I found out I could just prick using the lancet itself rather having to load it in the spring device.

So I got diagnosed with diabetes type 1 a couple of days ago and exactly a week from now I am going to a concert. The doctors have already told me that I should be fine to fly to London over the weekend to attend this concert so that’s not the issue, the thing is is that this is my absolute favorite artist and I have VIP tickets and was planning on getting there early to get barricade. I am just very unsure of how this could interfere with my diabetes, I was planning on eating breakfast/brunch before getting there so I would take my insulin like normal but once I’m there I’m not gonna have a proper lunch or dinner. I’m gonna talk with a doctor abt this to get some professional advice but I was just wondering if anyone here has done something similar and how it has worked out?

For some unknown reason, I see very little discussion of future treatments. Maybe this is completely the wrong place to discuss this. If you know a better place, I'd be happy to receive links there, as it might be more about investing capital.

Biotech in Sweden is getting worse as the development of new drugs is extremely expensive and especially in autoimmune diseases such long study times are required that investors are not interested but want a quick return.

Practice in the media is not to publish articles about ongoing studies.

The Swedish biotech company Diamyd medical AB had 2 Phase III studies in the USA that were started in 2008. In May 2011, the results from the 3 Phase III studies conducted in Europe were published. The result was negative, just under half of the participants had no benefit from the treatment.

https://www.diamyd.com/docs/newsWatch.aspx

9 years later, an article was published in Diabetologia with the title:

"Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes"

https://link.springer.com/article/10.1007/s00125-020-05227-z

That article showed that less than half of those diagnosed with TD1 have genetics that respond to treatment.

When Diamyd medical AB revised the European Phase III from 2011 (the 2 Phase III in the USA were terminated and never evaluated) the result was that everyone with the right HLA benefited from the treatment.

Diamyd medical AB has restarted studies under the name Diagnode-.

Diagnosis-1

In this study, Gad-65 is not given subcutaneously but into a lymph node.

Diagnode-2

Same as Diagnode-1. Was carried out with 109 participants.

Based on the results in Diagnode-1 and 2, Diamyd medical AB received permission to provide additional treatments (boosters) with good results for those who had the right HLA.

Based on the 2020 article, the Diagnode-3 study was revised so that only those with the correct HLA participate. That is, slightly less than half are offered a place in the Diagnode-3 study. Then the study outcome should be closer to 100% who benefit from it.

https://www.diagnode-3.com/

https://www.breakthrought1d.org/for-the-media/press-releases/diamyd-medical-partners-with-jdrf-to-advance-the-diagnode-3-phase-3-trial-in-type-1-diabetes/

Hi everyone! I’m looking for some advice. We live in Pakistan, and we’ve been using cranberry sachets, but they contain sugar, which we’d like to avoid. I recently came across Cran Max Aqua, which I believe is sugar-free. Has anyone tried it?

Also, do you think cranberry capsules might be a good alternative? Any recommendations on sugar-free cranberry options (sachets, capsules, or otherwise) available in Pakistan would be much appreciated. Thanks in advance for any help!

Whenever I wear a Libre 2 sensor, where the sticky patch is in contact with my skin it always sends the area red and blotchy. I know that the skin will do this anyway having something stuck to it for 14 days with no air contact but this look sort like some sort of reaction.

The photo shows what my skin was like after only 1 hour of having a sensor attached. It took 3 days for it to completely fade 😕 That's just a mild one as it was only on for an hour but if it's on for the full two weeks then it's a lot angrier and the redness is a lot bigger. Also, only seems to happen on my left arm bizarrely

(UK)

I've on the Freestyle Libre 2, have been for a couple of years, but lately (within the last 6 months or so) I've been finding that the sensor is very unreliable when it comes to applying a new one.

For instance, last week, my sensor ran out after the normal 14 days. Did the usual and affixed a new one and started it off with the 1hr setup time. 60mins passed and when I tried to scan it, a message popped up saying that there is a error with the sensor and to use a new one. Immediately set off a second and went to bed. When I woke up did a scan "Please wait 10mins". The same message popped up twice more with no data being collected. At this point I ripped it off and went back to traditional blood tests.

This sort of thing has, like I said, happened multiple times this year - not just once or twice but to the point now that I'm questioning if it's just going to be a waste of time and not work anyway...

Has anyone else had this at all?

Does anyone have experience with this and how to potentially handle it? Please note I have advised with my doctor, who suggested increasing basal insulin which didn’t work but I had hypos throughout the day every two hours, so that’s a no go option.

