Hoi, ik heb een paar vragen een huis te vinden rond A'dam.

1-) Is het echt moeilijk om een huis te vinden in Randstad, niet precies in A'dam?

2-) Ik zoek alleen maar een studio of een appartement, zolang waarvan ik huurtoeslag krijg. Ik krijg bijstanduitkering.

3-) In welke dorpen, steden kan ik snelste een huis vinden, ik heb geen hoge wactpunten dus ik weet dat ik niet kan 2000/2300 lijstje staan. Dan heb ik geen kans om het huis te huren.

Als je realistisch kijkt, zie je dat echt een kleine kans om een huis te vinden. Wat is jouw mening of ervaring?

Hello, I buy my dinner's ingrediants nearly every day, and I usually get bread from AH then pass by lidl for chicken or meat - they are really close by and near my home (ah's bread last longer and taste better imo but their chicken always gave me stomach ache so I stopped buying any meat from there)

The thing is, there is one cashier - who by today- asked me for the 3rd time to look in my AH bag, and I showed her AH's bills before and I did today, but today since its the 3rd time it was so weird, especially that other cashiers never asked to look into my bag, since its the 3rd time I asked her why is it the 3rd time she ask me to check and she said they always ask in lidl to check bags and she pointed to another casheir even others check bags, I told her I buy groceries nearly every day at this lidl and no one asks to check but her and its the 3rd time thats why I am asking and she said its not personal they search bags of foreigners and the dutch too, but it really made me feel uncomfortable especially that I always see her smiling and chatting with others but not with me, and I never seen anyone's bags being searched... I wished her a good day and left.

Does anyone work in lidl and know if there is a rule or something for bags to be checked? Or did any got their bags checked??? I might be oblivious to these things but I want to know in case I was wrong about this.

Hallo iedereen,

Graag zou ik econometrie willen studeren. Ik heb veel interesse in wiskunde en ik kan me lang in verdiepen, alleen twijfel ik of ik het wel aan zou kunnen.

Zelf doe ik nu HBO civiele techniek en zit ik in mijn tweede jaar, maar ik ben van plan om ermee te stoppen omdat ik er geen toekomst meer in zie voor mij zelf en omdat teveel stages zijn vind ik waar ik persoonlijk niet zoveel in heb.

Ik vind de stof (buiten het projectwerk) best makkelijk, ook het wiskundedeel (vooral integreren) heb ik makkelijk gehaald met alleen beetje zelfstudie.

Ik ben van plan om mijn wiskunde B deel-certificaat te halen, zodat ik hopelijk mijzelf kan inschrijven voor het begin van het nieuwe schooljaar.

Alleen heb ik enige twijfels aan mijzelf of ik de studie wel zou kunnen halen. Ik heb op de havo wiskunde B afgerond met 7 zonder al te veel ervoor te doen en ik heb geen economische achtergrond.

Op het YouTube kanaal van de UvA staan een aantal filmpjes online (linkje naar de playlist: https://youtube.com/playlist?list=PLyqDMruigg0Ife5ckVdFyo7Ds8fqFlH2C&si=YuT0rLwBG7FXIpT4) en ik begreep de filmpjes eigenlijk al best wel snel.

Ik ben bereid om heel hard te werken om deze studie hopelijk werkelijkheid te maken.

Mochten de mensen die weten of deze studie wel echt haalbaar is voor mij mij misschien een inschatting kunnen geven.

Alvast bedankt.

Hoi allemaal!

Voor mijn studie heb ik een klein vragenlijstje voor een project dat ik met mijn groep maak.

De doelgroep is studenten op minimaal MBO niveau.

Het onderwerp: Een AI chatbot in het klaslokaal met eventueel een hologram.

Mocht je toch een mening hebben over het onderwerp, laat deze ook gerust achter in de comments! De vragenlijst is super kort en de antwoorden helpen een deel van mijn verslag te schrijven, dus je zou me enorm helpen.

https://forms.gle/WBdHaHtPpYnzQQJFA

Alvast enorm bedankt!

