Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle | bioRxiv

Would you get sick with both at the same time??

or would the stronger of the two virus win out and infect you???

If the later is true could we potentially use other viruses to stop other viruses from killing us...

Imagine if we found an aggressive influenza strain (or really any type of virus we had immunity too) that had the ability to knock other viruses out of the cell. Then our immune system could take care of that virus

I understand experimental research into this topic would be immoral and impractical but I always thought it was an interesting concept...

I don’t have a medical background and am certainly not a virologist, so apologies in advance if this is a really dumb question. I just haven’t seen it asked elsewhere and am curious.

Could the RNA fragments that are being found in pasteurized milk samples produce any kind of immune response?

Hi all.

I'm quite frustrated with my thesis at the moment as my supervisor keeps telling me I need to add the data from my plaque assays. But I have. I have included pictures (not too much) labeled them, calculated the PFU/ml, and wrote about 80-100 words on each section. I'm confused about what more she wants? The reasoning and problems and similar study findings have gone in my discussion section so I have no idea what she actually means. I would appreciate any help 🙏🏻

I know this will probably get deleted or reported and I'm sorry but I've been kind of spiraling on here over the last few days because of H5N1 and all this speculation in the news and on that r/H5N1_AvianFlu subreddit which reminds me of r/Coronavirus especially during the early parts of 2020.

​

Not to sound melodramatic but with H5N1 do we need to head for the hills again like its 2020? Professor Vincent Racaniello doesn't seem convinced but others seem pretty worried right now.

Hi everyone, does anyone know the best online video lectures specifically for Medical/Clinical Virology, the kind taught in Med school. Now before you go off the rail with Racaniello's Virology lectures, they are much more virobiology than Clinical virology, I have also seen lecturio, osmosis and sketchy but I need something really detailed on a graduate level that goes in to the molecular mechanisms of the disease causes and the according pathophysiology. Thank you!

I need to create a viral culture, I intended on incubating some cells in FBS and infecting it with my virus, then incubate for a few hours at 36-37C. And then storing the culture at -20C, or perhaps dilute it first in some glycerin before storing at -20C.

I know it would be ideal to store the virus at a temperature like -80C but currently my lab can only provide -20C. Can anyone provide me with any insight in how I can store the cultured virus healthy for as long as possible? Should I dilute the FBS culture with glycerol? Maybe with something else? Should I try separating the virus with a centrifuge for storage, or perhaps leave it with some cell in FBS?

The BV-BRC is tracking the H5N1 spread very closely, and we want to remind researchers we can help ease sequence submission to Genbank- our team is ready to help make this genomic information accessible - check out our sequence submission tool here.

https://www.bv-brc.org/app/SequenceSubmission

It is standard practice to obtain an HA titer of 8 with an influenza virus sample before conducting the Hemagglutination Inhibition Assay.

Where did 8 come from, and what is the logic behind this standardisation?

Both types can infect animal and human hosts and undergo recombination? I’m curious why Influenza B cannot undergo antigenic shift like A can and acquire new antigen genes following co infection with another virus

I am terrified about H5N1. Like really terrified.

Hi all,

I wanted to reach out and see if anyone has some good resources around surveillance data regarding Chikungunya. I have found some decent sites like PAHO/WHO Data - Weekly Report and Chikungunya worldwide overview (europa.eu) but I'm curious if anyone has any others.....or if anyone living in places like South America have information based off of their own experiences.

Now that I have a vaccine to use for patients (I see a lot of international travelers), I want to be able to give the best advice. I am indeed aware of CDC recommendations and the indications of use for IXCHIQ, but a lot of times my patients come in needing a whole variety of stuff and they try to ask me for quite granular detail so they can justify the expense of the vaccines recommended.

I know it is a really awful illness - every patient I've met that has personally had it in their past has terrible things to say. So it's definitely a vaccine I don't just want to brush off.

I know Brazil has a high case count, Paraguay, Argentina, and even some in Bolivia......Timor Leste....but just curious about any other input you might have

Hi! I'm 19 and currently doing a bachelor's in Biological Sciences here in Brazil, I have a huge interest in infectious diseases and for the past few years viruses have really caught my attention (I suppose the pandemic had some sort of effect on it).

However I'm quite confused about how to pursue career in the field. I know that have to get a PhD, and I'm more than willing to do that!

I tried searching around the web for info on career paths and tried asking some of my professors, but some ideas clashed, such as: Part of the internet seems to highlight doing a graduate studies in Molecular Biology first as it would give me a more solid grasp of the molecular techniques and concepts that permiate virology, how ever my professors recommend going straight for a microbiology master's and PhD focused in virology.

What is the difference between working for Industry and working Academia? I did have an interest more for academia, but everywhere in the internet basically screamed "Academia is literal hell"

I'm sorry if this is a dumb question, I've just been trying to find an answer, I was kinda reluctant to post this here but here we go! Thanks in advance!

How would you describe reasons behind viruses origins? to my understanding its a foreign DNA/RNA fragment that circulates in nature,infecting everything from fungi to plants and animals. but does it imprint its DNA into what/who it infects? are viruses necessary for evolution? I am looking to find good theories and literature on this subject.

Hi there I’m 19 years old and I am about to go back go community college, and virology has always been a huge fascination and interest of mine! It’s so amazing and scary how something so small can affect so many living things. I’m writing this because I’m curious how much effort and work it would take to get a masters or PhD in virology? I’ve always had a bit of trouble with school but I really want to try and reach my goal! Any advice is appreciated

Just wondering with the milk thing nowadays.

I read Quamen's Spillover, Preston's The hot zone and Demon in the freezer and recently Level 4 virus hunters of the cdc.

Anyone have any similar non textbook but non fiction recommendations for similar virology books ?

Maybe focusing more on the laboratory aspect of virology or just similar stuff ???

What’s approximately the probability of transmission from skin to skin or mucosa to mucosa/skin contact?

I've been trying to figure this out for days, and I am stumped. In Shiga toxin producing E. coli, the toxin is encoded in a prophage element and cleaves the 60S portion of the ribosome inhibiting protein production.

How does this benefit the virus? The virus needs the ribosome to produce their proteins.

Recently while searching on the internet on how to get into disease ecology came across the term virus hunters which blew up during covid19 correct me if I am wrong isn't it a glorified term for disease ecological cause the people shown in the videos and articles are not virologist by training like professor Racaniello they are mostly ecologist with zoonotic infection specialization.Also would like to get into disease ecology so any advice would be great Ps I have a bachelor's triple majors in Chemistry, Botany and zoology from India any advice for masters would be great. Thank you!!

Not sure if this is entirely allowed but I’m working on a sci-fi story that revolves around a virus, its potential effects on a species, as well as the development of an antiviral/vaccine. I would love to make this fictional story seem at least semi-plausible. I've done a bit of research, but can't find straightforward answers for some of it, so I've come here to pick some brains. It’s important to me for readers with a scientific/medical background to feel like the science is well represented…er,  as well represented as it can be considering the hypotheticals are on the extreme end haha

If you’re open to DM’ing, let me know!