entry and some posts, which made it seem to be a non-euphoric stimulating substance with almost no side effects and comedown. The first dosage was around 15 mg, which gave me a stimulating and motivating boost that lasted for 4 hours. After that, I took 25 mg, which gave me a euphoric rush similar to 4F-MPH but also some noticeable side effects. These worsened after the rush fell off, and I felt a lot of body and mind anxiety, which lasted even after the IPPH wore off. Ist das normal? In my experience, it feels better and worse than the article and post made it seem. Also, I woke up today really motivated and energized, similar to the rush after ingesting, usually I feel anxious and lazy. I don't know if it's really IPPH or something else. Has somebody had similar experiences?

8 Comments
2025/02/02
12:40 UTC

7

4-methylmethlyphenidate

How does it compare to Ritalin/Concerta/Adderall? Does it have a dirty body load type stimulation? Any euphoria or empathic effects? (Like wanting and enjoying socializing) what doses would you recommend for someone who doesn’t do stimulants a lot?

15 Comments
2025/02/02
06:12 UTC

3

anything like phentermine?

is there anything like this? like energy wise. don’t care much about appetite.

3 Comments
2025/02/02
05:37 UTC

1

How do different empathogens/entactogens compare?

What entactogens have y'all tried, and how do they compare in terms of 1) social effects 2) euphoria 3) stimulation 4) psychedelic effects 5) health risks?

I'm looking for a good entactogen, I've only tried MDMA. It's pretty great, but I'd love if I could find something with less in the way of stimmy side effects, longer lasting and less neurotoxic would also be good. 6-APB sounds promising, but I'd love some other people's opinions.

11 Comments
2025/02/02
04:49 UTC

1

Introspective RC psychedelics

I am looking into some options available to me for the purpose of personal/spiritual insight. I recently returned to the realm of psychedelics after roughly 4 1/2 years substance free as the result of being in recovery from drug addiction and was gifted some LSD which I accepted. Initially I microdosed, to nice effects, and have had two and a half large dose experiences which also brought me close to some sort of mystical consciousness and led to significant insight. LSD tends to have a tense and unpleasant body load, regardless of what I've got going on and even when it is super clean and relaxing to others and I'd prefer something less uncomfortable.

What I'm looking at are dissociatives and tryptamine analogues. Substances like cathinones, MDMA, and 6-APBish stuff are off the table due to brutal comedowns and compulsive redose/addict behavior and a total lack of desirable insight/connection. Specifically, I am looking to find the 4-aco-XXX(X)/4-ho-XXX(X) substances that tend to be more thought provoking than strictly visual. 4-ho-met was vibrant and strongly visual, but rather lacking in the internal aspect. 4-aco-dmt was great but I am unable to obtain it at the moment, so the next best ones would be great. I also aim to do low doses once a week along with a larger dose once a month at most. Not looking for something to provide a light show or to simply get high on.

So far, 4-HO-MiPT seems a great one but I'd like additional input.

9 Comments
2025/02/02
03:12 UTC

19

"FXE" sample may be 4F-DCK. Anyone heard of this?

I received some "FXE" somewhat recently and decided to NMR test it. The results were a little unexpected. I'm quite confident that this compound is substituted at the 4' position, unlike both canket (2') and true FXE (3'). As far as the rest of the identification goes, there is a strong anomalous peak which may be acetone, but otherwise, the results are fairly well-resolved (at least, given the resolution of my instrument), and to me, they suggest that this sample is 4'-fluoro-2-Oxo-PCM, aka 4F-DCK.

My question is, has anyone ever heard of this chem - or, for that matter, the PCE analogue ("4-FXE") - being synthesized? u/nervewing, I'm looking at you... I can't seem to find any info on this stuff. I should also note that I have yet to personally test this batch, but others who bought from the same vendor report that it is indeed active, though possibly less potent than would be expected for genuine FXE.

If any more experienced NMR users happen to see this, feel free to DM me for the spectrum. Maybe I'm missing something.

EDIT: Here's the NMR spectrum for those curious. Solvent is CDCl3, resolution 500MHz. https://imgur.com/a/66kQpmK

10 Comments
2025/02/02
02:15 UTC

2

Any New or Interesting Opioid RCs out there to Research?

Any new and interesting Opioid or Opioid-like RCs out there or suggestions on things to research? Not sourcing, only looking for suggestions on research :)

22 Comments
2025/02/02
00:31 UTC

22

Are there any potentially new psychedelic classes out there?

You've got the tryptamines, the phenethylamines, lysergamides. Are there potentially more classes out there that we haven't discovered yet? Not hallucinogens in general, serotonergic classical psychedelics specifically. So no dissociatives for example, no deliriants.

