/r/AskMtFHRT

Photograph via snooOG

A subreddit for questions about transfeminine hormone therapy, also known as male-to-female hormone replacement therapy (MtF HRT).

This subreddit is intended to be a general forum for transfeminine HRT questions and basic discussion. Transfeminine hormone replacement therapy (HRT) is sometimes referred to as male-to female (MtF) HRT or feminizing hormone therapy.

The aim of r/AskMtFHRT is to provide a space to learn and understand more about HRT, whether you are being prescribed HRT by a medical professional, self-medicating, or seeking to learn more with a view to beginning HRT.

Basic level questions are very welcome, though if you are new to the subject a good overview can be found here.

For in-depth informational posts, guides, and advanced discussion on transfem HRT, see r/TransfemScience.

Please direct any questions about purchasing medication or suppliers to r/TransDIY, it is the established forum for those enquiries.

Members identifying themselves as a legal minor (as defined under the law of their jurisdiction) should only ask about HRT in general educational terms & not about specific meds, doses or buying of HRT as it applies to them. Likewise those responding to questions are requested not to provide specific med/dose info to those clearly identifying themselves as a minor.

No advertising or soliciting meds: Vendors of HRT should not advertise or market medications on this subreddit, & similarly, please avoid the soliciting of prescription medications.

Respect for others: It is required that at all times, comments and discussion are kept civil and respectful towards others. If this rule is breached, consideration will be given to restricting a user's access to r/MtFHRT, r/TransfemScience and r/AskMtFHRT.

Disclaimers: (a) The content in this subreddit is educational only & not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician with any questions or issues you may have regarding HRT; (b) Posts and comments represent the view of the author and not necessarily of the subreddit; (c) In accordance with the fair use provisions in Title 17 U.S.C. Section 107, the material on this subreddit is distributed without profit for research and educational purposes. For more information see here.

/r/AskMtFHRT

22,862 Subscribers

2

Ev 5 mg is high?

So, my endo put me on 5 mg ev twice a week instead of 4 mg twice a week (10 mg) and I don't know if that's too high? Even if there is any risk? I'd love to hear what you think?

1 Comment
2024/12/21
22:33 UTC

3

Worried about needle length

I’m relatively new to injections and have been injecting 5mg of EV intramuscularly into the thigh every week. The pharmacy gave me 1 inch long needles but I’m worried that they aren’t long enough to reach the muscle? It certainly feels like I’m hitting the vastus lateralis but I’m also a bit overweight so I’m wondering if I should upgrade to 1.5 inch? Or am I just overthinking things?

1 Comment
2024/12/21
20:04 UTC

2

Is there still hope for me?

I've been on hrt for 8,5 months, haven't had any progress after the first 1,5 months with some progress even reversing. I always assumed the cause of that is me being stuck at 3 mg of E a day because of my endo not letting me go any higher (before anyone asks no i can't switch endos and i'm also not in a situation that allows me to DIY) but the problem is that there are people with a dose even lower than mine that get a lot more changes than I do and then theres also the fact that some of the changes that happen as a result of low T, that usually happen really early for seemingly every other trans person still haven't happened to me despite my T levels being undetectably low (erections including morning erections are still there, my libido is still there and higher and bot even kow, my body odor hasn't changed one bit). My only suspicion is that my DHT levels are still too high but i dont know if that's even possible with T levels as low as mine and if it is, what can i even do about it or how would i even find out because my endo doesn't test for DHT. Im really worried that my masculine body odor and libido will stay because my T can't get any lower than it is now and that even if i have a higher E dose one day, it still won't change anything.

7 Comments
2024/12/21
18:25 UTC

3

Clenching pain in left side of chest… hrt, anxiety or neither?

Around the time of restarting hrt a few months ago I would get chest pains on my left side.

The fist time it happened it was when my levels where extremely low and I had a panic attack from mood swings but it went away.

The second time was after I did a higher level injection, when after I was in the shower about a month ago and it suddenly happened it was between my nipple and the middle of the left side of my chest.

