/r/HumanMicrobiome

Photograph via snooOG

This sub is a haven from the flood of misinformation that is widespread on Reddit and over much of the internet. We have an evidence-based focus on the complex ecosystem in our guts that regulates the entire body.

Studies, articles, and discussion related to the human microbiome. With an evidence-based focus.

This sub is a haven from the flood of misinformation that is widespread on Reddit and over much of the internet. We have an evidence-based focus on the complex ecosystem in our guts that regulates the entire body.


Our Wiki. FAQ page.

New forum:

We encourage you to post on the Human Microbiome forum https://forum.humanmicrobiome.info/ and then link to it here.

Related:


  • Animal studies with implications for humans are allowed.

  • Health/medical discussion related to the microbiome is allowed, but may be restricted if it becomes too dominant. For general health try:

/r/HealthDiscussion

/r/Maternity's wiki.

FYI if you mention this sub in /r/science your comment will be silently, automatically removed.


Rules:

Full rules and submission guidelines: https://old.reddit.com/r/HumanMicrobiome/about/rules/

  1. If you are new to this sub please take some time to review the info in the sidebar & wiki before contributing. This area of research is growing rapidly. If you do not follow the research closely, please refrain from making authoritative statements.
  2. Do not use downvotes for disagreement. Use your words or the report function. We are here to learn and discuss, not to reinforce our preconceived notions. See: https://old.reddit.com/wiki/reddiquette
  3. Please use the stickied thread to give feedback/suggestions about the sub & its rules. Meta discussion elsewhere will be removed.
  4. This is a science/evidence based sub. Usage of scientific citations to support your claims is highly encouraged and may become mandatory. Citing your degree/education is almost never appropriate.
  5. Re "go ask a doctor". There are times where this is appropriate, and times where it is not. In general, we are here to share evidence-based information, so "go ask someone else" isn't a useful contribution. Especially since most medical providers are not knowledgeable on the majority of information shared in this sub.
  6. Be civil & constructive. Engage in good faith. Trolls/agitators will be banned. Address the arguments, not the person. The subject of your sentence should be "the evidence" or "this source" or some other noun directly related to the topic of conversation. "You" statements are suspect.
  7. Memes as top level submissions are not appropriate, but can be posted in the comments. Other low-scientific-quality content may be removed as well. You need to have a good reason for submitting old studies.

Excessive rule breaking may result in a ban.


General info:


Sort by flair:

Age | Aging | Antibiotics | Archaea |

Causation |

Discussion |

FMT | Fungi | FVT |

Impact of Genetics |

Mucosa |

Oral | Origins |

Peptides | Phages | Probiotics |

Review |

Small intestine/upper GI | Sex differences | Skin |

Testing |

Vaccines | Vagina | Virome |

Weight |


You can use sci-hub to access paywalled studies.


Our mod logs are public: View. Our mod ethos is "transparency; community run".


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/r/HumanMicrobiome

37,480 Subscribers

1

Severe Burning and bloating up both sides of colon only when having any carbs and sugars.

Could this be a herximer reaction?

4 Comments
2024/10/29
17:32 UTC

1

Those who got fmt’s did you inherit any non digestive traits from the donor?

I may be due to get one but I’m a little scared about what I traits might be passed to me for mine donor

2 Comments
2024/10/29
10:10 UTC

3

Probiotic causing burning & watery eyes, dry skin and bloating. Is there an alternative for recommendation?

So I’ve dealt with SIBO and since gotten rid of it but had such bad anxiety & fatigue because of it. I was told to start a probiotic and it’s been great in terms of energy and anxiety almost gone. But the side effects above are making me rethink what I’m on. I’ve been taking it every day for over a week. The one I got was the bioglan platinum 20 billion gut health which has:

