Has anyone else encountered this? Four days of taking 50mg diphenhydramine hydrochloride and my face is furious. I honestly never put the two together until today. I’m 98% certain there’s a connection here.

Hello everyone!

I have not had histamine issues in the past. I was taking NAC 600mg for a few days, and maybe on the fourth day I had a histamine response (scratchy throat, congestion, dry eyes). I have stopped taking NAC. However, I still have minor episode of histamine after eating occasionally - still the congestion, dry eyes, and scratchy throat. It's been a week now.

Ive seen some people post about this. Has this cleared up for anyone? What helped? I'm a bit lost and very anxious that I potentially gave myself a histamine intolerance? Looking for guidance!

I’ve been doing really well and recently started a Vitamin E supplement that’s derived from Annatto. I felt really good the first few days but have since had a huge flare. My lymph nodes are swollen and my anxiety is through the roof. I went to the dentist to double check that it wasn’t a tooth thing. She initially thought there could be something going on with one of my teeth but took a different X-ray and decided it was just a swollen lymph node. Does anyone have experience with Annatto? I took a Benadryl and really hopes it helps like it did the last time I felt like this. This is awful.

I’ve struggled with anxiety for years, but for the last two, my sleep has been awful. I wake up at around 2 a.m. every morning with a racing heart and night sweats, which I think might be linked to histamine intolerance. I recently started a low-histamine diet, and it’s helping during the day—I feel less anxious, have more energy, and my mind feels clearer. But I’m still waking up at 2 a.m. every night.

My main issue is that any time I take a supplement (whether it’s a powdered capsule or a tablet), I get histamine intolerance symptoms, especially waking up at 2 a.m., and even worse than usual. I want to take DAO or other supplements to help with the histamine issues, but I’m afraid they’ll trigger a reaction. I’ve tried both cheap and high-quality supplements, so I don’t think it’s a quality issue.

Has anyone else experienced this? Will sticking with the low-histamine diet eventually make supplements easier to tolerate? Any advice or similar experiences would be really helpful!

So after doing just about anything (exercising, walking in the sun, eating most foods) I’ve been getting facial flushing amongst many other things. I was on Mirtazapine 3 months ago and I’m worried I picked up MCAS somehow. Anybody have experience/knowledge with this?

I commonly have acid reflux and other reactions with both.

Hi, i lost weight from 74kg to 63. Can someone have a experience about taking maltodextrin for weigh gain? I know, its not a great product for microbiom.

Hey friends- I feel like this might be a strange question, but I recently started a LH diet (literally three days ago) and was shocked at the almost immediate difference I felt and saw in my body, but have also been having really bad brain fog. I was in an EoE and interstitial cystitis flare for weeks and it has stopped almost completely when starting the diet. I am most definitely stoked about this, but the brain fog is incredibly gnarly. I was wondering if anyone else experienced a worsening of brain fog after coming down off a flare? I’m guessing it makes sense with the amount of inflammation that has come down + my nervous system being wayyyyy more relaxed than usual but I figured I would ask.

Hello everybody,
Just a general question—my wife has been managing histamine intolerance for some time now, and recently, something strange occurred. A few days before a major flare-up, she experienced episodes of shortness of breath and general weakness. Has anyone else noticed pre-flare symptoms like this? Is there a pattern to it, or could it be just a coincidence? Any insights or shared experiences would be greatly appreciated.

I’m new to understanding histamine, but I know that I suffer from sensitivity to it

My main symptoms are itching and hives, I don’t get too many other bad symptoms thankfully

I’m amidst a flare up ATM so I’m avoiding the obvious culprits like fermented foods, wine, leftovers

I absolutely do not want to take anti histamines as I was on a regular dose for 5 months and they made me rapidly gain weight and caused memory less for me

So I’m looking for tried and tested things that help

I’m aware of ginger, vitamin C, syncing circadian rhythm, stress reduction, estrogen …

But I’m less aware of what to actually practically do

So please - comment your best tips!