I’m from a Caribbean island where it’s difficult to get access to a credit card as nobody I know has them. But I have a friend who is a girl that lives in Lemmer and I just wanted to get her some flowers to make her feel better about a personal situation she is going through. Would anyone be able to provide some assistance to me please?

I am currently writing the acknowledgments for my dissertation. One of the people I worked with was Dutch. We only worked together for a few months but we became really good friends. I want to include a little shout out to her in Dutch, and I was hoping I could get some help with translating a sentence as my Dutch is only very rudimentary.

I want to write “can you believe some of my clothes still have mud on them?”

Weird sentence I know, but the site we worked on was super muddy and got all over everything.

Thanks in advance!

Google gives alot of different meanings, help me out?

I’m just curious for those who live in the Netherlands, Amazon has opened there for only a couple of years now, it’s fairly new with not a huge choice compared with other countries like Germany where it’s been around longer.

If you order items from the German Amazon is it an easy process? Is the delivery a similar time frame or is it quite long? Does it need to pass checks at the border?

Sometimes when we order things on Amazon UK and the item is from outside the UK, we will get notified about customs checks etc.

Thanks for your help

Ik ben samen met mijn vriendin/co-host Jordan op rondreis. onze eerste stop: het zonnige Thailand! 🇹🇭

Voor de mensen die het leuk vinden, hier de video:

https://youtu.be/62_jljKW01k?si=88Ka5CUUOuUfDDkN

Voor leuke verhalen die bij onze reis passen: https://www.polarsteps...

Het gaat om verschillende citaten die zijn verwijderd, omdat ze niet duidelijk zouden zijn, hier het eerste citaat:

BERBERINE werkt beter dan metformine en heeft onder meer antimicrobiële, weerstandsverhogende, ontstekingsremmende, immunomodulerende, pijnstillende, anti-allergische, antioxidatieve, bloedglucose- en lipidenverlagende, orgaanbeschermende, neuroprotectieve, atheroscleroseremmende en bloeddrukverlagende effecten. Berberine heeft een gunstige invloed op darmmicrobioom en darmbarrièrefunctie en gaat diarree tegen. Ook is berberine al voorgeschreven bij diabetes type 2, hypertensie, hartfalen, ontstekingen en leverziekten.

Citaat 2:

Because of poor antioxidant capacity, beta cells are vulnerable to the oxidative stress induced by both T1D insulitis and T2D glucotoxicity (Sharma et al., 2009). Therefore, drugs and phytochemicals that improve glycemia and/or oxidative stress ameliorate or prevent islet lesions. In this regard, protective effect of some phytochemicals on pancreas has been found to be mediated through their antioxidant effects. Zhou et al. (2009) reported that treatment with berberine restored the reducedsuperoxide dismutase activity and increased lipid peroxidation of pancreas of diabetic animals to the near control level. These antioxidant effects of berberine, therefore, mediate its anti-apoptotic action against beta cell apoptosis in insulin-resistant animal models and against palmitate-induced lipoapoptosis in HIT-T15 insulin producing cells.

Citaat 3, een hele lap tekst:

Berberine with lifestyle intervention tended to lower the level of FPG (fasting plasma glucose) , PPG (postprandial plasma glucose) and HbA1c -more- than lifestyle intervention alone or placebo. As for the treatment of hyperlipidemia, berberine with lifestyle intervention was better than lifestyle intervention, berberine with oral lipid lowering drugs was better than lipid lowering drugs alone in reducing the level of TC and LDL-C, and raising the level of HDL-C. In the comparative study between berberine and oral lipid lowering drugs, there was no statistical significance in reducing the level of TC and LDL-C, but berberine shows better effect in lowering the level of TG and raising the level of HDL-C. In the treatment of hypertension, berberine with lifestyle intervention tended to lower the level of blood pressure more than the lifestyle intervention alone or placebo did; The same occurred when berberine combined with oral hypotensor was compared to the same hypotensor. Notably, no serious adverse reaction was reported in the 27 experiments.