Each Hard Capsule contains: Bifidobacterium animalis ssp lactis (B-420) 400 Million CFU Bifidobacterium lactis (Bi-07) 300 Million CFU Bifidobacterium infantis (Bi-26) 100 Million CFU Bifidobacterium lactis (BL-04) 1 Billion CFU Bifidobacterium animalis ssp lactis (DSM15954) 1 Billion CFU Lactobacillus rhamnosus (GG) 10 Billion CFU Lactobacillus rhamnosus (HN001) 500 Million CFU Bifidobacterium lactis (HN019) 2 Billion CFU Lactobacillus acidophilus (LA-14) 200 Million CFU Lactobacillus casei (LC-11) 400 Million CFU Lactobacillus gasseri (LG-36) 100 Million CFU Lactobacillus plantarum (LP-115) 1.7 Billion CFU Lactobacillus paracasei (LPC-37) 1 Billion CFU Lactobacillus rhamnosus (LR-32) 100 Million CFU Lactobacillus salivarius ssp salivarius (LS-33) 200 Million CFU Lactobacillus acidophilus 1 Billion CFU

7 Comments
2024/10/29
09:12 UTC

2

What is the best probiotic? How to choose a probiotic? Are fermented foods better? | Probiotic guide

1 Comment
2024/10/28
12:31 UTC

2

Seeking Advice for Gut Health and Candida Overgrowth

Hello everyone,

I’ve been dealing with Candida overgrowth in my gut for the past few months, and I’m looking for advice on how to normalize my stools and improve my microbiome.

I recently had a stool test that showed 70 colonies (with only 20 considered normal). My symptoms include occasional loose stools, anxiety, and panic attacks. I’ve tried the Candida diet and took oregano oil for 20 days about four months ago, along with a short course of Nystatin. I’ve also started making homemade kefir and plan to incorporate sauerkraut, kombucha, and sourdough into my diet.

As a pescatarian, I typically consume a decent amount of fiber, but I’m looking to increase it further. I tolerated carbs well before this overgrowth, and I suspect antibiotics may have disrupted my gut microbiome.

Has anyone experienced something similar? What strategies have worked for you in managing Candida and restoring gut health? Any advice on improving my stools and overall microbiome would be greatly appreciated!

Thank you!

11 Comments
2024/10/28
11:24 UTC

1

Craving for high fiber foods while on antibiotics. Any experiences and is this bad?

As above. Ill cut to the chase. I had a surgical site infection in mid september that led me to having a minor surgical washout and drainage of a superficial abscess. I was then put on 5 days of Kefzol then 4 days of Ampicllian once lab cultures came back. Was discharged on 35 days oral amoxicillian at max standard dose.

I have found since going on antibiotics I am craving high fiber foods. Such as high fibre bran, whole meal bread, oatmeal etc. I have been focusing on my diet alot and have included fiber supplementation, pea protein, yougart, kefir etc. I am approaching the end of the therapy which totals it to about 6 weeks of antibiotics. Symptoms such as cramps and diarhea have been transient and minimal so far and I can count on one hand the amount of times I had watery stools

Is this craving just psychological or does gut bacteria composition play a role?

1 Comment
2024/10/27
03:15 UTC

1

Young People Aged 12-17yrs with Stomach Problems Needed for Short Anonymous Survey [Research Survey]

We are looking for young people aged 12-17 years from all around the world who suffer from chronic stomach symptoms, including chronic nausea, vomiting, pain, and gastroparesis.

Participation is easy and completely anonymous. The study involves a 15-minute anonymous, online survey that includes questions about your demographics, symptoms, and wellbeing. Your survey responses will help researchers and doctors better understand and treat young people with chronic stomach problems. 

*We are especially in need of more males to complete this survey*

More information about the survey and the survey link can be found here: https://auckland.au1.qualtrics.com/jfe/form/SV_8fibsg84DNDz3lY 

This study is being conducted by the University of Auckland in New Zealand and has been approved by the Health and Disability Ethics Committee, Northern A, on 24/04/2024, Reference Number 2024 FULL 19553.

1 Comment
2024/10/24
20:18 UTC

8

Which probiotic is best for replenishing the gut microbiome after countless rounds of antibiotics?

