Dr. TDC the guy who used to (and still has some) underground synthesis in youtube now made a website to charge a ton for new footage. Anyone got time to take a look at them? Have they been leaked?

https://www.bunmurralabs.store/video-course

I remember once reading about a ssri that apparently it was possible to turn into something either fun or useful

Ring a bell? Or any ideas?

I’m an OrgChem optimist, and think there’s loads of things out here that we can use, but don’t know about yet, so thought I’d ask the trusty hivemind

https://preview.redd.it/odrz6oliib4e1.jpg?width=435&format=pjpg&auto=webp&s=01ebd465f5181eb4f753a7cdf239079cce0d2424

I produced this analog and I'm going to try it for a second time. Had to of course form the imine and then reduce the imine and reflux with equimolar Bromo cyclopentane.

https://preview.redd.it/2gixtacyib4e1.jpg?width=480&format=pjpg&auto=webp&s=ec63db9f2a047a9b0e4d46d5205e26287f763e4a

any suggestions on the possible outcomes of using butyl acetate for this specific SN2 reaction?, unable to find any mention about this on the web.

EDIT: thanks for the suggestions, i am aware of the solvents that do work, i wanted to see if Butyl Acetate would work mainly because of its High boiling point (126C*) that could potentially minimize side reactions and eliminate the need for a condenser, anyhow i couldn't find any references on the use of butyl acetate as solvent for haloketone amination on the net, so i went ahead and tried it, did many small scale experiments with different timeframes and temperatures, none of which crystallized at all after acidification.

so for methylated cathinones, Butyl Acetate = no good

solvent I've used with most success is Ethyl Acetate, its Pros compared to DCM for example are higher boiling point, as well as much faster reaction with no need for external heating in small scale, since the heat produced exothermically when adding Methylamine is enough to complete the reaction in around 30 minutes, Ethyl Acetate is also much less toxic and Friendly for the environment since it just decomposes to Ethanol and Acetic Acid when discarded.

Hello, i have been interested in desomorphine synthesis by P/I2 reduction and i have some questions regarding my theorethical way of workup and synthesis.

Its very hard to find details on this reaction, i found the pathway but it still leaves me with questions.

The pathway i found looks like this :

codeine + PI3 -> α-iodocodeine + HI + H3PO3 -> α-iododehydro-desomorphine + HI -> dehydro-desomorphine + HI -> desomorphine

P + I2 - > PI3 + H2O -> HI + H3PO3 -> I2

( https://ars.els-cdn.com/content/image/1-s2.0-S0379073815003205-gr2.gif )

my questions are as follows :

is the water supplied by the reaction forming α-iodocodeine

does the type of salt of codeine matter since everyone just says that it should be hydrochloride or sulfate since if pure phosphate is available then whats the point of using different one

can the workup be just passing oxygen through final rxn mix diluted with water to destroy the HI and leave just H3PO3 (the iodine would be filtered) and the desomorphine is slightly soluble even as the freebase (1,425mg/ml 25C) so it should stay in solution

should phosphorus or iodine be used in excess and why (based on the reaction of P and I2 forming PI3)

Hey I found this book in the erowid library, and it piqued my interest https://www.erowid.org/library/books/pharmacology_recreational_drugs.shtml, however I'm trying to track a digital copy down, because the paperback is prohibitively expensive.

High bees,

the Bruylants reaction is for us mostly known by the synthesis of Pcp via the a-aminonitrile intermediate. Cyanides are hard to get for some of us and anhydrous sulfonic acids are harder to aquire too. But nowhere on the archives we read, the possible use of pyrazoles/triazoles instead of cyanide is mentioned. The use of benzotriazole is said to be produce less side reactions/ toxic products.

Ive found 2 papers synthing pcp via the benzotriazole leaving group. The yield in both papers were around ~72%. Benzotriazole is easy to get and not that expensive, and it's also possible to recycle it. Only drawbacks are the use of a dean and stark trap, the use of 4mol equivalents grignard reagent and the prolonged reaction time.

"The Bruylants and related reactions"

Is a overview article easy to find as pdf.

Will post my bruylants trials in the near future.

Keep flying bees

I have atrocious sleep issues, I have tons of chemical solutions to the problem obviously, but none of them are both:

• effective
• sustainable long term

I have discovered that this med is now available in my country: https://en.m.wikipedia.org/wiki/Daridorexant

From what I've read it seems to be worth a shot. Firstly of course, it has reportedly shown at least some degree of efficacy. There is potential for abuse, too, according to the official reports. That's always a good sign. They say it is close to negligible, yet at doses 3x/4x higher than prescribed they compare daridorexant to zolpidem in terms of intensity of craving (or whatever word they used, I don't speak marketing) and zolpidem is a fun one as far as I'm concerned.

But long story short doctors can't really prescribe me anything actually effective due to my brain-frying past.

