Vape fiend have the 3 pack of cooling units on offer...might be worth a look!

https://vapefiend.co.uk/products/venty-cooling-unit-x-3

Just want to know if it's worth saying that I know the medicatin will work because I've tried it already.

Cheers.

Hi guys, I have just bought myself the Tiny Might 2 and I was wondering what are the recommended must haves for this vaporiser?

I am new to vaping and after reading a lot about the Venty, Mighty plus and Tiny Might 2, I have decided to go for the Tiny Might 2.

Previously I was a pipe/bong user.

Has anybody got any experience of obtaining a medical cannabis license after being sectioned? I will be discharged from a section 3 in a couple days from “drug induced psychosis”

I am wondering if this will affect my ability to obtain a cannabis license. I have chronic pain and wish to treat it with Medical marijuana but am cautious with my medical record now if it will clash with the psychiatrists I will be seeing as part of my after care from discharge. And whether the doctors at curaleaf will deny me based on recently being sectioned. Thanks in advance to anyone who knows anything

Should I be concerned? My parcel hasn’t been updated since leaving South Midlands MC. Yesterday was bank holiday in Scotland but as far as I’m aware this shouldn’t have affected mail sorting at large distribution centers

Sativex / nabiximols contains 4% thc and 4% cbd. it costs £375 for a 30ml bottle.

My 2% thc from curaleaf costs £80 at 2%, so £160 for 4%. I buy CBD isolate for £6 a gram so £166

£209 overcharge???????????

and pound for pound, if we look at the 5% oil its £115 (+6=121). a £254 overcharge

and for the 10% oil its £195 (+6 = 201). its 2.5 times stronger, so 201 /2.5 = £80. a £295 overcharge

So we or the NHS are paying £295 extra in a £375 bottle. a staggering 79% mark up.

and lets face it, that sativex oil contains 1200mg of thc. one plant can produce 100grams (very low estimate) of 20% thc for 20grams of thc. This makes one plant worth 20/1.2 x £375. = £6 250.

Its ridiculous.

Has anyone tried saw this on Montu may try it out

The more I get used to vaping my cannabis, (I've never had any cannabis before), the more I realise I can't put up with the taste. I find myself only drawing from the vape 3-4 times as I try to get the taste off my breath, as it's gross. I think my neurospicy brain has decided it doesn't like the taste and that dislike is now being amplified. Which has really annoyed me because it's working well.

I've got some spearmint tea to sprinkle in with it, but is there anything else I can do?!

Anyone got experience of sending poor quality meds back? My partner has tried Grow original blitz this month and it's really poor, dry as shit with no calming effect, he's got 20g was wondering whether we could send 10g back and get a prescription for 10g of something else? Has anyone had similar experience? If you order meds that are poor quality or negative effects for you do you still have to wait for a new prescription to be due to get different meds or can you send back? Thanks 🙏

You said:

Do humans naturally produce cannabinoids to interact with the receptors of the endocannabinoid system?

ChatGPT said:

Yes, humans naturally produce cannabinoids known as endocannabinoids that interact with the receptors of the endocannabinoid system (ECS). The ECS is a complex cell-signaling system present in the human body and plays a critical role in maintaining homeostasis, regulating various physiological processes like mood, appetite, sleep, immune response, and pain sensation.

Key Components of the ECS:

1. Endocannabinoids: These are lipid-based neurotransmitters that the body produces naturally. The two most well-studied endocannabinoids are:
   • Anandamide (AEA): Often called the "bliss molecule," it is associated with mood regulation, pain, and appetite.
   • 2-Arachidonoylglycerol (2-AG): Plays a role in immune system function and inflammation.
2. Cannabinoid Receptors: These are the sites where endocannabinoids bind to exert their effects. The two primary receptors are:
   • CB1 receptors: Found mostly in the brain and central nervous system.
   • CB2 receptors: Found mainly in the immune system and peripheral tissues.
3. Enzymes: These break down endocannabinoids after they have carried out their function. The key enzymes are:
   • Fatty acid amide hydrolase (FAAH): Breaks down anandamide.
   • Monoacylglycerol lipase (MAGL): Breaks down 2-AG.

