I only tried Ephenidine once in 2022 and don't even remember anything of it.

Anybody tried Ephenidine, Diphenidine or any other phenidine analogues? Share your experiences with them.

Also how close are they in comparison to DXM in terms of trippy effects and euphoria? since some of these are sigma-1 receptor agonists

.5 ket 1 cart 4mgs kpins 15mg oxy

I shall ingest all of them once I reach a safe space before the bomb hits or zombies eat me.

I’ve reached a point where I need to take more of a dose than a normal person due to having permatolerance. It’s not too crazy - a normal dose of 3hopcp is about 10-12mg for me and o-pce is about 15mg for a non hole dose but this is causing me issues. This was not a problem when my doses were lower but at this point these dosages cause me to accumulate too much norepinephrine. I’ve developed some sort of sensitivity to norepinephrine and having too much of it gives me real bad arrhythmia, weakness, inability to stand and walk because of running out of breath, bad tingly numb feeling going across my veins, pressure in the head.

Is there any disso that is strictly an NMDA antagonist?

I've been using FXE for over 2 months regularly throughout the day (8+ times a day) and my tolerance built to where my doses were 220mg before I stopped. This sounds like a lot, but I was taking it therapeutically and as needed; you can disagree, but that's a different topic of discussion.

I'm now in the middle of taking a 2 week tolerance break from FXE, and my question is, what should I expect when I start again? Should I expect my doses to be halved, or more? Or is that too optimistic? Keep in mind, I've never had any kind of permanent/long-term tolerance problems with any other dissoc I've taken, including DCK, DXM, 3-MeO-PCE. I've used all of these in the same constant (some might say "binge-like") way, and hardly run into any tolerance issue worth mentioning. FXE seems to be a lot less forgiving about that.

Help greatly appreciated.

Hi dear researchers <3

Yesterday I tried 2-FDCK spray from a trusted source. Just a one pump (20mg) into one nosehole. It felt kinda psychedelic I also have psychedelic thoughts (I read from other reports it is kinda psychedelic), and dissociative and not that dumb or happy as I mention below.

But when i had the spray before from the same trusted source. The same doses or even higher didnt feel psychedelic at all. I felt just dumb, happy, disso (a little less disso then yesterday, by 20 mg) and my depression episode was away and didn't came back for like 3 months.

Could this difference be caused just by new batch? By any chem i didn't feel so much different by different batch. It is possible that my source mislabel the spray before? What could be the thing?

been a month since i used any dissos, last 2 times i wasnt able to get in a hole even though i dosed high. i was thinking for the next time i could combine opce or dmxe with a quarter of a hhc gummy and i was wondering how it would be. hhc is strong and i have basically no tolerance. im not really looking to get stoned more so a small dose to unlock/enhance the effects of the disso. does anyone have any experiences with these combos? doesnt need to be hhc just cannabinoids in general.

I have some 3-MeO-PCP from 2020-ish laying around here, never tried it yet. I want to try a small dose at first, just a little above threshold. On psychonaut wiki it says that a threshold dosage for smoking is 2mg and a light one is about 5-10mg.

My question is, can I just dissolve around 3-5mg in water and soak a cigarette in it, like they do it with regular PCP? Or should I smoke it on foil or a glass/oil pipe? I'm really tempted to try the cigarette one. A second question would be, what can I expect from smoking a dosage like this? Btw, it's a white and very fine powder.

I do not plan on going anywhere higher than 10mg, ever. I have experience with Ketamine, 2f-dck, DCK, N2O, MXPR, DMXE, MXP, DXM, O-PCE and Ephenidine.

I've ony ever done it as a party drug– but I am thinking to start taking it on the regular to combat depression, which is messing up my life right now. Has anyone found ketamine to be good for coping with / overcoming chronic depression?

Hello, everybody. :)

I have a question about the best way to take DMXE.

I have already tried once in a pallet 20mg orally and everything was fine, no side effects.

The second time I tried 60mg orally with giving 40mg and then 20mg redose. Again no side effects. Next day lovely afterglow.

However, yesterday was my first time to try snorting 60-70mg at a time and although the condition when I was lying down and not moving was great I had a kind of severe headache if I moved, little bit of nausea but not vomiting and diarrhea. Which made the first less than an hour quite unpleasant. Plus I felt quite numbness all over my face and a buzzing in my head during the come up. But apart from the side effects, the heads pace and feeling was absolutely great.

Today on day two I feel like I had a little drink yesterday, minor headache. Everything is legally bought and imported from a supplier in Holland.