Most recent was a few minutes ago.. and it happened when I was laying in bed. It was towards my collar bone and above my breast on the left side…

I’m assuming it isn’t heart or really blood related but I have no idea. I will say that my levels have been everywhere trying to attempt to do 0.28ml injections instead of 0.3 monotherapy 50mg/ml valerate injections where my levels where in cis range… I think I’m gonna keep doing 0.3 because at this point I’m tired of not having steady levels. They’re wasting my time. And I’ve been on an emotional and physical roller coaster for months

Hell I’m even having hot flashes right now :,)

2 Comments
2024/12/21
15:13 UTC

2

3.5 day dosing vs 7 day

Hi. I dose 0.24ml of EEn (40g/ml) subcutaneously every 7 days but wondered if amending this to 0.12ml every 3.5 days would give less of an initial spike ensure there’s no down regulation of my E receptors but still support my monotherapy.

Thanks

10 Comments
2024/12/21
08:57 UTC

1

Japan trip

Hey so I'm going to Japan next year in Jan and I'm on injections anyone know if I'm allowed to take them or do I need to sign something

0 Comments
2024/12/21
08:53 UTC

9

My boobs haven't grown since my 7month mark

I've been on HRT for 1y2m and I haven't seen further breast growth than the one I've gotten from the 1st/2nd month to the 7th. I got decent growth, I'd say I'm a B cup(I have photos on transbreasttimelines) but I'd like to see more. I've even started progesterone two weeks ago in hope of unlocking growth and speeding feminization and haven't noticed anything different. Not physically nor mentally.

What's your experience? How many phases of growth/stallment have you had? How long was the longest stallment phase?

19 Comments
2024/12/21
08:38 UTC

3

Is my testosterone high again? (Sorry this is rlly gross)

I used to be on estrogel monotherapy for the first 6 months of hrt. It worked with high peaks and low troughs so my estrogen was at 50pg/ml on average but my testosterone was pretty good at below 10ng/dl.

I wanted to switch to injections monotherapy since it was cheaper and less time consuming.did that about 2 months ago.

The thing ive noticed ever since I started, there have been a few white particles in my ejaculation. I freaked out.( its not completely white like it used to be tho)

Now the weird thing is thats the only symptom. Absolutely no other symptoms. Im still pretty young so my libido used to be very high but rn its still as low as it was when my T was supressed by estrogel. My skin also hasnt returned to being greasy. My voice hasnt gotten any deeper and my sweat still doesnt smell manly. All in all, the only symptom is the white particles. My face has continued femininzing and so has my figure.

Should I be concerned? I started with high dose injections (10mg een weekly) just so I dont get high testosterone again. If my e turns out high after a blood test, ill lower it but i definitely cant increase if if my testosterone turns out to not be supressed. Im doing IM injections btw

16 Comments
2024/12/21
08:24 UTC

2

A question about HRT effects

Hi everyone, I’m 17 MtF(but I’m gonna be 18 in like a month) and I recently started HRT. I’m taking lupron and 0.05mg estrodiol patches. And it’s been 6 days and my nipples are really sore and I can feel like a tiny lump behind my nipples.

The only reason I’m bringing this up is because the doctor said it’ll take around 1-2 months for breast growth to start. So is what I’m feeling breast growth? Or is it a side effect I should tell my doctor?

12 Comments
2024/12/21
04:03 UTC

26

At what point during HRT did you see the most rapid facial changes?

Curious to hear from others. I'm at 4.5 months and seeing some skin softening, but if it continues at this rate it's going to take a loooooong time.

Sometimes I hear that it kicks into next gear after a few months, sometimes that it only happens in the second year.

I know it varies by person, just curious to hear people's experiences.

27 Comments
2024/12/21
00:04 UTC

1

Blood test results

I got my blood result from medicheck but they didn’t mention anything about my hormone results and if they are at the correct level I am currently doing mono therapy my oestrogen is at 804pmol/L And my testosterone is at 0.58nmol/L are these normal levels?

1 Comment
2024/12/20
22:42 UTC

2

Is pace of E relevant?

