I'll start off by saying I know combining dissociatives may be more neurotoxic than doing one on its own. I do not currently plan on making the combination a regular occurrence. 

That being said, I have not done Memantine in months, and I did Nitrous for the first time (and the only time I've done it) over a month ago. I've also only taken Memantine a handful of times, and I think the most I've done is 100 or 125mg. 

Given my low tolerance, how much Memantine should I take before I use my Nitrous? And how long should I wait after taking the Memantine before using the Laughing Gas? 

I don't mind M-holing, but I don't want to hole from the Memantine alone. (Ie, I don't want to be holing for several hours.)

Also, how long before I use the Nitrous should I take the Memantine?

Thanks in advance. And happy Halloween!

All that I know is that are prescribed in AD when other meds just don't work. I've never seen anyone with a script of memantine where I'm from. How you all can get it?
I'm on antipsychotic drugs that I take along with biperiden, but my doc refused when I asked him to switch biperiden for amantadine. Even amantadine could be fine for me, maybe more easy to get because is used to treat other conditions. I just don't know what to do.

EDIT: I'm not asking where to get it, I'm curious to know how is easy or harder to get in other places.

took 100 mg memantine, 1 gram of amantadine and 30 minutes later 450 mg of dxm, 3 dissociates together and i took 5 grams of piracetam in the morning which might potentiate this even more

I currently have depression, anhedonia, brain fog and dissociation.
I took memantine (few times, up to 80mg) a few years ago before I started to have these severe disorders and it did boost my mood greatly. Last time I tried was a smaller dose(40mg) when I already had dpdr, and I found its dissociation is different from my DPDR.
Now I'm thinking of using it again at 80mg to test its effect on DPDR and depression.
Is this stupid? I'm thinking maybe dpdr is caused by my TRD , so maybe it could help lift up the fog. Or maybe it will do it as it wears off.
Thank you.

Got my hands on some pharmaceutical memantine and decided to try it for the first time. I wish I had gotten more sleep the night before though because I woke up at 2 am and just stayed up from there. I had a cart throughout all this but it was super low already so I didn't hit it much.

9 pm: took 9 pills divided into 3 capsules on an empty stomach

10 pm: kinda feel like something already happening and my vision seems different.

11 pm: can definitely feel it coming on. music was more enjoyable and I had more energy. something was definitely going on with my vision but I was in a dark room so I couldn't tell exactly what.

12 am: come up hitting harder now. it felt comparable to nitrous but I was getting nauseous which made the come up anxiety also hit harder.

1 am: nausea gone down but still feel nervous so I took a little kratom to chill and I'm definitely in the trip atp but I still feel super aware and could walk mostly fine. it did come in waves for me like one moment I'll be super dissociated then I'll come back. my short term memory and attention span felt pretty low throughout it all tho.

2 am: here's where it becomes a mix of the trip and me trying not to fall asleep which also is where it peaked from my pov. the waves of dissociation were stronger and the clarity in-between from before wasn't as apparent. I definitely saw a couple visuals but they weren't visuals I could focus on and I don't remember if it had my eyes open or closed because I'd get super dissociated when they happened. the visuals aren't really something I can explain. for one of them I remember thinking it looked like it was folding over itself and it was red and white kinda. after those few visuals I could tell I was getting super sleepy because I couldn't even keep my eyes open anymore and I just let it happen.

10 am: woke up still kinda dissociated sorta like the afterglow of a big dxm trip but nothing crazy and by the night I felt normal.

I wish I stayed up longer to see if that was the actual peak. I might do this again at a higher dosage but with more sleep prior and a proper meal beforehand. also might not because it made my heart rate pretty high which always wigs me out but that could've been from not drinking enough water.

Im taking ndma antagonists to help with tolerance of other drugs and excess glutamate. Is taking memantine worth taking it I'm taking other nmda antagonists like agmatine or magnesium? Does memantine have other benefits over other nmda antagonists other than a longer half life?

Guys, help. A friend drank beer and 7 memantine tablets. He fell on the street and lost consciousness. I was scared. He passed out for a minute, I picked him up, we took a taxi home. He is now conscious but it is hard for him to get up. What should I do?

Experienced any synergy or cancelling out of properties?

