Hello all!

I've been on hrt for about 3 and a half months. I started on 2 mg oral E and 100mg spiro 2x a day for 3 months and have since been instructed to add an additional 2mg of E per day for a total of 6mg.

After about a week on hrt I started to realize I was lacking in energy and motivation and that I was feeling a mild depression.

I brought this up to my doctor who told me that this is the "expected result of testostirone supression". This particularly confused me and I wanted to clarify here if this is the case or if I'm may be misunderstanding what they meant.

If this is the case I also understand that spiro has depression as a risk, how can I determine if I am experiencing side effects or not?

Ill leave some info about my Lab results (I hope this is the relevant info)

Testosterone: 20 ng/dL Free Testosterone (direct): 1.7 pg/mL Estradiol: 222 pg/mL

Thanks!

I need advices to be encouraged to start my course i need some friends that supports me

Louisiana Law that says all hrt for menopausal and pre menopausal women are to be covered. Also. No prior auth. The dr should be able to put you on the hormones they would like to without starting you one one and moving up till u get to the hrt that best suites you.

My question is this. I’m on Medicaid currently and started bio identical hrt cream and it worked. There was just one problem and it happened to be in the bedroom. Then dr put me on a diff combo of est and pro. This was the regular, not bio identical hrt. It did not work. Ran tests and they showed that my body was not absorbing them. Then I mentioned I’d like a tad bit of testosterone and she switched it. Now it went from free to $86 a month.

Can someone who knows this law please tell me where to find in it the specifics. I think simply because the other ones did not work these would have been next in line and I would get them free anyway.

I’m so annoyed at this. I have read thru all I possibly can about the August 1st law in Louisiana but shows nothing.

My skin was not very good before hrt. Oily skin, sebum, etc. Usual stuffs. But right after I started hrt, all the skin problems disappeared!

My regimen was estradiol and cypro. But after 1 yrs of hrt, my prolactin went really high on the blood test, and my endocrinologist switched my hrt to monotherapy, removing cypro from my regimen. So I started taking only injections, no cypro pills, and my skin went bad all again. Oily skin went back, sebum formed again, etc. I took blood test again and told endo about my skin problem but she said my T level didn't elevate at all and actually remained same as before. (E level also didn't decline)

So have my skin problem nothing to do with cypro? Or can there be another factor in relation to cypro aside from T level?

If I got an orchi and they banned HRT x sex would that mean that I would qualify (potentially) for same sex hrt? since im severely hormone defient..... /s

Then I wonder if I showed my bro's all the T i got and they showed me all the E their trans gf's got we could laugh about it?

Something that I would like if I can get it is a partial orchi. Mainly because if I were to loose access to estradiol for a period of time i wouldn't have to worry about getting on an AA. I would love GRS but the waitlist is just to long and Im not sure what my insurance situation would be. I hear partials are the best option to keep material around.

I recently went to my 2.5 month check-up. I've been on 1mg estradiol and 50 mg spiro twice a day. I had my levels checked and my E levels just came back at 456.0 pg/mL. The problem is due to just not knowing I took my pills about an hour before my test so I'm sure this inflated my E levels, my dose was also doubled before my test results came back for both spiro and estro. I wanted to know if this is normal or if I should be concerned with my dose being increased?

I’m getting on bicalutamide because spiro has been affecting my blood pressure. I had two other questions about bica:

1. If I’m taking 100mg spiro (twice per day), what would be the equivalent bica dosage?

2. I know finasteride doesn’t block the DHT pathways that are related to progesterone. Is it true that bicalutamide can be effective at blocking the DHT possibly produced by progesterone? I can’t get my DHT tested for awhile and I’m super paranoid.

After about 3 months of taking Estradiol (and 2 months of Finasteride), I started tapering off my dose over the course of a few weeks before stopping altogether for two more. This was because of some questioning that re-emerged paired with a really bad reaction to a second breast growth spurt (which may be hereditary).

During this time, I did some more soul searching and did some major social transition stuff I had been putting off. I realized that despite everything, I still wanted to be a girl and enjoyed presenting as one much more than presenting as a male. I also hated the subtle ways my body started re-masculinizing, such as body hair regrowth, the cartilage in my hands and feet expanding again, and more. I just wanted to be a girl.

To that end, I started taking Estradiol again yesterday, but I'm already having some weird side effects. The headaches, nausea, and body temperature changes I expected, but my anxiety has skyrocketed. I don't think the anxiety is from any single external source, but I feel incredibly tense and have random instances of a falling sensation that I never had without Estradiol. It's very different from the kind of anxiety I had without E.

Has anyone else had issues like this with E monotherapy? I maintain a healthy diet with plenty of water, so I'm not entirely sure what might be causing it and how I might go about fixing it.