This daridorexant is said to work as an orexine antagonist and I had never even heard of these receptors before, the med is part of a seemingly rather recent class of drugs, and in the same class there are antidepressants and other things under research; it's not just sleep. This drug is supposed to be non addictive so I can very probably get it prescribed to me.

Anyways I've read a lot of medical stuff about it and I'll talk with my doc, but I was wondering if any of you were able from the info about the molecule to understand if it seemed interesting for its stated purpose or if to the contrary you were doubtful for some reason.

My chemistry skills are way too limited to have insight on this, but I know there are very skilled people here. And it's not everyday that a brand new class of sleeping medications is born, so I thought people around here might like to know about it.

The racemization of DXM.HBr into levormethorphan

1. Radical Generation:
   • Hydrogen peroxide, in the presence of an acidic environment provided by acetic acid, decomposes to form highly reactive hydroxyl radicals.
   • These radicals can abstract hydrogen atoms from DXM.HBr, generating carbon-centered radicals at the chiral centers.
2. Hydrogen Atom Abstraction and Bond Rotation:
   • The carbon-centered radicals formed in the previous step are highly reactive and can undergo bond rotation, leading to the formation of different stereoisomers.
   • Isopropanol, acting as a hydrogen donor, can provide hydrogen atoms to stabilize these radicals, facilitating the bond rotation process.
3. Product Formation:
   • The stabilized radicals can then abstract hydrogen atoms from isopropanol, regenerating the DXM molecule with inverted stereochemistry.
   • This process continues until a racemic mixture of DXM.HBr is obtained.

Optimizing Reaction Conditions

To maximize the efficiency of the racemization process, several factors should be considered:

• pH: A slightly acidic pH (around 3-5) is optimal for the reaction, as it enhances the reactivity of hydrogen peroxide without compromising the stability of DXM.HBr.
• Temperature: Elevated temperatures can accelerate the reaction rate, but excessive heat can lead to degradation of the compound. Microwave irradiation can be used to efficiently heat the reaction mixture.
• Solvent: Isopropanol serves as both a solvent and a hydrogen donor. Its ability to dissolve DXM.HBr and participate in the reaction is crucial.
• Hydrogen Peroxide Concentration: A higher concentration of hydrogen peroxide can increase the rate of radical generation, but it can also lead to side reactions and degradation of the product.
• Reaction Time: The optimal reaction time depends on various factors, including the concentration of reactants, temperature, and microwave power. Experimentation is necessary to determine the optimal conditions.

By carefully controlling these factors, it is possible to achieve high yields of racemic DXM.HBr with minimal side products.

thermal decomposition is associated with isomeriztion of many alkaloids microseconds before its destroyed to release nitrogen oxide gasses... the purpose of this synthesis is the ability to lower the activation energy barriers so that it can proceed without meltdown, once inversion occours in dxm forming levo, it does not revert back. so simply doing quick microwave heating in pulses consecutively increases the racemization without effecting the lvm

From Full article link

"Synthesis of 7-chloro-5-phenyl-1H benzo[e][1,4]diazepin2(3H)-one (nordiazepam) (1) To a vigorously stirred of 2-amino-5-chloro benzophenone (0.232 g, 1 mmol), chloro acetyl chloride (1.2 mL, 2 mmol) was added drop wise at room temperature under solvent-free conditions during 30 min and the progress of reaction was monitored by TLC. After completion of the reaction, NH4OAc (0.23 g, 3 mmol) and K2CO3 (0.42 g, 3 mmol) were added to the mixture at room temperature under solvent-free conditions and stirred for 2.5 h. When the reaction was completed, as it was shown by TLC, the water (30 mL) was added and the product was filtered off, washed with more water (2 9 100 mL) and dried. The product was obtained in high yield and purity (94 % yield) and was used in the next step without any purification."

Have anyone ever replicate this route? This is very attractive to me since any access of organic solvents is likely to be marked suspicious in my region. Also iirc in one step of the traditional route hexamine is required, which is a controlled explosive precursor. The aforementioned route don't even need fancy glasswares which is another cause of suspicion. A flask with glass rod will do the job. Any ideas on this?

I found an old synthesis on hyperlab where a man methylated tryptamine hcl with betaine while I was looking for the simplest way to make dmt. He used three times as much betaine he did tryptamine hcl for 3 hours at 250 C

https://hyperlab.info/inv/index.php?s=8460759e1130a3feff2b182904ed9bf8&act=ST&f=17&t=29119&hl=tryptophan?s=8460759e1130a3feff2b182904ed9bf8&act=ST&f=17&t=29119&hl=tryptophan

I have no clue what he made though. It might be something called nmt, maybe some dmt. If you guys think there's only some dmt in it like I do, how would the procedure be tweaked to produce more dmt instead? Could a solvent be used to help?

I've looked around and found the use of THF in the synthesis of 2C-H freebase (for the subsequent synthesis of 2C-b) to be commonplace. In-fact

I was surprised not to come across a report wherein diethyl ether is used instead of THF. While I can get THF my reasoning is simply that its about 2.5× the price in comparison at my region.