Thank you 🙏🏼

Hi there. I recently got diagnosed with MCAS and I'm trying to understand how exactly histamine develops on leftover food

So far I learned that cooking plays a big role and protein somehow too but I can't really research too much because of a cognitive condition

It would be amazing if somebody could explain it in simple terms for my goofed up brain 🙏

Hi,

For the past 2 or 3 years I have struggled with sleeping more than 6 hours at night. In contrast when between 20-26 (I'm 31 now) I was able to easily get 8 hours of sleep, so I consider that the "normal" for me.

Lately I have been consistenly going to sleep at 22:30 but I am still waking up at least an hour before my alarm with just 5-6 hours of sleep and it only seems to go in the direction of waking up earlier and earlier.

Summary of things I think might be symptoms:

• Maintenance insomnia. I struggle with sleeping more than 6 hours which is not normal for me. Even if I have slept poorly the day before and I yawn like crazy, Sleepiness seems to evade me.
• I went to another part of the country and got several mosquito bites and got skeeter syndrome. Which is the first time in my life I've had such a severe allergic reaction. I got some anti histamines and noticed my sleep was better. Even though it was supposed to be a "non-slowing" antihistamine.
• I feel bloated easily, especially lately
• I feel like my body is "warm" or like my skin is flushing, even though I dont sweat easily Although this is mild
• I have also had a couple of instances where I feel like my head "spins" and I get dizzy. This happens when im sitting down or standing still.
• I also feel like my chest is tight, and its sometimes hard to get the air completely down into my lungs. But when I exercise I never feel more out of breath than normal.

I dont really feel tired during the day, but I still feel like my brain works slower and I don't remember as well as I used to. I also recently went through a weight loss of 30 kg. For reference I am 183 cm and 95 kg now.

I have no allergies I know of, and my doctor took all sorts of blood tests, and said I everything was normal. But something is definitely wrong.

Any input would be greatly appreciated!

I can tolerate NAC because of High methylation So I decided to take Glutathione Directly Does this increase Histamine

I’m at a loss. I haven’t had a flare for at least 6 months, at that time I was trying to quit cannabis. After about a month of being sober I started back up with the flares. I started smoking again to test if the cannabis was aiding in reducing the antibodies to block the histamine. Here I am again trying to quit again and was 3 days sober on Sunday. Come Monday I had smoked again. Also on Monday I had two plates of leftovers from a restaurant. Before I went to bed I started to feel a headache creeping in. Come Tuesday and it had progressed to a full blown severe migraine, vomiting and nausea. I was bedridden until this morning. I’m seemingly okay now and trying to figure out if it was actually the leftovers, the withdrawal(even though I smoked Monday,) or both. Idk, I’m wondering if maybe I should go low histamine with some supplement supports and then try to quit again. I really want to quit the inhaling, psychoactive aspect. Would a full spectrum CBD be a good alternative?

i had just gotten over a head cold. i was feeling much better with the meds i was given. while i was at a house watching a dog, i had a severe allergic reaction. i'm slightly allergic to dander but take zyrtec to help with that. haven't really had an issue since. i felt like i couldn’t breathe, i was wheezing, my heart rate was very high (150s, 160s), and every movement was unbearable. nyquil and my cough syrup didn’t do anything, which was very unusual (i was sleeping over at their house).

the next day i went to urgent care. i couldn’t take it anymore and i got no sleep. when i left, 15-20 minutes later, i actually felt like i could breathe again. the only thing that happened was when i went up to pay, i felt nauseous, dizzy and like i was gonna pass out. nothing really new when i don’t feel well. but when i went back to the house all the symptoms came back again.

urgent care asked if i had asthma, i said no. my primary asked if i had an epipen, i said no. my primary nurse was actually shocked i don’t have an epipen and wants me to have one. they were all very concerned and could still hear the wheezing yesterday when i went.

my mind is going crazy thinking this could be connected to my head cold. but to be completely honest, nothing like this has ever happened to me before. it was incredibly scary. i’m also happy to say i now have an epipen on me which i’m very grateful about.

i’m going in for allergy testing next week. i am incredibly lucky to get in so soon, it’s very rare. but i am still very shaken up and not sure what to expect. not how i wanted my week to go 🥲

I found something out a couple of days that really shocked me. I'm currently suffering from a wide range of health issues caused by histamine intolerance/MCAS. I now know that this is actually causing the movement I’ve been feeling in my teeth the last few years. I was just about to get braces but now I’m concerned that until my MCAS is under control they may move again! I’m in my 30s.

