I’m hoping to learn more about genome editing and the possible benefits in the medical community.

Personally I would love to see the day where we can edit out the possibility of certain neurological conditions.

Hi all,

I'm an Azure cloud engineer, and while my current position doesn't have me working with the genome, I am interested in AI. I found an ai tool on Azure called Microsoft Genomics, which I'd like to do something with but don't quite know what yet. I'm going to be purposefully kinda vague because I don't know if I'm asking the right questions to begin with, but could someone direct me to a (hopefully small/relatively non-technical) resource on:

• where to get a copy of my genome in a data form compatible with Burrows-Wheeler Aligner (BWA) and the Genome Analysis Toolkit (GATK)
• a brief understanding of what each is used for and the type of data I'll receive from it
• perhaps a criteria I can look for in the resulting data to validate my data as well as test something new

If there's a fault with my understanding please guide me towards a better understanding. I think it'd be interesting to build something with this and I'd like to put out a post once I'm done of what I did in case it helps anyone here to run an experiment.

How long does gonl take to approve a data request? Does anybody know?

https://doi.org/10.3389/fpubh.2019.00079

​

Involving people in the future of genomics research is an essential aspect in maintaining public trust, improving research outcomes, and ensuring that access to the benefits of genomics research is equitable. The limited number of initiatives reporting public involvement and its impact in this study suggests there would be significant value in developing a more systematic method of both reporting and evaluating how people are involved in human genomics research. Data from such reporting could provide the evidence required to inform future policy around involvement of the public, as human genomics research continues to grow.

I am from Singapore and 23andMe's health kit is not available here due to regulations etc. But I managed to get the test done when I was in US. Apart from expanding to countries such as Singapore after complying to regulations, what do you think the road ahead is for 23andMe? What is its competitive advantage over other companies doing the same thing?

Genomenon has replaced the manual search process in gene and variant interpretation with THE genomic search engine and database of all the disease-gene-variant relationships found in the full text of the scientific literature called Mastermind.

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I am editing a fiction novel and the author has written the following sentence in regards to a virus:

"We've discovered the strand of DNA that deals with it, but it is so complex we are still just scratching the surface of how to understand the genome behind it."

I am not that educated on the subject of genomics but I know enough that this sentence doesn't make technical sense. I'm aware this isn't the typical question in this sub, but help would be appreciated. Thank you.

Porphyrins combine readily with metals (vitamin B12) of the atoms involved of an electronegativity difference less than 1.67 but greater than zero. To derive theoretical accuracy requirements photo physical properties quantum yield of photocurrent generation by exploiting the existing morphometric data.

– a Stat1, which lacks p48 a repressor region) to mycobacterial disease (disseminated BCG infection or vaccinated BCG locus: 2q32-37) https://www.ncbi.nlm.nih.gov/pubmed/17942530?dopt=Abstract FIGHTING MYOCARDIAL INFARCTION WITH NANOPARTICLE TANDEMS December 2, 2017

http://infowebbie.com/scienceupdate/fighting-myocardial-infarction-nanoparticle-tandems/

Struggling with understanding and calculating qPCR amplification efficiency? This article breaks it down for you in an easy and comprehensible way. It also provides a treasure chest of resources that will bring your qPCR game to the next level -> https://biosistemika.com/blog/qpcr-efficiency-over-100/

Organoid https://m.facebook.com/story.php?story_fbid=10155494290915589&id=96191425588 dynamic communication compartments can ·temporally and spatially· regulate organoid structures dependent on various molecular components and the signal diversification correlates·itself· Cytoplasmic accumulation identified the intracellular hyaluronic acid binding protein* (iHABP) as a potential regulator resulting in cytoplasmic accumulation*.  https://www.ncbi.nlm.nih.gov/pubmed/15809329?dopt=Abstract Along with the regulation further refinements of human Fascin1 function in neuronal morphogenesis with nonrelevant specificities where dendrites contain dendritic spines, small mushroom like protrusions in the parenchyma that offer isolated computational compartments wheremushroom bodies (MBs) are remodeled during metamorphosis into denrites, expression increases with differentiation in culture until nearly all dendritic cells are fascin-positive, confirmed as an SPTLC1 T399G mutation 1q23-q25 Lab-grown ‘minibrains’ are revealing what makes humans special http://www.sciencemag.org/news/2017/11/lab-grown-minibrains-are-revealing-what-makes-humans-special?utm_source=sciencemagazine&utm_medium=facebook-text&utm_campaign=minibrains-16329