Hello, has anyone been prescribed memantine for OCD and / or depression ? If so, how long did it take for you to see improvement?

i'm diagnosed with adhd and bpd. my psychiatrist prescribed me 10 mg of mem and 150 mg of bupropion daily. I'm going to a festival and i already know i'll take mdma, lsd and ketamine: which are the interactions?

I continue taking it "just because." 10mg 2x a day for OCD, rumination, depression, and any psychiatric issue you can think of I probably deal with. I take 1g of Agmatine daily too. I'm wondering, would it be safe to increase my daily mg of Memantine if I take daily Agmatine? Thanks.

Is it possible to take memantine after two days in a high dosage for a trip? How much should I increase for effect if I took 120 mg?

I have ADHD-I and was reading how this could be beneficial as a mono therapy for adhd. However, I also know it can reduce tolerance and potentiate stimulates.

What is a good dose to avoid lethargy with taking these two in conjunction? I’m going to Mexico this week and plan on getting Memantine over the counter.

Does this ever go away? I can’t sleep until 2 hours past my normal bedtime and I’m taking very low doses ( 2.5 mg). I also get a dopaminergic spike at the time and my sex drive increases 14 hours after dosing the drug . Is there any way around this?

Hey everybody! Just wanted to introduce myself as the new mod for r/memantineHCl !

I decided to cross post a post I had made on the other memantine sub of some of my compiled research articles on memantine. Hopefully y'all will find it useful & educational <3

https://www.reddit.com/r/Memantality/comments/1bwmtr5/list_of_research_articles_i_have_compiled/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button

I had an appointment with the nephrologist and was diagnosed with Berger's disease.

When I was a child, I had a severe inflammation that led to kidney failure. My immune system has been overactive since I was young, and I was advised to see a rheumatologist. I have been given many blood tests to do.

I think everything makes sense. I have read various scientific studies that say severe chronic inflammations in childhood can lead to the underdevelopment of certain neurons. So, my sensory issues, severe emotional instability, anxiety, and ADHD are an effect of this problem.

I feel lost; I don't know if there is a way to recover those neurons or improve my condition. Memantine seems to have improved these conditions for some people.

I tried to take 5mg memantine and i had bad reaction. My legs were shaking and lost feelings to my hands. Could the side effect of memantine have increased my anxiety to astronomical levels?

I heard also about peptides, is it possible to feel better? This is not life.
Just pregabalin (minimum 300mg) helped to feel better, i red that also pregabalin helps to reduce glutamate.

This is not what I initially wanted to do with this community, but sadly I have little time to moderate r/MemantineHCl. The reason is actually simple -- I live in Ukraine and power outages have become very frequent. I have only 4-5 hours of guaranteed electricity, most of other time is basically a coinflip. As you can guess, I can't moderate the community with such constraints, I have to support my life too.

The requirements for a mod are simple -- just send a mod mail with a request. Make sure to have a fair bit of activity and have an open profile so I can have a clear picture of who you are and whether I can trust you with this community. I don't want to lose it the second time, so some scrutiny is required.

Once again, I'm sorry it had to came down to this, but such is life. War is a bitch and you can't do anything about it. While the powerful hold lavish feasts, we the people suffer our lot. Anyway, peace out.

Hi everyone, I wanted to share with you what happened to me today. I have suffered from body inflammation and allergies since I was born. I have several neurological problems: anxiety, depression, sensory issues like sensitivity to light, textures, and the taste of food. My legs are always super tense and it's almost impossible to build decent muscle. I have constant headaches. Pregabalin has helped me a lot with mood and sensory issues, but it’s not effective enough and the side effects are too many.

Today, I tried 5 mg of memantine for the first time, thinking that since it blocks glutamate (as pregabalin does but to a lesser extent), it might help me greatly.

I almost fainted, had muscle spasms in my legs, sweating, and worsened light sensitivity. I went to the emergency room, and now 12 hours have passed, but I still feel exhausted and unwell. I'm sad that memantine didn't help me and actually worsened my condition. Why did this happen? What is the chemical problem? I feel lost.