Regarding its protective/regenerative effect on pancreas, Tang et al. (2006) demonstrated that oral administration of berberine decreased the levels of FBG and serum lipids and restored the damage of pancreas tissue in alloxan-induced diabetic rats. Another study reported that berberine increased insulin sensitization, insulin secretion, and beta cell regeneration in STZ- and high carbohydrate/fat diet-induced diabetic rats (Zhou et al., 2009).

In a randomized, double-blind, and placebo-controlled trial, decreased fasting and postprandial plasma glucose with body weight reduction were observed in type 2 diabetic patients after three months of treatment with berberine Efficacy of Berberine in Patients with Type 2 Diabetes

Significant decreases in hemoglobin A1c (from 9.5%+/-0.5% to 7.5%+/-0.4%, P<.01),

fasting blood glucose (from 10.6+/-0.9 mmol/L to 6.9+/-0.5 mmol/L, P<.01),

postprandial blood glucose (from 19.8+/-1.7 to 11.1+/-0.9 mmol/L, P<.01),

and plasma triglycerides (from 1.13+/-0.13 to 0.89+/-0.03 mmol/L, P<.05)

were observed in the berberine group (3-month trial).

In tweede studie:

Berberine (icm metformine) acted by lowering FBG and PBG from one week to the end of the trial. HbA1c decreased from 8.1% ± 0.2% to 7.3% ± 0.3% (P<0.001). Fasting plasma insulin and HOMA-IR were reduced by 28.1% and 44.7% (P<0.001), respectively. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) were decreased significantly as well. During the trial, 20 (34.5%) patients suffered from transient gastrointestinal adverse effects.

Citaat 4, nadelen van berberine:

Maar helaas, berberine heeft ook dezelfde nadelen als metformine en het lijkt er steeds meer op dat dit voor vrijwel alle diabetes medicijnen geldt, ze werken op basis van anti absorptie, (tetris vs lock key) wat o.a. tot aanzienlijke spierdegradatie leidt:

Atrogin-1 Affects Muscle Protein Synthesis and Degradation When Energy Metabolism Is Impaired by the Antidiabetes Drug Berberine Berberine impairs muscle metabolism by two novel mechanisms. It impairs mitochonidrial function stimulating the expression of atrogin-1 without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulated protein degradation but also suppressed protein synthesis, causing muscle atrophy.

Some mild symptom of low amount of berberine and its compounds poisoning has been seen in dogs. These symptoms are salivation, nausea, diarrhea, emesis, muscular tremor, and sometimes paralysis also appeared in dogs (Lampe, 1992). The sub-acute toxicity of berberine shows gastric ulcers (Kupeli et al., 2002), Mahmoudi et al. (2016) has reported some immunotoxic effects of berberine. It is reported that 10 mg/kg of berberine administration is responsible for reduced number of leukocytes, neutrophils, lymphocytes (blood cell count), and spleen weight. Significant decrease generation/differentiation of B- and T-cells and splenic CD19+ B-cells, CD4+ and CD8+ T-cells is also associated with berberine. Totally, 5 mg/kg of berberine is responsible for only influence the proliferation of lymphocytes and delayed-type hypersensitivity response while 10 mg/kg of berberine is responsible for suppressed both cellular and humoral immune functions (Mahmoudi et al., 2016) (kennelijk geschreven door Chinezen of zo, vandaar al die taalfouten, dat gaat hieronder nog even door)

Sub-chronic toxicity of berberine has reported to damages lung and liver by increasing alanine aminotransferase (ALT) and aspartate aminotransferase (AST), significantly (Ning et al., 2015). In another study on mosquito larvae ofAedes atropatpus, effects of berberine showed chronic toxicity and significantly increased cumulative mortality (Philogene et al., 1984). Another study has revealed that in diabetic rats after 16 weeks of berberine administration at concentrations >50, 100, and 150 mg/kg induces liver tissue damages but these symptoms do not appear in healthy rats (Zhou et al., 2008). Berberine in ApoE-/- mice evokes atherosclerosis after IP treatment for 15 weeks with 5 mg/kg/day (Li et al., 2009). Further, exposure to berberine results into uterine contraction and also may lead to teratogenic effects (the substances responsible for inducing developmental toxicity in an organism from the time of conception till birth) (Table 2).