My question is:

1. Are these side effects normal or maybe caused by me snorting a large dose at one time or side effects are caused by maybe toxic impurities?
2. Should I try dissolving the powder orally in water next time?
3. Is it better to spread the 60mg over multiple doses or better all at once?
4. If I want to give DMXE 2 days in a row and then take a month off, is that very bad or okay?

Thanks a lot everyone and have a great day!! <3

With DXM at least, weed brings the trip to another level, adding crazy music enhancement and a mystical-feeling atmosphere. So much so that it's commonly considered a requirement to have the full DXM experience. But I've got some FXE coming in now and am also interested in the PCP analogues, so can users of those provide insight onto how weed affects them/or if it's just not a good combo? Or if there's another relevant disso you want to talk about that's cool too. Thanks

i started with dxm freshman year and eventually got ketamine iv treatment in 2020 so at age 30 i have decided my favorite drugs to be dissos. i've been doing way too much dxm lately, but i keep reading about all these research chems and designer drugs. where do i start if i want to try other options for dissociatives, and how easy is it to find? not looking for specific sources thank you, just a general idea. i like being k-holed and i like how dxm feels like a roller coaster made of music. would like to get as gone as possible for as long as possible. tia

When I bought 1g of FXE and ketamine, months apart, I would hole once and then use the rest to just get a lil wonky every few nights or so. Each lasted for 3 weeks to a lil over a month. With FXE I would do it more often bc it’s smokable.

Anyways my question is how do yall use? Do yall binge it and wait a few months or do it every few nights. How do yall hole? I do a couple lines spaced 5 mins apart or so. And when I come out I just go to sleep after, or try to.

It would literally take me put of my current depression. I never thought K would "help withvthe trauma I had". But it worked wonders after 6 sessions. Now medical insurance says no... any help would be appreciated. Thank you in advance.

Welp, looks like I am done with dissos forever. I have come to realize after a terrifying experience that I am just not able to do dissos anymore. Let this be a lesson to everyone else out there who is falling down the path of disso abuse/addiction.

Background:
I have been using/abusing dissos for over a decade, and have heavily used everything from DXM, to ketamine, to good ole MXE, to 3-meo-pcp, and everything in between. For most of my disso use I have had mostly positive experiences, magical holes that cannot be adequately described using the english language, flying through space and deep underground caverns and unlocking secrets to existence, as well as relief from depression and rumination. I have also had some not so great experiences, everything from scary holes, to mental breakdowns, to blackouts, to hospitalizations.

Over the past two years (and with FXE coming onto the disso market) my dissociative use accelerated. I have gone through literal ounces of FXE, using for days and weeks on end, to the point where my FXE tolerance became so obscene that it was no longer worth it to continue using. I had to do ridiculous amounts to hole (like close to a gram in one sitting) and the holes were no longer magical experiences, but fucked up nightmarish blackouts that lasted no longer than 10-15 minutes.

Instead of listening to the warning signs, I switched back to stronger PCP analogues (3-ho and 3-meo) to overpower my massive tolerance. This is where the real problems began. Whenever I would push the dosage into a medium-high dose territory, I would have strange manic blackouts. At the first the blackouts were relatively benign, I would move furniture around, climb on furniture, get naked, and throw stuff. Then they progressed to outright animalistic destruction. I would do a dose and immediately blackout, only to come to a few hours later, confused and naked in a destroyed room, wooden furniture literally ripped apart, 65 inch tvs destroyed beyond recognition, and much more.

The incident:
Again instead of listing the warning signs I continued. I tried switching back to things like ketamine and FXE but my tolerance was still pretty high. I then tried ordering something listed as "canket" thinking it would be similar or the same as the FXE I was used to, but it was not. It had the consistency of wet baking soda and burned like hell to snort, the high was dirty and gross and not fun. But being a disso addict I continued. I pushed the dosage again and boom, blackout. I came to in my bedroom, smoke and dust and the smell of burnt gunpowder in the air, my ears ringing and a pistol in a my hand. In a confusion I tried to piece together what had happened. I looked in the master bathroom and saw that my glass shower doors were completely shattered, glass everywhere. I realized I had shot my shower door with my 9 millimeter, in a residential neighborhood.

This was the final wake up call I needed, I realized if I don't stop now, I am going to end up killing myself or someone else.
Let this be a lesson to everyone on here, don't abuse dissos, listen to your body, if you are having bad reactions or losing control of your usage then just fucking quit before something happens that you can't take back.

TLDR: I kept abusing dissos until I would go into violent blackouts, culminating with me firing an actual gun off in my house in a disso blackout. Don't be like me.

TL;DR: Used dissociatives for 3 years daily and developed ADHS. Anybody else having noticed something alike and possibly found something that helps and isn't a stim?