I've seen numerous times where the two are interchangeable due to being quite unreactive, as well as a perfectly fitting example of an anhydrous reagent to be utilized merely as a solvent, rather than take part in the actual reaction. Like in Grignard reactions and such.

Is this also the case in regards to the 2C-H synthesis? I couldn't find any record featuring diethyl ether. Usually you come across mixed use of both where possible. Hence why I'm asking...

Thanks for any help fellow bees

I searched around many places looking for a synthesis method and was unable to find one has anyone attempted or known of a synth that is available thank you very much bees.

https://doi.org/10.1016/0167-0115(94)90353-0

https://www.tesble.com/https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/(SICI)1098-2299(199610)39:2%3C131::AID-DDR3%3E3.0.CO;2-Q

What do you guys think?

Dihydroetorphine may have the potential to detoxificate from other opioids without major withdrawal symptoms.

I just stumbled across this awesome paper detailing how CBD can be converted to THC with surprisingly high yields using just a microwave oven or an ultrasonic bath. The process involves a simple solvent-acid pairing, and the researchers explored a wide range of combinations to optimize results:

CBD conversion comparing solvent and acid used

As you can see, the highest delta-9-THC yield was from a reaction in chloroform and camphorsulfonic acid, and it only took 5 minutes! Now, obviously, both of these reagents are toxic (lil carcinogenic too) so one would be ill-advised to attempt this without proper decontamination.

Link to the paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC10956408/pdf/ao3c09794.pdf

I have found a video that seems to at least partially confirm that methylamine can be produced through hydroxyzine. The route in the video proceeds with forming fomaldoxime, I believe by reacting hydroxylamine with formalin, then reducing that with zinc powder and ammonium formate.

It doesn't seem any real analysis was done, but he seemed at least somewhat confident that it works to an extent. I for onne appreciate this as I've read about this on I think the vespiary a while back, but didn't get much traction.

Here is the link

https://youtu.be/28MML4vSc4k?si=0fkWcNEViocuGsbh

Is it possible to just hydrolize bupropion free into 2-Amino-1-(3-chlorophenyl)-1-propanone and eventually turn it into chloro-amphetamine?

300ml alcohol 400ml 12% H2O2 5ml sulfuric acid 5g Copper Sulfate pentahydrate (i used too much and it didnt need to be pentahydrate)

All in a 1000ml fbf MW at full power: 1000w??? About 2 consecutive mins

Id given it 30 sec of power three different times. Color changed, but no aldehyde smell.

Once reaction temp was reached, it refluxed under its own reaction heat for a good 10 mins and aldehyde smell filled the 2400sq ft dwelling.

Two layers appeared with product on the bottom.

Hey,

Trying to see if there are any solvents that can be used to either remove sorbitol or DHC (or others) form a syrup solution. I am trying to find a simple effective way but keep coming up short. I know this is not the hardest question but it does not seem as straight forwards as AB or similar. Any help is appreciated. thanks

CONTEXT - I recently received 500ml of GHB, but it’s yellow-tinged liquid, and both reeks + tastes like absolute death. Burnt rubber/tires, sounds like what people say GBL is like

I’ve tested it a few ways (pH is 6.5-6.75, and hot plating 1ml gave ~500mg of dried powder which has since reverted to liquid overnight, feels like GHB should), and I think it’s just a lower quality synth.

——

Anyway - I can’t enjoy this as-is, so I figured I’d clean it up:

1. Run it through a Brita filter (activated charcoal) a few times to eliminate the smell/taste/colour

2. Run an extra bit of water to get any remaining GHB out of the filter

3. Hot plate the liquid in a glass pot to reduce volume back to 500ml, so I have a 0.5g/ml concentration again

QUESTIONS:

• Is this advisable?

• And if so, what % of the GHB should I expect to lose to the Brita filter?

• And if there is GBL/freeGHB acid in the liquid, do they have different rates of expected yield loss?

I know Activated Carbon focuses on larger organic compounds, but am worried I could be sleepwalking into a wasted batch

——

Given the pH, I do suspect it could have some GBL in there still, so I’m planning on potentially cooking it with some Sodium Carbonate to react any into GHB & aim for a final pH of ~8-9

I do not have GBL, so I cannot add any to rebalance things if I overshoot, so I plan on just going low & slow with increments. Any tips on what starting weight of Sodium Carbonate to apply? And should I wait on Brita filtering it until after I do the Sodium Carbonate rebalancing?

I find endless references online to the reduction of phenol to benzene with zinc dust but most references seem to be like test questions or study material for chemistry exams… I can’t find and reference to an actual synthesis …. I’ve made benzene with sodium benzoate route but it’s not scaling up for me and I have access to and endless amount of cheap salicylic acid that I could convert to phenol and then reduce to benzene

All the info online says I need to distill the phenol with zinc dust or pass the phenol fumes over zinc dust at 400degrees … can’t do the latter so how do I go about distilling?

And real chemists mind telling me How much zinc dust to phenol would be needed for the reaction