I been thinking, and I'm not really seeing this anywhere, but I'm wondering if the pace we use to increase our E dose is relevant? When I started on E last year, my doctor started me on 1mg daily, then 2mg daily morning and evening, then 2mg morning and 2mg evening, then 6mg, then finally 8mg total; 4mg morning and 4mg evening. I went off HRT for three months. When I went back on recently, I began with 4mg daily for 1 week, and now this week I've moved to 6mg daily; 4mg morning and 2mg evening. I was thinking I would move to 8mg for the coming week, but now I'm wondering if there is such a thing as too much too soon? Would any of you have any thoughts or experience with too much too soon?

2 Comments
2024/12/20
22:11 UTC

8

Have to go off hrt for a month after being on it for about 2 months. How much will be undone?

Destroyed all of my hrt in a moment of deep self hatred and negative emotions. Now I’m stuck without anything until long after the holidays season. What should I expect? Is this gonna completely set me back to square one? I’m already feeling awful without it, my brains a mess. How badly did I screw myself?

7 Comments
2024/12/20
18:12 UTC

5

6 month test results

Just had my 6 month checkup and Testosterone is 20 ng/dl and estrodiol is 235 pg/nl. These are good normal levels right? Nothing I should be worried about? 6mg estradiol sublingual with 200 mg spiro.

4 Comments
2024/12/20
16:27 UTC

2

Hormone levels

Soooooo. A month ago I stopped gender GP, came off of 150mcg/day patches and started 0.1ml of 50mg/ml EEn every 7 days. So that's 5mg every 7 days.

Just had my blood works back after a month.. test was taken 5 days after last dose. That seems a bit higher than I was expecting! 👀 Should I give it another 3 months at current dose to see what happens, or reduce it slightly. What you think, hive mind?

2621 pmol/L estradiol 1.59 nmol/L testosterone

6 Comments
2024/12/20
14:54 UTC

6

HRT and head hair

What are the best options for scalp hair regrowth? Has anyone had regrowth with HRT alone or have you included other things like finasteride or dietary supplements? I am a late transitioner who just started on 4mg estradiol and 50 mg spiro and had lost quite a bit of my hair prior to starting HRT. Both receding and crown hair loss. My expectations are low but I want to try my luck. Does anyone here have any recommendations? Thank you!!

4 Comments
2024/12/20
14:05 UTC

1

Recent test results

So, I see my doc next month. Just had bloodwork done through my family doctor and had my E and T levels tested just to see where things are at.

Just for reference I started on 2mg Estradiol orally and 25mg Spiro for the first month (started Oct 1st) then doc raised my dosage to 4mg Estradiol orally and 50mg Spiro daily. I take 2mg Estradiol and the Spiro dose in the morning and then the other 2mg Estradiol about 12 hours later. Been taking the Estradiol bucally instead of swallowing it cause I read that the pill I take can be taken that way.

These are my latest results (blood drawn right before my morning dose). Are things on the right track here?

Estradiol, Serum, MS - 46 pg/ml Estrone, Serum, MS - 251 pg/ml Total Calculation - 297 pg/ml

Testosterone - 61 ng/dl Free Testosterone (Direct) - 3.6 pg/ml

I know my T needs to be lower, I'm hoping that she raises the Spiro to 100mg and also raises my E to 6mg daily or maybe 8mg daily.

Are these results heading in the right direction?

2 Comments
2024/12/20
04:56 UTC

3

Levels At Trough

Hi! My recent tests came back and I wanted to get input on my situation, 'cus I've heard that doctors can be a bit clueless at times.

Testosterone - 45.2 ng/dl

Estradiol - 90.50 pg/mL

Once a week estrogen shots of .20 ml from the little white and red estradiol valerate bottle that says "100 mg/5 mL (20 mg/mL).

I got my blood drawn at trough, about an hour before doing my injection.

I'm taking 100 mg of progesterone,

I'm taking 75 mg of spironolactone.

No orchi/srs.

Been doing HRT for 4 years with varying doses.