I had a painful break-up back in 2015 which left me home- and friendless. This made me one of the worst decisions of my life, as I remembered the solace MXE gave me, and quickly found the back then legal analogue deschloroketamine and acquired some. Began using and was completely careless about safer use, basically used 24/7 with ever increasing dosage and without proper weighing. Began neglecting basic stuff and just indulging in the high.

Fast forwards for 1 year I checked myself into rehab but the docs had zero knowledge about dissos and offered me morphine as a legal alternative (my country was cracking down on RCs and I was desperate for something legal). But of course it didn't work out and I began using both substances, which seemed to compliment each other but also exacerbating carelessness. Eventually I was on 600mg/d morphine and at least an equal value of DCK calculated in retrospection from my order frequency.

Again fast forwards for some years, I don't exactly remember what it was, but I gradually weaned myself off the DCK and continued only with morphine and venlafaxine. I had some symptoms of psychosis like hearing whispers in running water or fan noise and I had skipped many many nights due to the stimulatory properties which dissociatives exhibit on me so I am not sure what to blame but I think it's pretty clear from the current state of science that dissociatives were neurotoxic.

I am now off dissociatives for 3+ years, opioids and antidepressants 2 years with one small relapse of a total of 5g DCK 1.5 yrs ago. Part of the symptoms recovered, some fully, some partially.

Besides the psychotic stuff I developed ADHS like symptoms, in my life before I had an easy time learning new stuff but now I find myself switching tasks in like 3 minute frequency. I have zero drive to get shit done and often just listen to music or watch movies all day when I don't have to do more. I should learn a new language (Spanish) and tried countless times to force myself to do at least one exercise a day and failed cause it feels so dysphoric to force focusing. Once I got my hands onto some prolintane (desbetaketon of alpha-PVP) and it helped a fuckton but the only local vendor doesn't restock. Tried to get prescription stims but failed due to the docs being afraid of controlled substances and language barrier.

Also when I'm stressed out I get kind of a dissociation but only in my head and hear my own thoughts echoing. This is worrying but far less than the chaotic multiple streams of consciousness I had directly after quitting the dissoz.

I read in a meta paper that they found vacuoles in the brains of ketamine users with at least 0.5g per day over at least 6 months. My usage was, without a question, way above that level. Is there any chance that this damage might heal over time? Any other insights into NMDA antagonist mediated neurotoxicity?

I have tried all of the popular antipsychotics and they cause only side effects (the dopamine antagonists) or even worsening of the whispers (the partial agonists). But that was while I was still using. Still don't see any point in using antipsychotics or antidepressants. Am thinking about Auvelity (bupropion+DXM) which I would have to combine myself because it isn't approved here. Used this combo 10+ years ago with good results but no clue how to get my girlfriend. which I got to know after I quit use, to use experimental cocktail involving an abusable cough suppressant. And don't know whether it would help either, I do think so because said relapse into DCK had me feel whole again, but also induced kind of carelessness which isn't good for me.

Only drug I am still using to day is caffeine, which has little effects at all but at least it's causing some wakefulness.

Sorry for the probably chaotic wall of text. Maybe I'll rewrite it later. Thanks for your time!

Is there any research assignments or trials, specifically in the Wisconsin, Michigan, and Illinois area??

I made a post eariler about a friend trying pcp. Found out it was 3meopcp. How does he meassure it? What can kill/make a trip more chill. Best method of roa?smoking?

Got some DMXE on the way. First time with this chem, have read good things about it.

Only thing I can’t seem to find is a proper dosing recommendation, I’m experienced with dissos but I have been on a tolerance break. The tablets I ordered come in 40mg doses, I plan to dose orally. Psychonaut isn’t the most reliable for this chem.

I see people being good entire night of a 15 mg bump and others saying they got to dose 60-100mg atleast so it got me curious if I should start with half a tablet or just go with the entire 40mg?

Also if anyone has experience with this disso, is it true that it drains you a lot unlike other dissos so that you can’t use consecutive days or need to treat it the way you treat mdma or psychedelics and only take it once every month or so else it’s just too draining? Idk if that’s everyones experience or just the few I’ve read.

At the same time others state it has a nice afterglow the next day and not a hangover/comedown type of thing so I wonder which is true. I guess I’ll find out myself soon enough.

I like to watch shows or movies when on dissos, lay in bed with music aswell, dmxe is the first disso I’ll try that has a stimulatint component to it, most of my experience is with ketamine, some DCK and 2FDCK and MXE a long fucking time ago so I don’t even properly remember what I did or felt exactly on MXE just that is was amazing, but that memory deff faded so I don’t have any expectations of it being like MXE, imma treat it like it’s own chem

TLDR: got dmxe tablets coming in, 40mg per pill, plan to dose orally, dose recommendation for oral and experiences are welcome

I received 100mg of O-PCE as a freebie when ordering a different disso (2-FDCK).

