i just need to make ruse

I thought u were supposed to start at 12.5mg but the prescription bottle just says take one (25mg) tablet once daily

Is it ok to start at 25? Or should i cut one in half for the first night?

How slowly did you lower your dose and by what mg? How did you tolerate it? How long did it take for you to adjust?

Hello people,

I got sick since October 2021. I quit job and studies because if violent delusions. Have tried many different antipsyhotics or combinations of them. Nothing was working. Either I wasn't drinking them not long enough cause I couldn't bear the side effects, and I was decreasing the dosage. Or they were not helping me. In the year 2022, I got treatment with clozapine (200 mg) and abilify (15 mg), in the clinic. This wasn't helping me, and then after 6 months I changed meds to olanzapine and abilify, but lower dosages. Nothing. I was totally dysfunctional. So the year 2023 was basically just wasted as well, I was laying in bed thinking about my delusions. And in October 2023, I was talking with the psychiatrist, and asked that maybe I can give a try to clozapine again. But monotherapy.

So, I started to take 25 mg in October 2023, and after maybe 6 months, I started to have some improvements in my symptoms. When I was trying to increase it, I felt worse and went back to the 25 mg. At that time I was also taking antidepressant, which probably was doing worse to my symptoms. Then I quit paroxetine, and was taking only clozapine. I finally could go and make groceries, I started to talk with my friends and so on. But I still had the feeling that those weird thoughts are sometimes there. And it was really hard to understand whether I think about them because of the whole trauma and having them for such a long time, or there is not enough of meds. How to understand this?

Finally, I have decided to give it a try and increase the dosage to 37.5 mg of clozapine. First week I was feeling terrible, now it's a little bit better, but it became harder to think and find the right words when I talk. But generally, I think my thoughts are more calm.

And now the question comes, is it too late to increase the clozapine as I did, after 1 year because I thought I still have some breakthrough weird stuff in my head? Cause it's already 3 years since I am sick and I started to take it only one year ago. And maybe 25 mg were fine, I just don't know what I am doing know and if it's bullshit and I should come to the previous dosage. Kinda confused and so tired after all this at the same time. And the stupid thing is that I wasn't increasing it since I started in October 2023. I have no idea why. Maybe because I thought that it is somehow helping and I felt probably that's enough. And i was always home, there was no pressure on me to find the job and start doing smth.

I just want to come back to work at least. And I feel to stupid now. About studies I am not sure yet. Almost all of these 3 years I spent at home.

Need some advice.

Could a anticholinergic like Benztropine work since antispcyhotic withdrawal causes cholinergic rebound?

What symptoms does clozapine exactly help with? Just the positive? Can it help negative ones like anhedonia, avolation, asociality, alogia too?

As far as my symptoms go, I personally only have paranoia (only at night) as my delusions COMPLETELY disappeared after 3 doses of Invega (bizarre, I know). But I’m hoping it would help with flat affect, anhedonia, and all the other negative symptoms.

I’m EXTREMELY prone to akathesia, but from what I read clozapine targets dopamine receptors least associated with movement (and therefore less likely to get akathesia).

Do you guys think it’s worth a shot? Especially if I’ve tried over 10 antipsychotics without ANY benefit?

Anybody read up on niacin deficiency and schizophrenia? I want to start taking niacin but my psychiatrist is least interested. I'm thinking of starting it with very less dose. I want to know if it has any interraction.

What do you wish people would have told you before starting clozapine? Im due to start as soon as my labs come back and insurance approves it. Prolly early nxt wk since its already Friday and i just did lab work yesterday afternoon and my pdocs office closes at lunch today

What should I expect? This is one of two of basically my last options.

If it helps, i’ll be taking it for chronic active SI. I am dx with schizoaffective bipolar disorder.

I'm 3 kilos down in the past month. It's quite a struggle with constant food cravings, but I'm getting there with altered food choices/meal sizes and working out daily. I'm aiming for 10 kilos weight loss in the next two months.
How are others going with this?

I m dobe with this med. Did not feel any changes, but in my weight. I never gain 10kg, this is disrespect to me. I m done.

How many of you did experienced weight gain? I got 10kg in 1 month.

Should I ask my doctor tomorrow about it and maybe change it.