Would love feedback! Thanks! I've heart people say that 100-200 pg/ml at trough is good, and I've heard others say that double that can be fine. Really unsure. I think I want to start doing injections every 4/5 days, at possibly .15 mL per injection. I also want to up my spiro to 100mg per day, and possibly increase prog to 200 mg per day. I've messaged my doctor about this, and am kinda pushing for it. I've heard that there are two standards for trough, 100-200 and 200-400, and I wanna go higher. I still notice a tiny bit of facial hair coming in (hate hate hate it, I keep a baby face all the time, you'd have to be an inch away from my face to even slightly see it).

Just afraid my levels are too low. I think changing to twice a week injections, as well as making them a higher dosage, and upping my spiro might make some positive changes. My doc specializes in LGBTQIA+ endocrinology, but every time I've seen them, they just ask, "how are you feeling? If you feel fine, the levels are fine, just stay within the 'safe' range (100-200 at trough)." And I don't know if that "safe" level is outdated and too low, and I've never been particularly good at gauging my mood - always been depressed, and suicidal ideation ramped up on estrogen. Feel pretty lethargic and irritable and depressed in the few days leading up to my shot.

5 Comments
2024/12/19
23:15 UTC

2

Starting pioglitazone soon advice

I have ordered 180 x 30mg pioglitazone that i intend to cut in half so I'm taking 15 mg a day for the next year. Cost less than £50 from United Pharmacy UK think they are based in HK, no prescription required.

I'm around 65kg having weight cycled between 57kg and 70kg several times over the last 6 years on HRT / E, P and am post op 3 years. Currently on a 100mg E implant with oestradiol at 2300 pmol/L at one month (yes crazy high but its not like i can remove it easily :) and i feel ok in my early 40's.

I don't have any serous medical issues apart from chronic pain, anxiety, clinical depression and PTSD and they are all controlled at the moment.

I started monitoring my blood glucose a few days ago and according to the readings i am very healthy in that department. I will continue to monitor once taking pioglitazone just in case i go hypoglycemic when im fasting.

Is there anything else i should monitor ?

Any advice from those that are taking it?

I could post pics but they would just show my skinny arse and square body with not much of a waist at 33 inches ;( breast at 34B or small C hip 36 inches. Very unhealthy waist to hip ratio for a woman as far as i can tell. I would just love to have more of a feminine shape in tight clothes or when i go swimming.

Edit, i posted body pics on my profile. I'm not sure about the rules in here about nudity so will not link them.

4 Comments
2024/12/19
18:53 UTC

1

Low doses of E after not having injections?

I’m taking low doses of E after being on estradiol valerate. I stopped the injections 3months ago what are side effects if I’m going to 1mg morning and night? I have no progesterone and I’m hoping I’m not messing my levels up help please?!

1 Comment
2024/12/19
18:04 UTC

1

Need help figuring out my bloodtest results

Hey, i received my new bloodtest results today and im kind of devastaded about the results. I'm confused why my e2 level is lower since my last bloodtest even though i increased my dose.

I don't really feel mentally well right now. Would be nice if someone could help me figure out why my levels are shit and what im doing wrong. Otherwise im thinking about giving up doing injections.

DateDoseIntervalE2TestoSHBGDHTFSHLH
07.12.245mg EEn5 days64 pg/ml0.27 ng/ml61 nmol/l+174 pg/ml-<0.3 IU/ml-<0.3 mIU/ml-
29.08.244mg EEn5 days153 ng/l+0.29 µg/l-45,1 nmol/l---
14.07.247mg EEn10 days64 pg/ml0,27 ng/ml----

I've done the EEn Injections SubQ.

2 Comments
2024/12/19
17:24 UTC

21

Are injections every 10 days feasible or is it better to do them weekly?

I recently started with a dose of 7 mg which is equivalent to 0.18 ml of Estradiol Enanthate of astrovials, but I feel a little strange by day 8 or 9. I was previously on 4 mg of oral E and spironolactone. I'm not sure whether to stop taking spironolactone or change it to fina or bica?.

18 Comments
2024/12/19
15:39 UTC

9

Morning wood?

Hey I’ve heard that morning wood is supposed to go away almost immediately on HRT and yet I’m still having it almost a month in. I’m on 12.5mg of cypro a day

I’m trying to use my genitals often to prevent atrophy, could this be why?