Is there research being done on this? I mean, if there can be such a variety within just these few classes, who's to say there aren't more classes filled with undiscovered psychedelics that have unique effects. I find this idea fascinating.

47 Comments
2025/02/01
23:13 UTC

2

Accidentally put some water in my homemade C-liquid... bad or not? Please help

I just made my C-liquid as my bottle with one gram of liquid 5cl adba as my bottle with the liquefied PG + 5cl adba. I t was only about 10-30ml in 200ml PG/VG + active ingredient. Do I have a big problem now or not?

4 Comments
2025/02/01
19:54 UTC

3

Need info on 4aco/ho DET

I have tried multiple 4 sub tryptamines 4acoDMT, 4hoMET, 4homipt, 4acodpt, 4hodipt. Only the first two impressed me. I am debating on 4acoDET. Is there anything here worth exploring? I'm not wanting to spend money on every sucky 4sub out there. Please advise. What is it about this one that is unique or special if anything? Also wondering about 4hoMPT and 4acoEPT.

1 Comment
2025/02/01
18:49 UTC

2

Does 3mmc work well when you have Adhd? Do you have to take a lot more?

Would buying 3mmc with adhd be a waste? Any of you guys with adhd who tried 3mmc? Did you have to take a lot more to get proper high?

30 Comments
2025/02/01
18:32 UTC

1

Ephenedine HCl or freebase?

Kind of an odd question but I'm trying to figure out if the ephenedine that was around a few years ago was HCl or freebase?

Ephenedine freebase appears to be a solid and what I had vaped perfectly, but some HCl salts also vaporize well as is. I have only vaped a few chems, but nothing has vaped as well (next to impossible to burn) and as smoothly as ephenedine did.

Also, HCl is generally better for long-term storage, but would the FB really be that much worse?

6 Comments
2025/02/01
17:38 UTC

5

40mg 4 Ho MIPT trip report

[To preface, I have seen reports of people tripping balls off 20mg of MIPT, and others saying they need 80mg to get to that point.]

So, I loaded up a capsule with 40mg for myself (thinking okay I am going to trip hard) and I put 30mg in my girlfriends capsule (thinking okay, she's on abilify and it's 10mg less so she won't have a crazy experience) and then MIPT pulled the uno reverse card lol. The stuff I have is lab tested 98 percent purity, and a new package as I got it last week.

The come up for me was light, airy, not much body load, touches of nausea, and generally spacey, staring at things in a trance like state with little to no headspace or thought alongside. I was very cold on the come up, despite our room being 75 degrees. My girlfriend however, puked on the come up, and this was about 30 minutes after dosing. As soon as she threw up, she was catapulted into a full on, balls deep trip.

She explained to me she was quite overwhelmed, vivid closed eye, and open eye visuals that were intense, with a flowy organic nature. I however, did not have much visually at all. My body felt a little heavy when I would stand up. I was generally in a good mood, playful, and was helping her as an anchor to reality as she got ripped through the triptamine dimensionality.

About 2 hours in, we started talking about our relationship, and it was definitely therapeutic, and open, able to converse about things she was afraid about within the relationship. At this point, if I stared at something long enough, I would get slight organic patterns, and the lights we had going were very pretty. I was getting rainbow hues over everything.

The one thing that I really enjoyed, despite the lack of visual stimulation, was the music enhancement. We were listening to live songs from the band Dogs in a Pile, and they were quite orgasmic in an auditory sense. By hour 3, I had peaked, and was coming down at that point. By hour 5, my girlfriend was still having visual distortions.

She tried to eat mac n cheese, and said she couldn't because the noodles were moving and looked like maggots. Maggots and cheese lol. I had trouble falling asleep for a couple hours, and I would say By hour 7, I was able to finally knock out.

Overall, my dose left much to be desired, in terms of the full immersive experience, which my girlfriend got in earnest. Headspace was nearly non existent compared to mushrooms, but I still enjoyed myself despite the light trip I had.

I don't know another psychedelic that has this much variation in terms of what dose gets people to the full experience. 20mg to 80mg person to person is a widely unpredictable, and very strange indeed. I am curious as to what factors within a person dictate the dosage needed for an immersive trip.

My next trip, I will be dosing 70 to 80mg. However, I am going to try out my 4 aco DMT first, as it is more akin to the classic mushroom experience. If any of yall have tried 4 Ho MIPT, would be curious to hear how it went for you, what dosage you took, and how intense that was for you! Happy Saturday

6 Comments
2025/02/01
16:10 UTC

1

Which is less bad health wise - alcohol or 1,4 BDO?

I'm not doing so good right now, and would like to distract my mind with something. Which of these of two is the lesser evil?