To give you some context, I suffered from depression, anxiety, insomnia and adhd since I was a kid, I tried many psychiatric treatments and also tried alternative compounds, recreational and therapeutic ways. Last week I took 90mg of memantine and wow, everything felt just great, I felt like doing things, that's super uncommon for me because of my executive dysfunction and depression, I never have the motivation to do the most basic things. My anxiety just disappeared, my depression, and I felt energetic for the first time in idk weeks, months? The disassociative part made everything feel weird but in a cool way, almost like the euphoric you get from psychedelics. I felt like my brain was just fine. I redosed and took another 40mg and it just was awesome, the only issue I had was the lack of sleep, I couldn't sleep and didn't want to, the days before I already had insomnia and a lot of trouble to fall asleep, that was the only thing I didn't like. I was awake for two days until I started hearing voices, like the news from a radio in a non existent language, but it didn't bother me. But I get those experiences due to the lack of sleep so I took quetiapine and slept for 17 hours. A few days later I took 20mg of memantine and well, I didn't feel the disassociation of the first dose but I did feel cognitive effects, I always find stimulation when I read and think about my interests, and also my anxiety dissappeared and everything just felt right. I'm thinking about using it on therapeutic doses and make my own experiment, my only issue was the lack of sleep and the quality of sleep, but as I said, I had this problem since last month, my insomnia has like periods idk I looked for similar experiences in high doses of memantine and my husband also took it but my experience wasn't similar to every other thing I found. I want to know exactly what could have caused that

First of all, hello there and welcome back!

I will be brief. This subreddit will be read only from now on. It won't be like this forever, however. As a new mod, I'll make sure to clean up any possible mess that could've been missed by the absence of moderation, update the subreddit itself and then I'll open it up for further posting.

Hi y'all I just wanted to share my experience with memantine.

For the last year, I have been taking memantine, nearly daily, at differing doses. I started out Jan 2023 taking around 50mgs a day here and there, and slowly worked my way up to 100mgs daily. I took a break somewhere in July, about 6 months in. By September 100mgs was my daily dose. I even went higher, having sourced 30 gms myself. I ventured into the 300-400mg range and found myself feeling reminiscent of a pcp trip. I also felt similarlites to lsd. During this time I actually found memantine to be of help for my mental health, feeling more clear headed, calm, and less depressed. I considered lowering my dose and getting a prescription.

So by December 2023, I was somewhere around 100-400mgs, twice a day. I wanted out of this cycle of high dose memantine . I just wanted to feel better, without getting high. I told my psychiatrist about the memantine, how it was helping my depression, and that I wanted a prescription. So she wrote for 10mgs, twice a day. y'know I learned some stuff about myself, and made a lot of cool music.

I also take olanzapine, carbamazepine, and gabapentin. At this time (dec) my meds were Olan, carb, and buspirone. I had been running 4-7 miles daily, working and going to school. I also would supplement f phenibut and kratom daily.

Then, on new Year's Day 2024, I went for my daily early morning run. It was still dark out, and slippery from rain the night before.

I loved the feeling of dosing mem the night before and going for a run around the 7 hr mark of my mem trip. Idk something about the night scenery on a run during a mem trip is so beautiful.

I have a mile left in my run, when I tripped on a pothole in the parkway. I fell hard, concussing myself, breaking my shoulder, nose, and chipping my front tooth in the process. Somehow, I get back up and complete the run, falling a few more time in the process.

Now, I wear a Garmin 245, which detected the fall. In hindsight, I should have just looked at my watch and alerted my parents. But, hindsight is 20/20 and I toughed out the run, bleeding and battered I got myself home and into the ER.

This I when I had a change of heart. I realized I was taking way too much memantine, and threw the excess mems and f phenibut away, and decided to follow my doctors advice and only that from hear on out. I had my prescriptions for mems, gabapentin, and hydrocodone. I was set up for recovery.

On Jan 8, I had surgery, two screws in my right shoulder to repair it. It was chipped, badly fractured and in need of some serious hardware. Today I have my first PT appointment. I no longer take the hydrocodone. I still take kratom.

I have been through a lot. It seems like yesterday I was self medicating my depression and anxiety with dxm, and now I have a prescription for an nmda antagonist, and I couldn't ask for more. Finally I feel normal. Thanks for reading.

Ps: I actually prefer the lower dose of memantine. I feel more functional now, and occasionally I find myself feeling some psychedelia, but in a more manageable, healing way. It's pleasant. Memantine is a beautiful drug.