13 Comments
2024/12/19
08:34 UTC

18

Breasts or no breasts?

Someone tell me what's happening here. Actually, it's been happening for quite a while. I went off HRT for Sept, Oct, and November. I'm back on it now. Presently I'm at 6mg E daily. That will rise to 8mg daily with 4mg morning and 4mg evening. I also take a low dose of Finasteride at 2.5mg daily mornings. Soon, I will follow with low dose Bica; around 12.5mg daily. Prior to stopping end of August, I had been on HRT a full year. Here's the thing...my breasts have grown and I'm certain of this. I am a snug 42B now, being no more than a loose 42B or less when starting. I had the constant breast pain that we all experience. I could feel the hardeness behind my nipples, which is still there, and my arms constantly rub them when I reach for something (not sure how to explain that), but it was not something that was happening prior to HRT. I'm constantly aware of them and I can grab a handful for real. They're soft and a bit jiggly at times...like when I run or jump. When I look down at them, it looks like they've grown. My wife even acknowledges they have grown. When I look at myself in the mirror, however, they are barely noticable! Why do I think and feel like my breasts are larger than they appear to be? There's some sort of mental, visual, and physical disconnect. Anyone else experiencing this bit of weirdness?

9 Comments
2024/12/19
00:35 UTC

1

Blood test

So i have been on HRT for couple weeks now, im planing on getting tested once i reach 8-12 weeks, should i just ask about a normal blood test or about specifically something else (like that involves hormones levels etc)

1 Comment
2024/12/18
21:42 UTC

3

Tattoos while on HRT

This is very random i guess lol but can i get a Tattoo while being on HRT?

11 Comments
2024/12/18
21:20 UTC

4

what happens if your levels are too high?

i had an appointment with my endocrinologist last week. he said my levels were too high (and that my testosterone levels were nearly untraceable!). i’m not sure what unit of measurement he was referring too but he said i was at 560 and that they usually aim for 500.

i’m just wondering what can happen if your levels are too high? is there anything bad that could happen? cuz i’m actually really happy with the dose i’m currently on and i don’t wanna decrease.

5 Comments
2024/12/18
21:18 UTC

1

Ideal estradiol levels/ injection routine? EV

Hi everybody,

I have been doing DIY monotherapy now for about 2 months and a half. I definitely feel the difference as opposed to estrogen gels in combo with cyproterone in terms of my mood and feminization and libido. I am trying to follow estradiol valerate 3 mg/ 3-3.5 days. The day I take it 3 hours in I feel full of life and very happy, then the next day extremely sensitive, depressive, irritable and weeping during the day. I understand I haven’t been a serious regimen and for that reason may be the constant fluctuations of mood, but I want to know if anybody can recommend ideal levels or routine esp doing monotherapy? I haven’t been able to check my levels in a while so I don’t know what’s ideal or have a doctors consultation… any help is appreciated ❤️‍🩹🖊️

5 Comments
2024/12/18
21:14 UTC

3

Low values on estradiol tablets

I got my blood test results today.

3 and a half months without HRT, on purpose. With a level of 52 pg/ml estradiol.

Estradiol in the form of tablets was used a month ago. Oral. With a level of 42pg/ml.

Without estradiol, the level increased. But with estradiol, the level decreased at a dose of 3 times 2mg per day after 8 hours.

But SHBG increased from 51 nmol/l to 76.4 nmol/l.

Has anyone encountered this?

I am trying to adjust the dose as I am trying to get between 100 - 300pg/ml. But i'm out of luck. On the injections, the levels are 1909 pg/ml peak and at the end of the fifth day 87.4 pg/ml. So a really high swing.

1 Comment
2024/12/18
20:31 UTC

14

Cum randomly white after year of hrt

Currently 1 and 3 months i noticed my cum was suddenly white. It’s usually clear and watery but it white and Thick today. I think it might can be trapped segma cause I have phimosis and can’t pull the skin back and I tried squeezing out to see it rest was white and the usual clear liquid runny liquid came out.

Is this normal?

8 Comments
2024/12/18
13:44 UTC

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