Experimental studies validated by docking studies has been reported the mode of action (through hydrophobic interactions) and inhibitory effect of berberine against main neurological enzymes namely acetylcholinesterase (AChE), butyryl cholinesterase (BChE), and monoamine oxidase (MAO) (Ji and Shen, 2012). An LD50 of berberine that can inhibit AChE, BChE, MAO-A, and MAO-B are 0.44, 3.44, 126, and 98.2 μM, respectively (Ji and Shen, 2012). It was reported that treatment of 10 and 30 μM of berberine exposure to PC12 cells increased cyto-toxicity that was indicated by increase in apoptotic cell death. Thein vitro(5 and 30 mg/kg, i.p. for 21days) andin vivo(10 and 30 μM up to 48 h) studies with berberine against 6-hydroxydopamine (6-OHDA) induced neuro-toxicity in rats and PC-12 cells, respectively, have demonstrated inhibition of dopamine biosynthesis, accompanied by reduced levels of norepinephrine (NE) and dopamine (DA) (Kwon et al., 2010).

On the basis of extensive literature survey, berberine, and sanguinarine have been reported to cause toxicity in different living systems. In molecular structure of berberine and sanguinarine, both contain a positive moiety which interacts with a number of nucleophilic and anionic moieties of many biomolecules that distort their structure and further resulted in altered function of biomolecules. The sub-acute concentrations of berberine lead to altered liver function, gastric troubles, hepato and hematotoxicity, hemorrhagic inflammatory consequences, damage to immune cells and induced apoptosis. Effects and mechanisms of berberine in diabetes treatment

Volgens de site die deze informatie heeft verwijderd is er geen enkel bewijs dat berberine effect heeft. Niet verbazingwekkend dat die wordt gesponsord door de farmaceutische industrie, die nu ook bepaald wat je wel en niet mag zeggen op een forum en wat wel of niet waar is.

iemand noemde me omu terwijl ik aan het fietsen was en lachte me uit met zijn vrienden. wat betekent dat?

Hey allemaal,

Ik zit te twijfelen over wat ik wil gaan studeren. Biomedische technologie lijkt me superleuk, vooral omdat je techniek kunt toepassen in de geneeskunde. Dingen zoals protheses ontwerpen, medische robots of diagnostische apparatuur ontwikkelen spreken me echt aan.

Tegelijkertijd vraag ik me af of ik niet beter voor een bredere studie zoals werktuigbouwkunde of elektrotechniek kan kiezen. Ik hoor dat de baankansen daarmee vaak beter zijn en je kunt je daarna alsnog specialiseren in de biomedische richting. Misschien een veiligere keuze?

Daarnaast weet ik ook nog niet goed wat ik later precies wil doen. Het lijkt me bijvoorbeeld interessant om klinisch fysicus of qualified medical engineer te worden, maar ik ben nog niet zeker.

Heeft iemand ervaring met biomedische technologie of een soortgelijke keuze? Hoe zit het met de baankansen en mogelijkheden? En als je werktuigbouwkunde of elektrotechniek hebt gedaan, kun je dan ook makkelijk de biomedische kant op?

Ik ben heel benieuwd naar jullie advies of ervaringen. Alvast bedankt!

This is a notebook I found in Amsterdam 4 years ago on the street. Only the first page has some notes on it. I suspect is in dutch. I am wondering what was written on it, anyone can translate it to me please?

My sister is moving to the Netherlands for work. If I learn Dutch, would it help me find a job there as well?

I am tourism graduate, what do you suggest for me to increase my chance to find job in netherlands.