Hi - have anybody herd of this study? And what do you Think about it? https://www.tandfonline.com/doi/full/10.1080/2314808X.2024.2335855

https://apps.apple.com/au/app/mycloz/id6667110848

So I am taking 100mg on daily basis clozapine. Doctor prescribed me clozapine more than month ago.

And I really feel better (less mood swings and anxiety).

My mom started Clozapine last night as replacement for Rivotril. Can Clozapine handle the withdrawal symptoms of Rivotril?

The reason why the doctor prescribed her of Clozapine is because she started having hallucinations again from weaning her off of Rivotril.

She’s also taking Quetiapine 600 mg (300 mg jn the morning and 300 mg at night).

I just started on clozapine, I’m on day 4. I’m super dizzy, have trouble walking, and have spikes of anger. It also knocks out all energy. Should I stick with it? Does it get better?

Just wondering if anyone else goes through what I do.

This my therapy:

lamotrigine 200mg sertraline 125mg clozapine 100mg prazimen 100mg zopiklon 7.5mg

So this is my therapy, in two months I tappered first 50mg of sertraline last two weaks secondly 25mg -> so now I am on 125mg.

But I went trough some dark times, bc gf left me. So my mood went up and down ever two hours. So therapist put me gradually on 200mg (teo days ago went to 200mg). Also clozapine three weeks ago.

I' m also doing TMS.

Thank you for reading.

I was at 300 mg for several years for schizophrenia. After lowering the dosage slowly over a few years with doctor visits, I have now been stable at 50 mg for 3 years.

A 12.5 mg reduction and then wait 3 months seems to be the best way to do it. Your doctor may want to keep you at a higher dosage, this is just my story, everyones brain is different!

I actually went down to 25 for a period of time, but I could feel that it wasn't really doing its job, so I went back to 50 and it's been fine.

I just started a couple of weeks ago. I'm on 150 mg now and will increase to 200 mg on Monday. I get so so sedated from them. I take them at night and try to fall asleep before, but aren't always able. I also wake up from the severe sedation sometimes since it makes me uncomfortable and I drool my entire bed wet. Sometimes if I wake up and have to go to the toilet, I feel like I'm 90 yo, like I feel so weak I almost can't stand up from my bed or walk. I can't talk properly either. Feels awful. Is this something that's just in the beginning? I wake up in the morning without these symptoms, but I also struggle to wake up in the morning now (which I usually don't struggle with, I'm an early bird that prefers mornings so this really bugs me too), I struggled with waking up on Olanzapine too. Anyone else sleeping "too" much? I also feel more tired throughout the day, often in need of a nap.

I'm so nervous of the side effects. I hope it's worth it. At what dose do you start noticing a difference?

Anyone here on clozapine and some heart rate meds? Have they helped you? Which one are you on?

I’ve been on Clozapine for about 4 years now and I have been drooling a lot every night. It doesn’t bother me a whole lot unless I’m sleeping with someone or in someone’s else’s bed. Has anyone found a way to lessen the drooling side effect.

Update: I tried Atropine 1% in the tongue before I fall asleep, it worked very well. I would recommend it!

Just started Clozapine a week ago. I'm at 25 mg now. Anyone else having blurry vision? It's duable for me as long as the med will work, and I don't have a lisence or anything so that's no issue. My glasses will not correct this blurryness and I have no other explenation for it than it being the med. It can get very hard to read because of it.

My doctor may prescribe clozapine as nothing is working for me, but he said it would be the last one we try due to the monthly blood tests. What makes this medicine work when all others fail?

The mechanism by which clozapine exerts its effects involves the blocking of 5-HT2A/5-HT2C serotonin receptors and the D1-4 dopamine receptors, with the highest affinity for the D4 dopamine receptor.

Hi, I know this is a difficult question to ask since it differ so much, but I just started Clozapine and I wonder at what dosage people started feeling an effect? I'm still only at 25 and will increase to 50 tomorrow. Then increase by 25 later next week or beginning or the one after (I have some weird body that gets all the strange side effects so they're upping my dose really slow, but I'm struggling a lot with bad symptoms so it's hard).

Our psychiatrist wants to add latuda in addition to clozapine to help with stress-induced psychosis.

Has anyone else been on this combo? How did it work for you and what side effects did you experience?

sometimes i’m thinking about my limbs moving and it’s like the signal doesn’t go from my brain to my limbs and im paralysed

I was so happy to take it but then it turned out I can’t ,sad:/