Is there a way to convert tramadol into odsmt? I have like 35 grams of tramadol bought 970 50mg pills for $100 couldn't pass lol.

Ever since i saw the "Wolf of Wallstreet" i want to try these Qualudes. So i want to make some, but i´m an mouth breathing idiot and afraid to blow up my kitchen, if i try to nitrate toluene.

A few months ago i read about making o-toluidine and p-toluidine from methyl-aniline. But then i read in some paper that this would actually only produce P-toluidine.
Has anybody maybe tryed this?

Or would there be another way to make O-toluidine?

And also should it be possible to replace the O-Toluidine with aniline... iirc. I have found something in wich they have made this.

But how comparable or "useful" would the qualude derivate that is made with plaine Aniline (in place of the O-Toluidine)?

Does anybody maybee know this stuff?

with the push for all tge new ketamine therapy and new uses has there been any simplication in the synthesis of ketamine?

i know in the past when i have done some research ket synth always seemed.... not simple. lol

was wondering if there has been any new routes developed?

also, is "rock ketamine" just racemic K that is made in a batch and then broken free in chunks from the inside of the reaction vessel as opposed to a "shard" or "sand" type which appears to be a crystal (perhaps an isomer, perhaps not) crashed out of solution.

i have some friends swearing "rock" K is great (better?) than the shard that i prefer.

would love some proper insight

thanks all

If someone hypothetically left an amount of PG and “clam” on a mag stirrer overnight, at about 47 Celsius, would the aforementioned be degraded?

I got raided and the only illegal substances were a pound of mushrooms and 2.3g of cocaine. They also took thousands of dollars worth of chemicals and glassware that I wasn’t doing anything illegal with. Half of them were supplements/nootropics.

I’m especially upset about losing my 1.5kg of DMAA that was actually making me pretty decent side money.

But yeah, you aren’t protected by technical laws.

I made some by deethylation of ethyl vanillin with sulfuric acid and it looks like it worked as it can all dissolve now in water very well unlike ethyl vanillin which is almost insoluble in water.

I then followed a procedure to produce piperonal by a methylenation that was supposed to achieve a yield of 90%+ but I got 30% which is abysmal! However unlike other posts i've seen on the internet instead of getting white crystals upon recrystallisation I get purple crystals everytime using 60grams and 250ml of water at 70c and slowly recrystallised.

What could be the reason for this? Has anyone else performed this procedure? Let me know how yours went!

Having a hard time getting chloroform as a sole trader, despite the only legal requirement be that I am a business to purchase it. Are there any substitutes I can use for extracting codeine after washing up tablets? Thank you, I'm having a severe brain fart today.

Anyone got the mp3 of “thousand faces” by Worlock? All the links are for either archive.org (down maybe dead) & geocities (rip) and I’ve lost a lot of stuff I have been archiving

But then my heartache grew even more when I went to download the iconic “thousand faces” to try and do a cover & it wasn’t available </3

Pls share/upload the song for the good of the group—don’t let it die!

Even a vocal/guitar cover on YouTube is better than nothing

How do they make Krokodil in Russia? How do they demethilate the O in position 3 (NaOH)? And in pos. 6. I know they use chlorine, and then they leave it free, so the potency is higher. Technically, it isn't a bad molecule. The molecule is 10x Morphine, faster acting, and a a bit shorter duration. Here it is, it could be managed in a hospital or with a drip. The problem of Krokodil (Desomorphine) is that there is an entire region of Russia used to cut it (😂) and since Russia has no will to create at least an OAT (Opioid Agonist Treatment) program and nothing better on the market that can compete with prices people will continue to die. War on drugs failed under every aspect, whe should change mentality, also because there will be only deaths and drug sale (look at the USA the damages they made stopping prescribing opioids). However, guys, leave a comment below if you have an answer to my question or your idea/point of view on the argument I brought up. Thanks a lot

Any idea when they'll be back online and operating?

🧪⚛️

For example, ethyl acetate is super great for washing cocaine and never gets mentioned besides when I mention it.

Or chloroform can separate trimethylamine HCl from methylamine HCl via some voodoo.

What’s your secret weapon for cleaning things up?

It seems like acetone and ether are all people talk about. There are so many liquids. SO many liquids 🫨 I learned in washing some MDMA that the impurities are insoluble in acetone and ether. What then?

(We’re gonna pretend distillation doesn’t exist for this conversation)

Hello all. What is the time period for decay when stored in a closed jar in a solvent room for 20 years. I'm debating if my 4 methylaminorex synth failed from me or because my source of precursor was old.

Hello, just wondering whether there are any tried and tested instructions for this synthesis available online? I have found some using sodium bromate, but am looking to use calcium hypochlorite as the reagent as it seems less likely to leave the product dangerously adulterated.
Thanks!

Hello all. I was wondering if anyone has some advice for removing the manganese dioxide from a methcathinone solution after ephedrine oxidation

i may be guessing on these products entirely, but:

reaction 1
(1) PEA HCl + (1) NH4Cl ===DMSO===> + (0.5) Na2SO3 + (0.5) Na2S2O5 ===DMSO===> + (2)NH4Cl ===DMSO===> + (1)MgSO4 ===DMSO===> + (1) ethanol from witch hazel (reducing polyphenols acids incl.) ===DMSO===> thioethyl (R1,R2?) diethoxy PEA + (2) NaCl + (1) MgCl2

reaction 2
(1) thioethyl (R1,R2?) diethoxy PEA + (1) NH4Cl ===DMSO===> (1) chloro (R1,R2?) diethoxy PEA + (1) NH4SEt + (2) NaCl + (1) MgCl2

reaction 3
(1) PEA HCl + (1) NH4Cl ===DMSO===> + (1) NaOMe ===DMSO===> +(1)KBr ===DMSO===> + (1)NH4Cl ===DMSO===> +(1) NaOMe ====> bromo (R1,R2?) dimethoxy PEA +(2) NaCl + (1) KCl

reaction 4
basify cinnamon oil with naoh add ammonium chloride add citronella oil add borax

reaction 5
for nitrosamine in propylene glycol; add : ammonium chloride 0.5mol : 1mol Propylene glycol : 1mol glacial acetic acid (edited)
this leave hcl fumes, peracetic fumes, nitrosamine in glycol over 24hr +

Looking for discussions and procedures.