I use 1P-LSD 15 ug and memantine together for managing Borderline Personality Disorder pain, it helps to where I can function while being lucid and dissociated to the point where I still function and process the emotions in a more manageable matter.

I used to abuse the fuck out of dissociatives, such as; THC, DXM, and I have dabbled in ketamine, DCK, and O-PCE. My NMDA receptors are worrying, because I can take 900 mg of DXM and not feel much dissociation as I used to. I worry about the long term effects of using 20-30 mg of memantine on a near daily basis due to the permanent dissociative tolerance as people on the internet say, which, seems to be the case, but I cannot confirm this information with 100 percent certainty.

I need to know how you feel about microdosing memantine, 10-30 mg, on a regular, and or at least periodically basis in the long term? I am very cautious of what I put in my body and I want to make sure I am not a old man with an unbalanced brain chemistry when I become that age, I am only 22 now, but I need dissociatives to function.

If there is a dissociative nerd willing to elaborate on their research and findings I am all for it man. Cheers.

basically i have extended release memantine in my country its 28mg per capsule and its cheaper than tablets form so just so i save a few bucks is there any way to turn this into regular release? i would think taking the pellets out of the capsule and crushing it i think thats probably the only way right?

It has been 1 hour since taking 40mg of memantine. I have a moderate tolerance to dissociatives, especially in the form of DXM, which I ingest regularly at high dosages [600 to 700mg].

Right now I am quite impressed with the effects. I feel as if I have taken 3-4 beers without any discomfort or negative effects. Feeling very sedate and calm and relaxed, like I am on a cloud. No alarming headspace effects, very clear headed. Great music enhancement.

I give my approval to Memantine.

Hello. Since I'm a fool, I decided to try 220 mg of memantine. I’ll tell you about what I saw later. This time the condition worsened. Severe tachycardia and vomiting. I feel a strong fear of death (although we can discuss it) HELP

Is Memantine a good approach to combat that issue? I can only guess it’s extremely high glutamate accumulation since I suffer from VSS and CPTSD, which both already cause a dysregulation in glutamate receptors. I only took ritalin in a span of 1-2 months and in low doses (5-10mg) for my ADHD which I may add, which already caused side effects for me that were overdose like. I called an ambulance for the first time in my life after taking 10mg day one. It felt like I was having a heart attack. After 2 weeks of taking 5mg like recommended by my psychiatrist my overall condition has continue to worsen. Called an ambulance again, took an MRI of my brain, everything was fine. Continued taking it cause no one seemed to take ritalin and a possible glutamate excess resulting from it as an option. Even my psychiatrist continued to gaslight me and told me I’m exaggerating things. Quickly after those 2 weeks I began to build what I was thought a tolerance so I upped my dose again. I’ve already began to have some personality changes with high irritability and numbness. My anxiety began to aggravate. Taking 10mg for four days straight was my breaking point. I stopped taking it immediately after that. That was 4 months ago and since then I’ve been struggling with immense deliberating symptoms such as extreme fatigue, freezing, constant high pitched noise in both ears, drunkenness like state with foggy vision, dissociation, depersonalization, low pain tolerance, numbness, lack of joy, apathie and high aggression. I also suffered from uncontrollable tremors, nightly terrors, insomnia, sweating, hyperventilation and hypervigilance, but those have gotten slightly to significantly better. I went to the ER loads but my blood levels were always normal. They brushed me off with the typical “it’s probably depression/anxiety” bs. Sure I’ve had issues with that before but prior to me taking Ritalin ive never experienced such symptoms that almost drove me to madness. Managing VSS symptoms was already hard enough but this state im in isn’t even comparable to that. I’m completely helpless like this. The only instant improvement in my mood related symptoms was when they gave me electrolytes per Infusion that one time in the ER. I immediately felt energized and that overall numbness and pain was gone. Unfortunately the tinnitus and foggy vision was still a big of an issue but the others were not as noticeable anymore. Sadly that relieve only lasted overnight since infusions don’t stay long in the blood stream. I’m guessing what made me temporarily feel better was because of the magnesium in the infusion itself which is known to help regulate excess glutamate. Then Memantine should be an even better option to combat and get rid of those symptoms for good, right? I listened to my gut and finally made an appointment with a neurologist who I will be seeing in about a week and discuss my possible Memantine treatment.