To sum this up, been type 1 diabetic for 18 years now, last hba1c at 48mmol/mol or 6.5% so I like to think my glucose control is good, however the last 6-8 weeks I have been having the following issue. Every single morning there is a sharp spike in my glucose levels, exactly at 3am- have a cgm and I can see the graph, sugars going straight up, from 4.5-6 to 18-22, within one hour or so. My day goes the following way; wake up, stay fasted as long as my glucose levels allow, then eat high protein low carb meal one, pre workout snack, which is some fruits usually or the occasional chocolate, post workout/ dinner is carbs and some protein, I do a mix of weightlifting and cardiovascular training, depends on days; do on average 10-15k steps a day, so quite active. My dinner is around 7pm and I go to bed around midnight; taking Tresiba at approximately 11-11:30pm; my total unit of insulin intake throughout the day is less than my body weight in kilograms, so generally I don’t use to much insulin and my sugars are very steady and within range (5-9) throughout the day. I have tried not eating carbs at dinner but it didn’t work, tried upping my tresiba, didn’t work.

I am aware that it is either the somogyi sindrome or a hgh/ liver glycogen release triggering the sugar spikes, have advised with my doctor but they recommend I increase my tresiba, which seemed logical as I thought my basal insulin might not be covering the 24 hours window, however this was not the issue, as I increased my dosage by 2 units and it hit me with a million hypos so I had to decrease this.

Did anyone experience this and could maybe give a tip on what else to try out in order to stop the spikes?

Sorry this might be a long read - So about 3 months ago I found out my HbA1c was 7.3, I've never had any significant health issues other than being underweight my whole life. I scheduled an appointment with an endocrinologist who ran tests (thyroid, kidneys, liver, etc), diagnosed me with Type 2, gave me an Amaryl prescription, told me not to eat sugar, and sent me on my way. All tests were normal other than high A1c.

A few weeks later, I saw a different endocrinologist to get another opinion and asked about LADA. He said he disagreed with the Type 2 diagnosis, and scheduled me for an OGTT (Oral Glucose Tolerance Test) and to check C-Peptides. Yesterday I went back for the results and found out my fasting glucose was 210 (up from around 80-90 a few weeks ago), 2-hour OGTT glucose was 435, and C-Peptide was 1.7. He told me I needed to start insulin right away, and prescribed me Toujeo 8 units, once daily, as well as Metformin twice a day. I'm still learning about insulin and all the different types, and feeling a bit overwhelmed. I'm scheduled to go back in a month to test for GAD antibodies, to confirm LADA diagnosis.

So, the endo said he was 95% sure it's LADA, but can't confirm until I get the results from antibody tests. One thing I'm confused about is my C-Peptide level. According to my test results, the reference range is 0.9-7.1, with mine being at 1.7. This puts me in the low range. But everything I've been reading online gives different reference values, some say that 1.7 is low, others say it's normal, others even say it's high. There doesn't seem to be a concensus about what a "normal" C-Peptide level is. Does anyone know of any helpful literature that explains this?

The other thing I'm confused about is how much I should alter my diet now that I've started using insulin and Metformin. Because I'm very underweight (to a borderline unhealthy degree), I have to worry about getting enough calories daily. Obviously I won't be stuffing my face with donuts and white bread, but do I really need decrease my carb intake if I'm using insulin? It's just very difficult for me to get enough calories daily if I can't eat carbs. I know that the ideal diet is lots of protien and healthy fats, and vegetables, which I do eat, but it's a struggle to hit a healthy calorie goal with only those foods.

Anyway, thanks to anyone who read all this, I'm just feeling a bit overwhelmed with adapting to this new lifestyle and learning about it.

Curious if anyone had leep surgery and wore their CGM during it? Did you feel anything? I’ve sent a message to my doctor if I’m allowed to wear it during the surgery, and I’m awaiting their response.

A Loop Electrosurgical Excision Procedure (LEEP) is a minimally invasive procedure that removes abnormal tissue from the cervix. A thin wire loop is heated with an electric current to cut away tissue from the cervix.

Hi folks, I was recently diagnosed with type 2 diabetes, i'm sort of a newbie to it despite both parents also having it. If its alright I was wondering if anyone has any fun recipes or anything they can share regarding diet as i'm sort of an "all or nothing" person when it comes to things like this. I don't want to be stuck eating things I don't enjoy (e.g. salads for every meal) i've spoken to my doctors but haven't really gotten anywhere in that department

I'm a dad to a newly diagnosed six year old that now has type 1 alongside adhd and autism. It's the first three days back from the hospital after diagnosis and his numbers bounce around like a yo yo and freak me out. I feel like I'm doing the wrong things, is this normal as we lock in a dosage and stuff? Any advice for a parent? I want to make sure I'm doing this right by my son and any info you guys can offer me would be wonderful, I'm sorry if this isn';t the place for this kind of post but google is extraordinarily unhelpful on this topic.