How Endocannabinoids Work:

Endocannabinoids are synthesized on demand, meaning they are produced by the body only when needed. They bind to CB1 and CB2 receptors to regulate processes like pain signaling, immune response, and emotional states. This helps the body maintain balance and respond effectively to changes in the internal or external environment.

The discovery of the ECS highlights its role in overall health, and its interaction with plant-derived cannabinoids, such as THC and CBD from cannabis, has spurred interest in its therapeutic potential.

You said:

Could you argue that the cannabis plant is another natural source of cannabinoids?

ChatGPT said:

Yes, you could argue that the cannabis plant is another natural source of cannabinoids, but with an important distinction: the cannabinoids found in cannabis, known as phytocannabinoids, are external compounds that mimic or influence the activity of the body's naturally produced endocannabinoids.

Key Points Supporting This Argument:

1. Phytocannabinoids in Cannabis:
   • The cannabis plant produces phytocannabinoids, which are structurally and functionally similar to the body's endocannabinoids.
   • Notable phytocannabinoids include:
     • THC (tetrahydrocannabinol): Binds directly to CB1 receptors in the brain, producing psychoactive effects.
     • CBD (cannabidiol): Modulates receptor activity indirectly, promoting balance without psychoactivity.
     • Others include CBG (cannabigerol), CBN (cannabinol), and THCV (tetrahydrocannabivarin).
2. Interaction with the Endocannabinoid System:
   • Phytocannabinoids interact with the same receptors in the endocannabinoid system (CB1 and CB2) as the body's own endocannabinoids.
   • For example, THC mimics anandamide by binding to CB1 receptors, while CBD can inhibit the enzyme FAAH, increasing levels of anandamide in the body.
3. Natural Origin:
   • Cannabis is a naturally occurring plant that has evolved to produce cannabinoids as part of its secondary metabolites, potentially for self-defense or interaction with the environment.
   • Humans have a long history of using cannabis for medicinal, spiritual, and recreational purposes, suggesting a natural synergy between phytocannabinoids and the human ECS.
4. Supplementing the ECS:
   • Some people argue that phytocannabinoids can help "supplement" or "support" the endocannabinoid system, particularly in cases where endocannabinoid production is insufficient or dysregulated (a hypothesis referred to as Clinical Endocannabinoid Deficiency).

A Complementary Natural Source

While endocannabinoids are produced by the body, phytocannabinoids from cannabis offer an external, plant-based source of compounds that interact with the same system. This makes cannabis a unique plant in nature, capable of influencing a wide range of biological processes via the ECS. However, it's important to recognize that phytocannabinoids do not replace endocannabinoids; rather, they complement or modulate the system.

You said:

What causes endocannabinoid production to be insufficient or dysregulated (a hypothesis referred to as Clinical Endocannabinoid Deficiency) within humans?

ChatGPT said:

Clinical Endocannabinoid Deficiency (CECD) is a hypothesis suggesting that a dysfunction or insufficiency in endocannabinoid production or signaling within the endocannabinoid system (ECS) may contribute to the development of certain chronic conditions. While CECD is still being researched, there are several potential factors that might lead to insufficient or dysregulated endocannabinoid production:

1. Chronic Stress

• Impact: Prolonged stress can disrupt the balance of the ECS. High levels of cortisol (the stress hormone) may impair endocannabinoid synthesis or reduce the sensitivity of cannabinoid receptors.
• Outcome: Reduced ability of the ECS to regulate mood, pain perception, and other stress-related processes.