Because of a chronic UTI, I've been on many rounds of antibiotics since February of this year. I don't know the exact number because this has gone on for so long and become a blur but it might be upwards of 7-10 times with all the different antibiotics. I am also going to start hiprex soon but I don't if that affects the good bacteria. Basically, I have very little money so I want to make sure that whatever probiotic I get that it at least has a chance of working. Please let me know some good ones.

Also, how long should I be on the probiotics for? And will hiprex counteract it?

34 Comments
2024/10/23
20:18 UTC

5

Is dirt good for your microbiome? Will eating dirt improve gut health? Debunking the Hygiene Hypothesis

6 Comments
2024/10/21
12:02 UTC

2

Increase malabsorption after FMT? (SIBO)

Hello,

Long story short, I got SIBO after food poisoning several years ago. Initially, I thought I made something with probiotics ingestion, but then GI map shows extremely high levels of E. Coli (Enteropathogenic E. Coli). I tried many treatments during the years (antimicrobials, antibiotics, antifungals etc.), but nothing helped significantly. Even worse, my microbiome was wiped and got different sensitivities (salicylates, oxalates, sulfur etc.).

So, I decided to give a try to FMT (oral / rectal) from a clinic, which tests and monitor it's donor. I've done a course of 10 days treatment with Vancomycin to clear, followed by 5 days waiting to clear the antibiotic and then laxative (basically, colonscopy like prep before FMT).

Then, I got the FMT in the clinic rectally and orally at the same day. I felt relaxed afterwards and had a good sleep. Two days after I took another liquid solution (orally), as I got no bad reactions whatsoever.

Now almost ~2 months after, I continue to have yellow stool (fat malabsorption) - TUDCA/UDCA/Ox bile just worsen that. So, my doctor decide me to use frozen solution - basically, he prepared FMT with glycerol (frozen) and gave it to me (I am storing it at home at -22 C).

I have started to take 1 capsule per day (~700-800 mg of FMT orally). The reactions I got are mainly joint pains and stomach gurgling (like really noisy), but still nothing crazy.

I am taking it for about a week and I started to notice increase of overall malabsorption (food pieces in the stool, fat malabsorption, yellow stool etc.). I feel extreme hunger after a big meal, which indicates serious malabsorption.

However, at the same time my salicylate sensitivity dropped a bit, H2S doesn't seem to be SO hard as before and I am confused.


  1. Is it possible to get overgrowth in small intestine from FMT? (anyone with experience, please reply)
  2. Can I get temporary malabsorption when I introduce FMT orally or it's indication of something bad?

I am concerned because weight loss is there and I can't afford too much, because I already lost weight with SIBO for so many years. Dosages that I am taking a way too less compared to what they gave me initially.

7 Comments
2024/10/20
22:57 UTC

2

High biliar acids

Hi,

Just recived the microbiome results,and i m scary because i have high biliar acids,ancylostoma parasite,methane,fungi,mold,inflamation,infeections.

What is the root cause for high biliar acids?

Thanks

12 Comments
2024/10/18
21:26 UTC

4

Are prebiotics better than probiotics? | Microbiome FAQ | Some people say probiotics generally don't colonize the gut and thus prebiotics are better. Is this true?

9 Comments
2024/10/14
12:05 UTC

1

Hair and microbiome

So there is one report on someone curing Androgenetic Alopecia (typical receding hairline pattern) reporting that a FMT helped them. There are I believe two studies that report Alopecia Areata (Patchy hairloss across the body and scalp in seemingly random positions) growing their hair back.

I was interested in knowing if anyone has done a FMT or taken probiotics and seen regrowth of hair in the scalp?

The reason asking is because the I imagine the Gut Microbiome produces some resources to maintain a healthy scalp enviroment. During aging process the diversity of the gut also decreases. This would lead me to believe some of the bacteria that helps produce resource for a healthy scalp would maybe die out, which in turn causes the hairloss.

Thanks for reading this.

1 Comment
2024/10/11
15:52 UTC

1

Probiotics and beneficial yeast in milk kefir

What probiotics and yeast kefir contains And what probiotics and yeast kefir does not contain and needs to be suplemented?