EDIT: I'm even on a lower dose than my previous one, but sometimes it feels like my body is running on pure adrenaline. When it's like this, my arms feel really weird, and it can seemingly happen out of nowhere. It all feeds into other worries that I have, which tends to worsen the anxiety even more.

Is there any credible science about starting HRT later in life? Does anyone know if being older has any major cons to starting?

Hi hi

I've been on HRT for 9 months now: 2mg EV sublingual daily ,1mg every 12 hours and 12,5mg CPA every other day

As you may guess my T was suppressed really good but my E levels are low (round 80 pg/mL)

Had a long talk with my endo (public health assigned) about doing monotherapy with 6/8mg E sublingual (they don't use Injections and I don't have the resources to DIY) and removing CPA cause of side effects I'm having, wanting to maintain erections and high prolactine levels.

At the end she only settled to up my dose to 4mg EV and to do whatever I want with my current blocker, either stop taking it or take the dose I want (she tried to get me on Spyro and I wholeheartedly refused cause I don't really like what studies say about it)

I know that dose of E can't possibly work for monotherapy, but I wanna reduce my dose of blocker to the minimum until I can get more E one way or another.

I'm thinking about taking the same dose but in spaces of 4 days or so for example

What's the absolute minimum intake of CPA that will maintain T in the higher end female range?

Thank you 💜

I finally found an Endo who prescribed me Progesterone after a year and 7 months on hormones. I had been doing nightly 100mg rectally. I also take 50mg twice a day spiro and my T is well suppressed at 10ng.

I felt amazing at first on P, had energy, sex drive and seemed like I was feminizing more. However it seemed like my strength came back, less emotional sensitivity, less nipple sensitivity and the biggest sign that made me stop was I used to not ejaculate anything and then I started having decent amount of cum after sex. This was all within the course of two weeks.

I really want progesterone to work, was I overreacting? My doc has never heard of background DHT conversion he said I would be fine especially when my T is so low. Should I ask for finasteride is that the blocker that would be more helpful. Thank you in advance!

Moved here and need some estodial pills before my appointment thank you if you can help. I got 2 mg rn. Ik they low right now.

With Gender GP, 5 weeks on 10mg cyprotone acerate, 2 1.25g pumps a day oestrogel. Physical effects have been great (softening, some fat cycling/redistribution, budding) and feeling really happy looking in the mirror (like i never have before!)

Mood and energy is pretty meh though. Im tired all the time and feeling a bit depressed and not really myself. Havent had levels yet (quite looking forward to them at 3 months!) but does it sound like despite the physical changes i have experienced so far im likely experiencing low E and T at the same time? if anyone else has experience!

Basically title. I was on 100mg prog oral ages ago and didn’t experience DHT. But then tried 400mg. Got DHT - and have been off it for 11 months.

I want to try prog again but rectal - probably 100mg. Is there a risk of DHT?

I've been doing two 4 mg injections a week and am surprised my levels are so high. Could I still reasonably have faith in monotherapy or might a T blocker be necessary?

Hiii so I started E one month ago, and I have been paranoid the entire time about doing too much or too little. I bought a 10ml vial of estradiol valerate, and i have been using these syringes for the injections. The website for the estradiol said to use 0.18ml, so i have been filling the line up to the 20 mark. Is this correct? Sorry if i sound crazy lol

Hello girls and students of the subject, I am undergoing “hormone therapy” with Diane35 (Ethinylestradiol 0.035mg + 2mg of cyproterone acetate) and I know it is not recommended for us trans people but it was a choice I made, and my doubt is that I I would like you to answer is: can 2 Diane tablets compromise the results or can it only “potentiate” the effects? I know it's dangerous but I don't want advice, I want the answers to my question! Thank you for your attention <3

My doctor had me on 10mg of EV every 7 days and that was great. I got headaches initially that passed after week 3 or so, but I would feel dysphoric and more emotional the day before and the day of my injection. He then switched me to 6mg of EV and it's honestly more the same but different but also worse. I get emotional mood swings and pretty bad dysphoria before and the day of my injection.

I'm just wondering if switching to estradiol cypionate would get rid of any of this because I am tired of it. And to make things worse, EC is excluded from my insurance's formulary, so there's even more headaches and hoops to jump through there.

What's best here?

Edit: to make it more clear, I felt better/more stable on 10mg of EV than I did on 6mg. I still felt the drops, but it was infinitely better with higher estrogen levels.

I have a unique motivation for this question as I'm experimenting with a hypothesis.

I'm an experienced user of psychedelics for therapy/spirituality and I had my first trip recently since being on HRT and had a super unpleasant experience.