Here are a couple of links to the articles which talk about excessive histamine in the body affecting the tissues which hold teeth in place.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413485/

https://www.sciencedirect.com/science/article/abs/pii/S0889540610010267

I’m undiagnosed but suspect HI. I’ve been struggling to find an antidepressant that works for me. Prozac after a few days made me feel unbearably anxious, mirtazapine made me feel like I was burning from inside and out, now I’m on lexapro with olanzapine and it feels like lexapro is trying to give me a flare but olanzapine is acting as an antihistamine.

Has anyone had success with an antidepressant ?

I’m just so sick if how ridiculously itchy I get. I’m trying to take a break from antihistamines as I felt like my brain was turning to absolute mush after a year of taking them.

Does anyone else het extremely itchy + brain fog symptoms. Any tips on how to reduce the itchyness? It always moving around to different spots in my body. Often scalp, ears ,back of thighs, under my pecs, armpits. Also get tingly brow and mouth. I’m so over it.

Have been trying to eat low histamine and low fructose to avoid flareups. Just ate a pack of chips though and then went for a run and I was crqzy itchy after that. Had a shower and still itchy, idk what to do, I dont wanna have another antihistamine.

EDIT: interestingly eating a steak for dinner (the freshest I could find) eased up the itching. I have ordered some DAO enzyme so ill see how that goes. I think pollen could be contributing to the brain fog as well as allergies to certain foods, sometimes in the past I’ve noticed that my allergies go down after I run but might just be because I’m distracting myself idk.

For those that take Zyrtec every day, how many do you take?

I got no allegies per my blood qork and skin test bad and good thing can't be treated bad good thing it's not constant and got to take pills everyday..was told to take flonase though anyone know what works for this?

Hi all! I've been trying to do a low histamine diet for a couple months but I find it really difficult due to the amount of foods/ingredients I used to eat on the daily that I've had to cut out. I was wondering if there is anyone out there who was/is successfully able to eat a completely unrestricted diet (most/or all meals not low histamine) without any side effects just by purely relying on DAO supplements with every meal? (:

How did it go?

Hi! What's the most efficient method for getting diagnosed?

I want to see if I have a histamine issue due to various symptoms. I'm trying to do a low histamine diet trial, but not doing so well as a vegan (for ethical reasons) - it's super restrictive. I figured I'd try out the diet for 2 weeks and if I notice any positive changes, I'd see an allergist for confirmation. Is this the best route? I moved to a relatively rural area and am concerned that the only allergist in my health insurance network may not be aware of HIT.

Not related to the title, but I'm just not sure I can make it two weeks eating like this. I'm only a few days into the trial and each day I realize I've been eating something that I probably shouldn't (cinnamon was today's discovery). Which brings me to another issue - conflicting information...some say cinnamon is bad, the SIGHI list says it's fine. I'm also having trouble getting enough calories and enjoying my food. As you know, this is not fun. I'd rather not do this if it's not necessary.

Would using DAO for a week or two tell me anything? I've been lurking on here for a few weeks and I think I read that it can lose effectiveness over time if you use it routinely. Given your experiences, what would you recommend someone do to get diagnosed?

Any advice is appreciated!

Hi all,

I’m reaching out from desperation to figure out the mysterious cause of my symptoms!

After eating some meals (not every meal) I get palpitations, dry mouth, tingling in skin, burning in my eyes, slightly dizzy & brain fog.

I have also noticed a slight consistent redness around my lips.

Doctors haven’t been much help and I’ve really struggled to find a consistent correlation with food.

Does this sound like histamine intolerance or am I barking up the wrong tree?