1 Comment
2024/10/12
13:06 UTC

3

Maybe someone who follows this sub can advise this newbie

Hi I'm don't know much about probiotics except that I've gone to Sprouts or WholeFoods in the past and just bought Jarrow or something similar (both refrigerated and not). I guess I've read conflicting things about whether these things are useful and even survive stomach acid.

That said, my motility is low and at times when drinking kefir or magnesium can become more a daily output person. Otherwise I can get constipated, certainly air gassy with cheese and pizza (not smelly though). I used to feel bloated but not much anymore.

I took alot of antibiotics a couple of years ago (doxy, a few days of cipro, bactrim for 5 weeks, flagyl, maybe 1 or 2 more -luckily no c. diff). after 20 days of doxy, a medical scare led me to have anxiety and insomnia, the latter which continues to this day with 4-5 hours of natural unaided sleep vs 7 to 8 before. Melatonin and seratonin are majorly affected by the microbiome so I suspect my body is still not right.

2 Genova Diagnostics tests done a year apart show lower Akkermansia. I'm game for trying Pendulum but see that some recommend pairing it up with other pro/pre biotics. Can someone help me out and give me the digest recommendation? I'd hate to have to start reading this sub backwards for a year.

Thanks

6 Comments
2024/10/09
02:33 UTC

1

What an extended treatment of 4x daily Azithromycin help eradicate the microbiome enough to cure LGV?

So yea il not sure where to ask this but would and extended course a 500 mg azithromycin 4x daily help clean out my microbiome to cure LGV OR PID? so he's I've been struggling with PID {pelvic inflammatory disease} symptoms for almost 5 years now without the ability to get a proper cause of it. and have managed to figure out that it might be due to LGV from untreated gonorrhea or chlamydia, and as of now I am in severe pain. I was able to get a doctor to prescribe azithromycin 500 mg 4x a day for 30 days.

I've been on short amount of azithromycin that have helped in the past, [500mg 1x for 14 days]. which is why this doctor gave it to me now, however I have never taken it this often. Will this finally cure this infection, I've had for years and years? Why or why not? Or Have I been mistaken azithromycin for Erythromycin this entire time and was given the wrong antibiotic?

Any help or insite would be amazing I am really really really super scared! Also I am sorry if this isn't the place to post something like this I just had so many questions about the microbiome recently. Thank you! 💜

1 Comment
2024/10/09
13:09 UTC

5

Thorne stool test showing high amount of human DNA

Hello, I recently did a Thorne gut health test and the results are showing a very high amount of human DNA in the reading. 15% of retrieved DNA was human DNA, compared to a 0.4%-6% reference range (20th/80th percentiles).

Does anyone have any experience with this sort of result?

3 Comments
2024/10/09
19:56 UTC

3

How to increase bacteroides? decrease firmuctes?

Please don't suggest eating beans, plants, fruits as I already eat a lot of those. I believe many of my bacteroides species have been wiped out due to antibiotic use. Therefore, if the species are wiped out, they cannot feed on the plants because they aren't there in the first place.

Which probiotic supplements can I take along with eating diverse plants and a healthy diet to increase bacteroides?

13 Comments
2024/10/07
20:37 UTC

1

Help interpreting GI map and suggestions on how to fix these problems?

Symptoms

-sibo & massive uncomfortable bloating despite treatment (for the past ten years) - I eat a very healthy clean diet but bloat every time i eat (basically eating just fruit, protein, and veggies, and rice at this point)

-constipation and “overflow diarrhea” (i go every day but it feels like incomplete evacuation)

-PCOS and insulin resistance

-slow metabolism- easy to gain weight

-irregular periods

-hypothyroid

-water retention and inflammation

-low bacteroidites and high firmicutes despite eating very healthy diet full of diverse fruits and veggies

What should I do to eliminate the bad bacteria?

2 Comments
2024/10/07
20:24 UTC

1

Smoking is mitochondrial murder and drinking is assault and battery

Agree or disagree

1 Comment
2024/10/06
18:40 UTC

0

Should I do autologous FMT (aFMT) to restore my microbiome after I take antibiotics? | Microbiome FAQ

1 Comment
2024/10/06
12:33 UTC

1

Does enterococcus increase tyrosine hydroxylase levels?