2. Poor Diet and Nutritional Deficiencies

• Omega-3 Fatty Acids: Endocannabinoids are synthesized from fatty acids, especially omega-3 and omega-6. A deficiency in omega-3 fatty acids may impair endocannabinoid production and receptor function.
• Imbalance: Diets with an excessive omega-6 to omega-3 ratio may also lead to dysregulation.
• Nutrient Deficiencies: Deficiency in nutrients like magnesium, zinc, and vitamins D and E may negatively affect ECS functioning.

3. Lack of Physical Activity

• Impact: Regular physical activity has been shown to boost endocannabinoid levels (e.g., anandamide) and support ECS health.
• Outcome: Sedentary lifestyles might reduce endocannabinoid production and impair the system's efficiency.

4. Chronic Inflammation

• Impact: Inflammation can dysregulate the ECS by either overactivating or desensitizing cannabinoid receptors.
• Outcome: This creates a negative feedback loop, where the ECS struggles to restore balance.

5. Genetic Factors

• Variations in ECS Genes: Polymorphisms in genes coding for cannabinoid receptors (CB1, CB2), enzymes (FAAH, MAGL), or endocannabinoid synthesis pathways may reduce the system’s efficiency.
• Outcome: Some individuals may have a genetic predisposition to an underperforming ECS.

6. Exposure to Environmental Toxins

• Impact: Pesticides, heavy metals, and other environmental toxins may disrupt ECS signaling pathways by interfering with receptor binding or endocannabinoid metabolism.
• Outcome: This can impair the body's ability to maintain homeostasis.

7. Chronic Disease and Aging

• Impact: Conditions like obesity, diabetes, and neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) are associated with ECS dysfunction.
• Aging: As people age, natural endocannabinoid production tends to decline, leading to reduced ECS activity.
• Outcome: Impaired ECS function can exacerbate age-related or chronic health issues.

8. Psychological Conditions

• Impact: Depression, anxiety, PTSD, and other mental health conditions have been linked to altered ECS function, often involving reduced levels of endocannabinoids like anandamide.
• Outcome: This could result in reduced stress resilience and emotional regulation.

9. Sleep Deprivation

• Impact: Sleep deprivation has been shown to lower endocannabinoid levels, affecting mood, appetite, and cognitive function.
• Outcome: Chronic sleep issues may contribute to ECS dysregulation**.**

10. Drug Use and Overstimulation of the ECS

• Impact: Chronic or excessive use of exogenous cannabinoids (e.g., THC from cannabis) can desensitize CB1 receptors, making the ECS less responsive over time.
• Outcome: This can lead to a "downregulation" of receptors, where the body’s natural endocannabinoid system becomes less effective.

Conditions Linked to CECD

Several conditions have been hypothesized to involve CECD:

• Migraine
• Fibromyalgia
• Irritable Bowel Syndrome (IBS)
• Post-Traumatic Stress Disorder (PTSD)
• Chronic Pain Syndromes
• Neurological Disorders (e.g., epilepsy, multiple sclerosis)

Supporting ECS Health

To maintain a healthy ECS and potentially counteract CECD, people can focus on:

• Consuming an anti-inflammatory, omega-3-rich diet.
• Managing stress through mindfulness, meditation, or yoga.
• Exercising regularly.
• Getting enough sleep.
• Avoiding environmental toxins and excessive drug use**.**

While CECD remains a theoretical framework, ongoing research continues to explore its validity and implications for treating chronic conditions.

You said:

Could a once-a-week uptake of phytocannabinoids help to "supplement" or "support" the endocannabinoid system and produce positive effects?