There is very little information about it on psychonaut wiki, apart from some dosage guidelines.

Any tips on what I should expect? How does it compare to 2-FDCK, or normal ket? What ROI would you recommend?

I read it’s more stimulating than other dissos Im used to. Will I be fine just chilling in bed watching a movie and listening to music or will I be to antsy for that?

https://erasmusuniversity.eu.qualtrics.com/jfe/form/SV_38DALMR2nnLCr1s

Hey there, just wondering if anyone has had any experience with 4-fluoro-2-oxo pce? Otherwise known as 4-fluoro FXE. Looking for dosage and safety profiles. And maybe some insight as to what different effects and potency it would have compared to FXE?

whether it’s R or S the wonkyness shall progress cheers friends 🐴👃🏻

How much should I take for my first time? I also have needles and syringes available for IV use if that’s a better route to go. First time ever with K. have a ton of experience with DXM. Lost the magic already. Took 600-800mg last night. Have been taking dxm almost daily for a little while. So I have a pretty high tolerance to this dissociative. I know cross tolerance is a thing but to what degree? How much would you do for your first time in my situation? I also have today and tomorrow off so I’m good in that regard 😎 Really want to get the full K experience. I want to enjoy a nice blunt too. Not sure if I want to K hole my first time…

Any dangers I should be aware of? Not currently taking any meds besides my daily bad dxm habit. I’ll drink a lot of water with electrolytes, gonna eat a good meal today since I haven’t eaten in a while and am prone to seizures from abusing DXM. And low blood sugar sometimes sets me off.

Peace and love y’all✨💕

P.S. I’m posting this from my phone so I apologize for the formatting issues.

Hey dudes i got some MXP and 3-meo-PCE, i tried other acrylohexamines Like 2f-dch, DCK, hxe and a few Others, but These 2 substances i never tried before.

What would you try First? I am really interested in your thoughts.

Have a nice day Guys!

So often, artists gain a reputation for heavy use of psychedelics, opiates, amphetamines, etc, however I feel like I don't hear about dissociatives nearly as often. I find dissociatives to be among my favorite drugs and would lend themselves to excellent and weird art / music. Anyone know of any artists who choose dissociatives as their DOC?

There are so many glutamate receptors that we need to know about, excluding the common NMDA site which most dissociative drugs target.

There is AMPA receptor. Which unlike NMDA also seems to have some sort of function on color perception and visual acuity. But interestingly, AMPA direct agonists are almost as neurotoxic or even more so than NMDA agonists.

While AMPA PAMs(not direct agonists) include the Racetam family which improve cognitions like memory and verbal fluency. Sunifiram I believe is also a strong AMPA PAM.

AMPA antagonists come with a lot of side effects including impaired color perception, reduced visual acuity and excessive sedation.

Kainate receptor has some relation with GABA and also regulates serotonin system. It is way less known than NMDA and kainate receptor. It has linkage to schizophrenia, autism, huntington etc.

Then there's metabotropic glutamate receptors which are more closer to traditional neurotransmitter receptors (most serotonin, dopamine, neuropeptides and endocannabinoid receptors are metabotropic)

Metabotropic glutamate receptors are divided into three families. Now I won't go much into detail of them because you can check wikipedia and get a lot of insights.

Of particular interest is the Group II. An agonist of Group II decreases NMDA receptor activity and excitotoxicity. Meaning they act similarly to traditional NMDA antagonists. But interestingly, they actually decrease the effects of 5HT2A agonist. While conversely the antagonist of these group actually increases the behaviorial effect of 5HT2A agonist drugs.

Each glutamate receptors are super fascinating on their own. There is just so much potential research into them waiting to be done.

I would want to see if a glutamate receptor exists which doesn't build permatolerance like NMDA antagonists and maintains the positive neuroprotective effects. I would also want to know if there is any sort of glutamate agonist site that doesn't produce excitotoxicity.

There is a possiblity that some even more insane dissociative drugs exists that target other glutamate receptors.

I weigh like 140lbs so ts hit me like a fucking truck lmao. i put 20 robotabs in empty magnesium capsules with some ginger tumeric black pepper pills did like 5 dabs and got absolutely obliterated off my ass as soon as i thought it wasnt finna start hitting, my vision looked like a ps1 game. 😭😭 my max dose before this was like 330 free base or 450 poli so ts was a bit of a jump. I dont think ive ever walked as autistic than i did last night in my entire fucking life lmfao.

Update: afterglowing so hard rn lmao just smoked and i feel so fucking euphoric its not even funny.