Hi all.

Though this might be too basic for here, this is where I'll probably get the best answers:

what are your suggestions for a procedure for kratom extraction suitable for kitchen chemistry, with very limited ability to procure solvents?

From the research I've read, I'm surmising that acidic alcohol works well. Would ethanol work as well as methanol (the latter being typical in these papers)? Would 5% water reduce efficiency?

What should I use to lower pH? On hand, I have dilute acetic acid, tartaric acid, and fumaric acid, and could readily source citric or ascorbic acid. What pH should I shoot for?

Are there pre or post extractive steps that would be worthwhile (eg, any defatting, getting rid of chlorophyll somehow)? This is for oral administration, so I'm okay with pH buffering afterward and leaving in some of the alkalizing agent. Or would that be unnecessary? Will it just be sour but not dangerous?

Seeing as the claisen condensation works two ways, what are the possibilities one has when working with the easiest possible reagents? benzoic acid esters with ethyl acetate can lead to either the diketone (lpac but with two carbonyls basically) or it can lead to something similar to acetoacetic acid ethyl ester, depending on which way the condensation is run.

Now, I've seen sources where the diketone is hydrogenated and for some reason reductive amination is preferred for the second carbon, and OH is made on the other carbonyl, so you'd get an ephedrine derivative. Also, some similar routes lead to Lpac(racemic) as well. This is cool and all but are there any variation that don't use hydrogen?

Interestingly, since the other compound is VERY similar to the acetoacetic ester, I'm wondering if the position can be methylated easily? This then a hoffman would produce a cathinone.

Do these routes have any merit, other than the fact that the reagents are dirt cheap and universally available?

L-lysine-phenethylamine

is this a possible drug? how easy would it be to synth? looking for the most efficient way to make NMPEA or PEA long lasting as an extended release. inhibitors for sure would work, but I'm talking about alterations to the structure of NMPEA or PEA to increase both bioavailability and duration.

Hello everyone. I made a dumb error and didn't think about how polarity works very hard and realized that my NPS (toluene in this case, but could be xylene or fractioned napthas, whatever) is pretty miscible with the denatured ethanol (denaturred with methanol, isopropanol, and I want to say . 1% MEK or MBK, don't remember) I used as a deprotonation solvent. Interestingly, there is a small portion of alcohol that created an aqueus phase, but most of it mixed with the toluene. Is it possible that I could solve my problem by adding enough toluene and forcing the now smaller portion of the alcohol out of solution, or would I just be creating a larger solution of everything ? I'm hoping there is a mechanical way to separate , but I'm open to all ideas

G'day, I recently moved to another state where I can't get a reliable connection to heroin, I'm have many boxes of 30/500 codeine/APAP (get about 60 pills a month) I have been using CWE for the meantime, but I am a poor metabolizer of codeine. I'm looking to make desocodeine and possibly desomorphine (depending on how much stronger the morphine is and how difficuly a the methylation will be with minimal equipment. I studied pharmacy for a year and know basic organic chem, links to resources would be very helpful !

Atm I am unsure what method I should use, I am the nagai method/ shake and bake will make desocodeine and then I can methylate with pyridine from there.

To my understanding, the process involves a halogenation of the 3rd prime of the third ring then I'll catalytically reduce the iodine/chlorine (if i use phosphorus/iodine/conf. Hcl or something like thionly chloride? )

I then need to cleave the double bond at prime 3 after halogenation, does this happen naturally with the Byproducts of thionyl? And I will be unable to use pressurised hydrogen gas for this. I know this is a typical birch reduction and is where the lithium and lye come in for the nagai? Please correct me here. From my own understanding, something like hydrazine or sodium borohydride can also be used for this reaction.

Finally is the demrthylation metyhl ester on the 6 prime of ring 1 into an alcohol group. I heard pyridine works but it seems too expensive for how much I need. I know a lewis acid could work here, maybe making some aluminum Iodide from alfoil strips and iodine?

Anyway, my final comments are going to be asking for any help I can get and a nudge in the right direction

Should I bother extracting the codeine through cwe and then evaporate it? Would another solvent like diethyl ether be better for extracting the codeine from APAP ?

Again, what are your general thoughts? Should I just follow nagai? Or is there something more effective that I can do at home without and proper equipment?

Thank you everyone for reading/replying

Love from Australia x

I mean in the lab, not in a spoon. I am most interested in tablets based on hydroxyethyl/hydroxypropyl cellulose.

An idea I had was to first: grind the tablets to a fine powder, add it to dry isopropyl alcohol with a small amount of a base (too many to choose from) to convert the salts to free amines, stir for some time (not sure if it can be heated), filter, do a second extraction of the solids if needed, optionally acidify or add water to the combined extracts, evaporate, and purify with the usual methods.

Do you think that this method will work?

If there is nothing, would 1:1 ratio of Li/IEph work?

FeCl3 in toluene would yield an analogue?

There were some threads which showed a 5-meo-mipt synthesis with steps outlined and I think even a tek or two in some threads comments. After a search I can't find any of these threads. Is this the case for anyone else?