Do any of you experience back pain that seems to be related to your diabetes?

My loved one gets very severe lower right back pain, which doesn't seem to be tied to her glucose numbers. The doctors have ruled out anything that could be causing it, so I was wondering if it us maybe a common diabetes thing. Thanks.

Anyone here use Metaformin cream in Australia? I hear it is absorbed well and doesn't give you any side effects.

T2D. I tried metformin and had horrible side effects, my doctor told me to stop taking it immediately. (Throbbing headaches, shivering, and I felt so weak and lethargic). I was on 1000mcg daily to start, my A1C was 7.1 when prescribed, no insulin or anything else. I was taking it for less than a week and the symptoms kept getting worse each dose I had.

She now prescribed 10mg of Jardiance and I'm curious to know other peoples' experiences with it? I'm terrified to try another medication if I reacted that poorly to Metformin, which I understand is usually well tolerated. Hype me up please lol.

Hi ! so i’ve been on Metformin XR for about 4-5 months now (1000mg a day) to treat my PCOS and insulin resistance which has affected my A1C levels. i am a 25 year old female, i don’t drink often at all. pretty much just socially maybe once every month or so. and was just wondering if its okay to drink occasionally? and by drinking i mean around 1-3 drinks? i’ve seen mixed reviews online about it, and my doctor never mentioned anything about staying away from alcohol. so just wanted to know what you all here think :) thanks !

Pretty much the title says it all. I have MODY, but I don’t have the need for insulins and such. I was given a Dexcom once as a test before she discovered that I am pre-diabetic and have MODY, and have given me a second one to keep.

I am currently holding on to it and have zero purpose for it. Do I just use it whenever?

I'm prediabetic but when I'm bleeding my cravings and hunger are so insatiable. There's a lot of pain, eating and lack of physical activity. I'll talk to my primary about this when I see them but now I want to hear from other people.

I was recently diagnosed during a routine physical exam in late July. This diagnosis has been both a gift and a curse.

Since then, I’ve started working out 5-6 times a week, cut back on takeout, and reduced carbs overall. I’m aiming to reach a controlled, acceptable range the next time my A1C is tested. My cholesterol and triglycerides are also in a good range, which is encouraging.

The doctor started me on Mounjaro at 5mg, and I’m hopeful he’ll be pleased with my progress and won’t need to add any more medication.

For now, I’m counting this as a win!

Starting weight January: 450 lbs

Weight at diagnosis: 416lbs

Current weight: 375 lbs

Hello guys! Does anyone use Accu-check Instant to check their FBS? I'd like to ask if 10hrs of fasting still valid or should I follow the 8 hr fasting rule for FBS? Is water also okay while fasting for fbs test? Thank you

I was asked to use Agamatrix device to poke my fingers 4x per day, to test my blood glucose level.

I wonder at what time after having a meal should I conduct the test? The instruction says 1 hour after a meal. Say I start dinner at 7pm, and finish by 7:20pm, is my test at 8pm more accurate? Or at 8:20pm?

Hi I’m a women and recently my hair started falling out in chucks, let’s just say, I can see more scalp then hair. Has this happened to anyone else because of diabetes?

So my insurance has denied my insulin because it’s ’not medically necessary’ and I’ve been out of insulin for over a week now. I’m going out of town for work tomorrow morning. Anyone have any idea if the over the counter insulin will work in a pinch?

Edit: Thanks everyone. I called teladoc and got an emergency prescription and it’s been filled. Still not sure what I’m going to do with the mail prescription, but at least I’m covered for a bit

Sorry guys might be a girl thing but I’m new to all of this and I’m finding my average glucose the week of and the week prior to my time of the month run above 100 but below 110. And if I eat basically anything it jumps fast to 140-150 and stays for over an hour. However in comparison the following weeks after my period it’s like I don’t even have pre diabetes. Average bg is 90 and never goes above 120 after I eat and immediately goes down after the peak. My dr says it’s normal for women but it just doesn’t feel right. I have a cgm currently not covered by insurance and I prick my finger three times a day to check. I really don’t want to get full blown type two and I’m finding it really hard to manage in the two week time frame. Any advice or any help or suggestions would be lovely. Thank you in advance. Also I’m female age 28 and 175lbs (Trying to lose weight)

Newly diagnosed DM Male 38 years HbA1c 8.9 % Microalbumin 73 mg/mmol On dapaglifoxin/metformin 10/1000 mg What is the long term prognosis? How about progression to renal failure?