I've been looking into ways to boosting dopamine levels. My past approach primarily focused on supplementing precursors (i.e. phenylalanine; tyrosine; L-Dopa). I was so intrigued that about 50% of body Dopamine is made in the gut according to the citation below. I then bumped into this NCBI study discussing how microbes Enterococcus sp. has the capacity to produce dopamine in a gastrointestinal-like environment when supplied with the dopamine precursor L-3,4 dihydroxyphenylalanine (i.e L-dopa).

There're a handful of commercial probiotics with commensal enterococcus faecalis strains. I was toying with the idea if these probiotics may raise one's dopamine and help with depression/ADHD?

50% of body Dopamine is made in the gut

Dopamine production in Enterococcus faecium

Now i've read that dopamine from the gut doesn't pass the BBB, so there'd be no dopamine increase. but i've read elsewhere that it does somehow increase tyrosine hydroxylase levels

1 Comment
2024/10/05
10:35 UTC

1

Discontinuing clindamycin after possible strep?

2 Comments
2024/10/04
23:11 UTC

3

What can this be? Need urgent help!

I have started to get more gut problems again (have had problems since before but got it fairly under control) however which became worse after I’ve been on vacation! (No viruses or parasites). I suspected some kind of overgrowth after eating more fiber than usual on the trip and therefore tried a supplement with physsilium seeds which made me worse after a week, stopped it, got better but now getting worse and worse. I suspect that I have gotten some kind of overgrowth of bacteria or fungus or something else out of balance, now I need help knowing what it might be based on my symptoms!

Symptoms: lower abdominal pain 2-3 hours after eating, tingling sensation in hands, abdominal pain after pooping, exacerbated digestive issues (already have problems with that), worse when eating physilium seeds, increased bloating, trapped gas and flatulence.

3 Comments
2024/10/02
10:35 UTC

1

Is it possible to get a yeast infection on or in your anus?

Is it possible to get a yeast or bacterial infection inside or on your anus? How is this possible or how does this happen? What does an infection inside or on the anus look or feel like?

12 Comments
2024/10/02
19:06 UTC

1

How to get rid of the candida overgrowth in the gut??

Anyone had experience with candida overgrowth in the gut? How did you get rid of it?

3 Comments
2024/10/02
22:05 UTC

1

S. Boulardii causing ringworm/secondary fungal infection?

This is the second time I’ve contracted a skin case of ringworm on my leg while supplementing S.Boulardii.

Has anyone else noticed an increase in fungal infections while taking it? Been taking it for digestion and overall health.

1 Comment
2024/10/02
02:36 UTC

1

Question on gut health and antibiotics.

I’ve had to complete 9 weeks of antibiotics due to a diagnosis of septic arthritis and osteomyelitis. The first six weeks were via picc line and the last three are oral. What I’ve noticed in the last few weeks is fast weight gain which is not normal for me. I now the antibiotics have played hell with my gut, but can this cause weight gain?

I’m 43 and was very healthy before the infection.

3 Comments
2024/10/01
11:52 UTC

6

Do you or your child experience chronic stomach symptoms and are aged 12-17 years? [Research Survey]

Young people aged 12-17 years who suffer from chronic stomach symptoms, including chronic nausea, vomiting, pain, and gastroparesis, are needed to complete a short, anonymous survey. This survey is open to young people from anywhere in the world. 

Participation is easy and completely anonymous. Simply complete a 15-minute online questionnaire that includes questions about your demographics, symptoms, and wellbeing. Your valuable input will help researchers better understand and treat chronic stomach symptoms, including gastroparesis. 

More information about the survey and the survey link can be found here: https://auckland.au1.qualtrics.com/jfe/form/SV_8fibsg84DNDz3lY 

This study is being conducted by the University of Auckland in New Zealand and has been approved by the Health and Disability Ethics Committee, Northern A, on 24/04/2024, Reference Number 2024 FULL 19553.

2 Comments
2024/09/30
02:46 UTC

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