ChatGPT said:

A once-a-week uptake of phytocannabinoids could potentially help "supplement" or "support" the endocannabinoid system (ECS) and produce positive effects, depending on the individual's physiology, the type and dosage of phytocannabinoid, and the intended outcomes**.**

Here’s how and why this might work:

How Phytocannabinoids Can Support the ECS

1. Mimicking Endocannabinoids:
   • Phytocannabinoids like THC and CBD interact with the ECS by binding to or modulating CB1 and CB2 receptors, similar to the body's natural endocannabinoids (e.g., anandamide and 2-AG).
   • Regular but moderate supplementation could help maintain balance in cases where the body’s production of endocannabinoids is insufficient or dysregulated.
2. Prolonging Endocannabinoid Effects:
   • CBD, for instance, inhibits the enzyme FAAH, which breaks down anandamide. This can increase anandamide levels, potentially boosting mood, reducing stress, or alleviating pain.
3. Resetting Dysregulated Systems:
   • Occasional intake of phytocannabinoids may "nudge" an underactive or dysregulated ECS toward homeostasis without overstimulating it. For example, CBD's anti-inflammatory effects can help regulate immune responses.

Potential Benefits of Weekly Phytocannabinoid Use

1. Reduced Stress and Anxiety:
   • Moderate doses of CBD or THC have been reported to promote relaxation and reduce anxiety, providing a "reset" effect for stress-heavy weeks.
2. Improved Sleep:
   • A weekly dose of CBD (and in some cases THC) may help with occasional sleep difficulties by promoting relaxation and regulating circadian rhythms.
3. Pain and Inflammation Relief:
   • For those with chronic or intermittent pain, phytocannabinoids can provide anti-inflammatory and analgesic effects.
4. General Mood Support:
   • Elevating endocannabinoid levels or mimicking their activity can improve overall well-being and mood balance.
5. Neuroprotective Effects:
   • Regular but spaced-out phytocannabinoid use could help protect neurons, potentially benefiting cognitive health over time**.**

Why Weekly Use May Be Beneficial

1. Prevents Receptor Downregulation:
   • Frequent or excessive THC use can lead to CB1 receptor downregulation, reducing sensitivity over time. Occasional (e.g., weekly) use might avoid this issue, keeping the system responsive.
   • CBD does not cause downregulation, making it a safer option for regular use.
2. Supports Endocannabinoid Deficiency:
   • For individuals with suspected Clinical Endocannabinoid Deficiency (CECD), weekly phytocannabinoid supplementation could help "fill in the gaps" without risking over-reliance.
3. Minimizes Side Effects:
   • Spaced-out use reduces the risk of developing tolerance, dependency, or unwanted psychoactive effects (in the case of THC).

Considerations for Positive Effects

• Type of Phytocannabinoid:
  • CBD is generally non-psychoactive and well-tolerated, making it a good choice for weekly support.
  • THC may also be effective but should be used cautiously, especially if psychoactivity is a concern.
• Dosage:
  • Effects are highly dose-dependent. A low to moderate dose may be sufficient for benefits without side effects.
• Individual Variation:
  • Genetics, lifestyle, and baseline ECS activity all influence how phytocannabinoids affect an individual.
• Method of Administration:
  • Sublingual oils, edibles, or capsules are longer-lasting and may suit weekly use. Inhalation (e.g., vaping) offers quicker effects but shorter duration.

Caveats and Risks

• Not a Cure-All: While phytocannabinoids may help, they are not a substitute for a healthy lifestyle or medical treatment for chronic conditions.
• Legal and Safety Considerations: Ensure compliance with local laws and use products from reputable sources.
• Interaction with Medications: Phytocannabinoids can interact with medications, so consult a healthcare professional if you're taking other drugs.

Conclusion

A once-a-week phytocannabinoid regimen could help support the ECS and promote positive effects, particularly for individuals dealing with stress, mild inflammation, or occasional sleep disturbances. However, effects vary by individual, and a cautious, personalized approach is key to achieving the desired benefits.

I've been using an Arizer Solo 2 for a few years. This Mighty hits harder, for less time than the Solo 2. But the solo has better flavour I think, and the flavour lasts longer. The mighty takes an age to heat up, too.

