/r/neurobiology
This subreddit is for discussing a wide array of things related to neurobiology. We welcome posts and discussions of all sorts, about the biology of neurons, neural networks, and nervous systems. Questions about these topics are also encouraged.
This subreddit is for discussing a wide array of things related to neurobiology. We welcome posts and discussions of all sorts, about the biology of neurons, neural networks, and nervous systems. Questions about these topics are also encouraged.
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/r/neuro |
/r/scienceneuro |
/r/neuroscience |
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/r/neurobiology
If someone took a 5ar inhibitor like finasteride for many years (from 23-30), and then quits it forever, is it possible to increase 5ar with supplementation? In theory, 5ar should go back to normal but there are these horror stories of Post-Finasteride-Syndrome, which I assume is because 5ar enzyme activity does not go back to normal after quitting finasteride. And apparently, the only way for the brain to produce allopregnanelone is through 5ar and no other way around it, which is concerning.
I read that apparently Palmitoylethanolamide (PEA) can potentially increase allopregnanelone levels in the brain, but I am not sure if this is due to PEA increasing 5ar activity or not.. I also read that Tribulus Terrestris (a plant/herb supplement) can potentially increase 5ar but there is not much info on that either..
And I don't know if things like Vitamin D3, B-Complex vitamins, Omega3's DHA/EPA, Magnesium, Phosphatidylserine etc would help or not with 5ar enzyme activity...'
Also, thoughts on Cerebrolysin or that is overkill?
I am hoping you can share your thoughts on this.. thank you.
https://neuroendocrinology.org/a-potentially-new-treatment-for-post-finasteride-syndrome/
For some time now, I have been able to trigger adrenaline surges on command, similar to how one might flex a muscle. I can increase my heart rate to 145 bpm or higher while at rest, causing noticeable physiological effects, including uncontrollable tremors, faster and tighter breathing, and a rush through my body. I have been able to replicate this response at will, even while sitting down and in a relaxed state, without the use of techniques like breathing exercises or physical exertion. I have only seen 2 other cases exactly similar to mine on the internet and we all had the exact same effects. I understand this has some relation to neuroplasty, but I realize what I can do is so rare. I couldn’t find any cases about it before and I just wanted to share my ability with you guys. Maybe you can help me understand it more.
Artificially acidifying the astrocytes did not affect short-term memory but prevented memories from being remembered long-term.
One of the brain's greatest assets is its ability to store information as memories, enabling us to learn from mistakes. However, while some memories stay vivid, others fade. Unlike computers, our brains filter and prioritize which memories are significant enough to retain.
Astrocytes' role in the amygdala — a key brain region for regulating emotion and fear — was explored. Using optogenetics, astrocytes in mice were acidified or alkalized. A mild electrical shock was delivered to the mice, and the process of fear memory formation was studied.
Mice given a shock froze when returned to the same chamber the next day. When astrocytes were acidified after the shock, the mice retained the fear memory only briefly, forgetting it by the next day — suggesting that acidifying astrocytes blocks long- but not short-term memory.
While it is generally believed that memories are formed in a continuous process whereby short-term memories gradually solidify and become long-term memories, this research suggests they may actually develop in parallel.
Our next goal is to uncover the mechanisms by which astrocytes regulate emotional memory. Understanding these processes could pave the way for therapies that prevent traumatic memories from forming, offering a valuable approach to treating disorders like PTSD.
Hiroki Yamao, Ko Matsui (2024) Astrocytic determinant of the fate of long-term memory. Glia, available online Nov 4, 2024. https://doi.org/10.1002/glia.24636