Oh, and I'm also currently on O-DSMT, but it's not helping enough by itself, so which of these two has better synergy with it? "Safer-use yada yada", I know what I'm doing, just please give me a straightforward answer.

11 Comments
2025/02/01
14:18 UTC

6

Half marathon after 4MMC rave

Does anybody have experience how stims affect aerobic capacity? Until now after every „roll” with my wife I was doing lighter workouts for at least a week so my body could regenerate properly so I didn't test my body too much. In may, one week after our planned for a long time rave I have a half marathon. Does anyone tried to start in a race after 4MMC rave? How does it affected your result?

12 Comments
2025/02/01
14:31 UTC

3

Methiodone/ IC-26 Snorted onset? / should I get Fent patch or Iso/Protonizepyne?

Hallo my comrades and Psyconauts, I have a question regarding IC-26, I usually snort and it burns like hell for me (imo even worse than ap 237). How long do I have to let it sit in my Nose until I can clean it out? And do you have any other ROA that gives fast effects for this substance? Also in your experience how long does the onset last when snorted? I really can recommend IC-26 for getting of Zenes or also just for a decent Opioid (Not much euphoria or much of a rush, imo pretty close to the real deal + you can snort it and I don't think you can snort real methadone.

those are my main questions

Little side question: Do you think I should go for Proto/iso nitazepyne or get a Fent patch? I think the Fent will last longer bc it doesn't fuck up your tolerance that fast. Whats your opinion?

edit: so it‘s easier to read

3 Comments
2025/02/01
13:05 UTC

3

Question about side effects of 6-APB

Hey! Yesterday I took 6-APB (120mg pellets, took 150mg), but during the evening I consistently had the feeling of air in my stomach, basically needing to burp (something I can’t without throwing up), but I didn’t feel nauseous. Is this a common side effect? Could it be due to something in the pellets? The pellets themselves worked perfectly, except what I just wrote!

7 Comments
2025/02/01
10:42 UTC

5

A goodbye to one of my favorite drugs (let alone RCs), and a request for advice.

Hi all,

I occasionally like to take 4F-MPH for a nice mood boost and to get some boring, daunting, or repetitive work out of the way. I am not dependent on it at all; I take it at most twice a month. I have to say I love this drug. And it’s a shame it will now soon be prohibited. I checked to see if I could stock up on some more, but it’s all out of stock.

As an alternative, they (the vendor) recommends 4-Methylmethylphenidate (4-Me-TMP). I’ve checked this sub for info, and there’s lots of conflicting information. Some say it’s barely noticeable, while others claim it’s better than 4F-MPH and more recreational. I don’t know what to believe really. I suppose in the end these drugs affect us all differently, but usually there is a better consensus.

Perhaps there are other drugs any of you could recommend as a replacement to 4F-MPH? I’ll be sad to see this drug go—it was virtually harmless and was a great bimonthly reset to get some spring cleaning done and feel good without any negative side effects.

I have only two pellets left. I’d be willing to spend a good deal of money on a custom synth but I don’t knew whether that’s the best option (and may be complicated legally).

Thank you to the RC community for all its info that made me “discover” 4F-MPH. I’m confident it can help me again in moving forward.

22 Comments
2025/02/01
08:30 UTC

3

d-amp alternatives with non-conflicting pharmacokinetics?

I've been on adderall for 2 years and my dose has gradually increased to 60mg (3x20mg IR) a day. I noticed that my tolerance to my medication has increased quite rapidly the six months or generic medication has been vastly inconsistent over this time, with the former likely being true. I've always had a pretty high starting dose to begin with because my body metabolizes the drug within 3 hours consistently, sometimes two hours depending on diet.

I want to take a break from d-amp and find an alternative, preferably with non-conflicting action on the same receptors to give my body and brain time to recover. Adderall has greatly helped me in all aspects of my life (besides sleep lol) but I can't help but feel that I'm entering neurotoxicity hell at anything above this dose.

I have no history with rc's but I've used various nootropics with very little luck and am seeking advice or personal anecdotes with people that have been in a similar position.

2 Comments
2025/02/01
07:52 UTC

2

effects of different solvents when boofing O-DSMT

I'm not sure if anyone else experiences this, but whenever I've plugged O-DSMT dissolved in pure PG, I'd get this pretty uncomfortable sensation. It's something I've experienced with a couple other drugs as well. Dissolving in a mixture of PEG-400 and PG however, no discomfort.

Anybody have experience with using different solvents? Is this discomfort experience just me or it common? my doses are like 70mg btw

9 Comments
2025/02/01
01:54 UTC

2

Can I dose 4mmc oral after snorting all night?

I know it may be a stupid question but u never know

6 Comments
2025/02/01
01:44 UTC

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