I was thinking about upgrading to a Mighty or Solo 3. Having tried the mighty now I'd say if I was paying I'd opt for a Solo 3. Still, very happy to have this thing, might sell it though

Actually found this to be a pretty good read and good general exposure for medical cannabis. https://search.app?link=https%3A%2F%2Fwww.bbc.co.uk%2Fnews%2Farticles%2Fcrr5jr888p1o.amp&utm_campaign=aga&utm_source=agsadl2%2Csh%2Fx%2Fgs%2Fm2%2F4

Hi guys. A good friend has just got diagnosed with MS. I've recommended she self refer for pain, anxiety, inflammation etc associated with the condition. Can I ask anyone that's medicating for MS what their experiences are please? Best strains, effects on the condition or whatever you think would be useful to know? Thanks

Im fairly new to MC and have only tried a few of the cheaper strains on Curaleaf, GG4, Tripoli & cattatonic. Are the strains at the higher prices better and worth the extra?

I've posted this elsewhere and I just thought people here would be interested

https://petition.parliament.uk/petitions/700385

My medication arrived about 1 hour ago. The above pic it is with my new ‘gear’ (“I’ll take one medical cannabis please”).

My timeline (for those doing research) was as follows: completed the Alternaleaf online form on 12.11.24, had my first online appointment with the pharmacist on 18.11.24, second online appointment with the Doctor 26.11.24. He sent the prescription through the next day and it was delivered to my house today 30.11.24. The whole process took 18 days.

Thank you everybody on this sub for your help, the research and things I discovered on here has been incredible. Even the Dr directed me here to discuss strains etc.

If you’re considering it then please go for it. I love this stupid magical plant so much.

For anyone looking to travel to Sweden with their prescription, I can confirm it IS doable.

I'd previously read here that it looked pretty unlikely due to Swedish laws on cannabis, specifically flower, however after a few weeks and back and forth I've received permission to travel for four days with my prescription.

https://www.lakemedelsverket.se/en

Specifically this form:

https://www.lakemedelsverket.se/en/forms/application-for-dispensation-regarding-import-of-medicinal-products-for-personal-use

You need to upload a letter from your prescriber and need to input quite a few details, including how traveling without your medication would negatively affect you. They may get back to you wanting more information, but ultimately it was approved after a few weeks and they sent a letter to my home address to take with me if any issues came up.

Will update if there any issues.

Hi!

First issue I've had since being a MC patient with cantourage in 6 months- every month without fail, on mostly Saturdays ( I know that RM Special Delivery 1pm is not guaranteed until Monday) i would always receive my monthly repeat the day after providing paid for before 12:30/13:00.

I paid around 11:30 yesterday morning and called to cantourage to make sure all received and they said will be shipped today. This morning the only tracking event is 'sender preparing item' at 18:52pm yesterday.

Is this down to the Xmas rush or has it gone missing? Or is there a chance its going to come Monday? If so has anyone been able to have it delivered to a place of work before?

Thank you to any who read and reply :)

Will be excited to try this, I haven’t seen anything else this cheap on here

I find the Mamedica repeat prescription page an absolute nightmare to try and see what's available to order - I've had a script that I was running for a while to help display the available medications better and I figured more patients could benefit from it so I've turned it into a free web app at https://www.mamedtracker.co.uk . Hopefully someone finds it useful and please feel free to reach out if you have any feedback or suggestions.

If you had the option what one would you choose and why?

Just ordered the arizer air max was either this device or the solo 2 .. I hope I’ve made the correct choice

It’s seems to have very good reviews for the price of the unit

Will report back when it arrives

Any personal experience with the device is welcomed

Purchased it for a decent price .. £128.25 From magicvaporizers

It’s on discount but I added the code UKMEDICAL FOR MORE DISCOUNT 😍

Have a great day

Recieve my fine cookies this morning. And I'm impressed!! Looks 🔥 smells gassy. £5 G .For anyone who might be undecided!