Morphogenesis  is the biological process that causes an organism to develop its shape. It is one of three fundamental aspects  unified in evolutionary developmental biology (evo-devo) regulating embryonic Morphogenesis.

including sperm, eggs, and preimplantation embryos developed well until embryonic day 12.5  on day 16/17 at the early secretory phase of human endometrium https://www.ncbi.nlm.nih.gov/pubmed/7758945?dopt=Abstract  [Histological examination of embryos atE15.5 showed.  https://www.ncbi.nlm.nih.gov/pubmed/11807219?dopt=Abstract Lhx3 mRNA accumulates in the Rathke pouch, the primordium of the pituitary (earliest recoginzable embryonic stage) Onecut-2 gene is located on human chromosome 18 differ from, but overlap with, those of HNF-6 required for liver differentiation and metabolism during liver organogenesis, HNF-6 and OC-2 belong to a gene network which regulates liver bud at [day at E10. 5] https://www.ncbi.nlm.nih.gov/pubmed/18058600?dopt=Abstract the onset of liver development at embryonic day (E) 9, without a demonstrable structural pancreatic abnormality phenotype. https://www.ncbi.nlm.nih.gov/pubmed/9441665?dopt=Abstract The protein contains 3 hydrophobic regions in day-13.5 rat https://www.ncbi.nlm.nih.gov/pubmed/9722946?dopt=Abstract The mapping assignment of human IFRD1 to chromosome 7q22-q31  embryonic tissues locus: 7q22-q31 https://www.ncbi.nlm.nih.gov/pubmed/2467301 Revisiting the Warnock rule J Benjamin Hurlbut, Insoo Hyun[…]Laurie Zoloth Is it time to reassess the 14-day rule for human embryo research? https://www.nature.com/articles/nbt.4015

I'm doing the Helicoverpa armigera genome research now using BSA method, but the sequencing company returned me some data that i don't know how to analyze the genome data. If you know some steps or protocols or manuals, please tell me. BTW, I want to find out some resistance gene mutation point in H.armigera.

By evolutionary conflict between males and females, mothers and foetuses, hosts and parasites, and other parties with divergent fitness interests has led to the evolution of genetic systems control over fertilization and cellular resources. The genes involved in such systems promote risks as a secondary effect of their roles in antagonistic coevolution, which generates evolutionary disequilibrium and maladaptation. "It merits whatever except unfamiliarity" http://shoebat.com/2017/10/04/german-government-caught-running-major-slaughter-houses-for-children-fully-grown-babies-are-cut-to-pieces-and-kept-in-freezers-and-the-murderers-are-paid-directly-by-the-german-government/

The hypothalamus is responsible for the regulation of metabolic processes and other activities of the autonomic nervous system. In the understanding of the neuroendocrine regulation in the hypothalamus-pituitary-adrenal axis of normal and pathological hematopoiesis-the formation of blood cellular components of human life, it controls human reproduction signaling, and initiates puberty. The hypothalamic-pituitary-gonadal axis controls human reproduction signaling and implicated as an anorexigenic factor in the central control of food intake, generates seasonal variations in behavior, as well the circadian-rhythm in hypothalamus/pituitary/adrenal axis regulation and subordinate clocks found throughout the body. Biologically the hypothalamus serves the body tissues by attempting to maintain internal hemostasis with the endogenous homeostasis. To cite this AMA please use: https://doi.org/10.15200/winn.151057.77468 You can learn more and start contributing at authorea.com https://www.reddit.com/r/science/comments/7cmp94/science_ama_series_im_seth_blackshaw_i_study_the/

The triple syndrome epidermolysis bullosa/pyloric atresia/aplasia cutis congenita (EB-PA-ACC); being characteristic of lethal variants. Demonstrate for the mutations in nonlethal phenotype of epidermolysis bullosa with congenital pyloric atresia. Pyloric atresia is a primary manifestation rather than a scarring process secondary to JEB Junctional epidermolysis bullosa, excluding the Herlitz form of JEB the antibody which reacts to - subunits, of the triple syndrome epidermolysis bullosa/pyloric atresia/aplasia cutis congenita. Researchers took a dying boy's stem cells, corrected a faulty mutation within them, and used them to replace 80 percent of his skin. http://theatln.tc/2AquuSp

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