I think my hormones may be playing a factor and I want to temporarily pause and see if that's the culprit.

It's basically what's in the title. I've changed my hrt from oral to sublingual E2. How much time should i wait until my next blood test so i can get accurate resulta?

Hi! There have been several people who have switched to injections and then started experiencing masculinization symptoms shortly after. This is from my knowledge likely due to adrenal DHT production since they report having low T levels.

I switched from a gnrh antagonist to injections to try monotherapy about a year ago and while my t levels were good I still masculinized (I’m unable to test DHT)

I’m now back on Lupron injections and in the awful beginning stage when the androgens first rise to then lower again. Would this help with my issue?

I’m really wondering how you others solved your masculinization problems caused by injections? And could you ever precise what was causing the symptoms?

I asked my doctor recently to have my labs check as it has been WAY past due. This doctor has been notoriously dismissive to me and Franky treats HRT like a one size fits all despite me possibly having medical conditions or reasons I need HRT tailored to me. I am trying best to understand my body and HRT.

I asked my doctor to test for more ...again my concerns were not taken seriously. Are my doctors lab orders enough?

This doctor still follows old guidelines...

***Anyways my doctor test for -***CMP, CBC, DHEA Sulfate, Estradiol, Testosterone, and Sex Hormone Binding Globulin.

I asked for- 4021-estradiol
10231-comprehensive metabolic panel
6399-CBC
745-progesterone
15983-Testosterone,total,MS
23244-estrone
7137- FSH and LH
496-Hemoglobin A1c
36169- estradiol,free
30740-sex Hormone Binding Globulin
37104- Estrone Sulfate
7600- Lipid panel ,standard
90567 - Dihydrotestosterone
92208- 3A Androstanediol Glucuronide ,Elisa

I am asking if my doctor should be ordering test similar for my suggested. Is there use to testing for more than what he is already testing for ? I am hoping the test helps me better understand the effects HRT is having on my body now and if I need to adjust my dose.

Hey. So after getting my levels tested, my E levels were 317 and my T levels were 15. My plume endo says my levels for E need to be under 200. Every other trans woman I know has levels in the 300-400 range. What do I do?

Yeah, so Trump won so pretty all basic rights are gone...I was gonna start hrt this December on my annual checkup but now I'm cocontemplating about starting now... what should I do?

I'm trans, and one of the major fears I have is for some government to revers my gender change, either legally or medically. The Hungarian Orban government made legal gender change illegal and REVERSED all gender changes that had already been legally approved. The EU did next to nothing to stop it.

All it takes is one election win for far right parties to undo a century of transgender rights gains. They could change our legal gender at any moment, they could shut down trans clinics or make the waiting lists 20 years long, or they could throw up all kinds of barriers for us to get the medicine we need or to participate in public life and employment.

My plan is to build up a stock of HRT just in case they ever threaten to cut us off. What would be the most efficient way to store HRT for the long term? Mostly inquiring for MTF HRT. Should I store the raw estradiol valerate powder in several layers of ziploc and freeze it? Can I freeze vials of injectable estradiol? Should I store patches or pills?

So I started hrt last month, and started getting high on occasion a few months before that. I had been high 2 or 3 times before this no issue. But last night was the first night I tried it on hrt. I hit my brothers pen, and I'm told I didn't take that much. We were getting high to go to Dennys with some friends late at night. When I got in there I immediately knew something was wrong. I started getting really paranoid. I felt like everyone knew and was judging me. And I just freaked out. I asked my brother to let me in the back of the car (we carpooled) and I had a panic attack that lasted for like the rest of the night. This being the first time I got high since starting hrt, (2 mg sublingual estradiol daily and 100mg spirolactone daily), could that be it? Or did I just have a really unfortunately timed panic attack?

I'm currently in the hospital recovering from SRS. I've had to stop my HRT pre surgery, and I'll be able to resume this week. Before everything, I was doing injections and taking Spiro. Obviously I have no need for spiro cause I am not making testosterone anymore, but I was wondering if it's normal to adjust injections?

I'm trying to build a background understanding so I can ask better questions to my surgeon before I leave and properly move forward once I get home.

I've been on a low spiro dosage (25mg/day) for a bit over a month and I have not seen any noticeable effect to my libido since starting it. does this have any significance?

Just started Valerate injections this week, got HUGELY emotional around 48-72 hours so I know its working lol. Wondering, though, since I get my prescriptions filled monthly anyway, if I should be looking for a different estradiol Ester. Most of the charts I've seen make it look as though valerate burns off very quickly relative to most and might not keep me at a therapeutic dose through troughs. Should I ask my doc to switch me to Enanthate/Cypionate/ some other?